scholarly journals SDCBP Modulates Stemness and Chemoresistance in Head and Neck Squamous Cell Carcinoma through Src Activation

Cancers ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 4952
Author(s):  
Cristina Mir ◽  
Yoelsis Garcia-Mayea ◽  
Laia Garcia ◽  
Pol Herrero ◽  
Nuria Canela ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Survival Rates ◽  
Neck Squamous Cell Carcinoma ◽  
Advanced Tumor Stage ◽  
Ki 67 ◽  
Advanced Tumor ◽  
Src Activation

To characterize the mechanisms that govern chemoresistance, we performed a comparative proteomic study analyzing head and neck squamous cell carcinoma (HNSCC) cells: CCL-138 (parental), CCL-138-R (cisplatin-resistant), and cancer stem cells (CSCs). Syntenin-1 (SDCBP) was upregulated in CCL-138-R cells and CSCs over parental cells. SDCBP depletion sensitized biopsy-derived and established HNSCC cell lines to cisplatin (CDDP) and reduced CSC markers, Src activation being the main SDCBP downstream target. In mice, SDCBP-depleted cells formed tumors with decreased mitosis, Ki-67 positivity, and metastasis over controls. Moreover, the fusocellular pattern of CCL-138-R cell-derived tumors reverted to a more epithelial morphology upon SDCBP silencing. Importantly, SDCBP expression was associated with Src activation, poor differentiated tumor grade, advanced tumor stage, and shorter survival rates in a series of 382 HNSCC patients. Our results reveal that SDCBP might be a promising therapeutic target for effectively eliminating CSCs and CDDP resistance.

scholarly journals Frequent deletion of ING2 locus at 4q35.1 associates with advanced tumor stage in head and neck squamous cell carcinoma

2008 ◽  
Vol 135 (5) ◽  
pp. 703-713 ◽  
Author(s):  
Silvia S. Borkosky ◽  
Mehmet Gunduz ◽  
Hitoshi Nagatsuka ◽  
Levent Bekir Beder ◽  
Esra Gunduz ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Tumor Stage ◽  
Neck Squamous Cell Carcinoma ◽  
Advanced Tumor Stage ◽  
Advanced Tumor

Co-overexpression of p21 and Ki-67 in head and neck squamous cell carcinoma relative to a significantly poor prognosis

Head & Neck ◽  
2011 ◽  
Vol 33 (2) ◽  
pp. 267-273 ◽  
Author(s):  
Claude A. Fischer ◽  
Minoa Jung ◽  
Inti Zlobec ◽  
Edith Green ◽  
Claudio Storck ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Poor Prognosis ◽  
Neck Squamous Cell Carcinoma ◽  
Ki 67

scholarly journals Predictors of Survival After Head and Neck Squamous Cell Carcinoma in South America: The InterCHANGE Study

2020 ◽  
pp. 486-499 ◽  
Author(s):  
Renata Abrahão ◽  
Sandra Perdomo ◽  
Luis Felipe Ribeiro Pinto ◽  
Flávia Nascimento de Carvalho ◽  
Fernando Luis Dias ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
South America ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Cox Regression ◽  
Survival Rates ◽  
Stage Iv ◽  
Neck Squamous Cell Carcinoma ◽  
Stage Iv Disease

