scholarly journals In Vitro Susceptibility to Ceftazidime/Avibactam and Comparators in Clinical Isolates of Enterobacterales from Five Latin American Countries

Antibiotics ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 62
Author(s):  
Tobias Manuel Appel ◽  
María Fernanda Mojica ◽  
Elsa De La Cadena ◽  
Christian José Pallares ◽  
Marcela A. Radice ◽  
...  

Background: High rates of resistance to third-generation cephalosporins and carbapenems in Enterobacterales have been reported in Latin America. Ceftazidime/avibactam (CZA) is the combination of a third-generation cephalosporin and a non-β-lactam β-lactamase inhibitor, which has shown activity against isolates producing class A, C and D β-lactamases. Herein, we evaluated the activity of CZA and comparators against clinical isolates of Enterobacterales in Latin America. Methods: The activity of CZA and comparators was evaluated against clinical isolates of Enterobacterales from Argentina, Brazil, Chile, Colombia and Mexico that were collected between January 2016 and October 2017. One specific phenotypic subset was evaluated. A carbapenem non-susceptible (CNS) phenotype was defined as any isolate displaying a minimum inhibitory concentration (MIC) ≥1 mg/L for ertapenem. Results: CZA was active against 95.8% of all isolates and 77.5% of CNS isolates. Fosfomycin (FOS) and tigecycline (TGC) were the second most active antibiotics with 93.4% of Enterobacterales being susceptible. Conclusions: The results of this study underline the potential therapeutic role of CZA in Latin America.

1993 ◽  
Vol 7 (1) ◽  
pp. 15-17
Author(s):  
Alice B. Lentz

Alice Lentz offers a brief view of the role of the Americas Fund for Independent Universities (AFIU) in relation to significant initiatives in various Latin American countries. In a region where the function and development of private higher education institutions is especially important, the focus of the AFIU's activities is on private universities' ability to provide trained business leaders with the skills necessary to meet the challenges of enterprise growth in these developing economies. She mentions in particular the strengthening of financing capabilities within the university, and the evolution of three-way partnerships among business corporations, AFIU, and universities in Latin America.


2019 ◽  
Vol 58 (1) ◽  
pp. 54-60 ◽  
Author(s):  
Beatriz Bustamante ◽  
Luis Ricardo Illescas ◽  
Andrés Posadas ◽  
Pablo E Campos

Abstract Azole resistance among Aspergillus fumigatus isolates, which is mainly related to mutations in the cyp51A gene, is a concern because it is rising, worldwide disseminated, and associated with treatment failure and death. Data on azole resistance of aspergillus from Latin American countries is very scarce and do not exist for Peru. Two hundred and seven Aspergillus clinical isolates collected prospectively underwent mycology and molecular testing for specie identification, and 143 isolates were confirmed as A. fumigatus sensu stricto (AFSS). All AFSS were tested for in vitro azole susceptibility, and resistant isolates underwent PCR amplification and sequencing of the whole cyp51A gene and its promoter. The in vitro susceptibility showed a minimal inhibitory concentration (MIC) range, MIC50 and MIC90 of 0.125 to >16, 0.25, and 0.5 μg/ml for itraconazole; 0.25 to 2, 0.5, and 0.5 μg/ml for voriconazole; and 0.003 to 1, 0.06, and 0.125 μg/ml for posaconazole. Three isolates (2%) showed resistance to itraconazole and exhibited different mutations of the cyp51A gene. One isolate harbored the mutation M220K, while a second one exhibited the G54 mutation plus a modification in the cyp51A gene promoter. The third isolate, from an azole naive patient, presented an integration of a 34-bp tandem repeat (TR34) in the promoter region of the gene and a substitution of leucine 98 by histidine (L98H). The three source patients had a diagnosis or suspicion of chronic pulmonary aspergillosis.


