scholarly journals Malpigmentation of Common Sole (Solea solea) during Metamorphosis Is Associated with Differential Synaptic-Related Gene Expression

Animals ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 2273
Author(s):  
Menelaos Kavouras ◽  
Emmanouil E. Malandrakis ◽  
Ewout Blom ◽  
Kyriaki Tsilika ◽  
Theodoros Danis ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nervous System ◽  
De Novo ◽  
Close Association ◽  
Ionic Channels ◽  
Long Term Potentiation ◽  
General Term ◽  
The Difference ◽  
Common Sole

In farmed flatfish, such as common sole, color disturbances are common. Dyschromia is a general term that includes the color defects on the blind and ocular sides of the fish. The purpose was to examine the difference in gene expression between normal pigmented and juveniles who present ambicoloration. The analysis was carried out with next-generation sequencing techniques and de novo assembly of the transcriptome. Transcripts that showed significant differences (FDR < 0.05) in the expression between the two groups, were related to those of zebrafish (Danio rerio), functionally identified, and classified into categories of the gene ontology. The results revealed that ambicolorated juveniles exhibit a divergent function, mainly of the central nervous system at the synaptic level, as well as the ionic channels. The close association of chromophore cells with the growth of nerve cells and the nervous system was recorded. The pathway, glutamate binding–activation of AMPA and NMDA receptors–long-term stimulation of postsynaptic potential–LTP (long term potentiation)–plasticity of synapses, appears to be affected. In addition, the development of synapses also seems to be affected by the interaction of the LGI (leucine-rich glioma inactivated) protein family with the ADAM (a disintegrin and metalloprotease) ones.

scholarly journals Multiplexed neurochemical transmission emulated using a dual-excitatory synaptic transistor

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Mingxue Ma ◽  
Yao Ni ◽  
Zirong Chi ◽  
Wanqing Meng ◽  
Haiyang Yu ◽  
...  
Keyword(s):  
Neural Network ◽  
Central Nervous System ◽  
Nervous System ◽  
Long Term Potentiation ◽  
Short Term ◽  
Term Potentiation ◽  
Binary Neural Network ◽  
Neuromorphic Systems ◽  
Human Brains

AbstractThe ability to emulate multiplexed neurochemical transmission is an important step toward mimicking complex brain activities. Glutamate and dopamine are neurotransmitters that regulate thinking and impulse signals independently or synergistically. However, emulation of such simultaneous neurotransmission is still challenging. Here we report design and fabrication of synaptic transistor that emulates multiplexed neurochemical transmission of glutamate and dopamine. The device can perform glutamate-induced long-term potentiation, dopamine-induced short-term potentiation, or co-release-induced depression under particular stimulus patterns. More importantly, a balanced ternary system that uses our ambipolar synaptic device backtrack input ‘true’, ‘false’ and ‘unknown’ logic signals; this process is more similar to the information processing in human brains than a traditional binary neural network. This work provides new insight for neuromorphic systems to establish new principles to reproduce the complexity of a mammalian central nervous system from simple basic units.

scholarly journals GluA1 trafficking and metabotropic NMDA: addressing results from other laboratories inconsistent with ours

2014 ◽  
Vol 369 (1633) ◽  
pp. 20130145 ◽  
Author(s):  
Sadegh Nabavi ◽  
Rocky Fox ◽  
Stephanie Alfonso ◽  
Jonathan Aow ◽  
Roberto Malinow
Keyword(s):  
Fluorescent Protein ◽  
Long Term Potentiation ◽  
Long Term Depression ◽  
Mk 801 ◽  
Over Expression ◽  
Term Potentiation ◽  
The Difference ◽  
Green Fluorescent ◽  
Gfp Tag

We have previously shown that when over-expressed in neurons, green fluorescent protein (GFP) tagged GluA1 (GluA1-GFP) delivery into synapses is dependent on plasticity. A recent study suggests that GluA1 over-expression leads to its incorporation into the synapse, in the absence of additional long-term potentiation-like manipulations. It is possible that a GFP tag was responsible for the difference. Using rectification index as a measure of synaptic delivery of GluA1, we found no difference in the synaptic delivery of GluA1-GFP versus untagged GluA1. We recently published a study showing that while D-APV blocks NMDAr-dependent long-term depression (LTD), MK-801 and 7-chloro kynurenate (7CK) fail to block LTD. We propose a metabotropic function for the NMDA receptor in LTD induction. In contrast to our observations, recent unpublished data suggest that the above antagonists are equally effective in blocking LTD. We noticed different methodology in their study. Here, we show that their methodology has complex effects on synaptic transmission. Therefore, it is not possible to conclude that 7CK is effective in blocking LTD from their type of experiment.

