Potential of Fibrin Glue and Mesenchymal Stem Cells (MSCs) to Regenerate Nerve Injuries: A Systematic Review

Cell-based therapy is a promising treatment to favor tissue healing through less invasive strategies. Mesenchymal stem cells (MSCs) highlighted as potential candidates due to their angiogenic, anti-apoptotic and immunomodulatory properties, in addition to their ability to differentiate into several specialized cell lines. Cells can be carried through a biological delivery system, such as fibrin glue, which acts as a temporary matrix that favors cell-matrix interactions and allows local and paracrine functions of MSCs. Thus, the aim of this systematic review was to evaluate the potential of fibrin glue combined with MSCs in nerve regeneration. The bibliographic search was performed in the PubMed/MEDLINE, Web of Science and Embase databases, using the descriptors (“fibrin sealant” OR “fibrin glue”) AND “stem cells” AND “nerve regeneration”, considering articles published until 2021. To compose this review, 13 in vivo studies were selected, according to the eligibility criteria. MSCs favored axonal regeneration, remyelination of nerve fibers, as well as promoted an increase in the number of myelinated fibers, myelin sheath thickness, number of axons and expression of growth factors, with significant improvement in motor function recovery. This systematic review showed clear evidence that fibrin glue combined with MSCs has the potential to regenerate nervous system lesions.

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Therapeutic efficiency of bone marrow-derived mesenchymal stem cells for liver fibrosis: A systematic review of in vivo studies

World Journal of Gastroenterology ◽

10.3748/wjg.v26.i47.7444 ◽

2020 ◽

Vol 26 (47) ◽

pp. 7444-7469

Author(s):

Zaid Al-Dhamin ◽

Ling-Di Liu ◽

Dong-Dong Li ◽

Si-Yu Zhang ◽

Shi-Ming Dong ◽

...

Keyword(s):

Systematic Review ◽

Stem Cells ◽

Bone Marrow ◽

Mesenchymal Stem Cells ◽

Liver Fibrosis ◽

In Vivo Studies ◽

Therapeutic Efficiency

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The Efficacy of Stem Cells Secretome Application in Osteoarthritis: A Systematic Review of In Vivo Studies

Stem Cell Reviews and Reports ◽

10.1007/s12015-020-09980-x ◽

2020 ◽

Vol 16 (6) ◽

pp. 1222-1241 ◽

Cited By ~ 1

Author(s):

Maria Bousnaki ◽

Athina Bakopoulou ◽

Aristeidis Kritis ◽

Petros Koidis

Keyword(s):

Systematic Review ◽

Stem Cells ◽

In Vivo Studies

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Medicinal Plants with Anti-Trichomonas vaginalis Activity in Iran: A Systematic Review

Iranian Journal of Parasitology ◽

10.18502/ijpa.v14i1.712 ◽

2019 ◽

Cited By ~ 2

Author(s):

Hajar ZIAEI HEZARJARIBI ◽

Najmeh NADEALI ◽

Mahdi FAKHAR ◽

Masoud SOOSARAEI

Keyword(s):

Systematic Review ◽

Medicinal Plants ◽

Trichomonas Vaginalis ◽

Scientific Information ◽

Medicinal Herbs ◽

In Vivo Studies ◽

Eligibility Criteria ◽

Sexually Transmitted

Background: Trichomoniasis, due to Trichomonas vaginalis, is one of the most common sexually transmitted parasitic diseases in the world such as Iran. This systematic review aimed to explore the studies evaluating the medicinal herbs with anti- T. vaginalis activity which used in Iran. Methods: Articles published in 4 Persian and 4 English databases were obtained between 2000 and 2015 including Google Scholar, PubMed, Science Direct, Scopus, Magiran, Barakatkns (formerly IranMedex), Elm net, and SID (Scientific Information Database). Studies out of Iran, studies on animal models and articles on other parasite species than T. vaginalis were excluded from this review. Results: Twenty-one articles including in vitro experiments, met our eligibility criteria. Thoroughly, 26 types of plants were examined against T. vaginalis. Medicinal herbs such as Artemisia, Zataria multiflora, and Lavandula angustifolia are remarkably effective on T. vaginalis. As such, use of other parts of these plants in different concentrations and timelines is recommended for future in vivo studies. Conclusion: The present systematic review provides comprehensive and useful information about Iranian medicinal plants with anti-T. vaginalis activity, which would be examined in the future experimental and clinical trials and herbal combination therapy.

