Deep insights into urinary tract infections and effective natural remedies

Abstract Background Urinary tract infection (UTI) is a common occurrence in females, during pregnancy, and in peri- and postmenopausal women. UTIs are associated with significant morbidity and mortality, and they affect the quality of life of the affected patients. Antibiotic therapy is an effective approach and reduces the duration of symptoms. Development of resistance, adverse effects of antibiotics, and other associated problems lead to establishing the research framework to find out the alternative approaches in controlling UTIs. Natural approaches have been extensively used for the management of various diseases to improve symptoms and also improve general health. Main body Different databases were employed to identify studies reporting on natural options including herbal medicines, vitamins, trace elementals, sugars, and probiotics without time limitations. Conclusion Herbal medicines can be effective at the first sign of the infection and also for short-term prophylaxis. Using vitamins, trace elementals, and/or sugars is an effective approach in preventing UTIs, and a combination of them with other antibacterial agents shows positive results. Probiotics have great potential for the threat of antibiotic over-usage and the prevalence of antibiotic-resistant microorganisms. This study may be of use in developing the efficient formulation of treatment of UTI.

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The Role of Antibiotic Resistant A. baumannii in the Pathogenesis of Urinary Tract Infection and the Potential of Its Treatment with the Use of Bacteriophage Therapy

Antibiotics ◽

10.3390/antibiotics10030281 ◽

2021 ◽

Vol 10 (3) ◽

pp. 281

Author(s):

Natalia Bagińska ◽

Martyna Cieślik ◽

Andrzej Górski ◽

Ewa Jończyk-Matysiak

Keyword(s):

Urinary Tract ◽

Urinary Tract Infections ◽

Multi Drug Resistance ◽

Bacteriophage Therapy ◽

Antibiotic Resistant ◽

Promising Alternative ◽

Causative Agents ◽

Tract Infections

Acinetobacter baumannii are bacteria that belong to the critical priority group due to their carbapenems and third generation cephalosporins resistance, which are last-chance antibiotics. The growing multi-drug resistance and the ability of these bacteria to form biofilms makes it difficult to treat infections caused by this species, which often affects people with immunodeficiency or intensive care unit patients. In addition, most of the infections are associated with catheterization of patients. These bacteria are causative agents, inter alia, of urinary tract infections (UTI) which can cause serious medical and social problems, because of treatment difficulties as well as the possibility of recurrence and thus severely decrease patients’ quality of life. Therefore, a promising alternative to standard antibiotic therapy can be bacteriophage therapy, which will generate lower costs and will be safer for the treated patients and has real potential to be much more effective. The aim of the review is to outline the important role of drug-resistant A. baumannii in the pathogenesis of UTI and highlight the potential for fighting these infections with bacteriophage therapy. Further studies on the use of bacteriophages in the treatment of UTIs in animal models may lead to the use of bacteriophage therapy in human urinary tract infections caused by A. baumannii in the future.

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Hospitalization for urinary tract infections and the quality of preventive health care received by people with spina bifida

Disability and Health Journal ◽

10.1016/j.dhjo.2009.02.001 ◽

2009 ◽

Vol 2 (3) ◽

pp. 145-152 ◽

Cited By ~ 21

Author(s):

Brian S. Armour ◽

Lijing Ouyang ◽

Judy Thibadeau ◽

Scott D. Grosse ◽

Vincent A. Campbell ◽

...

