scholarly journals Oxidative Stress Status in COVID-19 Patients Hospitalized in Intensive Care Unit for Severe Pneumonia. A Pilot Study

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 257
Author(s):  
Joël Pincemail ◽  
Etienne Cavalier ◽  
Corinne Charlier ◽  
Jean-Paul Cheramy–Bien ◽  
Eric Brevers ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Intensive Care Unit ◽  
Trace Elements ◽  
Intensive Care ◽  
Vitamin C ◽  
Reference Values ◽  
Reference Value ◽  
Severe Pneumonia ◽  
Oxidative Stress Status ◽  
Thiol Proteins

Background: A key role of oxidative stress has been highlighted in the pathogenesis of COVID-19. However, little has been said about oxidative stress status (OSS) of COVID-19 patients hospitalized in intensive care unit (ICU). Material and Methods: Biomarkers of the systemic OSS included antioxidants (9 assays), trace elements (3 assays), inflammation markers (4 assays) and oxidative damage to lipids (3 assays). Results: Blood samples were drawn after 9 (7–11) and 41 (39–43) days of ICU stay, respectively in 3 and 6 patients. Vitamin C, thiol proteins, reduced glutathione, γ-tocopherol, β-carotene and PAOT® score were significantly decreased compared to laboratory reference values. Selenium concentration was at the limit of the lower reference value. By contrast, the copper/zinc ratio (as a source of oxidative stress) was higher than reference values in 55% of patients while copper was significantly correlated with lipid peroxides (r = 0.95, p < 0.001). Inflammatory biomarkers (C-reactive protein and myeloperoxidase) were significantly increased when compared to normals. Conclusions: The systemic OSS was strongly altered in critically ill COVID-19 patients as evidenced by increased lipid peroxidation but also by deficits in some antioxidants (vitamin C, glutathione, thiol proteins) and trace elements (selenium).

scholarly journals Oxidative Stress Status in COVID-19 Patients Hospitalized in Intensive Care Unit for Severe Pneumonia. A Pilot Study

2021 ◽  
Vol 177 ◽  
pp. S119-S120
Author(s):  
Joël Pincemail ◽  
Etienne Cavalier ◽  
Corinne Charlier ◽  
Jean-Paul Cheramy-Bien ◽  
Eric Brevers ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Pilot Study ◽  
Severe Pneumonia ◽  
Oxidative Stress Status

scholarly journals Avaliação dos níveis de selênio e glutationa peroxidase em pacientes críticos

2020 ◽  
Vol 35 (3) ◽  
pp. 222-229
Author(s):  
Neyla Edelwais Silva ◽  
Cervantes Caporossi ◽  
Alberto Bicudo Salomão ◽  
Diana Borges Dock Nascimento ◽  
Daniela Alencar Moreira
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
High Risk ◽  
Glutathione Peroxidase ◽  
Reference Values ◽  
Reference Value ◽  
Moderate Risk ◽  
Albumin Ratio ◽  
Reactive Protein

Introduction: The ability of selenium to reduce free radicals, associated with its performance as an essential cofactor for glutathione peroxidase, confers a potential role for patients in the intensive care unit. The aim of this study was to evaluate the plasma levels of selenium and glutathione peroxidase at admission and for the period of 7 days of evolution in hospitalized patients. Methods: Observational study with adult patients (n = 22) admitted to the intensive care unit. Three blood samples were taken, on days 1, 3 and 7, to assess selenium, and two for glutathione peroxidase, on days 1 and 7. There was no type of intervention. Results: Selenium levels at admission were below the reference values in half of the patients. When stratifying patients (n = 22) according to the risk of infectious and inflammatory complications (C-reactive protein / albumin ratio), patients classified as high risk had selenium dosage at admission below those of moderate risk (p = 0.032). Among patients with complete follow-up (all dosages were performed), 66.7% were at high risk and among them 75% had selenium below the reference values and below the moderate risk group (p = 0.014). Glutathione peroxidase dosages were normal in all patients, regardless of classification. Conclusion: Approximately 50% of critically ill patients were admitted to the intensive care unit with selenium below the reference values. On admission and progression to the seventh day, patients classified as high risk had selenium dosage below the reference value and below that of patients at moderate risk.

Mechanical Ventilation Antioxidant Trial

2015 ◽  
Vol 24 (5) ◽  
pp. 440-445 ◽  
Author(s):  
Kimberly P. Howe ◽  
John M. Clochesy ◽  
Lawrence S. Goldstein ◽  
Hugh Owen
Keyword(s):  
Oxidative Stress ◽  
Intensive Care Unit ◽  
Mechanical Ventilation ◽  
Intensive Care ◽  
Vitamin E ◽  
Length Of Stay ◽  
Vitamin C ◽  
Rank Statistic ◽  
Antioxidant Supplementation ◽  
All Cause Mortality

