scholarly journals Associations of Hyperactivity and Inattention Scores with Theta and Beta Oscillatory Dynamics of EEG in Stop-Signal Task in Healthy Children 7–10 Years Old

Biology ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 946
Author(s):  
Andrey V. Bocharov ◽  
Alexander N. Savostyanov ◽  
Helena R. Slobodskaya ◽  
Sergey S. Tamozhnikov ◽  
Evgeny A. Levin ◽  
...  
Keyword(s):  
Theta Rhythm ◽  
Spectral Power ◽  
Natural Variability ◽  
Stop Signal ◽  
Stop Signal Task ◽  
Healthy Children ◽  
Oscillatory Dynamics ◽  
Early Stages ◽  
Adhd Children ◽  
Arousal Model

In the current study, we aimed to investigate the associations between the natural variability in hyperactivity and inattention scores, as well as their combination with EEG oscillatory responses in the Stop-Signal task in a sample of healthy children. During performance, the Stop-Signal task EEGs were recorded in 94 Caucasian children (40 girls) from 7 to 10 years. Hyperactivity/inattention and inattention scores positively correlated with RT variability. Hyperactivity/inattention and inattention scores negatively correlated with an increase in beta spectral power in the first 200 ms after presentation of the Go stimulus. Such results are in line with the lack of arousal model in ADHD children and can be associated with less sensory arousal in the early stages of perception in children with symptoms of inattention. The subsequent greater increase in theta rhythm at about 300 ms after presentation of the Go stimulus in children with higher inattention scores may be associated with increased attention processes and compensation for insufficient vigilance in the early stages of perception.

scholarly journals Establishing a Right Frontal Beta Signature for Stopping Action in Scalp EEG: Implications for Testing Inhibitory Control in Other Task Contexts

2018 ◽  
Vol 30 (1) ◽  
pp. 107-118 ◽  
Author(s):  
Johanna Wagner ◽  
Jan R. Wessel ◽  
Ayda Ghahremani ◽  
Adam R. Aron
Keyword(s):  
Frontal Cortex ◽  
Inhibitory Control ◽  
Spectral Power ◽  
Stop Signal ◽  
Stop Signal Task ◽  
Beta Band ◽  
Unexpected Events ◽  
Time Frequency ◽  
Inferior Frontal Cortex ◽  
The Right

Many studies have examined the rapid stopping of action as a proxy of human self-control. Several methods have shown that a critical focus for stopping is the right inferior frontal cortex. Moreover, electrocorticography studies have shown beta band power increases in the right inferior frontal cortex and in the BG for successful versus failed stop trials, before the time of stopping elapses, perhaps underpinning a prefrontal–BG network for inhibitory control. Here, we tested whether the same signature might be visible in scalp electroencephalography (EEG)—which would open important avenues for using this signature in studies of the recruitment and timing of prefrontal inhibitory control. We used independent component analysis and time–frequency approaches to analyze EEG from three different cohorts of healthy young volunteers (48 participants in total) performing versions of the standard stop signal task. We identified a spectral power increase in the band 13–20 Hz that occurs after the stop signal, but before the time of stopping elapses, with a right frontal topography in the EEG. This right frontal beta band increase was significantly larger for successful compared with failed stops in two of the three studies. We also tested the hypothesis that unexpected events recruit the same frontal system for stopping. Indeed, we show that the stopping-related right-lateralized frontal beta signature was also active after unexpected events (and we accordingly provide data and scripts for the method). These results validate a right frontal beta signature in the EEG as a temporally precise and functionally significant neural marker of the response inhibition process.

scholarly journals Inhibitory Control on a Stop Signal Task in Tourette Syndrome before and after Deep Brain Stimulation of the Internal Segment of the Globus Pallidus

2021 ◽  
Vol 11 (4) ◽  
pp. 461
Author(s):  
Francesca Morreale ◽  
Zinovia Kefalopoulou ◽  
Ludvic Zrinzo ◽  
Patricia Limousin ◽  
Eileen Joyce ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Tourette Syndrome ◽  
Globus Pallidus ◽  
Brain Stimulation ◽  
Stop Signal ◽  
Stop Signal Task ◽  
Healthy Controls ◽  
Reactive Inhibition ◽  
Double Blind ◽  
Deep Brain

As part of the first randomized double-blind trial of deep brain stimulation (DBS) of the globus pallidus (GPi) in Tourette syndrome, we examined the effect of stimulation on response initiation and inhibition. A total of 14 patients with severe Tourette syndrome were recruited and tested on the stop signal task prior to and after GPi-DBS surgery and compared to eight age-matched healthy controls. Tics were significantly improved following GPi-DBS. The main measure of reactive inhibition, the stop signal reaction time did not change from before to after surgery and did not differ from that of healthy controls either before or after GPi-DBS surgery. This suggests that patients with Tourette syndrome have normal reactive inhibition which is not significantly altered by GPi-DBS.

