scholarly journals Antimicrobial Resistance Risk Assessment Models and Database System for Animal-Derived Pathogens

Antibiotics ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 829
Author(s):  
Xinxing Li ◽  
Buwen Liang ◽  
Ding Xu ◽  
Congming Wu ◽  
Jianping Li ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Drug Resistance ◽  
Antimicrobial Resistance ◽  
Disease Risk ◽  
Resistance Index ◽  
Database System ◽  
Assessment Model ◽  
Risk Assessment Model ◽  
E Coli ◽  
Risk Assessment Models

(1) Background: The high use of antibiotics has made the issue of antimicrobial resistance (AMR) increasingly serious, which poses a substantial threat to the health of animals and humans. However, there remains a certain gap in the AMR system and risk assessment models between China and the advanced world level. Therefore, this paper aims to provide advanced means for the monitoring of antibiotic use and AMR data, and take piglets as an example to evaluate the risk and highlight the seriousness of AMR in China. (2) Methods: Based on the principal component analysis method, a drug resistance index model of anti-E. coli drugs was established to evaluate the antibiotic risk status in China. Additionally, based on the second-order Monte Carlo methods, a disease risk assessment model for piglets was established to predict the probability of E. coli disease within 30 days of taking florfenicol. Finally, a browser/server architecture-based visualization database system for animal-derived pathogens was developed. (3) Results: The risk of E. coli in the main area was assessed and Hohhot was the highest risk area in China. Compared with the true disease risk probability of 4.1%, the result of the disease risk assessment model is 7.174%, and the absolute error was 3.074%. Conclusions: Taking E. coli as an example, this paper provides an innovative method for rapid and accurate risk assessment of drug resistance. Additionally, the established system and assessment models have potential value for the monitoring and evaluating AMR, highlight the seriousness of antimicrobial resistance, advocate the prudent use of antibiotics, and ensure the safety of animal-derived foods and human health.

scholarly journals Risk factors, risk assessment, and prognosis in patients with gynecological cancer and thromboembolism

2019 ◽  
Vol 48 (4) ◽  
pp. 030006051989317
Author(s):  
Xindan Wang ◽  
Jing Huang ◽  
Zhao Bingbing ◽  
Shape Li ◽  
Li Li
Keyword(s):  
Risk Assessment ◽  
Gynecological Cancer ◽  
Area Under The Curve ◽  
Assessment Model ◽  
Receiver Operating Curve ◽  
Risk Level ◽  
Control Group ◽  
Risk Assessment Model ◽  
Vein Thrombosis ◽  
Risk Assessment Models

Objective This study aimed to investigate a suitable risk assessment model to predict deep vein thrombosis (DVT) in patients with gynecological cancer. Methods Data from 212 patients with gynecological cancer in the Affiliated Tumor Hospital of Guangxi Medical University were retrospectively analyzed. Patients were risk-stratified with three different risk assessment models individually, including the Caprini model, Wells DVT model, and Khorana model. Results The difference in risk level evaluated by the Caprini model was not different between the DVT and control groups. However, the DVT group had a significantly higher risk level than the control group with the Wells DVT or Khorana model. The Wells DVT model was more effective for stratifying patients in the DVT group into the higher risk level and for stratifying those in the control group into the lower risk level. Receiver operating curve analysis showed that the area under the curve of the Wells DVT, Khorana, and Caprini models was 0.995 ± 0.002, 0.642 ± 0.038, and 0.567 ± 0.039, respectively. Conclusion The Wells DVT model is the most suitable risk assessment model for predicting DVT. Clinicians could also combine the Caprini and Wells DVT models to effectively identify high-risk patients and eliminate patients without DVT.

scholarly journals Quantitative Microbiological Risk Assessment of Two Street Foods Sold in a Kenyan Town with Regard to Salmonella Contamination

2018 ◽  
Vol 6 (1) ◽  
pp. 41-50 ◽  
Author(s):  
Samuel Imathiu
Keyword(s):  
Risk Assessment ◽  
Maximum Dose ◽  
Storage Period ◽  
Assessment Model ◽  
Health Concern ◽  
Risk Assessment Model ◽  
Food Hygiene ◽  
Public Health Concern ◽  
Point Of Sale ◽  
Risk Assessment Models

Street sold foods have gained popularity in recent times, particularly in developing countries where their sale is often unregulated, hence, has a potential to transmitting pathogenic microorganisms which are of public health concern. A survey of two street foods, kachumbari (a type of a vegetable salad) and mandazi (a type of a wheat-based flour snack) was carried out in a Kenyan town to determine the prevalence and conduct a quantitative microbiological risk assessment to estimate the risks of infection due to consumption of the two products contaminated with Salmonella. A prevalence of 19% (16 out of 86 samples) and 7% (6 out of 86 samples) was observed for kachumbari and mandazi respectively. A risk assessment model composed of three different steps (nodes) comprising finished product (processed ready-to-eat), waiting (storage) period and consumption was used for the microbiological risk assessment. Models built in excel spreadsheets using @Risk software package, version 6 (Palisade USA) was used to obtain the inputs, outputs, and run the Monte Carlo simulations at 5000 iterations. The model estimated that in 95% of the cases, the consumers of kachumbari would be exposed to a maximum dose of 8.30 x 104 Salmonella cells per single serving. On the other hand, in 95% of the cases, consumers of mandazi would be exposed to a maximum dose of 4.0 x 104 Salmonella cells per single serving. The model also predicted that 64.3% and 69% of the population was at risk of developing salmonellosis upon consumption of contaminated kachumbari and mandazi respectively. The results indicate that these two products can contribute to high levels of salmonellosis morbidity. Nevertheless, a significant reduction in the level of ingested Salmonella cells in kachumbari and mandazi could be attained through a reduction of the prevalence of the pathogen contamination at or before the point of sale by the employment of good hygienic practices during their preparation and subsequent handling, in addition to enforcement of food hygiene regulations regarding street foods to ensure microbiologically safe foods are sold to the consumers. In order to improve the accuracy of this risk assessment model, more data, whenever available should be used in such studies.