Background Many patients each year require prolonged mechanical ventilation. Inflammatory processes may prevent successful weaning, and evidence indicates that mechanical ventilation induces oxidative stress in the diaphragm, resulting in atrophy and contractile dysfunction of diaphragmatic myofibers. Antioxidant supplementation might mitigate the harmful effects of the oxidative stress induced by mechanical ventilation. Objective To test the clinical effectiveness of antioxidant supplementation in reducing the duration of mechanical ventilation. Methods A randomized, prospective, placebo-controlled double-blind design was used to test whether enterally administered antioxidant supplementation would decrease the duration of mechanical ventilation, all-cause mortality, and length of stay in the intensive care unit and hospital. Patients received vitamin C 1000 mg plus vitamin E 1000 IU, vitamin C 1000 mg plus vitamin E 1000 IU plus N-acetylcysteine 400 mg, or placebo solution as a bolus injection via their enteral feeding tube every 8 hours. Results Clinical and statistically significant differences in duration of mechanical ventilation were seen among the 3 groups (Mantel-Cox log rank statistic = 5.69, df = 1, P = .017). The 3 groups did not differ significantly in all-cause mortality during hospitalization or in the length of stay in the intensive care unit or hospital. Conclusions Enteral administration of antioxidants is a simple, safe, inexpensive, and effective intervention that decreases the duration of mechanical ventilation in critically ill adults.

Serum trace elements levels in patients transferred from the intensive care unit to wards

2021 ◽  
Author(s):  
Kursat Gundogan ◽  
Yasemin Emur Gunay ◽  
Nurhayat Tugra Ozer ◽  
Gulsah G. Sahin ◽  
Nilgun Ozlem Alptekinoglu Mendil ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Trace Elements ◽  
Intensive Care ◽  
Serum Trace Elements

scholarly journals Effect of Respiratory Rehabilitation for a Patient with Severe Pneumonia and Intensive Care Unit Acquired Weakness (ICU-AW) Due to COVID-19

2021 ◽  
Vol 36 (5) ◽  
pp. 747-752
Author(s):  
Shunsuke NAOI ◽  
Shunsuke NAKAZATO ◽  
Junya KAMESAKO ◽  
Shusuke SEKINE ◽  
Hitoshi IMAIZUMI
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Severe Pneumonia ◽  
Respiratory Rehabilitation

scholarly journals Evaluation of sediment contamination by trace elements and the zooplankton community analysis in area affected by gold exploration in Southeast (SE) of the Iron Quadrangle, Alto Rio Doce, (MG) Brazil

2013 ◽  
Vol 25 (2) ◽  
pp. 150-157
Author(s):  
Cláudia de Lima e Silva ◽  
Adivane Terezinha da Costa ◽  
Giovanni Guimarães Landa ◽  
Herton Fabrício Camargos Fonseca ◽  
Aléssio Silveira
Keyword(s):  
Trace Elements ◽  
Reference Values ◽  
Zooplankton Community ◽  
Reference Value ◽  
Community Analysis ◽  
Major And Trace Elements ◽  
Geochemical Composition ◽  
Gold Exploration ◽  
Local Reference ◽  
High Concentrations

AIM: The aim was to verify the geochemical composition of sediments samples (riverbed and bank) and the relationship of the following elements: Al, As, Cd. Cr, Cu, Fe, Mn, Ni and Zn with the zooplankton community. METHODS: Bank and riverbed sediments were collected in four sampling points along the studied area, in June/2010 (dry season) and March/2011 (rainy season). Three types of analysis were performed: granulometric, mineralogical (by X-Ray diffractometer) and geochemical (by ICPOES), where for the last two types, only a fraction of silt/clay (<0.062 mm) was used, and the results were compared with the following reference values: Local Reference Value (Costa et al., 2010), Quality Reference Values (São Paulo, 2005), PEC and TEC values (MacDonald et al., 2000). For identification of the zooplankton community, riverbed and bank samples were collected in polyethylene bottles, suspended with deionized water (bank sample only), stained with Rose Bengal and preserved in formalin at 4%. RESULTS: As concentrations at Col sampled point were 18 times greater than the Local Reference Value (3.84 mg.kg-1). Cd concentrations were greater than the values established by the QRV (<0.5 mg.kg-1) and PEC (4.98 mg.kg-1) in almost all the sampled points, regarding seasonality. The following zooplanktonic species were identified: Arcella costata (Ehrenberg, 1847), Arcella discoides (Ehrenberg, 1843), Arcella vulgaris (Ehrenberg, 1830), Centropyxis aculeata (Ehrenberg, 1838), Centropyxis ecornis (Ehrenberg, 1841), Difflugia sp., Difflugia acuminata (Ehrenberg, 1838), Euglypha laevis (Perty, 1849), Trynema enchelys (Ehrenberg, 1938), Asplanchna priodonta (Gosse, 1850), and Bedelloida, with, approximately 81% belonging to the Protozoa group. CONCLUSIONS: The studied area, with the exception of the Tripuí point, was found to be impacted by historical gold exploration in the region, as well as by the growing urbanization. Within the elements considered to be the most toxic to the biota, As and Cd violated all their reference values. In spite of high concentrations of major and trace elements encountered at downstream points, testacea species were identified, suggesting that this group has the capacity to adapt to adverse situations.

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