scholarly journals Effect of Octreotide Long-Acting Release on Tregs and MDSC Cells in Neuroendocrine Tumour Patients: A Pivotal Prospective Study

Cancers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2422
Author(s):  
Claudia von Arx ◽  
Giuseppina Rea ◽  
Maria Napolitano ◽  
Alessandro Ottaiano ◽  
Fabiana Tatangelo ◽  
...  
Keyword(s):  
Immune System ◽  
Prospective Study ◽  
Neuroendocrine Tumour ◽  
Hormone Secretion ◽  
Somatostatin Receptors ◽  
Growth Hormone Secretion ◽  
Suppressor Cells ◽  
Neuroendocrine Neoplasms ◽  
Long Acting ◽  
The Impact

Octreotide long-acting repeatable (LAR) is largely used to treat functional and/or metastatic neuroendocrine neoplasms (NENs). Its effect in controlling carcinoid syndrome and partially reduce tumour burden is attributable to the ability of octreotide to bind somatostatin receptors (SSTRs) on the tumour and metastasis, regulating growth hormone secretion and cell growth. Notably, SSTRs are also expressed, at different levels, on Tregs. Tregs, together with myeloid-derived suppressor cells (MDSCs), are key components in the anti-tumour immunoregulation. This is the first prospective study aimed to explore the impact of Octreotide (OCT) LAR on the immune system, with a particular focus on Tregs and MDSC cells. Here, we show that circulating Tregs are elevated in NENs patients compared to healthy donors and that treatment with OCT LAR significantly decrease the level of total Tregs and of the three functional Tregs populations: nTregs, eTregs and non-Tregs. Furthermore, OCT LAR treatment induces a functional impairment of the remaining circulating Tregs, significantly decreasing the expression of PD1, CTLA4 and ENTPD1. A trend in circulating MDSC cells is reported in patients treated with OCT LAR. The results reported here suggest that the effect of OCT LAR on Tregs could tip the balance of the patients’ immune-system towards a durable anti-tumour immunosurveillance with consequent long-term control of the NENs disease.

scholarly journals Body Image Disturbance in Acromegaly Patients Compared to Nonfunctioning Pituitary Adenoma Patients and Controls

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Helen M. Conaglen ◽  
Dennis de Jong ◽  
Veronica Crawford ◽  
Marianne S. Elston ◽  
John V. Conaglen
Keyword(s):  
Growth Hormone ◽  
Body Image ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Primary Diagnosis ◽  
Body Image Disturbance ◽  
Separate Analysis ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
The Impact

Purpose. Excess growth hormone secretion in adults results in acromegaly, a condition in which multiple physical changes occur including bony and soft tissue overgrowth. Over time these changes can markedly alter a person’s appearance. The aim of this study was to compare body image disturbance in patients with acromegaly to those with nonfunctioning pituitary adenomas (NFAs) and controls and assess the impact of obesity in these groups.Methods. A cross-sectional survey including quality of life, body image disturbance, anxiety and depression measures, growth hormone, and BMI measurement was carried out.Results. The groups did not differ with respect to body image disturbance. However separate analysis of obese participants demonstrated relationships between mood scales, body image disturbance, and pain issues, particularly for acromegaly patients.Conclusions. While the primary hypothesis that acromegaly might be associated with body image disturbance was not borne out, we have shown that obesity together with acromegaly and NFA can be associated with body image issues, suggesting that BMI rather than primary diagnosis might better indicate whether patients might experience body image disturbance problems.

Species differences between male rat and ram pituitary somatostatin receptors involved in the inhibition of growth hormone secretion

1997 ◽  
pp. 545-555 ◽  
Author(s):  
N Briard ◽  
A Dutour ◽  
J Epelbaum ◽  
N Sauze ◽  
A Slama ◽  
...  
Keyword(s):  
Binding Sites ◽  
Hormone Secretion ◽  
Somatostatin Receptors ◽  
Growth Hormone Secretion ◽  
Male Rat ◽  
Receptor Subtype ◽  
Binding Properties ◽  
Binding Characteristics ◽  
Gh Secretion ◽  
Inhibition Of Growth

The sheep is a valuable model in which to study GH neuroregulation as its pattern of GH secretion is very close to that in humans. Furthermore, important differences in somatostatin (SRIH) action between rats and sheep have been found previously. Our goal was to compare in male rat and ram pituitaries the binding characteristics of somatostatin receptors and the effect of SRIH and 17 analogues on GH release. Using radioautography, SRIH binding was seen to be evenly distributed over the anterior pituitary of both species. In the binding assay, binding sites were three times more concentrated in rats than in sheep. Important interspecies differences in the action of SRIH and its analogues were found: they inhibited GH at lower concentrations in rats than in sheep. Seven peptides displayed greater inhibitory ability in sheep than in rats while three were more potent in rats. Agonistic potencies to inhibit GH release in rats were correlated with somatostatin receptors subtype 2 (sst2) affinities. Our data confirm and extend the quantitative differences between rat and sheep in SRIH inhibitory action on GH secretion and confirm that ligand-binding properties of a given receptor subtype cannot be extrapolated across species.

