scholarly journals Can Naloxegol Therapy Improve Quality of Life in Patients with Advanced Cancer?

Cancers ◽  
2021 ◽  
Vol 13 (22) ◽  
pp. 5736
Author(s):  
Rita Ostan ◽  
Giuseppe Gambino ◽  
Italo Malavasi ◽  
Gianluca Ronga ◽  
Maria Solipaca ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Advanced Cancer ◽  
Rating Scale ◽  
Numerical Rating Scale ◽  
Bowel Function ◽  
Advanced Cancer Patients ◽  
Background Pain ◽  
Bowel Movements ◽  
Numerical Rating

This observational study aims to evaluate the efficacy of naloxegol therapy in resolving opioid-induced constipation (OIC) and in improving the quality of life in a home palliative care cancer setting. Advanced cancer patients with OIC (Rome IV criteria) not relieved by laxatives started a naloxegol therapy 25 mg/day for 4 weeks. Quality of life was evaluated by Patient Assessment of Constipation Quality-of-Life (PAC-QoL) at day 0 and day 28; background pain by Numerical Rating Scale, number of weekly spontaneous bowel movements and Bowel Function Index (BFI) were evaluated at day 0 and every week. Seventy-eight patients who completed the 4-week study improved all four PAC-QoL dimensions (physical and psychological discomfort, worries/concerns and satisfaction level). Weekly spontaneous bowel movements increased and BFI improved. Background pain reduced after seven days and remained lower during the following weeks. Seventy-two patients dropped out the study before day 28 with a reduced survival compared to patients completing the study. Even in these patients, an improvement of bowel function was observed after two weeks. Naloxegol was effective in improving the quality of life, resolving OIC and reducing overall pain in patients with advanced cancer.

The Development of the Mymop Pictorial Version

2004 ◽  
Vol 22 (2) ◽  
pp. 68-71 ◽  
Author(s):  
Anthony Day
Keyword(s):  
Quality Of Life ◽  
Complementary Therapies ◽  
Rating Scale ◽  
Numerical Rating Scale ◽  
Life Instrument ◽  
Numerical Rating

The MYMOP is a well accepted quality of life instrument that is particularly suitable for assessing the effect of complementary therapies; however, some groups of patients find it difficult to use. A pictorial version was developed using faces instead of the numerical rating scale – it is called MYMOP pictorial. This version appears to be more acceptable to patients but has not been formally validated.

scholarly journals Persistent Postsurgical Pain Following Thoracotomy: A Comparison of Thoracic Epidural and Paravertebral Blockade as Preventive Analgesia

Pain Medicine ◽  
2019 ◽  
Vol 20 (9) ◽  
pp. 1796-1802
Author(s):  
Jonathon Wong ◽  
Jackie Cooper ◽  
Rik Thomas ◽  
Richard Langford ◽  
Sibtain Anwar
Keyword(s):  
Quality Of Life ◽  
Neuropathic Pain ◽  
Rating Scale ◽  
Numerical Rating Scale ◽  
Short Form ◽  
Postsurgical Pain ◽  
Perioperative Analgesia ◽  
Thoracic Epidural ◽  
Numerical Rating

Abstract Objective Persistent postsurgical pain (PPP) is common following thoracotomy. Thoracic epidural (TEB) and paravertebral blockade (PVB) are both established forms of perioperative analgesia for thoracotomy. There is currently a lack of data on their influence on PPP; this study aims to evaluate both techniques on PPP. Design Observational study, prospectively collected data. Methods Adults who underwent thoracotomy had either TEB or PVB for analgesia and were prospectively interviewed at six months. A numerical rating scale, the short form of the Leeds Assessment of Neuropathic Symptoms and Signs, and the EuroQol-5 dimension (EQ-5D) index were used to assess pain, neuropathic pain, and quality of life. Results Eighty-two patients who underwent a thoracotomy were recruited (TEB N = 36, PVB N = 46). Pain scores had a median (interquartile range [IQR]) of 1 (0 to 4.5) and 1.5 (0 to 4, P = 0.89), presence of PPP was 58.3% (95% confidence interval [CI] = 40.0–74.5%) and 60.9% (95% CI = 45.4–74.9%, P = 0.81), and presence of neuropathic pain was 30.6% (95% CI = 16.3–48.1%) and 28.2% (95% CI = 16.0–43.5%, P = 0.85). Reported quality of life was 0.71 (0.14–0.85) and 0.80 (0.19–0.91, P = 0.21). Patients who had PPP reported worse quality of life measures compared with those who were pain free, with a median (IQR) EQ-5D index of 0.69 (–0.15 to 0.85) and 0.85 (0.72 to 1, P = 0.0007); quality of life was worst when there was a neuropathic component (median = 0.39, IQR = –0.24 to 0.75). Conclusions There was no statistical difference in the development of persistent postsurgical pain between patients who received a TEB or a PVB; however, patients who developed PPP had a significantly lower quality of life, which was worse with a neuropathic component.

scholarly journals Yangshimtang-gamibang Therapy for Sleep Disorder Caused by a Traffic Accident: A Case Report

2021 ◽  
Vol 42 (5) ◽  
pp. 1020-1026
Author(s):  
Jin-young Song ◽  
Geon-sik Kong ◽  
So-won Kim ◽  
Jin-hun Park ◽  
Yen-min Wang ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Case Report ◽  
Sleep Disorder ◽  
Traffic Accident ◽  
Rating Scale ◽  
Numerical Rating Scale ◽  
Scale Scores ◽  
Numerical Rating