Author(s):  
Angel Belzunegui Eraso ◽  
David Dueñas Cid

In this chapter we focus on the growth of “new religions” and new religious movements in Latin America and attempt to find explanations for this growth. Although other explanations for the increase in religious plurality exist, we focus on the role of women in this development. The expansion of movements such as Pentecostalism is challenging the centrality of Catholicism in many Latin American countries. Basically, we therefore aim to answer the following question: Why has Pentecostalism grown so much in some Latin American countries while Catholicism has experienced a certain decline? One possible explanation for this is the role of women in this expansion, which has fostered greater social cohesion within families and communities. Pentecostalism has led to a certain empowerment of the women living in precarious conditions, affording them greater visibility and importance within their communities and giving them a role in the re-education of behaviours that are rooted in male domination.


1978 ◽  
Vol 6 (2) ◽  
pp. 135-149 ◽  
Author(s):  
Rogelio Pérez Perdomo

SummaryRogelio Pérez Perdomo is a Professor of Law at the Central University of Venezuela and an active member of the Latin American Council of Law and Development. A longstanding student of the purposes and methods of legal education, he has also made a special point to acquire knowledge about legal education in Europe and the United States.In this article Professor Pérez Perdomo discusses the inadequacies and shortcomings of the existing legal education programs in Latin America. He recognizes the growing awareness of such inadequacies on the part of many Latin American law teachers, and their dissatisfaction with the traditional systems and methods of law teaching. This dissatisfaction has generated many studies and discussions in the different Latin American countries, and it has also produced some changes and improvements. Professor Pérez Perdomo believes, however, that such changes fall significantly short of modern needs of adequate legal education. Concentrating on the situation in Venezuela, he compares it with current legal education innovations and developments in other Latin American countries, as well as in the major European countries and the United States.Professor Pérez Perdomo clearly admits his preference for further reforms of the legal education methods and programs in Venezuela (and, presumably, in other countries of Latin America). He views, however, student unrests as an invalid reason for such reforms because improvements must emerge from substantive needs rather than the temporary considerations of political expediency. Reforms must proceed from an appreciation of the true role of law and the legal profession.In a brief survey of the traditional and modern role of the law, especially its use as a vehicle for social and economic development, Professor Pérez Perdomo demonstrates the significance of their impact on legal education. Equally important, in his opinion, is the influence of foreign financial aid, e.g., the Ford Foundation, the International Legal Center, etc., which must have had a considerable impact on the emergence of new legal education trends. The effect of such influences has not yet been evaluated, but it is an important topic in any study of the effectiveness and desirability of international transfers of educational methods from one country to another. Thus, the United States legal education model encountered many difficulties in Latin America when the attempt was made to apply it there, and it can be used there only in a limited sense and in a significantly modified form.Professor Pérez Perdomo notes the following trends of legal education reform in Latin America: 1)The reorganization and “semestization” of law courses.2)The use of new teaching methods–tutorials, class discussions, working groups, and legal clinics–by various law schools in their efforts to enrich the content of their educational programs.3)The identification of the purposes and responsibilities of legal education in coordination with the general aims of law and the legal system.Professor Pérez Perdomo recognizes that many of these aspirations for reform are seriously affected by such factual limitations as, for example, the unfavorable numerical ratio of students to law faculty, inadequate teaching abilities of the professors, poverty and the small size of libraries, and the encumbersome administrative organization and fiscal procedure of universities. Despite these difficulties, Professor Pérez Perdomo is confident that the reform efforts will prevail and that many salutory improvements will eventually become evident in Latin American legal education.


Author(s):  
Angel Belzunegui Eraso ◽  
David Dueñas Cid

In this chapter we focus on the growth of “new religions” and new religious movements in Latin America and attempt to find explanations for this growth. Although other explanations for the increase in religious plurality exist, we focus on the role of women in this development. The expansion of movements such as Pentecostalism is challenging the centrality of Catholicism in many Latin American countries. Basically, we therefore aim to answer the following question: Why has Pentecostalism grown so much in some Latin American countries while Catholicism has experienced a certain decline? One possible explanation for this is the role of women in this expansion, which has fostered greater social cohesion within families and communities. Pentecostalism has led to a certain empowerment of the women living in precarious conditions, affording them greater visibility and importance within their communities and giving them a role in the re-education of behaviours that are rooted in male domination.


