A Case of Stevens–Johnson Syndrome in Recurrent Late-Stage Ovarian Cancer Patient after Management of Chronic Pain with Elastomeric Pump

(1) Background. Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe mucocutaneous reactions, characterized by extensive necrosis and detachment of the epidermis. (2) Case presentation. We present a case of a 46-year-old patient with late-stage high-grade serous ovarian cancer who was primarily treated with neoadjuvant chemotherapy and interval debulking, which was followed by adjuvant chemotherapy. At first recurrence, she was again treated with chemotherapy, and due to severe abdominal pain, an elastomeric pump containing analgesics, anti-inflammatories, and ondansetron was administered. In the same month, she was admitted to the hospital due to severe dysphagia, and in the following days she developed haemorrhagic vesiculobullous lesions on the facial skin and trunk. Stevens–Johnson syndrome was confirmed and ondansetron as a plausible leading cause was discontinued. Despite multimodal treatment, her condition deteriorated, and she died. (3) Discussion and conclusion. Although gynaecologists rarely encounter Stevens–Johnson syndrome, high mortality of the disease should ensure a low threshold for diagnosing and treating this disease.

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A Case Report of Steven Johnson Syndrome

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i58a34098 ◽

2021 ◽

pp. 132-139

Author(s):

Archana Dhengare ◽

Ranjana Sharma ◽

Sonali Waware ◽

Pranali Wagh

Keyword(s):

Stevens Johnson Syndrome ◽

Skin Allograft ◽

Case Presentation ◽

Johnson Syndrome ◽

Chief Complaints ◽

Long Time ◽

History Of ◽

Long Term Consequences ◽

Steven Johnson Syndrome

Introduction: In 1922, two doctors, Albert Mason Stevens and Frank Johnson, examined purulent conjunctivitis.” Background: Stevens-Johnson syndrome was named after them as a result of their study. The incidence rate is 7 cases per million populations per year. Case Presentation: Master Yash Ghudam was brought to AVBRH by his parents with chief complaints of fever since 5 days and erythematous lesions all over body since 3 days. History of present illness: Patient was apparently alright 5 days back, and then he started having fever which was of high grade and was not associated with chills and rigor. Patient was treated on OPD basis and the symptoms of an unexplained disease in two young boys, aged 7 and 8, who had "an unusual, generalised eruption of continued fever, inflamed buccal mucosa, and extreme some antibiotic was given, but there was no relief, after 2 days there was ulcers formation inside the mouth for which some ointment and syrup becosule was started. But lesions were increasing. 3 days back the lesions first appeared on chest then got spread to legs and hands. For which patient was admitted in Chandrapur hospital from were the patient was referred to AVBRH for further management. Interventions: The patient was treated the patient was started on intravenous and orally Cortecosteroids, Omnacortil 10mg, Antibiotics- Inj. Ceftriaxone1gm IV 12 hourly [100mg/kg/day], inj. Amikacin 150mg IV 12 hourly [15mg/kg/day], Syp. Mucaine gel 2tsp BD – swish and swallow), Syp. Cital 2.5ml TDS, Tab. Chymoral Forte TDS, Inj. Pantop 20mg IV 24 hourly (1mg/kg/dose). Pandya’s Formula: Syp. Gelusil 5ml, Syp. Benadryl 5ml, Syp. Omnacortil 5ml. Skin allograft: It has been planned. Conclusion: In this study, we mainly focus on medical management and outstanding nursing care helped prevent farther complication. Overall, the patient's reaction was positive, though recovery time from Steven johnson syndrome varies from person to person, taking weeks, months, or even years. However, only a small number of people completely recover, while some have long-term consequences. She took a long time to get back on her feet.

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Systemic lupus erythematosus presenting as stevens johnson syndrome in a thirty years old female: a case report

Journal of Lung Pulmonary & Respiratory Research ◽

10.15406/jlprr.2019.06.00199 ◽

2019 ◽

Vol 6 (1) ◽

pp. 20-21

Author(s):

Mohammad Shariq Mukarram

Keyword(s):

Case Report ◽

Lupus Erythematosus ◽

Stevens Johnson Syndrome ◽

High Grade Fever ◽

Rheumatology Clinic ◽

Case Presentation ◽

Oral Ulcers ◽

Johnson Syndrome ◽

Dermatological Condition ◽

Autoimmune Condition

Background: SJS occurs almost exclusively secondary to drugs but very rarely, SLE can be an inciting factor for SJS without presence of an offending drug. The association is extremely rare, however few cases have been reported. Case presentation: We present a case report of a thirty year old female who presented to the rheumatology clinic with complaints of rash on her face, swelling of the lips and oral ulcers with severe hemorrhagic cheilitis. She also complained of persistent high grade fever with development of blisters on her face and oropharyngeal mucosa. She had been suffering from pain in multiple joints which did not respond to NSAIDs. A diagnosis of SLE presenting as SJS was established. Patient was given good supportive care, steroids, DMARDs and analgesics, to which she responded well and recovered. Conclusion: Stevens Johnson Syndrome is an uncommon, severe dermatological condition usually caused secondary to drugs. Secondary cause of the disease may rarely be co-existence of an autoimmune condition like SLE, as present in our patient.

