scholarly journals Antimicrobial Resistance among Beta-Hemolytic Streptococcus in Brazil: An Overview

Antibiotics ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 973
Author(s):  
Rosana Rocha Barros
Keyword(s):  
Antimicrobial Resistance ◽  
Streptococcus Pyogenes ◽  
Streptococcus Agalactiae ◽  
Continuous Monitoring ◽  
Fluoroquinolone Resistance ◽  
Streptococcus Dysgalactiae ◽  
Nucleotide Substitutions ◽  
Hemolytic Streptococcus ◽  
Beta Hemolytic Streptococcus ◽  
Life Threatening

Streptococcus pyogenes, Streptococcus agalactiae and Streptococcus dysgalactiae subsp. equisimilis (SDSE) are the beta-hemolytic streptococci species with the most clinical relevance to humans. These species are responsible for several infections, ranging from mild to life-threatening diseases. Although resistance to recommended drugs has not been so critical as detected in other species, it has occurred in diverse regions. In Brazil, it is possible to observe an increasing macrolide and lincosamide resistance trend due to the spread of polyclonal strains. Macrolide–lincosamide–streptogramin B (MLS) resistance phenotypes have been prevalent among S. agalactiae and S. pyogenes, while M phenotype (resistance only to macrolides) has prevailed among SDSE resistant isolates. Fluoroquinolone resistance is rare in this country, reported only in S.agalactiae and S.pyogenes. This is due to nucleotide substitutions in gyrA and parC genes. Reduced penicillin susceptibility and vancomycin resistance, detected in other regions, have not yet been reported in Brazil. Tetracycline is not a therapeutical option, and resistance has occurred at high levels, especially among S.agalactiae. These findings highlight the need for continuous monitoring in order to track the occurrence of antimicrobial resistance among beta-hemolytic streptococci species circulating in this country.

scholarly journals Beta-hemolytic Streptococcus dysgalactiae strains isolated from horses are a genetically distinct population within the Streptococcus dysgalactiae taxon

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Marcos D. Pinho ◽  
Erdal Erol ◽  
Bruno Ribeiro-Gonçalves ◽  
Catarina I. Mendes ◽  
João A. Carriço ◽  
...  
Keyword(s):  
Streptococcus Dysgalactiae ◽  
Distinct Population ◽  
Hemolytic Streptococcus ◽  
Beta Hemolytic Streptococcus

scholarly journals First Streptococcus agalactiae Isolates Highly Resistant to Quinolones, with Point Mutations in gyrA and parC

2003 ◽  
Vol 47 (11) ◽  
pp. 3605-3609 ◽  
Author(s):  
Yoshiaki Kawamura ◽  
Hiromitsu Fujiwara ◽  
Noriko Mishima ◽  
Yuko Tanaka ◽  
Ayako Tanimoto ◽  
...  
Keyword(s):  
Amino Acid ◽  
Sequence Analysis ◽  
Amino Acid Sequence ◽  
Streptococcus Agalactiae ◽  
Double Point ◽  
Point Mutations ◽  
Comparative Sequence Analysis ◽  
Hemolytic Streptococcus ◽  
Beta Hemolytic Streptococcus ◽  
Resistant Strains

ABSTRACT Three isolates of Streptococcus agalactiae highly resistant to multiple fluoroquinolones were isolated in Japan. Compared with susceptible strains of S. agalactiae, these quinolone-resistant strains had double point mutations within the quinolone resistance-determining regions of gyrA and parC; Ser-81 was changed to Leu (TCA → TTA) in the amino acid sequence deduced from gyrA, and Ser-79 was changed to Phe (TCC → TTC) in the amino acid sequence deduced from parC. Comparative sequence analysis revealed the possibility of gene transfer between S. agalactiae and another beta-hemolytic streptococcus, Streptococcus difficile.

Wound Erysipelas Following Appendectomy Caused by Group B Beta-hemolytic Streptococcus (Streptococcus agalactiae)

2001 ◽  
Vol 2 (1) ◽  
pp. 37-40 ◽  
Author(s):  
Miguel Caínzos ◽  
Ehijab Y. Hindi ◽  
Fernando Fernandez ◽  
Faustino Rodriguez-Segade ◽  
Aquilino Ferandez ◽  
...  
Keyword(s):  
Streptococcus Agalactiae ◽  
Hemolytic Streptococcus ◽  
Beta Hemolytic Streptococcus ◽  
Group B

ANTIMICROBIAL RESISTANCE AND CLINICAL SIGNIFICANT RESISTANCE MECHANISMS OF SALMONELLA ISOLATED IN 2014-2018 IN ST.PETERSBURG, RUSSIA

2019 ◽  
Vol 64 (10) ◽  
pp. 620-626 ◽  
Author(s):  
Svetlana A. Egorova ◽  
Lidiya A. Kaftyreva ◽  
Lyudmila V. Suzhaeva ◽  
Anna V. Zabrovskaia ◽  
Elena V. Voitenkova ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Bacterial Pathogen ◽  
Resistance Mechanisms ◽  
Quinolone Resistance ◽  
Fluoroquinolone Resistance ◽  
Nucleotide Substitutions ◽  
Single Nucleotide ◽  
Saint Petersburg ◽  
Cephalosporin Resistance ◽  
High Level

The article presents the results of antimicrobial resistance monitoring of Salmonella isolated from children and adults with diarrhea in St. Petersburg in 2014-2018. In 746 isolates of 42 serovars more than 90,0% belonged to three: S. enteritidis (79,6%), S. typhimurium (6,8%) and S. infantis (3,8%). The antimicrobial susceptibility testing (according the EUCAST) to 7 classes of antimicrobials revealed the resistance in 78,6% of Salmonella. Low-level quinolone resistance (MIC of ciprofloxacin 0,12-0,5 mg/l) was detected in 63,3% isolates (S. enteritidis -71,0%, S. typhimurium - 15,7%, S. infantis - 89,3%) and was due to five kinds of single nucleotide substitutions in gyrA: Asp87Tyr - 36,1% of studied isolates (only S. infantis); Ser83Phe - 22,2% (only S. enteritidis); Asp87Asn - 19,4% (S. enteritidis, S. typhimurium, S. hadar, S. newport); Ser83Tyr -11,1% (S. enteritidis and S. infantis) and Asp87Gly - 8,3% (only S. enteritidis). Only in one S. kentucky isolate with high-level fluoroquinolone resistance (MIC of ciprofloxacin > 8,0 mg/l) two substitutions (Ser83Phe and Asp87Asn) were detected. Two Salmonella isolates (S. typhimurium and S. corvallis) had plasmid-mediated quinolone resistance (qnrS). Extended-spectrum cephalosporin resistance was found in 6 Salmonella serovars (1,6%). The bla-genes were detected: of genetic group CTX-M1 - in 10 isolates (serovars S. typhimurium, S. enteritidis, S. abony, S. coeln and S. virchow), CTX-M2 - in 2 S. typhimurium isolates, CTX-M9 - in three S. enteritidis isolates. In one S. typhimurium CTX-M1 and CTX-M2 were detected. The gene of CMY-2 (molecular class C cephalosporinase) was revealed in two isolates (S. newport and S. enteritidis). Our study showed that Salmonella (the main bacterial pathogen of acute diarrhea in children and adults) isolated in Saint-Petersburg had antimicrobial resistance to drugs of choice for salmonellosis treatment.

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