Author(s):  
O. Tkach ◽  
V. Tsvykh ◽  
M. Khylko ◽  
O. Batrymenko ◽  
D. Nelipa

Formulation of the problem. The authors analyze the current state and prospects for the development of the oil and gas complex and their role in the foreign policy of the Latin American states, policies of the use of oil and gas resources as a tool for enhancing influence in the region, as well as the functioning of multilateral oil supply agreements. The possibilities of realization of joint energy projects in Latin America are analyzed. The presence of oil and gas in the region has always been used as a political tool. The United States' reliance on Middle Eastern oil and the carbon emissions produced by the surging demand for fossil fuels in Asia tend to dominate discussions about the role of energy in U.S. foreign policy. But in recent years, the energy relationship between the United States and Latin America has perhaps become more important than other issues, as the largest share of the United States international trade and investment in the energy sector has occurred within the Western Hemisphere. Purpose of the researchis to study the role of the oil and gas complex in the foreign policy of Latin American countries. The oil and gas complex plays an important role in the foreign policy of Latin American countries. The Latin American energy market is quite attractive to transnational energy companies due to the huge volumes of cheap energy resources, the consumer market with growing energy demand. The energy markets of the Americas are deeply integrated. Despite the shale boom, which led to a sharp increase in U.S. oil production and a drop in imports, the United States still relies on Latin America for more than 30 percent of the oil it buys from abroad. The gas and gas complex part of the geological section is characterized by a similar lithological composition and the underlying rocks, containing oil and gas in industrial volumes. Research methods: The following research methods were used to address the issues set in the article: general scientific methods – descriptive, hermeneutic-political, systemic, structural-functional, comparative, institutional-comparative; general logical methods – empirical, statistical, prognostic modeling and analysis; special methods of political science. The preference was given to the method of political-system analysis, by which the common and distinctive characteristics of the basic components of immigration policy strategies were identified, reflecting existing political, public, information and other challenges for international relations and global development. The article of analysis. Latin America, a growing importer of U.S. natural gas and the largest market for U.S., makes refined petroleum products, such as gasoline. American oil companies and utilities are big investors in Argentina, Brazil, Mexico, and Venezuela, helping to develop the energy resources of all those countries. In Brazil, the United States direct investment in oil and gas extraction reached $2,4 billion in 2015; in Mexico, the figure was $420 million. Washington's financing and technical cooperation programs have further helped the development of new energy resources in the region. U.S. institutions and funds back up clean energy investments and provide regulatory and technical guidance to tap the region's shale fields.


2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S287-S287
Author(s):  
Tobias M Appel ◽  
Maria F Mojica ◽  
Elsa De La Cadena ◽  
Christian Pallares ◽  
Maria Virginia Villegas