Development of resistance to a long-acting somatostatin analogue during treatment of two patients with metastatic endocrine pancreatic tumours

1988 ◽  
Vol 119 (4) ◽  
pp. 561-566 ◽  
Author(s):  
S. W.J. Lamberts ◽  
G. F. F. M. Pieters ◽  
H.J. Metselaar ◽  
G. L. Ong ◽  
H. S. Tan ◽  
...  
Keyword(s):  
Clinical Effect ◽  
Hormone Secretion ◽  
Somatostatin Receptors ◽  
Inhibitory Effect ◽  
Somatostatin Analogue ◽  
Pancreatic Tumours ◽  
Development Of Resistance ◽  
Clinical Observations ◽  
Transient Improvement ◽  
Long Acting

Abstract. Two patients with metastatic endocrine pancreatic tumours initially responded well to therapy with the long-acting somatostatin analogue SMS 201-995. In the first patient with an insulinoma both the number of hypoglycemic attacks and the increased insulin levels decreased initially, but returned to pretreatment intensity and concentrations within 9 days after the start of therapy with 200–300 μg SMS 201-995 daily. After a short interruption, no effect was observed of re-institution of therapy at a dose of 400 μg SMS 201-995 daily. In the other patient with a metastatic vipoma both diarrhea, hypokalemia and plasma VIP levels reacted initially well to SMS 201-995 treatment with 300 μg per day, but resistance to therapy developed after 2 weeks. An increase in the dose of the analogue to maximally 600 μg/day was followed by a transient improvement, but finally both the volume of diarrhea and the levels of vasoactive intestinal polypeptide were higher than those before the start of therapy. Conclusions: Development of resistance to SMS 201-995 both with regard to the clinical effect and to the inhibitory effect on tumour hormone secretion can be expected in some patients with metastatic endocrine pancreatic tumours. On the basis of our clinical observations down-regulation of somatostatin receptors is suggested to be one of the mechanisms of this development.

P.049 The impact of depot and long acting injectable antipsychotics on BDNF serum levels in psychosis: a 24-month longitudinal prospective study

2019 ◽  
Vol 29 ◽  
pp. S54-S55
Author(s):  
M. Manchia ◽  
D. Primavera ◽  
L. Deriu ◽  
E. Caboni ◽  
N. Iaselli ◽  
...  
Keyword(s):  
Prospective Study ◽  
Serum Levels ◽  
Long Acting ◽  
The Impact

scholarly journals THE IMPACT OF RAMAZAN I’TIKAF ON IMMUNE SYSTEM

2017 ◽  
Vol 17 (3) ◽  
pp. 104-108
Author(s):  
Hasan Huseyin Eker ◽  
Mehmet Derya Onuk ◽  
Caglayan Geredeli ◽  
Maihebureti Abuduli
Keyword(s):  
Immune System ◽  
Waist Circumference ◽  
Prospective Study ◽  
Hematological Parameters ◽  
Hip Circumference ◽  
Immunological Parameters ◽  
Before And After ◽  
A Prospective Study ◽  
The Impact ◽  
Ig G

I'tikaaf is a worship maintained by very deep hunger in fasting month of Ramadan. Hunger causes different results on the immune system. This is a prospective study. In this study, the changes in the immune system were investigated during the period of the i’tikaf, which is deep hunger worship. In the last 10 days of Ramadan, before and at the end of i’tikaf blood was taken from 46 male volunteers who performed i’tikaf worship and various biochemical and immunological parameters were examined. Comparison of the measures taken before and after i’tikaf indicated a statistically significant decrease in weight, BMI, waist circumference and hip circumference (p<0.001). Of the hematologic parameters, the lymphocyte count increased significantly (p=0.009). Also, a significant increase was observed in the values of IgA, IgM ve Ig G within the hematological parameters (p<0.001). During the period of i’tikaf, feeding with very low calories (1000 calories) caused an increase in the levels of lymphocyte and immunoglobulins and got the immune system stronger.

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