scholarly journals Is motor inhibition involved in the processing of sentential negation? An assessment via the Stop-Signal Task

2021 ◽  
Author(s):  
Martina Montalti ◽  
Marta Calbi ◽  
Valentina Cuccio ◽  
Maria Alessandra Umiltà ◽  
Vittorio Gallese
Keyword(s):  
Reaction Time ◽  
Language Processing ◽  
Stop Signal ◽  
Stop Signal Task ◽  
Motor Inhibition ◽  
Good Tool ◽  
Scientific Debate ◽  
Sentential Negation ◽  
Stop Signal Reaction Time ◽  
Methodological Considerations

AbstractIn the last decades, the embodied approach to cognition and language gained momentum in the scientific debate, leading to evidence in different aspects of language processing. However, while the bodily grounding of concrete concepts seems to be relatively not controversial, abstract aspects, like the negation logical operator, are still today one of the main challenges for this research paradigm. In this framework, the present study has a twofold aim: (1) to assess whether mechanisms for motor inhibition underpin the processing of sentential negation, thus, providing evidence for a bodily grounding of this logic operator, (2) to determine whether the Stop-Signal Task, which has been used to investigate motor inhibition, could represent a good tool to explore this issue. Twenty-three participants were recruited in this experiment. Ten hand-action-related sentences, both in affirmative and negative polarity, were presented on a screen. Participants were instructed to respond as quickly and accurately as possible to the direction of the Go Stimulus (an arrow) and to withhold their response when they heard a sound following the arrow. This paradigm allows estimating the Stop Signal Reaction Time (SSRT), a covert reaction time underlying the inhibitory process. Our results show that the SSRT measured after reading negative sentences are longer than after reading affirmative ones, highlighting the recruitment of inhibitory mechanisms while processing negative sentences. Furthermore, our methodological considerations suggest that the Stop-Signal Task is a good paradigm to assess motor inhibition’s role in the processing of sentence negation.

scholarly journals Effect of obesity on inhibitory control in preadolescents during stop-signal task. An event-related potentials study

2021 ◽  
Author(s):  
Graciela C. Alatorre-Cruz ◽  
Heather Downs ◽  
Darcy Hagood ◽  
Seth T. Sorensen ◽  
D. Keith Williams ◽  
...  
Keyword(s):  
Inhibitory Control ◽  
Event Related Potentials ◽  
Stop Signal ◽  
Stop Signal Task ◽  
Related Potentials

scholarly journals Cortical silent period reflects individual differences in action stopping performance

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mario Paci ◽  
Giulio Di Cosmo ◽  
Mauro Gianni Perrucci ◽  
Francesca Ferri ◽  
Marcello Costantini
Keyword(s):  
Individual Differences ◽  
Response Inhibition ◽  
Primary Motor Cortex ◽  
Silent Period ◽  
Intracortical Inhibition ◽  
Stop Signal ◽  
Stop Signal Task ◽  
Behavioral Differences ◽  
Cortical Silent Period ◽  
Stop Signal Reaction Time

AbstractInhibitory control is the ability to suppress inappropriate movements and unwanted actions, allowing to regulate impulses and responses. This ability can be measured via the Stop Signal Task, which provides a temporal index of response inhibition, namely the stop signal reaction time (SSRT). At the neural level, Transcranial Magnetic Stimulation (TMS) allows to investigate motor inhibition within the primary motor cortex (M1), such as the cortical silent period (CSP) which is an index of GABAB-mediated intracortical inhibition within M1. Although there is strong evidence that intracortical inhibition varies during action stopping, it is still not clear whether differences in the neurophysiological markers of intracortical inhibition contribute to behavioral differences in actual inhibitory capacities. Hence, here we explored the relationship between intracortical inhibition within M1 and behavioral response inhibition. GABABergic-mediated inhibition in M1 was determined by the duration of CSP, while behavioral inhibition was assessed by the SSRT. We found a significant positive correlation between CSP’s duration and SSRT, namely that individuals with greater levels of GABABergic-mediated inhibition seem to perform overall worse in inhibiting behavioral responses. These results support the assumption that individual differences in intracortical inhibition are mirrored by individual differences in action stopping abilities.

scholarly journals Comparing three portable, tablet-based visuomotor tasks to laboratory versions: An assessment of test validity

2018 ◽  
Vol 2 ◽  
pp. 205970021879914 ◽  
Author(s):  
Christopher D Bedore ◽  
Jasmine Livermore ◽  
Hugo Lehmann ◽  
Liana E Brown
Keyword(s):  
Test Validity ◽  
Neurological Status ◽  
Stop Signal ◽  
Stop Signal Task ◽  
Response Patterns ◽  
Double Step ◽  
Movement Timing ◽  
Visuomotor Processing ◽  
Visuomotor Tasks ◽  
Portable Tablet

