scholarly journals Correlation of Somatostatin Receptor 1–5 Expression, [68Ga]Ga-DOTANOC, [18F]F-FDG PET/CT and Clinical Outcome in a Prospective Cohort of Pancreatic Neuroendocrine Neoplasms

Cancers ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 162
Author(s):  
Susanna Majala ◽  
Tiina Vesterinen ◽  
Hanna Seppänen ◽  
Harri Mustonen ◽  
Jari Sundström ◽  
...  
Keyword(s):  
Prospective Study ◽  
Fdg Pet ◽  
Somatostatin Receptor ◽  
Proliferation Index ◽  
Neuroendocrine Neoplasms ◽  
Ki 67 ◽  
Pet Ct ◽  
Sstr Subtype ◽  
Node Metastases ◽  
Fdg Pet Ct

Purpose: The aim of this study was to correlate immunohistochemical (IHC) tissue levels of SSTR1-5 with the receptor density generated from [68Ga]Ga-DOTANOC uptake in a prospective series of NF-PNENs. Methods: Twenty-one patients with a total of thirty-five NF-PNEN-lesions and twenty-one histologically confirmed lymph node metastases (LN+) were included in this prospective study. Twenty patients were operated on, and one underwent endoscopic ultrasonography and core-needle biopsy. PET/CT with both [68Ga]Ga-DOTANOC and [18F]F-FDG was performed on all patients. All histological samples were re-classified and IHC-stained with monoclonal SSTR1-5 antibodies and Ki-67 and correlated with [68Ga]Ga-DOTANOC and [18F]F-FDG PET/CT. Results: Expression of SSTR1-5 was detected in 74%, 91%, 80%, 14%, and 77% of NF-PNENs. There was a concordance of SSTR2 IHC with positive/negative [68Ga]Ga-DOTANOC finding (Spearman’s rho 0.382, p = 0.043). All [68Ga]Ga-DOTANOC-avid tumors expressed SSTR2 or SSTR3 or SSTR5. Expression of SSTR5 was higher in tumors with a low Ki-67 proliferation index (PI) (−0.353, 95% CI −0.654–0.039, p = 0.038). The mean Ki-67 PI for SSTR5 positive tumors was 2.44 (SD 2.56, CI 1.0–3.0) and 6.38 (SD 7.25, CI 2.25–8.75) for negative tumors. Conclusion: SSTR2 was the only SSTR subtype to correlate with [68Ga]Ga-DOTANOC PET/CT. Our prospective study confirms SSTR2 to be of the highest impact for SST PET/CT signal.

Classification Model to Estimate MIB-1 (Ki 67) Proliferation Index in NSCLC Patients Evaluated With 18F-FDG-PET/CT

2020 ◽  
Vol 40 (6) ◽  
pp. 3355-3360
Author(s):  
BARBARA PALUMBO ◽  
ROSANNA CAPOZZI ◽  
FRANCESCO BIANCONI ◽  
MARIO LUCA FRAVOLINI ◽  
SILVIA CASCIANELLI ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Classification Model ◽  
Proliferation Index ◽  
Ki 67 ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Nsclc Patients ◽  
Mib 1

SUV on Dual-Phase FDG PET/CT Correlates With the Ki-67 Proliferation Index in Patients With Newly Diagnosed Non-Hodgkin Lymphoma

2012 ◽  
Vol 37 (8) ◽  
pp. e189-e195 ◽  
Author(s):  
Chin-Chuan Chang ◽  
Shih-Feng Cho ◽  
Yu-Wen Chen ◽  
Hung-Pin Tu ◽  
Chia-Yang Lin ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Fdg Pet ◽  
Proliferation Index ◽  
Dual Phase ◽  
Newly Diagnosed ◽  
Ki 67 ◽  
Non Hodgkin Lymphoma ◽  
Pet Ct ◽  
Fdg Pet Ct

scholarly journals Correlation of 18F-FDG PET/CT SUVmax with clinical features, D-dimer and LDH in patients with primary intestinal lymphoma

2021 ◽  
Vol 49 (7) ◽  
pp. 030006052110298
Author(s):  
Shuo Zhou ◽  
Wenxin Chen ◽  
Meifu Lin ◽  
Guobao Chen ◽  
Cailong Chen ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Clinical Staging ◽  
Imaging Features ◽  
Intestinal Lymphoma ◽  
Ki 67 ◽  
Positive Correlation ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
D Dimer

