scholarly journals The Role of Antibiotic Resistant A. baumannii in the Pathogenesis of Urinary Tract Infection and the Potential of Its Treatment with the Use of Bacteriophage Therapy

Antibiotics ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 281
Author(s):  
Natalia Bagińska ◽  
Martyna Cieślik ◽  
Andrzej Górski ◽  
Ewa Jończyk-Matysiak
Keyword(s):  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Multi Drug Resistance ◽  
Bacteriophage Therapy ◽  
Antibiotic Resistant ◽  
Promising Alternative ◽  
Causative Agents ◽  
Tract Infections

Acinetobacter baumannii are bacteria that belong to the critical priority group due to their carbapenems and third generation cephalosporins resistance, which are last-chance antibiotics. The growing multi-drug resistance and the ability of these bacteria to form biofilms makes it difficult to treat infections caused by this species, which often affects people with immunodeficiency or intensive care unit patients. In addition, most of the infections are associated with catheterization of patients. These bacteria are causative agents, inter alia, of urinary tract infections (UTI) which can cause serious medical and social problems, because of treatment difficulties as well as the possibility of recurrence and thus severely decrease patients’ quality of life. Therefore, a promising alternative to standard antibiotic therapy can be bacteriophage therapy, which will generate lower costs and will be safer for the treated patients and has real potential to be much more effective. The aim of the review is to outline the important role of drug-resistant A. baumannii in the pathogenesis of UTI and highlight the potential for fighting these infections with bacteriophage therapy. Further studies on the use of bacteriophages in the treatment of UTIs in animal models may lead to the use of bacteriophage therapy in human urinary tract infections caused by A. baumannii in the future.

Effect of Vaccinium vitis-idaea tea and Arctostaphylos uva-ursi tea on growth of causative agents of urinary tract infections

2021 ◽  
Vol 3 (1) ◽  
Author(s):  
Lamija Hafizović ◽  
Selma Karup ◽  
Almin Hadžialić
Keyword(s):  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Colony Growth ◽  
Hospital Environment ◽  
Herbal Remedies ◽  
Antibiotic Resistant ◽  
Mueller Hinton ◽  
Causative Agents ◽  
Mueller Hinton Agar ◽  
Tract Infections

- Urinary tract infections pose a serious problem to people, both in the hospital environment and outside world. They are characterized by high mortality and ability to cause health problems in areas of the human body other than the urinary tract. It has been long clinical practice to treat these infections with antibiotics, a tactic made very ineffective with the advent of antibiotic-resistant microbial strains. The research has turned to alternative modes of treatment, such as use of herbal remedies to combat urinary tract infections. Effect of two types of herbal teas was observed through use of broth microdilution assay, to test varying concentrations of teas on the growth of selected microorganisms. Results were verified by assessment of colony growth on Mueller Hinton Agar plates. Tested microorganisms exhibited very dense colony growth. Similarity of conditions between urinary retention and conditions under which microorganisms were cultured in 96-well plates possible reason for density of growth. Methods with higher degree of confidence in treatment of urinary tract infections could likely be the combination of antibiotics with herbal teas.

scholarly journals Deep insights into urinary tract infections and effective natural remedies

2021 ◽  
Vol 27 (1) ◽  
Author(s):  
Bibi Sedigheh Fazly Bazzaz ◽  
Sareh Darvishi Fork ◽  
Reza Ahmadi ◽  
Bahman Khameneh
Keyword(s):  
Urinary Tract ◽  
Herbal Medicines ◽  
Main Body ◽  
Antibiotic Resistant ◽  
Duration Of Symptoms ◽  
Development Of Resistance ◽  
Natural Remedies ◽  
Tract Infections ◽  
Time Limitations

Abstract Background Urinary tract infection (UTI) is a common occurrence in females, during pregnancy, and in peri- and postmenopausal women. UTIs are associated with significant morbidity and mortality, and they affect the quality of life of the affected patients. Antibiotic therapy is an effective approach and reduces the duration of symptoms. Development of resistance, adverse effects of antibiotics, and other associated problems lead to establishing the research framework to find out the alternative approaches in controlling UTIs. Natural approaches have been extensively used for the management of various diseases to improve symptoms and also improve general health. Main body Different databases were employed to identify studies reporting on natural options including herbal medicines, vitamins, trace elementals, sugars, and probiotics without time limitations. Conclusion Herbal medicines can be effective at the first sign of the infection and also for short-term prophylaxis. Using vitamins, trace elementals, and/or sugars is an effective approach in preventing UTIs, and a combination of them with other antibacterial agents shows positive results. Probiotics have great potential for the threat of antibiotic over-usage and the prevalence of antibiotic-resistant microorganisms. This study may be of use in developing the efficient formulation of treatment of UTI.

