scholarly journals Sex Differences in the Effect of Diabetes on Cerebral Glucose Metabolism

Biomedicines ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 1661
Author(s):  
Chun-Yi Wu ◽  
Yu-Hsin Lin ◽  
Hsin-Hua Hsieh ◽  
Jia-Jia Lin ◽  
Shin-Lei Peng
Keyword(s):  
Sexual Dimorphism ◽  
Glucose Metabolism ◽  
Intraperitoneal Injection ◽  
Brain Metabolism ◽  
Cerebral Metabolism ◽  
Brain Regions ◽  
Diabetic Rats ◽  
Cerebral Glucose Metabolism ◽  
Single Intraperitoneal Injection ◽  
Positron Emission

The neuroimaging literature indicates that brain structure and function both deteriorate with diabetes, but information on sexual dimorphism in diabetes-related brain alterations is limited. This study aimed to ascertain whether brain metabolism is influenced by sex in an animal model of diabetes. Eleven rats (male, n = 5; female, n = 6) received a single intraperitoneal injection of 70 mg/kg streptozotocin (STZ) to develop diabetes. Another 11 rats (male, n = 5; female, n = 6) received the same amount of solvent through a single intraperitoneal injection. Longitudinal positron emission tomography scans were used to assess cerebral glucose metabolism before and 4 weeks after STZ or solvent administration. Before STZ or solvent injections, there was no evidence of sexual dimorphism in cerebral metabolism (p > 0.05). Compared with healthy control animals, rats with diabetes had significantly decreased brain metabolism in all brain regions (all p < 0.05). In addition, female diabetic rats exhibited further reduction in cerebral metabolism, relative to male diabetic rats (p < 0.05). The results of this study may provide some biological evidence, supporting the existence of a sexual dimorphism in diabetes-related complications.

scholarly journals Reproducibility of Cerebral Glucose Metabolic Measurements in Resting Human Subjects

1988 ◽  
Vol 8 (4) ◽  
pp. 502-512 ◽  
Author(s):  
Elsa J. Bartlett ◽  
Jonathan D. Brodie ◽  
Alfred P. Wolf ◽  
David R. Christman ◽  
Eugene Laska ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Brain Metabolism ◽  
Human Subjects ◽  
Normal Subjects ◽  
Time Of Day ◽  
Cerebral Glucose Metabolism ◽  
Whole Brain ◽  
Positron Emission ◽  
Subcortical Regions ◽  
Regional Cerebral Glucose Metabolism

Positron emission tomography with 11C-2-deoxyglucose was used to determine the test-retest variability of regional cerebral glucose metabolism in 22 young normal right-handed men scanned twice in a 24-h period under baseline (resting) conditions. To assess the effects of scan order and time of day on variability, 12 subjects were scanned in the morning and afternoon of the same day (a.m.-p.m.) and 10 in the reverse order (p.m.-a.m.) with a night in between. The effect of anxiety on metabolism was also assessed. Seventy-three percent of the total subject group showed changes in whole brain metabolism from the first to the second measurement of 10% or less, with comparable changes in various cortical and subcortical regions. When a scaling factor was used to equate the whole brain metabolism in the two scans for each individual, the resulting average regional changes for each group were no mote than 1%. This suggests that the proportion of the whole brain metabolism utilized regionally is stable in a group of subjects over time. Both groups of subjects had lower morning than afternoon metabolism, but the differences were slight in the p.m.-a.m. group. One measure of anxiety (pulse at fun 1) was correlated with run 1 metabolism and with the percentage of change from run 1 to run 2. No significant run 2 correlations were observed. This is the first study to measure test-retest variability in cerebral glucose metabolism in a large sample of young normal subjects. It demonstrates that the deoxyglucose method yields low Intrasubject variability and high stability over a 24-h period.

scholarly journals Changes in cerebral glucose metabolism caused by morphologic features of prodromal idiopathic normal pressure hydrocephalus

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Koichi Miyazaki ◽  
Kohei Hanaoka ◽  
Hayato Kaida ◽  
Yasutaka Chiba ◽  
Kazunari Ishii
Keyword(s):  
Glucose Metabolism ◽  
Normal Pressure ◽  
Cerebral Glucose Metabolism ◽  
Emission Tomography ◽  
Fluorodeoxyglucose Positron Emission Tomography ◽  
Temporal Lobes ◽  
Parietal Lobes ◽  
Positron Emission ◽  
Asymptomatic Subjects ◽  
Fluorodeoxyglucose Positron Emission

Abstract Background Decreased cerebral glucose metabolism has been reported in idiopathic normal pressure hydrocephalus (iNPH). However, the timing of appearance in the preclinical stage of iNPH remains unknown. Herein, we evaluated the changes in regional cerebral glucose metabolism with respect to the characteristic morphologic features of iNPH. Methods We performed a cross-sectional study in > 2000 elderly patients who received a whole body 18F-fluorodeoxyglucose-positron emission tomography/computed tomography scanning and recruited subjects with clinical and preclinical iNPH. We included 12 subjects with iNPH, 32 subjects with asymptomatic ventriculomegaly with features of iNPH on magnetic resonance imaging (AVIM), and 33 subjects with preclinical morphologic features of DESH (PMD). We previously reported that iNPH develops in the order of PMD (asymptomatic subjects with incomplete DESH), AVIM (asymptomatic subjects with DESH), and iNPH (symptomatic subjects with DESH). We measured the median regional standardized uptake value ratio (SUVR) on 18F-fluorodeoxyglucose-positron emission tomography/computed tomography images between the three groups and compared them with background-matched normal controls in the frontal lobes, temporal lobes, medial parietal lobes, striata, and thalami. Results In the frontal and temporal lobes, the SUVR distributions of the PMD, AVIM, and PMD groups were significantly lower than for each NC (p < 0.05 for all). In the medial parietal lobes, the SUVR distributions were significantly higher in PMD and AVIM groups (p < 0.05 for all). In the thalami and striata, the SUVR distributions were significantly lower in the iNPH group (p < 0.05 for all). Conclusions Changes in brain glucose metabolism in the cortices are observed in preclinical iNPH, while metabolic decline in the basal ganglia is only detected in clinical iNPH.

