O113 Head and neck squamous cell carcinoma in non-smoking and non-drinking patients with multiple tumors: etiologic significance of p53 overexpression and ki-67 suprabasal expression in non tumorous epithelium

2007 ◽  
Vol 2 (1) ◽  
pp. 95
Author(s):  
F. Farshadpour ◽  
G.J. Hordijk ◽  
R. Koole ◽  
P. Slootweg
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Ki 67 ◽  
P53 Overexpression ◽  
Multiple Tumors

Co-overexpression of p21 and Ki-67 in head and neck squamous cell carcinoma relative to a significantly poor prognosis

Head & Neck ◽  
2011 ◽  
Vol 33 (2) ◽  
pp. 267-273 ◽  
Author(s):  
Claude A. Fischer ◽  
Minoa Jung ◽  
Inti Zlobec ◽  
Edith Green ◽  
Claudio Storck ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Poor Prognosis ◽  
Neck Squamous Cell Carcinoma ◽  
Ki 67

Roles of Ki-67 and p16 as biomarkers for unknown primary head and neck squamous cell carcinoma

2019 ◽  
Vol 276 (4) ◽  
pp. 1221-1229 ◽  
Author(s):  
Toshiya Maebayashi ◽  
Naoya Ishibashi ◽  
Takuya Aizawa ◽  
Masakuni Sakaguchi ◽  
Tsutomu Saito ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Unknown Primary ◽  
Ki 67

scholarly journals p53 mutation, but not p53 overexpression, correlates with survival in head and neck squamous cell carcinoma

1998 ◽  
Vol 78 (8) ◽  
pp. 1084-1090 ◽  
Author(s):  
H Mineta ◽  
Å Borg ◽  
M Dictor ◽  
P Wahlberg ◽  
J Åkervall ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
P53 Mutation ◽  
Neck Squamous Cell Carcinoma ◽  
P53 Overexpression

scholarly journals SDCBP Modulates Stemness and Chemoresistance in Head and Neck Squamous Cell Carcinoma through Src Activation

Cancers ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 4952
Author(s):  
Cristina Mir ◽  
Yoelsis Garcia-Mayea ◽  
Laia Garcia ◽  
Pol Herrero ◽  
Nuria Canela ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Survival Rates ◽  
Neck Squamous Cell Carcinoma ◽  
Advanced Tumor Stage ◽  
Ki 67 ◽  
Advanced Tumor ◽  
Src Activation

To characterize the mechanisms that govern chemoresistance, we performed a comparative proteomic study analyzing head and neck squamous cell carcinoma (HNSCC) cells: CCL-138 (parental), CCL-138-R (cisplatin-resistant), and cancer stem cells (CSCs). Syntenin-1 (SDCBP) was upregulated in CCL-138-R cells and CSCs over parental cells. SDCBP depletion sensitized biopsy-derived and established HNSCC cell lines to cisplatin (CDDP) and reduced CSC markers, Src activation being the main SDCBP downstream target. In mice, SDCBP-depleted cells formed tumors with decreased mitosis, Ki-67 positivity, and metastasis over controls. Moreover, the fusocellular pattern of CCL-138-R cell-derived tumors reverted to a more epithelial morphology upon SDCBP silencing. Importantly, SDCBP expression was associated with Src activation, poor differentiated tumor grade, advanced tumor stage, and shorter survival rates in a series of 382 HNSCC patients. Our results reveal that SDCBP might be a promising therapeutic target for effectively eliminating CSCs and CDDP resistance.

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