Abstract Background Ceftazidime/avibactam (CZA) is a combination of a third-generation cephalosporin and a diazabicyclooctane β-lactamase inhibitor, which is active against a broad range of class A, C and D β-lactamases. In Colombia, high rates of multidrug-resistant Enterobacteriaceae (Ent)and P. aeruginosa (Pae) have been reported. Of special concern are KPC enzymes endemic in Ent and found in Pae, which are associated with higher mortality and healthcare costs, as well as limited therapeutic options. Herein, we evaluate the susceptibility of clinical isolates of carbapenem nonsusceptible Ent (CNS-E) and Pae (CNS-P) to CZA with the aim of understanding its role as a therapeutic option for these bacteria. Methods Three hundred ninety-nine nonduplicate clinical isolates of carbapenem nonsusceptible Gram-negative bacilli were collected in 13 medical centers from 12 Colombian cities, from January 2016 to October 2017 (137 K. pneumoniae [Kpn], 76 E. coli, 34 Enterobacter spp., 21 S. marcescens [Sma] and 131 Pae). CNS-E was defined as minimum inhibitory concentrations (MIC) ≥1 mg/L for ertapenem and CNS-P was defined as MIC ≥4 mg/L for meropenem. MIC were determined by broth microdilution and interpreted according to current CLSI guidelines. CZA MIC were determined using double dilutions of ceftazidime and a fixed concentration of avibactam of 4 mg/L. Comparator agents were ceftazidime, cefepime, piperacillin/tazobactam, imipenem, meropenem, tigecycline (TGC), and fosfomycin (FOS). Results Antimicrobial activity of CZA and comparators is shown in Table 1. CZA susceptibility ranged from 69% in Kpn to 81% in Sma, whereas 49% of CNS-P were susceptible to CZA. In both, CNS-E and CNS-P, CZA was superior to all other tested β-lactam compounds. Notably, in CNS-E CZA susceptibility was comparable to FOS and TGC (except for TGC in Sma). Conclusion CZA is the most active β-lactam against CNS-E and CNS-P. CZA nonsusceptibility suggests the presence of other resistance mechanisms, such as class B β-lactamases that are not inhibited by avibactam, and which are more frequently reported in CNS-P. Our results highlight the key role of new agents such as CZA in KPC endemic countries and the need for surveillance studies to determine the nature of resistance mechanisms. Disclosures All authors: No reported disclosures.


2019 ◽  
Vol 24 (1) ◽  
pp. 59-78 ◽  
Author(s):  
Pedro Pineda ◽  
Gustavo Gregorutti ◽  
Bernhard Streitwieser

Analyzing the number of publications and proportion of corresponding authors of Latin American scholars and scholars from the German Max Planck Society (MPS) and the Leibniz Association (LA; 1954–2018), this article asks if North–South partnerships continue to represent power imbalances. Our bibliometric analysis indicates that (a) in comparison with the LA, the MPS’s scientists published more articles with Latin American countries, led by Brazil, Chile, Argentina, and Mexico; (b) researchers from the MPS and the LA frequently took the role of corresponding author; (c) researchers from Brazil, Chile, Argentina, and Mexico primarily controlled their region’s productivity, but (d) Brazil built its own multinational research networks; and (e) countries with less productivity, such as Colombia and Uruguay, are on peripheries of research networks. Our findings indicate that the decolonial perspective needs further development to identify multipolar relationships of dominance and collaboration have developed out of a dichotomy world of North–South relations.


2017 ◽  
Vol 18 (2) ◽  
pp. 20170083
Author(s):  
Ryan Joy ◽  
Cesar M. Rodriguez ◽  
Inder J. Ruprah

This paper analyzes the long-run relationship between labor share and its determinants for 20 Latin American countries from 1980 to 2014. Using the pooled mean group estimator, we find evidence that technological change, the globalization process, and financial integration, have contributed to the decline of labor share in Latin America. We also find evidence of the importance of institutional factors and public spending for the labor share. Finally, we discuss the role of the informal sector on the dynamics of the decline. Our key findings are robust to various specifications and methodologies.


2020 ◽  
Vol 54 (1) ◽  
pp. 11-31
Author(s):  
Fabrício Ramos Neves ◽  
Mauricio Gómez-Villegas

Abstract Latin American countries have undergone a growing interest in international accounting standards. Several countries are making progress in the adoption of international standards driven by different internal factors as well as external dynamics. The role of experts in the design of public policies associated with international standards has been studied by the epistemic community theory, which is the theoretical framework used in this study to address the influence of different international organizations on the adoption of IPSAS in Brazil and Colombia. This paper discusses the isomorphic institutional pressure exerted over the governments of these two countries in order to meet an international standard considered to be adequate. Meanwhile, the emerging trend towards the adoption of IPSAS in Latin America continues to grow, although some obstacles to achieving the goals defined in the reform arise.


Sign in / Sign up

Export Citation Format

Share Document