scholarly journals The Role of Gut, Vaginal, and Urinary Microbiome in Urinary Tract Infections: From Bench to Bedside

Diagnostics ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 7
Author(s):  
Tomislav Meštrović ◽  
Mario Matijašić ◽  
Mihaela Perić ◽  
Hana Čipčić Paljetak ◽  
Anja Barešić ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Subsequent Development ◽  
Potential Influence ◽  
Urinary Microbiome ◽  
Important Field ◽  
Tract Infections ◽  
The Relationship ◽  
Current Paradigm

The current paradigm of urinary tract infection (UTI) pathogenesis takes into account the contamination of the periurethral space by specific uropathogens residing in the gut, which is followed by urethral colonization and pathogen ascension to the urinary bladder. Consequently, studying the relationship between gut microbiota and the subsequent development of bacteriuria and UTI represents an important field of research. However, the well-established diagnostic and therapeutic paradigm for urinary tract infections (UTIs) has come into question with the discovery of a multifaceted, symbiotic microbiome in the healthy urogenital tract. More specifically, emerging data suggest that vaginal dysbiosis may result in Escherichia coli colonization and prompt recurrent UTIs, while urinary microbiome perturbations may precede the development of UTIs and other pathologic conditions of the urinary system. The question is whether these findings can be exploited for risk reduction and treatment purposes. This review aimed to appraise the three aforementioned specific microbiomes regarding their potential influence on UTI development by focusing on the recent studies in the field and assessing the potential linkages between these different niches, as well as evaluating the state of translational research for novel therapeutic and preventative approaches.

scholarly journals Characterization of Anti-Bacterial Effect of the Two New Phages against Uropathogenic Escherichia coli

Viruses ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1348
Author(s):  
Lívia Slobodníková ◽  
Barbora Markusková ◽  
Michal Kajsík ◽  
Michal Andrezál ◽  
Marek Straka ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Therapeutic Potential ◽  
Medical Intervention ◽  
Uropathogenic Escherichia Coli ◽  
E Coli ◽  
Phage Cocktail ◽  
Causative Agents ◽  
Tract Infections

Urinary tract infections (UTIs) are among the events that most frequently need medical intervention. Uropathogenic Escherichia coli are frequently their causative agents and the infections are sometimes complicated by the presence of polyresistant nosocomial strains. Phage therapy is a tool that has good prospects for the treatment of these infections. In the present study, we isolated and characterized two bacteriophages with broad host specificity against a panel of local uropathogenic E. coli strains and combined them into a phage cocktail. According to genome sequencing, these phages were closely related and belonged to the Tequatrovirus genus. The newly isolated phages showed very good activity on a panel of local clinical E. coli strains from urinary tract infections. In the form of a two-phage cocktail, they were active on E. coli strains belonging to phylogroups B2 and D, with relatively lower activity in B1 and no response in phylogroup A. Our study is a preliminary step toward the establishment of a national phage bank containing local, well-characterized phages with therapeutic potential for patients in Slovakia.

439 THE ROLE OF THE URINE PRODUCTION IN RECURENT URINARY TRACT INFECTIONS IN WOMEN

2009 ◽  
Vol 8 (4) ◽  
pp. 230
Author(s):  
E.P. Van Haarst ◽  
E.B. Cornel ◽  
B.L. Ronkes ◽  
E.A. Heldeweg
Keyword(s):  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Urine Production ◽  
Tract Infections

Hospitalization for urinary tract infections and the quality of preventive health care received by people with spina bifida

2009 ◽  
Vol 2 (3) ◽  
pp. 145-152 ◽  
Author(s):  
Brian S. Armour ◽  
Lijing Ouyang ◽  
Judy Thibadeau ◽  
Scott D. Grosse ◽  
Vincent A. Campbell ◽  
...  
Keyword(s):  
Health Care ◽  
Urinary Tract ◽  
Spina Bifida ◽  
Urinary Tract Infections ◽  
Preventive Health Care ◽  
Preventive Health ◽  
Tract Infections

Role of NO in Urinary Tract Infections

1997 ◽  
pp. 428-442
Author(s):  
Robert M. Weiss ◽  
Marcia A. Wheeler ◽  
Shannon D. Smith
Keyword(s):  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Tract Infections

Role of Vaginal Colonization in Urinary Tract Infections (UTIs)

1999 ◽  
pp. 339-349 ◽  
Author(s):  
Anthony J. Schaeffer ◽  
Nithya Rajan ◽  
E. Thorburn Wright ◽  
James L. Duncan ◽  
Byron E. Anderson
Keyword(s):  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Vaginal Colonization ◽  
Tract Infections
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