scholarly journals Cerebral Glucose and Dopa Metabolism in Movement Disorders

1987 ◽  
Vol 14 (S3) ◽  
pp. 448-451 ◽  
Author(s):  
W.R. Wayne Martin ◽  
Michael R. Hayden
Keyword(s):  
At Risk ◽  
Glucose Metabolism ◽  
Normal Subjects ◽  
Cerebral Glucose Metabolism ◽  
Nigrostriatal Pathway ◽  
Age Related ◽  
Positron Emission ◽  
Asymptomatic Individuals ◽  
Regional Cerebral Glucose Metabolism

ABSTRACT:The development of positron emission tomography (PET) has enabled us to perform in vivo measurements of certain aspects of regional cerebral function. Regional cerebral glucose metabolism may be readily quantified with [18F] fluoro-2-deoxyglucose (FDG) and presynaptic dopaminergic function may be studied with the labelled dopa analog 6-[18F] fluoro-L-dopa. We have applied a model to the analysis of 6-FD/PET data with which in vivo age-related changes in dopaminergic function may be demonstrated in normal subjects. With this technique, we have studied a series of asymptomatic MPTP-exposed subjects and have shown evidence of subclinical nigrostriatal pathway damage. Studies of regional cerebral glucose metabolism with FDG in early Huntington's disease have shown a characteristic impairment in caudate function which precedes the development of caudate atrophy. In addition, some asymptomatic individuals who are at risk for HD have caudate hypometabolism. We feel that, at the present time, PET provides information which is complementary to the clinical examination in establishing a diagnosis of HD. In the future these studies may also help in the investigation of at risk individuals

Serotonin modulation of cerebral glucose metabolism measured with positron emission tomography (PET) in human subjects

Synapse ◽  
2002 ◽  
Vol 45 (2) ◽  
pp. 105-112 ◽  
Author(s):  
Gwenn S. Smith ◽  
Yilong Ma ◽  
Vijay Dhawan ◽  
Handan Gunduz ◽  
Maren Carbon ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Glucose Metabolism ◽  
Human Subjects ◽  
Cerebral Glucose Metabolism ◽  
Emission Tomography ◽  
Positron Emission

29 POSITRON EMISSION TOMOGRAPHY IMAGING OF BRAIN METABOLISM AND DOPAMINERGIC NEURON DESTRUCTION IN PARKINSON'S DISEASE MODEL PIG

2017 ◽  
Vol 29 (1) ◽  
pp. 122
Author(s):  
H. J. Oh ◽  
J. Moon ◽  
G. A. Kim ◽  
S. Lee ◽  
S. H. Paek ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Dopaminergic Neuron ◽  
Brain Metabolism ◽  
Brain Research ◽  
Brain Regions ◽  
Emission Tomography ◽  
Positron Emission ◽  
Significant Difference ◽  
And Control ◽  
The Brain

Due to similarities between human and porcine, pigs have been proposed as an excellent experimental animal for human medical research. Especially in paediatric brain research, piglets share similarities with human infants in the extent of peak brain growth at the time of birth and the growth pattern of brain. Thus, these findings have supported the wider use of pigs rather than rodents in neuroscience research. Previously, we reported the production of porcine model of Parkinson's disease (PD) by nuclear transfer using donor cell that had been stably infected with lentivirus containing the human α-synuclein gene. The purpose of this study was to determine the alternation of brain metabolism and dopaminergic neuron destruction using noninvasive method in a 2-yr-old PD model and a control pig. The positron emission tomography (PET) scan was done using Biograph TruePoint40 with a TrueV (Siemens, Munich, Germany). The [18F]N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl) nortropane (FP-CIT) was administrated via the ear vein. Static images of the brain for 15 min were acquired from 2 h after injection. The 18F-fluorodeoxy-D-glucose PET (18F-FDG PET) images of the brain were obtained for 15 min at 45 min post-injection. Computed tomography (CT) scan and magnetic resonance imaging (MRI) were performed at the same location of the brain. In both MRI and CT images, there was no difference in brain regions between PD model and control pigs. However, administration of [18F]FP-CIT was markedly decreased in the bilateral putamen of the PD model pig compared with the control pigs. Moreover, [18F]FP-CIT administration was asymmetrical in the PD model pig but it was symmetrical in control pigs. Regional brain metabolism was also assessed and there was no significant difference in cortical metabolism of PD model and control pigs. We demonstrated that PET imaging could provide a foundation for translational Parkinson neuroimaging in transgenic pigs. In the present study, a 2-yr-old PD model pig showed dopaminergic neuron destruction in brain regions. Therefore, PD model pig expressing human α-synuclein gene would be an efficient model for human PD patients. This study was supported by Korea IPET (#311011–05–5-SB010), Research Institute for Veterinary Science, TS Corporation and the BK21 plus program.

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