scholarly journals The Relationship between Telomere Length and Gestational Weight Gain: Findings from the Mamma & Bambino Cohort

Biomedicines ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 67
Author(s):  
Andrea Maugeri ◽  
Roberta Magnano San Lio ◽  
Maria Clara La Rosa ◽  
Giuliana Giunta ◽  
Marco Panella ◽  
...  
Keyword(s):  
Weight Gain ◽  
Telomere Length ◽  
Gestational Weight Gain ◽  
Molecular Mechanisms ◽  
Quantitative Polymerase Chain Reaction ◽  
Well Being ◽  
Early Effect ◽  
Gestational Weight ◽  
Relative Telomere Length ◽  
The Relationship

Inadequate gestational weight gain (GWG) affects a growing number of pregnancies, influencing intrauterine environment and long-term health. Uncovering molecular mechanisms associated with GWG could be helpful to develop public health strategies for tackling this issue. Here, our study aimed to understand the relationship of DNA telomere length with weigh gain during pregnancy, using data and samples from the ongoing prospective “Mamma & Bambino” study (Catania, Italy). GWG was calculated according to the Institute of Medicine (IOM) guidelines. Relative telomere length was assessed by real-time quantitative polymerase chain reaction in 252 samples of maternal leucocyte DNA (mlDNA) and 150 samples of cell-free DNA (cfDNA) from amniotic fluid. We observed that relative telomere length of mlDNA seemed to weakly increase with GWG. In contrast, telomere length of cfDNA exhibited a U-shaped relationship with GWG. Women with adequate GWG showed longer telomere length than those who gained weight inadequately. Accordingly, the logistic regression model confirmed the association between telomere length of cfDNA and adequate GWG, after adjusting for potential confounders. Our findings suggest an early effect of GWG on telomere length of cfDNA, which could represent a molecular mechanism underpinning the effects of maternal behaviours on foetal well-being.

445: The relationship between gestational weight gain and gestational diabetes mellitus

2015 ◽  
Vol 212 (1) ◽  
pp. S229
Author(s):  
Amy O'Higgins ◽  
Lisa O'Higgins ◽  
Anne Fennessy ◽  
Thomas McCartan ◽  
Laura Mullaney ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Weight Gain ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Gestational Weight Gain ◽  
Gestational Weight ◽  
The Relationship

scholarly journals Higher gestational weight gain and lower serum estradiol levels on the day of human chorionic gonadotropin administration are associated with increased risk of preeclampsia after in vitro fertilization

2020 ◽  
Author(s):  
Yu-Chen Chen ◽  
Yun-Ju Lai ◽  
Yu-Ting Su ◽  
Ni-Chin Tsai ◽  
Kuo-Chung Lan
Keyword(s):  
Weight Gain ◽  
In Vitro Fertilization ◽  
Gestational Weight Gain ◽  
Chorionic Gonadotropin ◽  
Serum Estradiol ◽  
Vitro Fertilization ◽  
Gestational Weight ◽  
Relationship Of ◽  
The Relationship

Abstract Background Very few previous studies have examined the effect of endocrine parameters during ART on preeclampsia. Moreover, there is little known about the relationship of steroid hormone levels on development of the placenta. The purpose of this study is to assess the association of preeclampsia with serum estradiol (E2) and progesterone (P4) levels on the day of human chorionic gonadotropin (hCG) administration during controlled ovarian hyperstimulation (COH) for in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). Methods This was a hospital-based cohort study using clinical data from the Kaohsiung Chang Gung Memorial Hospital Obstetric and Neonatal Database (KCGMHOND) from Jan 1, 2001 to December 1, 2018. Eligible women underwent at least one autologous IVF/ICSI cycle and had a live-born infant with a gestational age (GA) of more than 20 weeks. Results A total of 622 women who had live births after fresh IVF/ICSI-ET during the study period met our inclusion criteria. Twenty-eight women (4.5%) met the diagnostic criteria for preeclampsia. However, women in the preeclampsia group had a significantly higher body mass index (22 vs. 24, p =0.05), body weight at delivery (70.0 vs. 80.5 kg, p <0.001) and gestational weight gain (13.0 vs. 19.6 kg, p =0.002) and had lower use of ICSI (29.9% vs. 10.7%, p =0.021). Logistic regression analysis of the relationship of patient and treatment characteristics with preeclampsia. The crude ORs indicated that young female age >34, not using ICSI, E2 peak <1200 pg/mL and gestational weight gain >20 kg were associated with preeclampsia. After adjustment for confounding, the only factors that remained significant were E2 peak <1200 pg/mL (aOR = 4.634, 95% CI = 1.061 to 20.222), and gestational weight gain >20 kg (aOR: 13.601, 95% CI: 3.784, 48.880). Conclusions For women receiving IVF/ICSI, lower estradiol hormone levels on the day of hCG administration and higher pregnancy weight gain are related with subsequent preeclampsia.

scholarly journals Pre-Pregnancy Obesity, Excessive Gestational Weight Gain, and the Risk of Pregnancy-Induced Hypertension and Gestational Diabetes Mellitus

2020 ◽  
Vol 9 (6) ◽  
pp. 1980 ◽  
Author(s):  
Małgorzata Lewandowska ◽  
Barbara Więckowska ◽  
Stefan Sajdak
Keyword(s):  
Weight Gain ◽  
Pregnant Women ◽  
Gestational Weight Gain ◽  
Pregnancy Complications ◽  
Gestational Hypertension ◽  
Institute Of Medicine ◽  
Maternal Weight ◽  
Odds Ratios ◽  
Gestational Weight ◽  
The Relationship