The assessment of visuomotor function can provide important information about neurological status. Many tasks exist for testing visuomotor function in the laboratory, but the availability of portable, easy-to-use versions that allow reliable, accurate, and precise measurement of movement timing and accuracy has been limited. We developed a tablet application that uses three laboratory visuomotor tests: the double-step task, interception task, and stop-signal task. We asked the participants to perform both the lab and tablet versions of each task and compared their response patterns across equipment types to assess the validity of the tablet versions. On the double-step task, the participants adjusted to the displaced target adequately in both the lab and tablet versions. On the interception task, the participants intercepted nonaccelerating targets and performed worse on accelerating targets in both versions of the task. On the stop-signal task, the participants successfully inhibited their reaching movements on short stop-signal delays (50–150 ms) more frequently than on long stop-signal delays (200 ms) in both versions of the task. Our findings suggest that the tablet version of each task assesses visuomotor processing in the same way as their respective laboratory version, thus providing the research community with a new tool to assess visuomotor function.

scholarly journals How to Predict the Impact of Methylphenidate on Cardiovascular Risk in Children with Attention Deficit Disorder: Methylphenidate Improves Autonomic Dysfunction in Children with ADHD

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Reiner Buchhorn ◽  
Christian Müller ◽  
Christian Willaschek ◽  
Kambiz Norozi
Keyword(s):  
Sudden Cardiac Death ◽  
Attention Deficit ◽  
Attention Deficit Disorder ◽  
Cardiac Death ◽  
Control Group ◽  
Healthy Children ◽  
Children With Adhd ◽  
Heart Defect ◽  
Adhd Children ◽  
The Impact

Background. Although stimulants have long been touted as treatments for attention deficit disorder with or without hyperactivity (ADHD), in recent years, increasing concerns have been raised about the cardiovascular safety of these medications. We aimed to prove if measurements of autonomic function with time domain analysis of heart rate variability (HRV) in 24-hour Holter ECG are useful to predict the risk of sudden cardiac death in ADHD children and adolescents. Methods. We analysed HRV obtained from children with the diagnosis of ADHD prior to (N=12) or during medical therapy (N=19) with methylphenidate (MPH), aged 10.8±2.0 years (mean ± SD), who were referred to our outpatient Paediatric Cardiology Clinic to rule out heart defect. As a control group, we compared the HRV data of 19 age-matched healthy children without heart defect. Results. Average HRV parameters from 24-hour ECG in the ADHD children prior to MPH showed significant lower values compared to healthy children with respect to rMSSD (26±4 ms versus 44±10 ms, P≤0.0001) and pNN50 (6.5±2.7% versus 21.5±9.0%, P≤0.0001). These values improved in MPH-treated children with ADHD (RMSSD: 36±8 ms; pNN50: 14.2±6.9%). Conclusion. Children who suffer from ADHD show significant changes in HRV that predominantly reflects diminished vagal tone, a well-known risk factor of sudden cardiac death in adults. In our pilot study, MPH treatment improved HRV.

scholarly journals Cognitive Modeling Suggests That Attentional Failures Drive Longer Stop-Signal Reaction Time Estimates in Attention Deficit/Hyperactivity Disorder

2019 ◽  
Vol 7 (4) ◽  
pp. 856-872 ◽  
Author(s):  
Alexander Weigard ◽  
Andrew Heathcote ◽  
Dóra Matzke ◽  
Cynthia Huang-Pollock
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Reaction Time ◽  
Attention Deficit ◽  
Cognitive Modeling ◽  
Stop Signal ◽  
Stop Signal Task ◽  
Unbiased Estimation ◽  
Children With Adhd ◽  
Hyperactivity Disorder ◽  
Stop Signal Reaction Time

Mean stop-signal reaction time (SSRT) is frequently employed as a measure of response inhibition in cognitive neuroscience research on attention deficit/hyperactivity disorder (ADHD). However, this measurement model is limited by two factors that may bias SSRT estimation in this population: (a) excessive skew in “go” RT distributions and (b) trigger failures, or instances in which individuals fail to trigger an inhibition process in response to the stop signal. We used a Bayesian parametric approach that allows unbiased estimation of the shape of entire SSRT distributions and the probability of trigger failures to clarify mechanisms of stop-signal task deficits in ADHD. Children with ADHD displayed greater positive skew than their peers in both go RT and SSRT distributions. However, they also displayed more frequent trigger failures, which appeared to drive ADHD-related stopping difficulties. Results suggest that performance on the stop-signal task among children with ADHD reflects impairments in early attentional processes, rather than inefficiency in the stop process.

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