184 CHANGES IN GENE EXPRESSION IS ASSOCIATED WITH SPINAL CORD LONG-TERM POTENTIATION

2006 ◽  
Vol 10 (S1) ◽  
pp. S50c-S50
Author(s):  
L.M. Jacobsen ◽  
L.M. Pedersen ◽  
J. Gjerstad
Keyword(s):  
Gene Expression ◽  
Spinal Cord ◽  
Long Term Potentiation ◽  
Term Potentiation

Changes in gene expression of Zif, c-fos and cyclooxygenase-2 associated with spinal long-term potentiation

Neuroreport ◽  
2005 ◽  
Vol 16 (13) ◽  
pp. 1477-1481 ◽  
Author(s):  
Johannes Gjerstad ◽  
Guro F. Lien ◽  
Linda M. Pedersen ◽  
Elin C. Valen ◽  
Steen Mollerup
Keyword(s):  
Gene Expression ◽  
Long Term Potentiation ◽  
Cyclooxygenase 2 ◽  
Term Potentiation

scholarly journals Gene Expression in Hippocampal Long-Term Potentiation

1999 ◽  
Vol 5 (5) ◽  
pp. 275-279 ◽  
Author(s):  
Serena M. Dudek ◽  
R. Douglas Fields
Keyword(s):  
Gene Expression ◽  
Long Term Potentiation ◽  
Term Potentiation

scholarly journals FORMATION MECHANISMS OF LONG-TERM POTENTIATION IN THE HIPPOCAMPUS NEURONS

2021 ◽  
Vol 67 (6) ◽  
pp. 74-83
Author(s):  
A.O. Nastenko ◽  
◽  
N.S. Veselovsky ◽  
Keyword(s):  
Nervous System ◽  
Axonal Transport ◽  
Living Organism ◽  
Long Term Potentiation ◽  
Synaptic Activity ◽  
Formation Mechanisms ◽  
Glutamatergic Synapses ◽  
Physiological Mechanisms ◽  
Term Potentiation

Long-term potentiation is involved in the mechanisms of synaptic plasticity, provides such processes as memory and learning, and allows the nervous system of a living organism to adapt to changing environmental conditions. It is an increase in the efficiency of glutamatergic synapses, which lasts much longer than other types of potentiation in the nervous system. Despite the fact that long-term potentiation has been studied in detail, the physiological mechanisms of its formation, which lead to an increase of synaptic weight, remain incompletely understood. Well known that long-term potentiation is closely dependent on the processes of rapid axonal transport. However, how axonal transport is related to the mechanisms of long-term potentiation induction and expression, what substances are transported through axons, and how they affect the synaptic activity of postsynaptic neurons is currently unknown. We review here the main physiological mechanisms that occur in the neurons of the hippocampus and contribute to the formation of long-term potentiation. The works of recent years devoted to the study of the participation of synaptic tagging, retrograde signaling, morphological modifications and axonal transport in formation of the long-term potentiation are analyzed.

Spinal cord long-term potentiation (LTP) is associated with increased dorsal horn gene expression of IL-1β, GDNF and iNOS

2010 ◽  
Vol 14 (3) ◽  
pp. 255-260 ◽  
Author(s):  
Linda M. Pedersen ◽  
Line M. Jacobsen ◽  
Steen Mollerup ◽  
Johannes Gjerstad
Keyword(s):  
Gene Expression ◽  
Spinal Cord ◽  
Dorsal Horn ◽  
Long Term Potentiation ◽  
Term Potentiation
Sign in / Sign up

Export Citation Format

Share Document