Excessive pre-pregnancy weight is a known risk factor of pregnancy complications. The purpose of this analysis was to assess the relationship between several categories of maternal weight and the risk of developing hypertension and diabetes in pregnancy, and the relationship of these complications with the results of the newborn. It was carried out in a common cohort of pregnant women and taking into account the influence of disturbing factors. Our analysis was conducted in a prospective cohort of 912 Polish pregnant women, recruited during 2015–2016. We evaluated the women who subsequently developed diabetes with dietary modification (GDM-1) (n = 125) and with insulin therapy (GDM-2) (n = 21), as well as the women who developed gestational hypertension (GH) (n = 113) and preeclampsia (PE) (n = 24), compared to the healthy controls. Odds ratios of the complications (and confidence intervals (95%)) were calculated in the multivariate logistic regression. In the cohort, 10.8% of the women had pre-pregnancy obesity (body mass index (BMI) ≥ 30 kg/m2), and 36.8% had gestational weight gain (GWG) above the range of the Institute of Medicine recommendation. After correction for excessive GWG and other confounders, pre-pregnancy obesity (vs. normal BMI) was associated with a higher odds ratio of GH (AOR = 4.94; p < 0.001), PE (AOR = 8.61; p < 0.001), GDM-1 (AOR = 2.99; p < 0.001), and GDM-2 (AOR = 11.88; p <0.001). The threshold risk of development of GDM-2 occurred at lower BMI values (26.9 kg/m2), compared to GDM-1 (29.1 kg/m2). The threshold point for GH was 24.3 kg/m2, and for PE 23.1 kg/m2. For GWG above the range (vs. GWG in the range), the adjusted odds ratios of GH, PE, GDM-1, and GDM-2 were AOR = 1.71 (p = 0.045), AOR = 1.14 (p = 0.803), AOR = 0.74 (p = 0.245), and AOR = 0.76 (p = 0.672), respectively. The effect of maternal edema on all the results was negligible. In our cohort, hypertension and diabetes were associated with incorrect birth weight and gestational age at delivery. Conclusions: This study highlights the importance and influence of excessive pre-pregnancy maternal weight on the risk of pregnancy complications such as diabetes and hypertension which can impact fetal outcomes.

285: The relationship between gestational weight gain and infant body composition at birth

2015 ◽  
Vol 212 (1) ◽  
pp. S154-S155
Author(s):  
Amy O'Higgins ◽  
Thomas McCartan ◽  
Anne Doolan ◽  
Laura Mullaney ◽  
Sophie Gray ◽  
...  
Keyword(s):  
Body Composition ◽  
Weight Gain ◽  
Gestational Weight Gain ◽  
Gestational Weight ◽  
The Relationship

scholarly journals 1422 Study of the Relationship Between Gestational Weight Gain (GWG), Cultural Level (CL), Birth Weight (BW) and Overweight/Obesity (OW/OB) Outcome

2012 ◽  
Vol 97 (Suppl 2) ◽  
pp. A404-A405
Author(s):  
D. Guttadoro ◽  
R. Mercurio ◽  
M. Podagrosi ◽  
A. Grimaldi ◽  
A. Giacomini ◽  
...  
Keyword(s):  
Weight Gain ◽  
Birth Weight ◽  
Gestational Weight Gain ◽  
Gestational Weight ◽  
The Relationship

A longitudinal study on the relationship between eating style and gestational weight gain

Appetite ◽  
2014 ◽  
Vol 83 ◽  
pp. 304-308 ◽  
Author(s):  
Carla L. van der Wijden ◽  
Stefanie Steinbach ◽  
Hidde P. van der Ploeg ◽  
Willem van Mechelen ◽  
Mireille N.M. van Poppel
Keyword(s):  
Weight Gain ◽  
Longitudinal Study ◽  
Gestational Weight Gain ◽  
Eating Style ◽  
Gestational Weight ◽  
The Relationship

scholarly journals Disordered Eating Behaviors Are Associated with Gestational Weight Gain in Adolescents

Nutrients ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 3186
Author(s):  
Reyna Sámano ◽  
Luis Ortiz-Hernández ◽  
Hugo Martínez-Rojano ◽  
Oralia Nájera-Medina ◽  
Gabriela Chico-Barba ◽  
...  
Keyword(s):  
Weight Gain ◽  
Birth Weight ◽  
Disordered Eating ◽  
Gestational Weight Gain ◽  
Eating Behaviors ◽  
Linear Regression Models ◽  
Disordered Eating Behaviors ◽  
Gestational Weight ◽  
Relationship Of ◽  
The Relationship

Disordered eating behaviors (DEBs) and adolescent pregnancy are public health problems. Among adolescents, there is little evidence concerning the relationship of DEB with gestational weight gain (GWG) and the birth weight and length of their offspring. We aimed to determine the association between DEB with GWG and the weight and length of adolescents’ offspring. We conducted a study with 379 participants. To evaluate DEB, we applied a validated scale. We identified three factors from DEB by factorial analysis: restrictive, compensatory, and binge–purge behaviors. The main events were GWG and offspring’s birth weight and length. We performed linear regression models. We found that 50% of adolescents have at least one DEB. Excessive and insufficient GWG were 37 and 34%, respectively. The median GWG was 13 kg; adolescents with restrictive behaviors had higher GWG (13 vs. 12 kg, p = 0.023). After adjusting for pregestational body mass index and other covariables, the restrictive (β = 0.67, p = 0.039), compensatory (β = 0.65, p = 0.044), and binge–purge behaviors (β = 0.54, p = 0.013) were associated with higher GWG. We did not find an association between the birth weight and length of newborns with DEB, and suggest that DEB is associated with GWG but not with the birth weight or length of the offspring.

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