Improving the Therapeutic Potential of Human Granzyme B for Targeted Cancer Therapy

: Nucleolin is a protein abundantly present in the nucleolus, but its expression on the surface of cells is potentially associated with various types of malignancies. So far, several nucleolin-targeting strategies, including the nucleolin-targeting peptide, anti-nucleolin pseudopeptides, anti-nucleolin antibodies, and the anti-nucleolin aptamer, AS1411, have been developed and investigated in different types of studies. The AS1411 aptamer has been known as the outstanding approach for targeting nucleolin with superior specificity and therapeutic potential in comparison with other targeting strategies. In this review, we highlight different nucleolin-targeting strategies for the targeted delivery of chemotherapeutic drugs, proteins with therapeutic potential, and toxins.

Download Full-text

Targeted Cancer Therapy; Nanotechnology Approaches for Overcoming Drug Resistance

Current Medicinal Chemistry ◽

10.2174/0929867322666150209151851 ◽

2015 ◽

Vol 22 (11) ◽

pp. 1335-1347 ◽

Cited By ~ 12

Author(s):

Yan Gao ◽

Jacson Shen ◽

Lara Milane ◽

Francis Hornicek ◽

Mansoor Amiji ◽

...

Keyword(s):

Drug Resistance ◽

Cancer Therapy ◽

Targeted Cancer Therapy

Download Full-text

Biological Carrier Molecules of Radiopharmaceuticals for Molecular Cancer Imaging and Targeted Cancer Therapy

Current Pharmaceutical Design ◽

10.2174/1381612819666140110114902 ◽

2014 ◽

Vol 20 (32) ◽

pp. 5218-5244 ◽

Cited By ~ 8

Author(s):

A. Aerts ◽

N.R.E.N. Impens ◽

M. Gijs ◽

M. D'Huyvetter ◽

H. Vanmarcke ◽

...

Keyword(s):

Cancer Therapy ◽

Cancer Imaging ◽

Targeted Cancer Therapy

Download Full-text

Tumour Mutation Profiling with High-throughput Multiplexed Genotyping: A Review of its Use for Guiding Targeted Cancer Therapy

Current Cancer Therapy Reviews ◽

10.2174/157339470904140418093822 ◽

2014 ◽

Vol 9 (4) ◽

pp. 236-244

Author(s):

Mark McKeage ◽

Phillip Shepherd ◽

Masato Yozu ◽

Donald R. Love

Keyword(s):

Cancer Therapy ◽

High Throughput ◽

Targeted Cancer Therapy ◽

Mutation Profiling

Download Full-text

Classic and Novel Signaling Pathways Involved in Cancer: Targeting the NF-κB and Syk Signaling Pathways

Current Stem Cell Research & Therapy ◽

10.2174/1574888x13666180723104340 ◽

2019 ◽

Vol 14 (3) ◽

pp. 219-225 ◽

Cited By ~ 6

Author(s):

Cong Tang ◽

Guodong Zhu

Keyword(s):

Cancer Therapy ◽

Tyrosine Kinase ◽

Signaling Pathways ◽

Molecular Mechanisms ◽

Therapeutic Potential ◽

Cell Receptor ◽

Transmembrane Receptors ◽

Biological Responses ◽

Different Types

The nuclear factor kappa B (NF-κB) consists of a family of transcription factors involved in the regulation of a wide variety of biological responses. Growing evidence support that NF-κB plays a major role in oncogenesis as well as its well-known function in the regulation of immune responses and inflammation. Therefore, we made a review of the diverse molecular mechanisms by which the NF-κB pathway is constitutively activated in different types of human cancers and the potential role of various oncogenic genes regulated by this transcription factor in cancer development and progression. We also discussed various pharmacological approaches employed to target the deregulated NF-κB signaling pathway and their possible therapeutic potential in cancer therapy. Moreover, Syk (Spleen tyrosine kinase), non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immune-receptors like the B-cell receptor (BCR), which can also activate the inflammasome and NF-κB-mediated transcription of chemokines and cytokines in the presence of pathogens would be discussed as well. The highlight of this review article is to summarize the classic and novel signaling pathways involved in NF-κB and Syk signaling and then raise some possibilities for cancer therapy.

Download Full-text