scholarly journals Chemotherapeutic, Toxin, and Therapeutic Protein Delivery via Nucleolin Aptamer-functionalized Nanoplatforms for Targeted Cancer Therapy

2021 ◽  
Vol 1 (1) ◽  
Author(s):  
Pouya Safarzadeh Kozani ◽  
Pooria Safarzadeh Kozani ◽  
Fatemeh Rahbarizadeh
Keyword(s):  
Cancer Therapy ◽  
Targeted Delivery ◽  
Protein Delivery ◽  
Therapeutic Potential ◽  
Therapeutic Protein ◽  
Targeted Cancer Therapy ◽  
Chemotherapeutic Drugs ◽  
Different Types ◽  
As1411 Aptamer ◽  
Targeting Peptide

: Nucleolin is a protein abundantly present in the nucleolus, but its expression on the surface of cells is potentially associated with various types of malignancies. So far, several nucleolin-targeting strategies, including the nucleolin-targeting peptide, anti-nucleolin pseudopeptides, anti-nucleolin antibodies, and the anti-nucleolin aptamer, AS1411, have been developed and investigated in different types of studies. The AS1411 aptamer has been known as the outstanding approach for targeting nucleolin with superior specificity and therapeutic potential in comparison with other targeting strategies. In this review, we highlight different nucleolin-targeting strategies for the targeted delivery of chemotherapeutic drugs, proteins with therapeutic potential, and toxins.

Classic and Novel Signaling Pathways Involved in Cancer: Targeting the NF-κB and Syk Signaling Pathways

2019 ◽  
Vol 14 (3) ◽  
pp. 219-225 ◽  
Author(s):  
Cong Tang ◽  
Guodong Zhu
Keyword(s):  
Cancer Therapy ◽  
Tyrosine Kinase ◽  
Signaling Pathways ◽  
Molecular Mechanisms ◽  
Therapeutic Potential ◽  
Cell Receptor ◽  
Transmembrane Receptors ◽  
Biological Responses ◽  
Different Types

The nuclear factor kappa B (NF-κB) consists of a family of transcription factors involved in the regulation of a wide variety of biological responses. Growing evidence support that NF-κB plays a major role in oncogenesis as well as its well-known function in the regulation of immune responses and inflammation. Therefore, we made a review of the diverse molecular mechanisms by which the NF-κB pathway is constitutively activated in different types of human cancers and the potential role of various oncogenic genes regulated by this transcription factor in cancer development and progression. We also discussed various pharmacological approaches employed to target the deregulated NF-κB signaling pathway and their possible therapeutic potential in cancer therapy. Moreover, Syk (Spleen tyrosine kinase), non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immune-receptors like the B-cell receptor (BCR), which can also activate the inflammasome and NF-κB-mediated transcription of chemokines and cytokines in the presence of pathogens would be discussed as well. The highlight of this review article is to summarize the classic and novel signaling pathways involved in NF-κB and Syk signaling and then raise some possibilities for cancer therapy.

scholarly journals Therapeutic potential of CAR-T cell-derived exosomes: a cell-free modality for targeted cancer therapy

Oncotarget ◽  
2015 ◽  
Vol 6 (42) ◽  
pp. 44179-44190 ◽  
Author(s):  
Xiang-Jun Tang ◽  
Xu-Yong Sun ◽  
Kuan-Ming Huang ◽  
Li Zhang ◽  
Zhuo-Shun Yang ◽  
...  
Keyword(s):  
T Cell ◽  
Cancer Therapy ◽  
Therapeutic Potential ◽  
Targeted Cancer Therapy ◽  
Car T Cell ◽  
Car T ◽  
A Cell

scholarly journals Conducting polymer nanoparticles for targeted cancer therapy

RSC Advances ◽  
2015 ◽  
Vol 5 (47) ◽  
pp. 37943-37956 ◽  
Author(s):  
Mona Doshi ◽  
Marissa Krienke ◽  
Saeid Khederzadeh ◽  
Henry Sanchez ◽  
Alicja Copik ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cancer Therapy ◽  
Conducting Polymer ◽  
Targeted Delivery ◽  
Reactive Oxygen ◽  
Polymer Nanoparticles ◽  
Oxygen Species ◽  
Targeted Cancer Therapy ◽  
Fluorescence Bioimaging

Functionalized conducting polymer nanoparticles allow for targeted delivery, tracking by fluorescence bioimaging, and therapeutics through formation of reactive oxygen species.

Co-administration of biocompatible self-assembled polylactic acid–hyaluronic acid block copolymer nanoparticles with tumor-penetrating peptide-iRGD for metastatic breast cancer therapy

2018 ◽  
Vol 6 (19) ◽  
pp. 3163-3180 ◽  
Author(s):  
Caifeng Deng ◽  
Xiaohong Xu ◽  
Drunp Tashi ◽  
Yongmei Wu ◽  
Bingyin Su ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hyaluronic Acid ◽  
Metastatic Breast Cancer ◽  
Block Copolymer ◽  
Cancer Therapy ◽  
Polylactic Acid ◽  
Targeted Delivery ◽  
Metastatic Breast ◽  
Chemotherapeutic Drugs ◽  
Breast Cancer Therapy