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Characterization of patient-derived bone marrow human mesenchymal stem cells as oncolytic virus carriers for the treatment of glioblastoma

Journal of Neurosurgery ◽

10.3171/2021.3.jns203045 ◽

2021 ◽

pp. 1-11

Author(s):

Yuzaburo Shimizu ◽

Joy Gumin ◽

Feng Gao ◽

Anwar Hossain ◽

Elizabeth J. Shpall ◽

...

Keyword(s):

Stem Cells ◽

Bone Marrow ◽

Mesenchymal Stem Cells ◽

Human Mesenchymal Stem Cells ◽

Oncolytic Viruses ◽

In Vivo Studies ◽

Systemic Delivery ◽

Previously Treated

OBJECTIVE Delta-24-RGD is an oncolytic adenovirus that is capable of replicating in and killing human glioma cells. Although intratumoral delivery of Delta-24-RGD can be effective, systemic delivery would improve its clinical application. Bone marrow–derived human mesenchymal stem cells (BM-hMSCs) obtained from healthy donors have been investigated as virus carriers. However, it is unclear whether BM-hMSCs can be derived from glioma patients previously treated with marrow-toxic chemotherapy or whether such BM-hMSCs can deliver oncolytic viruses effectively. Herein, the authors undertook a prospective clinical trial to determine the feasibility of obtaining BM-hMSCs from patients with recurrent malignant glioma who were previously exposed to marrow-toxic chemotherapy. METHODS The authors enrolled 5 consecutive patients who had been treated with radiation therapy and chemotherapy. BM aspirates were obtained from the iliac crest and were cultured to obtain BM-hMSCs. RESULTS The patient-derived BM-hMSCs (PD-BM-hMSCs) had a morphology similar to that of healthy donor–derived BM-hMSCs (HD-BM-hMSCs). Flow cytometry revealed that all 5 cell lines expressed canonical MSC surface markers. Importantly, these cultures could be made to differentiate into osteocytes, adipocytes, and chondrocytes. In all cases, the PD-BM-hMSCs homed to intracranial glioma xenografts in mice after intracarotid delivery as effectively as HD-BM-hMSCs. The PD-BM-hMSCs loaded with Delta-24-RGD (PD-BM-MSC-D24) effectively eradicated human gliomas in vitro. In in vivo studies, intravascular administration of PD-BM-MSC-D24 increased the survival of mice harboring U87MG gliomas. CONCLUSIONS The authors conclude that BM-hMSCs can be acquired from patients previously treated with marrow-toxic chemotherapy and that these PD-BM-hMSCs are effective carriers for oncolytic viruses.

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Adipose-Derived Mesenchymal Stem Cells Applied in Fibrin Glue Stimulate Peripheral Nerve Regeneration

Frontiers in Medicine ◽

10.3389/fmed.2019.00068 ◽

2019 ◽

Vol 6 ◽

Cited By ~ 11

Author(s):

Ruslan Masgutov ◽

Galina Masgutova ◽

Adelya Mullakhmetova ◽

Margarita Zhuravleva ◽

Anna Shulman ◽

...