Keyword(s):

Health Care ◽

Urinary Tract ◽

Spina Bifida ◽

Urinary Tract Infections ◽

Preventive Health Care ◽

Preventive Health ◽

Tract Infections

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Advances in the Management of Neurogenic Detrusor Overactivity in Multiple Sclerosis

International Journal of MS Care ◽

10.7224/1537-2073.2012-031 ◽

2013 ◽

Vol 15 (2) ◽

pp. 66-72 ◽

Cited By ~ 10

Author(s):

Gael J. Yonnet ◽

Anette S. Fjeldstad ◽

Noel G. Carlson ◽

John W. Rose

Keyword(s):

Quality Of Life ◽

Multiple Sclerosis ◽

Botulinum Toxin ◽

Urinary Tract ◽

Detrusor Overactivity ◽

Anticholinergic Drugs ◽

Neurogenic Detrusor Overactivity ◽

Botulinum Toxin Therapy ◽

Tract Infections

Bladder dysfunction in multiple sclerosis (MS) can be socially disabling, have negative psychological and economic consequences, and impair patients' quality of life. Knowledge of the functional anatomy and physiology of the urinary tract is essential to understand the symptoms associated with central nervous system lesions and the pharmacotherapies used to treat them. Treatments for neurogenic detrusor overactivity (NDO) have consisted mainly of administration of anticholinergic drugs, which have been shown to provide suboptimal clinical benefits and be poorly tolerated. The US Food and Drug Administration (FDA) approval of intravesicular botulinum toxin therapy provides a second-line option for MS patients with NDO not responsive to anticholinergic drugs. We performed a review of key literature pertaining to the intravesicular application of botulinum toxin. In the management of NDO, administration of intravesicular botulinum toxin using clean intermittent catheterization decreases the incidence of urinary tract infections, promotes urinary continence, and improves quality of life for 9 months after a single injection; moreover, those benefits are maintained with repeated injections over time.

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Summary of ‘Modes of administration for antibiotics for symptomatic severe urinary tract infections’, including tables of key findings and quality of included trials

Evidence-Based Child Health A Cochrane Review Journal ◽

10.1002/ebch.298 ◽

2009 ◽

Vol 4 (1) ◽

pp. 288-291

Author(s):

A. Pohl

Keyword(s):

Urinary Tract ◽

Urinary Tract Infections ◽

Tract Infections

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W069 RECURRENT LOWER URINARY TRACT INFECTIONS HAVE A DETRIMENTAL EFFECT ON PATIENT QUALITY-OF-LIFE

International Journal of Gynecology & Obstetrics ◽

10.1016/s0020-7292(12)61794-9 ◽

2012 ◽

Vol 119 ◽

pp. S727-S727

Author(s):

J. Renard ◽

M.T. Da Quinta e Costa de Mascarenhas Sa ◽

G.J. Wirth ◽

M. Zahran ◽

E. Quimper ◽

...

Keyword(s):

Quality Of Life ◽

Urinary Tract ◽

Urinary Tract Infections ◽

Lower Urinary Tract ◽

Detrimental Effect ◽

Tract Infections ◽

Lower Urinary

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Bladder Pain: The Patient Perspective

Urologia Journal ◽

10.5301/uj.5000261 ◽

2017 ◽

Vol 84 (1_suppl) ◽

pp. 5-7 ◽

Cited By ~ 3

Author(s):

Jane M. Meijlink

Keyword(s):

Quality Of Life ◽

Chronic Pain ◽

Urinary Tract ◽

Patient Perspective ◽

Pain Syndrome ◽

Bladder Pain Syndrome ◽

Bladder Pain ◽

Practical Support ◽

Tract Infections

Patients with chronic pain, discomfort and other urinary symptoms related to bladder pain syndrome or urinary tract infections may experience severely diminished quality of life and psychological and social problems, including depression, anxiety, and a sense of helplessness and hopelessness. These patients require empathy, understanding and practical support to allow them to cope with their chronic bladder disorder.