PURPOSE Head and neck squamous cell carcinoma (HNSCC) incidence is high in South America, where recent data on survival are sparse. We investigated the main predictors of HNSCC survival in Brazil, Argentina, Uruguay, and Colombia. METHODS Sociodemographic and lifestyle information was obtained from standardized interviews, and clinicopathologic data were extracted from medical records and pathologic reports. The Kaplan-Meier method and Cox regression were used for statistical analyses. RESULTS Of 1,463 patients, 378 had a larynx cancer (LC), 78 hypopharynx cancer (HC), 599 oral cavity cancer (OC), and 408 oropharynx cancer (OPC). Most patients (55.5%) were diagnosed with stage IV disease, ranging from 47.6% for LC to 70.8% for OPC. Three-year survival rates were 56.0% for LC, 54.7% for OC, 48.0% for OPC, and 37.8% for HC. In multivariable models, patients with stage IV disease had approximately 7.6 (LC/HC), 11.7 (OC), and 3.5 (OPC) times higher mortality than patients with stage I disease. Current and former drinkers with LC or HC had approximately 2 times higher mortality than never-drinkers. In addition, older age at diagnosis was independently associated with worse survival for all sites. In a subset analysis of 198 patients with OPC with available human papillomavirus (HPV) type 16 data, those with HPV-unrelated OPC had a significantly worse 3-year survival compared with those with HPV-related OPC (44.6% v 75.6%, respectively), corresponding to a 3.4 times higher mortality. CONCLUSION Late stage at diagnosis was the strongest predictor of lower HNSCC survival. Early cancer detection and reduction of harmful alcohol use are fundamental to decrease the high burden of HNSCC in South America.

scholarly journals Cancer Stem Cell Markers in Head and Neck Squamous Cell Carcinoma

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Aidan G. Major ◽  
Luke P. Pitty ◽  
Camile S. Farah
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Survival Rates ◽  
Neck Squamous Cell Carcinoma ◽  
Treatment Modalities ◽  
Stem Cell Markers ◽  
Cancer Stem Cell Markers

Head and neck squamous cell carcinoma (HNSCC) is one of the world’s top ten most common cancers. Current survival rates are poor with only 50% of patients expected to survive five years after diagnosis. The poor survival rate of HNSCC is partly attributable to the tendency for diagnosis at the late stage of the disease. One of the reasons for treatment failure is thought to be related to the presence of a subpopulation of cells within the tumour called cancer stem cells (CSCs). CSCs display stem cell-like characteristics that impart resistance to conventional treatment modalities and promote tumour initiation, progression, and metastasis. Specific markers for this population have been investigated in the hope of developing a deeper understanding of their role in the pathogenesis of HNSCC and elucidating novel therapeutic strategies.

scholarly journals Impact of a tobacco treatment program on abstinence and survival rates among current smokers with head and neck squamous cell carcinoma

Head & Neck ◽  
2020 ◽  
Vol 42 (9) ◽  
pp. 2440-2452
Author(s):  
Andrew T. Day ◽  
Kristina R. Dahlstrom ◽  
Rebecca Lee ◽  
Maher Karam‐Hage ◽  
Erich M. Sturgis
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Treatment Program ◽  
Survival Rates ◽  
Neck Squamous Cell Carcinoma ◽  
Tobacco Treatment

scholarly journals The radiobiology of HPV-positive and HPV-negative head and neck squamous cell carcinoma

2020 ◽  
Vol 22 ◽  
Author(s):  
Chumin Zhou ◽  
Jason L. Parsons
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Survival Rates ◽  
Cell Cycle Checkpoint ◽  
Neck Squamous Cell Carcinoma ◽  
Hpv Status ◽  
Hnscc Cell

Abstract Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, with reported incidences of ~800 000 cases each year. One of the critical determinants in patient response to radiotherapy, particularly for oropharyngeal cancers, is human papillomavirus (HPV) status where HPV-positive patients display improved survival rates and outcomes particularly because of increased responsiveness to radiotherapy. The increased radiosensitivity of HPV-positive HNSCC has been largely linked with defects in the signalling and repair of DNA double-strand breaks. Therefore, strategies to further radiosensitise HPV-positive HNSCC, but also radioresistant HPV-negative HNSCC, have focussed on targeting key DNA repair proteins including PARP, DNA-Pk, ATM and ATR. However, inhibitors against CHK1 and WEE1 involved in cell-cycle checkpoint activation have also been investigated as targets for radiosensitisation in HNSCC. These studies, largely conducted using established HNSCC cell lines in vitro, have demonstrated variability in the response dependent on the specific inhibitors and cell models utilised. However, promising results are evident targeting specifically PARP, DNA-Pk, ATR and CHK1 in synergising with radiation in HNSCC cell killing. Nevertheless, these preclinical studies require further expansion and investigation for translational opportunities for the effective treatment of HNSCC in combination with radiotherapy.

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