Objective To investigate the characteristics of fluorine-18-deoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) maximum standardized uptake value (SUVmax) in primary intestinal lymphoma (PIL) and its correlation with D-dimer and lactate dehydrogenase (LDH). Methods Fifty-two patients diagnosed with PIL from June 2016 to December 2019 were analyzed. All patients underwent 18F-FDG PET/CT. The relationships between SUVmax and different pathological subtypes, clinical stages and risk grades were analyzed. The correlations between SUVmax and Ki-67, LDH and D-dimer were determined. Additionally, PET/CT imaging results were collected from 35 patients with primary intestinal cancer (PIC) and compared with the imaging features of PIL. Results SUVmax was significantly different between PIL and PIC groups and various PIL pathological subgroups. Patients in the high-risk PIL group had markedly higher SUVmax values than the intermediate-risk and low-risk groups. A significant positive correlation was observed between SUVmax and Ki-67 in patients with PIL. SUVmax was significantly different between the elevated and normal D-dimer groups. D-dimer showed a positive correlation with SUVmax. Conclusion 18F-FDG PET/CT SUVmax reflects the aggressiveness of lymphoma to a certain degree, is correlated with Ki-67 and determines the risk grades of PIL. Moreover, it facilitates differential diagnosis, clinical staging and treatment based on D-dimer levels.

scholarly journals FDG-PET/CT in high-risk primary breast cancer—a prospective study of stage migration and clinical impact

2020 ◽  
Author(s):  
Marianne Vogsen ◽  
Jeanette Dupont Jensen ◽  
Ivar Yannick Christensen ◽  
Oke Gerke ◽  
Anne Marie Bak Jylling ◽  
...  
Keyword(s):  
Breast Cancer ◽  
High Risk ◽  
Prospective Study ◽  
Fdg Pet ◽  
Primary Breast Cancer ◽  
Clinical Impact ◽  
Stage Migration ◽  
Pet Ct ◽  
A Prospective Study ◽  
Fdg Pet Ct

Additional Prone 18F-FDG PET/CT Acquisition to Improve the Visualization of the Primary Tumor and Regional Lymph Node Metastases in Stage II/III Breast Cancer

2016 ◽  
Vol 41 (4) ◽  
pp. e181-e186 ◽  
Author(s):  
Suzana Cipriano Teixeira ◽  
Bas B. Koolen ◽  
Wouter V. Vogel ◽  
Jelle Wesseling ◽  
Marcel P. M. Stokkel ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Primary Tumor ◽  
Fdg Pet ◽  
Regional Lymph Node ◽  
Pet Ct ◽  
Node Metastases ◽  
18F Fdg ◽  
Fdg Pet Ct

P.10.7 THE VALUE OF (18)FDG-PET/CT IN PATIENTS WITH RESECTABLE PANCREATIC CANCER: A PROSPECTIVE STUDY

2013 ◽  
Vol 45 ◽  
pp. S160 ◽  
Author(s):  
S. Crippa ◽  
M. Salgarello ◽  
S. Laiti ◽  
S. Partelli ◽  
C. Zardini ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Prospective Study ◽  
Fdg Pet ◽  
Resectable Pancreatic Cancer ◽  
Pet Ct ◽  
A Prospective Study ◽  
Fdg Pet Ct

scholarly journals Effect of Peptide Receptor Radionuclide Therapy on Somatostatin Receptor Status and Glucose Metabolism in Neuroendocrine Tumors: Intraindividual Comparison of Ga-68 DOTANOC PET/CT and F-18 FDG PET/CT

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Sowon Oh ◽  
Vikas Prasad ◽  
Dong Soo Lee ◽  
R. P. Baum
Keyword(s):  
Glucose Metabolism ◽  
Neuroendocrine Tumors ◽  
Fdg Pet ◽  
Radionuclide Therapy ◽  
Somatostatin Receptor ◽  
Peptide Receptor Radionuclide Therapy ◽  
Receptor Expression ◽  
Peptide Receptor ◽  
Pet Ct ◽  
Fdg Pet Ct

The heterogeneous nature of the neuroendocrine tumors (NET) makes it challenging to find one uniformly applicable management protocol which is especially true for diagnosis. The discovery of the overexpression of somatostatin receptors (SMS-R) on neuroendocrine tumor cells lead to the generalized and rapid acceptance of radiolabeled somatostatin receptor analogs for staging and restaging of NET as well as for Peptide Receptor Radionuclide Therapy (PRRNT) using Y-90 and Lu-177 DOTATATE/DOTATOC. In this present work we tried to look in to the effect of PRRNT on the glucose metabolism assessed by F-18 FDG PET/CT and SMS-R density assessed by Ga-68 DOTANOC PET/CT. We observed a complex relationship between the somatostatin receptor expression and glucose metabolism with only 56% (77/138) of the lesions showing match, while the others show mismatch between the receptor status and metabolism. The match between receptor expression and glucose metabolism increases with the grade of NET. In grade 3 NET, there is a concurrence between the changes in glucose metabolism and somatostatin receptor expression. PRRNT was found to be more effective in lesions with higher receptor expression.

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