The safe and efficient targeted delivery of chemotherapeutic drugs has remained a challenge in metastatic breast cancer therapy.

scholarly journals Single Step Synthesis of Glutamic/tartaric Acid-stabilised Fe3O4 Nanoparticles for Targeted Delivery Systems

2020 ◽  
Vol 71 (2) ◽  
pp. 230-238
Author(s):  
Vladimir Lucian Ene ◽  
Ionela Andreea Neacsu ◽  
Ovidiu Oprea ◽  
Vasile Adrian Surdu ◽  
Roxana Doina Trusca ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Tartaric Acid ◽  
Targeted Delivery ◽  
Single Step ◽  
Targeted Cancer Therapy ◽  
One Pot ◽  
Transmission Electron ◽  
Negative Side Effects ◽  
Co Precipitation ◽  
Coating Agents

This paper aims to improve medical strategies regarding cancer treatment, by developing new targeted cancer therapy nanostructured systems, based on magnetite and natural catabolism products as coating agents (glutamic acid, tartaric acid), with induced cellular internalization. In order to create hydrophilic, biocompatible systems, suitable for targeted cancer therapy, and minimize the negative side effects of current approaches, a one-pot synthesis by co-precipitation technique, starting from Fe2+ and Fe3+ inorganic precursors and multifunctional organic compounds, carefully controlling the reaction parameters (concentration of precursors, pH, temperature etc.) was performed. The obtained Fe3O4 stabilised nanoparticles were subjected to morphological and structural characterization. The formation of inorganic-organic hybrid systems was evaluated using FTIR spectroscopy and complex thermal analysis (TG / DSC) for determining the content of the organic component, while X-ray Diffractometry and Scanning and Transmission Electron Microscopy were used to characterize the crystallinity and particle dimensions and distribution. The magnetic properties at room temperature were also evaluated, recording the magnetic susceptibility relative to the applied magnetic field.

Transferrin-conjugated paclitaxel prodrugs for targeted cancer therapy

RSC Advances ◽  
2016 ◽  
Vol 6 (81) ◽  
pp. 77987-77998 ◽  
Author(s):  
Lingling Shan ◽  
Xin Shan ◽  
Tinging Zhang ◽  
Kefeng Zhai ◽  
Guizhen Gao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Wide Spectrum ◽  
Targeted Cancer Therapy ◽  
Chemotherapeutic Drugs

Paclitaxel (PTX) is one of the most effective chemotherapeutic drugs ever developed and is effective against a wide spectrum of tumors.

Polymer-Lipid Hybrid Nanoparticles: A Next-Generation Nanocarrier for Targeted Treatment of Solid Tumors

2020 ◽  
Vol 26 (11) ◽  
pp. 1206-1215 ◽  
Author(s):  
Md. Rizwanullah ◽  
Meraj Alam ◽  
Harshita ◽  
Showkat R. Mir ◽  
Mohd. M.A. Rizvi ◽  
...  
Keyword(s):  
Drug Release ◽  
Solid Tumors ◽  
Targeted Delivery ◽  
Therapeutic Potential ◽  
Drug Loading ◽  
Building Blocks ◽  
Targeted Treatment ◽  
Hybrid Nanoparticles ◽  
Hybrid Architecture ◽  
Chemotherapeutic Drugs

: At present, cancer is the most deadly disease and one of the most common causes of death worldwide providing different obstacles to chemotherapy including non-specific biodistribution of chemotherapeutic drugs, dose-related adverse effects, development of metastasis and chemoresistance. Nanoparticle-based targeted delivery of chemotherapeutics gained enormous attention in the treatment of solid tumors as they provide many significant advantages including prolonged drug release, enhanced systemic half-life, decreased toxicity and targeted drug delivery. Polymer–lipid hybrid nanoparticles (PLHNPs) are the most effective nanoplatform that develop from building blocks of polymers and lipids. PLHNPs combine the unique advantages of both lipid-based nanoparticles as well as polymeric nanoparticles. PLHNPs integrate biocompatible polymers and biomimetic lipids in their architecture, which imparts PLHNPs with wide versatility for delivering chemotherapeutic drugs of different physicochemical characteristics to their target site of action. The hybrid architecture of PLHNPs provides many exceptional advantages such as small particle size, encapsulation of more than one anticancer drugs, high drug loading capacity and modified drug release profile. Furthermore, the surface decoration of PLHNPs improves the therapeutic potential of the chemotherapeutic drug by selective targeting of tumor tissue and reduces the side effects by decreasing non-specific biodistribution. This review highlights the challenges in the treatment of solid tumors by using nanoparticles system, rationale and targeting strategies of PLHNPs in the targeted treatment of solid tumors, and current progress of PLHNPs in the management of different types of solid tumors.

scholarly journals Improving the Therapeutic Potential of Human Granzyme B for Targeted Cancer Therapy

Antibodies ◽  
2013 ◽  
Vol 2 (4) ◽  
pp. 19-49 ◽  
Author(s):  
Grit Hehmann-Titt ◽  
Sonja Schiffer ◽  
Nina Berges ◽  
Georg Melmer ◽  
Stefan Barth
Keyword(s):  
Cancer Therapy ◽  
Therapeutic Potential ◽  
Granzyme B ◽  
Targeted Cancer Therapy
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