Risk assessment model for venous thromboembolism in hospitalized surgical and non-surgical patients in the 4th Hungarian Antithrombotic Guidelines entitled “Diminution and Treatment of Venous Thromboembolism”

2010 ◽  
Vol 151 (34) ◽  
pp. 1365-1374 ◽  
Author(s):  
Marianna Dávid ◽  
Hajna Losonczy ◽  
Miklós Udvardy ◽  
Zoltán Boda ◽  
György Blaskó ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Venous Thromboembolism ◽  
Assessment Model ◽  
Surgical Patients ◽  
Risk Assessment Model

A kórházban kezelt sebészeti és belgyógyászati betegekben jelentős a vénásthromboembolia-rizikó. Profilaxis nélkül, a műtét típusától függően, a sebészeti beavatkozások kapcsán a betegek 15–60%-ában alakul ki mélyvénás trombózis vagy tüdőembólia, és az utóbbi ma is vezető kórházi halálok. Bár a vénás thromboemboliát leggyakrabban a közelmúltban végzett műtéttel vagy traumával hozzák kapcsolatba, a szimptómás thromboemboliás események 50–70%-a és a fatális tüdőembóliák 70–80%-a nem a sebészeti betegekben alakul ki. Nemzetközi és hazai felmérések alapján a nagy kockázattal rendelkező sebészeti betegek többsége megkapja a szükséges trombózisprofilaxist. Azonban profilaxis nélkül marad a rizikóval rendelkező belgyógyászati betegek jelentős része, a konszenzuson alapuló nemzetközi és hazai irányelvi ajánlások ellenére. A belgyógyászati betegek körében növelni kell a profilaxisban részesülők arányát és el kell érni, hogy trombózisrizikó esetén a betegek megkapják a hatásos megelőzést. A beteg trombóziskockázatának felmérése fontos eszköze a vénás thromboembolia által veszélyeztetett betegek felderítésének, megkönnyíti a döntést a profilaxis elrendeléséről és javítja az irányelvi ajánlások betartását. A trombózisveszély megállapításakor, ha nem ellenjavallt, profilaxist kell alkalmazni. „A thromboemboliák kockázatának csökkentése és kezelése” című, 4. magyar antithromboticus irányelv felhívja a figyelmet a vénástrombózis-rizikó felmérésének szükségességére, és elsőként tartalmazza a kórházban fekvő belgyógyászati és sebészeti betegek kockázati kérdőívét. Ismertetjük a kockázatbecslő kérdőíveket és áttekintjük a kérdőívekben szereplő rizikófaktorokra vonatkozó bizonyítékokon alapuló adatokat.

Signature Analysis: Statistical Models and Their Application to FA

1996 ◽  
Author(s):  
C.K. Lakshminarayan ◽  
S. Pabbisetty ◽  
O. Adams ◽  
F. Pires ◽  
M. Thomas ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Failure Analysis ◽  
Statistical Models ◽  
Essential Elements ◽  
Assessment Model ◽  
Signature Analysis ◽  
Risk Assessment Model ◽  
Sample Sizes ◽  
Reliability Engineering ◽  
Semiconductor Chips

Abstract This paper deals with the basic concepts of Signature Analysis and the application of statistical models for its implementation. It develops a scheme for computing sample sizes when the failures are random. It also introduces statistical models that comprehend correlations among failures that fail due to the same failure mechanism. The idea of correlation is important because semiconductor chips are processed in batches. Also any risk assessment model should comprehend correlations over time. The statistical models developed will provide the required sample sizes for the Failure Analysis lab to state "We are A% confident that B% of future parts will fail due to the same signature." The paper provides tables and graphs for the evaluation of such a risk assessment. The implementation of Signature Analysis will achieve the dual objective of improved customer satisfaction and reduced cycle time. This paper will also highlight it's applicability as well as the essential elements that need to be in place for it to be effective. Different examples have been illustrated of how the concept is being used by Failure Analysis Operations (FA) and Customer Quality and Reliability Engineering groups.

A semi-quantitative risk assessment model for the outbreak of grass carp hemorrhage

2013 ◽  
Vol 19 (3) ◽  
pp. 521-527 ◽  
Author(s):  
Song YANG ◽  
Shuqin WU ◽  
Ningqiu LI ◽  
Cunbin SHI ◽  
Guocheng DENG ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Grass Carp ◽  
Assessment Model ◽  
Quantitative Risk Assessment ◽  
Risk Assessment Model
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