This report describes the efficacy of using Yangshimtang-gamibang for a sleep disorder caused by a traffic accident. We treated a patient with Yangshimtang-gamibang for 12 days for sleep disorder caused by a traffic accident. To evaluate the results, we used the Korean Modified Leeds Sleep Evaluation Questionnaire (KMLSEQ) to measure sleep disorder. The degree of sleep disorder was also evaluated using the Numerical Rating Scale (NRS). The generic health status was evaluated using the European Quality of Life-5 Dimensions (EQ-5D) scale. Improvements in the NRS and EQ-5D scale scores were observed after the treatments. The change in the KMLSEQ score indicates that the patient's sleep disorder was relieved. The results of this case study suggest that Yangshimtang-gamibang may be an effective treatment for sleep disorders caused by traffic accident.

Use of time in people with a life-limiting illness: A longitudinal cohort feasibility pilot study

2019 ◽  
Vol 33 (10) ◽  
pp. 1319-1324
Author(s):  
Terry A Jones ◽  
Timothy S Olds ◽  
David C Currow ◽  
Marie T Williams
Keyword(s):  
Quality Of Life ◽  
Pilot Study ◽  
Time Use ◽  
Repeated Measures ◽  
Rating Scale ◽  
Numerical Rating Scale ◽  
Karnofsky Performance Status ◽  
Use Of Time ◽  
Numerical Rating

Background: To date, time-use studies in palliative care have been limited to exploration of time commitments of caregivers. Understanding time-use in people with a life-limiting illness might provide insight into disease progression, symptom management and quality of life. Aim: To determine the feasibility of a repeated-measures, time-use study in people with a life-limiting illness, and their primary caregivers, and to explore associations between time-use and perceived quality of life. Design: An observational repeated-measures feasibility pilot study. A priori criteria were established for study uptake (70%), retention (80%) and study value/burden (⩾7 Numerical Rating Scale 0–10). Burden and value of the study, use of time (Multimedia Activity Recall for Children and Adults with adjunctive accelerometry) and quality of life data (EuroQol-5 Dimension-5-Level Health Questionnaire and Australia-modified Karnofsky Performance Status scale) were assessed at time-points across five consecutive months. Setting/participants: People living with a life-limiting illness and caregivers recruited from Southern Adelaide Palliative Services outpatient clinics. Results: A total of 10 participants (2 caregivers and 8 people with a life-limiting illness) enrolled in the study. All but one of the criteria thresholds was met: 66% of participants who consented to be screened were enrolled in the study, 80% of enrolled participants ( n = 8) completed all assessments (two participants died during the study) and mean Numerical Rating Scale scores for acceptable burden and value of the study exceeded the criteria thresholds at every time-point. Conclusion: A repeated-measures time-use study design is feasible and was not unduly burdensome for caregivers and people living with a life-limiting illness.

scholarly journals Effectiveness of Operative and Nonoperative Care for Adult Spinal Deformity: Systematic Review of the Literature

2017 ◽  
Vol 7 (2) ◽  
pp. 170-178 ◽  
Author(s):  
Alisson R. Teles ◽  
Tobias A. Mattei ◽  
Orlando Righesso ◽  
Asdrubal Falavigna
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Rating Scale ◽  
Numerical Rating Scale ◽  
Short Form ◽  
Adult Spinal Deformity ◽  
Numerical Rating ◽  
Short Form Health

Study Design: Systematic review. Objective: There is a need for synthesizing data on effectiveness of treatments for patients with adult spinal deformity (ASD) due to its increasing prevalence and health care costs for these patients. The objective of this review was to estimate the effectiveness of surgery versus nonoperative care in patients with ASD. Methods: A systematic review of articles in published in English using PubMed between 2005 and 2015. Surgical and nonsurgical series that reported baseline and follow-up health-related quality of life measures of patients with ASD with a minimum 2 years of follow-up were selected. Independent extraction of articles by 2 authors using predefined data fields, including risk of bias assessment. Results: Surgery significantly reduces disability, pain, and improves patients’ quality of life. The average postoperative improvement in Oswestry Disability Index was −19.1 (±9.0), Numerical Rating Scale back pain −4.14 (±1.38), Numerical Rating Scale leg pain −3.36 (±1.33), Short-Form Health Survey 36-SF36-Physical Component score 11.2 (±5.07), and Short-Form Health Survey 36-Mental Component score 9.93 (±4.96). The complication rate ranged from 9.52% to 81.52% (mean = 39.62%), and the need for revision surgery ranged from 1.72% to 40.0% (mean = 15.71%). The best existing evidence about nonoperative care of ASD is provided from observational studies with very high risk of bias. Quantitative analyses of nonsurgical cohorts did not demonstrate significant changes in quality of life of patients after 2 years of observation. Conclusions: This data may assist clinicians to counsel patients, as well as to inform health care providers and policymakers about what to expect from the treatment for ASD.

Predictive factors of overall quality of life in advanced cancer patients using EORTC QLQ-C30

2013 ◽  
Vol 14 (1) ◽  
pp. 139-146 ◽  
Author(s):  
Gemma Cramarossa ◽  
Liang Zeng ◽  
Liying Zhang ◽  
Ling-Ming Tseng ◽  
Ming-Feng Hou ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cancer Patients ◽  
Advanced Cancer ◽  
Predictive Factors ◽  
Advanced Cancer Patients ◽  
Eortc Qlq C30 ◽  
Eortc Qlq
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