Parental education is associated with differential engagement of neural pathways during inhibitory control

Response inhibition and socioeconomic status (SES) are critical predictors of many important outcomes, including educational attainment and health. The current study extends our understanding of SES and cognition by examining brain activity associated with response inhibition, during the key developmental period of adolescence. Adolescent males (N = 81), aged 16–17, completed a response inhibition task while undergoing fMRI brain imaging and reported on their parents’ education, one component of socioeconomic status. A region of interest analysis showed that parental education was associated with brain activation differences in the classic response inhibition network (right inferior frontal gyrus + subthalamic nucleus + globus pallidus) despite the absence of consistent parental education-performance effects. Further, although activity in our main regions of interest was not associated with performance differences, several regions that were associated with better inhibitory performance (ventromedial prefrontal cortex, middle frontal gyrus, middle temporal gyrus, amygdala/hippocampus) also differed in their levels of activation according to parental education. Taken together, these results suggest that individuals from households with higher versus lower parental education engage key brain regions involved in response inhibition to differing degrees, though these differences may not translate into performance differences.

Mechanism and Performance Differences between the SSG/LRR-ω and SST Turbulence Models in Separated Flows

Accurate predictions of flow separation are important for aerospace design, flight accident avoidance, and the development of fluid mechanics. However, the complexity of the separation process makes accurate predictions challenging for all known Reynolds-averaged Navier–Stokes (RANS) methods, and the underlying mechanism of action remains unclear. This paper analyzes the specific reasons for the defective predictions of the turbulence models applied to separated flows, explores the physical properties that impact the predictions, and investigates their specific mechanisms. Taking the Menter SST and the Speziale-Sarkar–Gatski/Launder–Reece–Rodi (SSG/LRR)-ω models as representatives, three typical separated flow cases are calculated. The performance differences between the two turbulence models applied to the different separated flow calculations are then compared. Refine the vital physical properties and analyze their calculation from the basic assumptions, modeling ideas, and construction of the turbulence models. The numerical results show that the underestimation of Reynolds stress is a significant factor in the unsatisfactory prediction of separation. In the SST model, Bradshaw’s assumption imposes the turbulent energy equilibrium condition in all regions and the eddy–viscosity coefficient is underestimated, which leads to advanced separation and lagging reattachment. In the SSG/LRR-ω model, the fidelity with which the pressure–strain term is modeled is a profound factor affecting the calculation accuracy.

The RBF Hyperparameter in Metamodel-Assisted Evolutionary Search

RBF metamodels, which are commonly used in expensive optimization problems, rely on a hyperparameter which affects their prediction. The optimal hyperparameter value is typically unknown and hence needs to be estimated by additional procedures. As such this study examines if this overhead is justified from an overall search effectiveness perspective, namely, if changes in the hyperparameter yield significant performance differences. Analysis based on extensive numerical experiments shows that changes are significant in functions with low to moderate multimodality but are less significant in functions with highly multimodality.

EXPRESS: The Best Broths are Cooked in the Oldest Pans: An Empirical Test of the Practice-based View in the Wine Industry

The practice-based view (PBV) has recently been proposed as a counter to the resource-based view of the firm (RBV). Unlike the RBV, the PBV contends that performance differences among firms can accrue from readily available practices. Using a large sample of wines over a 20-year period, I find evidence of a significant relationship between the implementation of practices and performance. Findings also indicate that the strength of this relationship is contingent on the possession of valuable, rare, inimitable and non-substitutable (VRIN) resources (a firm-level moderator) and the prevalence of practices (an industry-level moderator). The impact of practices on performance is less pronounced when firms possess VRIN resources. It also declines as they become more widespread in an industry.

Protein Function Prediction Based on PPI Networks: Network Reconstruction vs Edge Enrichment

Over the past decades, massive amounts of protein-protein interaction (PPI) data have been accumulated due to the advancement of high-throughput technologies, and but data quality issues (noise or incompleteness) of PPI have been still affecting protein function prediction accuracy based on PPI networks. Although two main strategies of network reconstruction and edge enrichment have been reported on the effectiveness of boosting the prediction performance in numerous literature studies, there still lack comparative studies of the performance differences between network reconstruction and edge enrichment. Inspired by the question, this study first uses three protein similarity metrics (local, global and sequence) for network reconstruction and edge enrichment in PPI networks, and then evaluates the performance differences of network reconstruction, edge enrichment and the original networks on two real PPI datasets. The experimental results demonstrate that edge enrichment work better than both network reconstruction and original networks. Moreover, for the edge enrichment of PPI networks, the sequence similarity outperformes both local and global similarity. In summary, our study can help biologists select suitable pre-processing schemes and achieve better protein function prediction for PPI networks.

Diverging Playing Positions do not Lead to Differences in YBT-UQ Performance in Youth Handball Players

Handball playing positions can be differentiated between first line players who position themselves near the 6-m line and second line players who typically play outside the 9-m space. Handball is characterized by a high number of throwing actions that cause adaptations in the throwing shoulder. The objective of this cross-sectional study was to assess whether the specific physiological positional demands in handball lead to functional performance differences between the playing positions (N=196; goalkeepers: n=25; backcourt: n=99; pivots: n=21; winger: n=51) in terms of shoulder mobility and stability in any reach direction as assessed through the Upper Quarter Y Balance Test (YBT-UQ). Contrary to our hypothesis, the results did not show significant differences between the playing positions in shoulder mobility and stability in youth handball players, irrespective of reach arm and reach direction. The obtained effect sizes (η p 2) were solely small and ranged between 0.01 and 0.03. The adaptations following the demands of the diverging playing positions do not lead to significant differences in shoulder mobility and stability on the basis of the YBT-UQ. The overall training load of youth handball players may not be sufficient to lead to significant position-specific differences in shoulder mobility and stability.