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Peripheral Nerve ◽

Nerve Regeneration ◽

Fibrin Glue ◽

Peripheral Nerve Regeneration

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Therapeutic Potential of Mesenchymal Stromal Stem Cells in Rheumatoid Arthritis: a Systematic Review of In Vivo Studies

Stem Cell Reviews and Reports ◽

10.1007/s12015-020-09954-z ◽

2020 ◽

Vol 16 (2) ◽

pp. 276-287 ◽

Cited By ~ 5

Author(s):

Alexia Karamini ◽

Athina Bakopoulou ◽

Dimitrios Andreadis ◽

Konstantinos Gkiouras ◽

Aristeidis Kritis

Keyword(s):

Rheumatoid Arthritis ◽

Systematic Review ◽

Stem Cells ◽

Therapeutic Potential ◽

In Vivo Studies ◽

Stromal Stem Cells

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Research Status of Mesenchymal Stem Cells in Liver Transplantation

Cell Transplantation ◽

10.1177/0963689719874786 ◽

2019 ◽

Vol 28 (12) ◽

pp. 1490-1506 ◽

Cited By ~ 2

Author(s):

Yu You ◽

Di-guang Wen ◽

Jian-ping Gong ◽

Zuo-jin Liu

Keyword(s):

Stem Cells ◽

Liver Transplantation ◽

Clinical Trials ◽

Mesenchymal Stem Cells ◽

In Vivo Studies ◽

Cell Contact ◽

Clinical Effects ◽

Clinical Safety

Liver transplantation has been deemed the best choice for end-stage liver disease patients but immune rejection after surgery is still a serious problem. Patients have to take immunosuppressive drugs for a long time after liver transplantation, and this often leads to many side effects. Mesenchymal stem cells (MSCs) gradually became of interest to researchers because of their powerful immunomodulatory effects. In the past, a large number of in vitro and in vivo studies have demonstrated the great potential of MSCs for participation in posttransplant immunomodulation. In addition, MSCs also have properties that may potentially benefit patients undergoing liver transplantation. This article aims to provide an overview of the current understanding of the immunomodulation achieved by the application of MSCs in liver transplantation, to discuss the problems that may be encountered when using MSCs in clinical practice, and to describe some of the underlying capabilities of MSCs in liver transplantation. Cell–cell contact, soluble molecules, and exosomes have been suggested to be critical approaches to MSCs’ immunoregulation in vitro; however, the exact mechanism, especially in vivo, is still unclear. In recent years, the clinical safety of MSCs has been proven by a series of clinical trials. The obstacles to the clinical application of MSCs are decreasing, but large sample clinical trials involving MSCs are still needed to further study their clinical effects.

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Adipose-Derived Mesenchymal Stem Cells for the Treatment of Articular Cartilage: A Systematic Review on Preclinical and Clinical Evidence

Stem Cells International ◽

10.1155/2015/597652 ◽

2015 ◽

Vol 2015 ◽

pp. 1-13 ◽

Cited By ~ 47

Author(s):

Francesco Perdisa ◽

Natalia Gostyńska ◽

Alice Roffi ◽

Giuseppe Filardo ◽

Maurilio Marcacci ◽

...

Keyword(s):

Systematic Review ◽

Stem Cells ◽

Mesenchymal Stem Cells ◽

Articular Cartilage ◽

Clinical Evidence ◽

Cartilage Regeneration ◽

Therapeutic Approaches ◽

Differentiated Cells ◽

Cartilage Disease

Among the current therapeutic approaches for the regeneration of damaged articular cartilage, none has yet proven to offer results comparable to those of native hyaline cartilage. Recently, it has been claimed that the use of mesenchymal stem cells (MSCs) provides greater regenerative potential than differentiated cells, such as chondrocytes. Among the different kinds of MSCs available, adipose-derived mesenchymal stem cells (ADSCs) are emerging due to their abundancy and easiness to harvest. However, their mechanism of action and potential for cartilage regeneration are still under investigation, and many other aspects still need to be clarified. The aim of this systematic review is to give an overview ofin vivostudies dealing with ADSCs, by summarizing the main evidence for the treatment of cartilage disease of the knee.

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