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Prevalence and antibiogram profile of uropathogens isolated from hospital and community patients with urinary tract infections in Dhaka City

Journal of Bangladesh Academy of Sciences ◽

10.3329/jbas.v37i1.15681 ◽

2013 ◽

Vol 37 (1) ◽

pp. 57-63 ◽

Cited By ~ 7

Author(s):

Afsana Fatema Noor ◽

Fariza Shams ◽

Saurab Kishore Munshi ◽

Munir Hassan ◽

Rashed Noor

Keyword(s):

Urinary Tract ◽

Resistance Rate ◽

E Coli ◽

Development Of Resistance ◽

Enterococcus Spp ◽

Tract Infections ◽

Academy Of Sciences ◽

Klebsiella Spp ◽

Effective Medication ◽

Culture Positive

Urinary tract infection (UTI) is increasingly rising in Bangladesh due to the development of resistance of causative pathogens against commonly prescribed antibiotics. Present study attempted to examine the prevalence of such uropathogens and their antibiogram profiles. Among 462 urine samples collected from patients with UTI, 100 were found to be culture positive. Escherichia coli (70%) was predominating, while Klebsiella spp. (11%) and Enterococcus spp. (6%) were also prevalent. About 96% uropathogens were sensitive against imipenem, and 75% against amikacin. The resistance rate of E. coli and Klebsiella spp. against ampicillin was 98.5 and 100%, respectively, and to cefotaxime, 84.3 and 72.8%, respectively. More than 80% resistance against these antibiotics was scored for other isolates. The frequency of drug resistance was found to be comparatively elevated in E. coli, Pseudomonas spp. and Proteus spp. Overall, the present investigation emphasized the need for routine screening of antibiotic resistance to promote effective medication against UTI. DOI: http://dx.doi.org/10.3329/jbas.v37i1.15681 Journal of Bangladesh Academy of Sciences, Vol. 37, No. 1, 57-63, 2013

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Quality of the diagnostic process in patients presenting with symptoms suggestive of bladder or kidney cancer: a systematic review

BMJ Open ◽

10.1136/bmjopen-2019-029143 ◽

2019 ◽

Vol 9 (10) ◽

pp. e029143 ◽

Cited By ~ 3

Author(s):

Yin Zhou ◽

Marije van Melle ◽

Hardeep Singh ◽

Willie Hamilton ◽

Georgios Lyratzopoulos ◽

...

Keyword(s):

Systematic Review ◽

Urinary Tract ◽

Kidney Cancer ◽

Cancer Diagnosis ◽

Data Extraction ◽

Diagnostic Delay ◽

Diagnostic Process ◽

Tract Infections ◽

Sex Disparity

ObjectivesIn urological cancers, sex disparity exists for survival, with women doing worse than men. Suboptimal evaluation of presenting symptoms may contribute.DesignWe performed a systematic review examining factors affecting the quality of the diagnostic process of patients presenting with symptoms of bladder or kidney cancer.Data sourcesWe searched Medline, Embase and the Cochrane Library from 1 January 2000 to 13 June 2019.Eligible criteriaWe focused on one of the six domains of quality of healthcare: timeliness, and examined the quality of the diagnostic process more broadly, by assessing whether guideline-concordant history, examination, tests and referrals were performed. Studies describing the factors that affect the timeliness or quality of the assessment of urinary tract infections, haematuria and lower urinary tract symptoms in the context of bladder or kidney cancer, were included.Data extraction and synthesisData extraction and quality assessment were independently performed by two authors. Due to the heterogeneity of study design and outcomes, the results could not be pooled. A narrative synthesis was performed.Results28 studies met review criteria, representing 583 636 people from 9 high-income countries. Studies were based in primary care (n=8), specialty care (n=12), or both (n=8). Up to two-thirds of patients with haematuria received no further evaluation in the 6 months after their initial visit. Urinary tract infections, nephrolithiasis and benign prostatic conditions before cancer diagnosis were associated with diagnostic delay. Women were more likely to experience diagnostic delay than men. Patients who first saw a urologist were less likely to experience delayed evaluation and cancer diagnosis.ConclusionsWomen, and patients with non-cancerous urological diagnoses just prior to their cancer diagnosis, were more likely to experience lower quality diagnostic processes. Risk prediction tools, and improving guideline ambiguity, may improve outcomes and reduce sex disparity in survival for these cancers.

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