Systematic Investigation of Biocompatible Cationic Polymeric Nucleic Acid Carriers for Immunotherapy of Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is the third-largest cause of cancer death worldwide, while immunotherapy is rapidly being developed to fight HCC with great potential. Nucleic acid drugs are the most important modulators in HCC immunotherapy. To boost the efficacy of therapeutics and amplify the efficiency of genetic materials, biocompatible polymers are commonly used. However, under the strong need of a summary for current developments of biocompatible polymeric nucleic acid carriers for immunotherapy of HCC, there is rare review article specific to this topic to our best knowledge. In this article, we will discuss the current progress of immunotherapy for HCC, biocompatible cationic polymers (BCPs) as nucleic acid carriers used (or potential) to fight HCC, the roles of biocompatible polymeric carriers for nucleic acid delivery, and nucleic acid delivery by biocompatible polymers for immunotherapy. At the end, we will conclude the review and discuss future perspectives. This article discusses biocompatible polymeric nucleic acid carriers for immunotherapy of HCC from multidiscipline perspectives and provides a new insight in this domain. We believe this review will be interesting to polymer chemists, pharmacists, clinic doctors, and PhD students in related disciplines.

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Biocompatible Polymers for Nucleic Acid Delivery

Biodegradable Polymers in Clinical Use and Clinical Development ◽

10.1002/9781118015810.ch15 ◽

2011 ◽

pp. 519-563

Author(s):

Jeff Sparks ◽

Khursheed Anwer

Keyword(s):

Nucleic Acid ◽

Biocompatible Polymers ◽

Nucleic Acid Delivery

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Design of Lipid and Polymeric Carriers for Nucleic Acid Delivery

10.21007/etd.cghs.2010.0384 ◽

2010 ◽

Author(s):

Lin Zhu

Keyword(s):

Nucleic Acid ◽

Nucleic Acid Delivery ◽

Polymeric Carriers

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Multifunctional polymeric micelle-based nucleic acid delivery: Current advances and future perspectives

Applied Materials Today ◽

10.1016/j.apmt.2021.101217 ◽

2021 ◽

Vol 25 ◽

pp. 101217

Author(s):

Ivana Jarak ◽

Miguel Pereira-Silva ◽

Ana Cláudia Santos ◽

Francisco Veiga ◽

Horacio Cabral ◽

...

Keyword(s):

Nucleic Acid ◽

Polymeric Micelle ◽

Nucleic Acid Delivery ◽

Future Perspectives

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Scaling the effect of hydrophobic chain length on gene transfer properties of di-alkyl, di-hydroxy ethylammonium chloride based cationic amphiphiles

RSC Advances ◽

10.1039/c7ra02271a ◽

2017 ◽

Vol 7 (41) ◽

pp. 25398-25405 ◽

Cited By ~ 6

Author(s):

Ankita A. Hiwale ◽

Chandrashekhar Voshavar ◽

Priya Dharmalingam ◽

Ashish Dhayani ◽

Rajesh Mukthavaram ◽

...

Keyword(s):

Nucleic Acid ◽

Gene Transfer ◽

Transfection Efficiency ◽

Systematic Investigation ◽

Cationic Lipids ◽

Nucleic Acid Delivery ◽

Hydrocarbon Chains ◽

Hydrophobic Chain ◽

Transfer Properties

Asymmetric hydrocarbon chains influence the efficiency of cationic lipids based liposomes in nucleic acid delivery. A systematic investigation of role of asymmetry in transfection efficiency.

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Polymeric Carriers for Nucleic Acid Delivery: Current Designs and Future Directions

Biomacromolecules ◽

10.1021/acs.biomac.9b00999 ◽

2019 ◽

Vol 20 (10) ◽

pp. 3613-3626 ◽

Cited By ~ 15

Author(s):

Lun Peng ◽

Ernst Wagner

Keyword(s):

Nucleic Acid ◽

Nucleic Acid Delivery ◽

Future Directions ◽

Polymeric Carriers

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Nucleic Acid Delivery with Red-Blood-Cell-Based Carriers

International Journal of Molecular Sciences ◽

10.3390/ijms22105264 ◽

2021 ◽

Vol 22 (10) ◽

pp. 5264

Author(s):

Giulia Della Pelle ◽

Nina Kostevšek

Keyword(s):

Drug Delivery ◽

Blood Cells ◽

Drug Delivery Systems ◽

Review Article ◽

Nucleic Acid Delivery ◽

The Third ◽

The Past ◽

Loading Methods ◽

Poor Stability

Gene therapy has the potential to become a staple of 21st-century medicine. However, to overcome the limitations of existing gene-delivery therapies, that is, poor stability and inefficient and delivery and accumulation of nucleic acids (NAs), safe drug-delivery systems (DDSs) allowing the prolonged circulation and expression of the administered genes in vivo are needed. In this review article, the development of DDSs over the past 70 years is briefly described. Since synthetic DDSs can be recognized and eliminated as foreign substances by the immune system, new approaches must be found. Using the body’s own cells as DDSs is a unique and exciting strategy and can be used in a completely new way to overcome the critical limitations of existing drug-delivery approaches. Among the different circulatory cells, red blood cells (RBCs) are the most abundant and thus can be isolated in sufficiently large quantities to decrease the complexity and cost of the treatment compared to other cell-based carriers. Therefore, in the second part, this article describes 70 years of research on the development of RBCs as DDSs, covering the most important RBC properties and loading methods. In the third part, it focuses on RBCs as the NA delivery system with advantages and drawbacks discussed to decide whether they are suitable for NA delivery in vivo.

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Sugar Functionalized Synergistic Dendrimers for Biocompatible Delivery of Nucleic Acid Therapeutics

Polymers ◽

10.3390/polym10091034 ◽

2018 ◽

Vol 10 (9) ◽

pp. 1034 ◽

Cited By ~ 1

Author(s):

Shuqin Han ◽

Tsogzolmaa Ganbold ◽

Qingming Bao ◽

Takashi Yoshida ◽

Huricha Baigude

Keyword(s):

Nucleic Acid ◽

Sirna Delivery ◽

Green Fluorescence Protein ◽

Nucleic Acid Delivery ◽

Cationic Polymers ◽

Nucleic Acid Therapeutics ◽

Fluorescence Protein ◽

Interfering Rna

Sugars containing cationic polymers are potential carriers for in vitro and in vivo nucleic acid delivery. Monosaccharides such as glucose and galactose have been chemically conjugated to various materials of synergistic poly-lysine dendrimer systems for efficient and biocompatible delivery of short interfering RNA (siRNA). The synergistic dendrimers, which contain lipid conjugated glucose terminalized lysine dendrimers, have significantly lower adverse impact on cells while maintaining efficient cellular entry. Moreover, the synergistic dendrimers complexed to siRNA induced RNA interference (RNAi) in the cells and profoundly knocked down green fluorescence protein (GFP) as well as the endogenously expressing disease related gene Plk1. The new synergic dendrimers may be promising system for biocompatible and efficient siRNA delivery.

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