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Stevens-Johnson Syndrome: Case Presentation Related to the Use of Antiepileptic Medications

Medicine Science | International Medical Journal ◽

10.5455/medscience.2015.04.8383 ◽

2016 ◽

Vol 5 (1) ◽

pp. 1

Author(s):

Nur Iris ◽

Funda Simsek ◽

Taner Yildirmak ◽

Arzu Kanturk ◽

Muret Arat

Keyword(s):

Stevens Johnson Syndrome ◽

Case Presentation ◽

Johnson Syndrome ◽

Antiepileptic Medications

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Stevens- Johnson syndrome: case presentation

Journal of Clinical Pediatric Dentistry ◽

10.17796/jcpd.27.1.r476g4640244t45g ◽

2003 ◽

Vol 27 (1) ◽

pp. 71-76 ◽

Cited By ~ 3

Author(s):

K. Donta –Bakoyianni ◽

A. Mitsea ◽

K. Deodoropoulou-Papadimitriou

Keyword(s):

Erythema Multiforme ◽

Clinical Manifestations ◽

Stevens Johnson Syndrome ◽

Ocular Involvement ◽

Oral Lesions ◽

Cutaneous Lesions ◽

Case Presentation ◽

Course Of Disease ◽

Johnson Syndrome ◽

Clinical Disorders

Erythema Multiforme (EM) is a rare mucocutaneous disease with a variety of clinical manifestations. EM it was recognized in the early 1800's, and still the etiology is unknown. It has been recently suggested erythema multiforme (EM) major and Stevens-Johnson Syndrome (SJS) could be separated as two distinct clinical disorders with similar mucosal erosions, but different patterns of cutaneous lesions. In particular SJS should be used for a syndrome characterized by mucous membrane erosions and widespread small blisters that appear on erythematous or purpuric maculae, which are different from classic targets. In SJS mouth, eyes, skin, genitalia and occasionally the esophagus and respiratory track may be affected. Oral lesions may cause severe pain and usually lips may become encrusted. Concerning ocular involvement, if there is conjunctivitis or uveitis this may lead to scarring and blindness. Also, the course of disease and the prognosis are in most cases severe.

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Nevirapine induced Stevens Johnson syndrome

Journal of Pharmacovigilance and Drug Research ◽

10.53411/jpadr.2020.1.2.6 ◽

2020 ◽

Vol 1 (2) ◽

pp. 35-38

Author(s):

Himani Prajapati ◽

Neetu Bala ◽

Dinesh Kansal

Keyword(s):

Adverse Effect ◽

Adverse Event ◽

Causality Assessment ◽

Burning Sensation ◽

The Body ◽

Stevens Johnson Syndrome ◽

Case Presentation ◽

Johnson Syndrome ◽

Life Threatening ◽

History Of

Introduction: Severe and life-threatening SJS is more common with nevirapine than with other NNRTIs Case presentation: A 56-year-old male patient presented with a complaint of lesions all over the body with a burning sensation for 4 days. He was on an ART regimen, containing zidovudine, lamivudine, and efavirenz combination for 4 years. But patient accidentally started nevirapine and after 10 days he developed maculopapular lesions which were diagnosed as SJS syndrome. There was a history of rash with nevirapine when ART was started initially in 2012. This incident of an adverse event could be assigned a term "probable" according to the WHO-UMC scale for causality assessment as the re-challenge was found positive. Conclusion: Physicians and patients must be aware of this adverse effect on early diagnosis and treatment.

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Is It Stevens–Johnson Syndrome or MIS-C with Mucocutaneous Involvement?

Case Reports in Pediatrics ◽

10.1155/2021/1812545 ◽

2021 ◽

Vol 2021 ◽

pp. 1-4

Author(s):

Abdollah Karimi ◽

Elham Pourbakhtiaran ◽

Mazdak Fallahi ◽

Fereshteh karbasian ◽

Shahnaz Armin ◽

...

Keyword(s):

Stevens Johnson Syndrome ◽

Positive Polymerase Chain Reaction ◽

Case Presentation ◽

Reactive Protein ◽

Johnson Syndrome ◽

Initial Care ◽

Mucosal Involvement ◽

Polymerase Chain ◽

Maculopapular Rashes ◽

Inflammatory Syndrome

Background. Severe acute respiratory syndrome coronavirus-2 (SARS-COV-2) can be present in the form of multisystem inflammatory disease in children. Case Presentation. A 25-month-old boy presented with fever, malaise, diffuse maculopapular rashes, and mucosal involvement during the COVID-19 pandemic. He was first diagnosed with Stevens–Johnson syndrome (SJS). Further evaluation revealed lymphopenia, thrombocytopenia, and elevated levels of C-reactive protein (CRP), ferritin, and fibrinogen. This was followed by a positive polymerase chain reaction (PCR) test for COVID-19. In addition to receiving initial care for SJS, he was treated for MIS-C, which led to his recovery after four days. Conclusion. COVID-19 infection should be considered in children with fever and dermatological features during the pandemic because it may cause different features of the multisystem inflammatory syndrome in children (MIS-C), suggestive of delayed hyperimmune response.

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