scholarly journals Skeletal Muscle Metastasis in Papillary Thyroid Microcarcinoma Evaluated by F18-FDG PET/CT

Diagnostics ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 100 ◽  
Author(s):  
Hitu ◽  
Cainap ◽  
Apostu ◽  
Gabora ◽  
Bonci ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Thyroid Cancer ◽  
Erector Spinae ◽  
Biological Behavior ◽  
Papillary Thyroid Microcarcinoma ◽  
Papillary Thyroid ◽  
Skeletal Muscle Metastasis ◽  
Thyroid Microcarcinoma ◽  
Muscle Metastasis ◽  
Skeletal Muscle Metastases

Papillary thyroid cancer (PTC) is the most common type of thyroid malignancy and is characterized by slow growth and an indolent biological behavior. Papillary thyroid microcarcinoma is the PTC with the maximum size of the tumor <1cm, considered the most indolent form of thyroid cancer. PTC is usually metastasizes in cervical lymph nodes, lungs and bones and, less commonly, in brain or liver. Skeletal muscle metastases from PTC are extremely rare, a retrospective review of the literature revealed only 13 case reports. Among them, six cases are solitary skeletal muscle metastases, and seven are multiple metastases, most of them being associated with lung lesions. It seems that PTC is prone to metastasizing to the erector spinae and thigh muscles groups with unique cases located in trapezoid, biceps, deltoid, gastrocnemius and rectus abdominis muscles. Although extremely rare, one must bear in mind the fact that muscle metastasis from PTC is possible, and that is the reason we would like to discuss the existing clinical cases and to add a unique case of solitary skeletal muscle metastasis from papillary microcarcinoma.

scholarly journals Missing Skeletal Muscle Metastases of Papillary Thyroid Carcinoma

Diagnostics ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 457
Author(s):  
Leszek Herbowski
Keyword(s):  
Skeletal Muscle ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
Skeletal Muscle Metastasis ◽  
Thyroid Microcarcinoma ◽  
Pet Ct ◽  
Muscle Metastasis ◽  
Fdg Pet Ct ◽  
Skeletal Muscle Metastases

With regard to several important gaps in the work “Skeletal Muscle Metastasis in Papillary Thyroid Microcarcinoma Evaluated by F18-FDG PET/CT” [...]

Papillary thyroid microcarcinoma and papillary thyreoid cancer at the Department of Surgery, EUC Clinic Zlín

2020 ◽  
Vol 99 (11) ◽  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Nodes ◽  
Biological Behavior ◽  
Evidence Based ◽  
Papillary Thyroid ◽  
Invasive Procedures ◽  
The Czech Republic ◽  
Thyroid Microcarcinoma ◽  
Group 2 ◽  
Group 1

Introduction: Papillary thyroid cancer (PTC), especially micropapillary variant (MPTC), is the most common thyroid malignancy. Biological behavior is not aggressive and the patient’s prognosis is satisfactory. The objective of our comparative retrospective study was to evaluate whether the incidence is rising in the Region of Zlín and if less extensive approach was adopted by Czech endocrinologists. Methods: We compared 2 groups from years 2005–2008 and 2014–2018. The incidence of thyroid cancer, the PTC and the MPTC, the extent of the surgery and the lymphadenectomy, number of removed lymph nodes and the number of positive lymph nodes were observed. Results: We gathered 1353 patients in group 1. We found 220 malignancies (16.3%), 180 (81.8%) were PTC with MPTC variant in 44.4% (80 patients). All patients underwent a total thyroidectomy. We made 18 central and 10 lateral lymphadenectomies, 280 lymph nodes were collected with metastasis in 29,3 %. In group 2 with 1569 patients we found 318 (20.3%) carcinomas, PTC in 302 (94.6%) cases. The MPTC accounted for 215 (67.4%) cases. 10 patients with MPTC underwent hemithyroidectomy only. Numbers of central and lateral lymphadenectomies rose to 52 and 24 respectively. We gathered 376 lymph nodes with proven metastasis in 44.4% of these nodes. Conclusion: Both, the incidence and the frequency of PTC and MPTC are rising in our region. However, the number of less invasive procedures is not increasing significantly despite representing a sufficient way of treatment. We need wider adoption of these evidence-based recommendations by indicating endocrinologists in the Czech Republic.

MULTIFOCAL PAPILLARY THYROID MICROCARCINOMA WITH A TOTAL TUMOR DIAMETER> 1 CM INDICATE POOR BIOLOGICAL BEHAVIOR? - THE EVIDENCE IS INSUFFICIENT

2020 ◽  
Author(s):  
Bin Zhou ◽  
Lin Wei ◽  
Jianwu Qin
Keyword(s):  
Lymph Node ◽  
Biological Behavior ◽  
Papillary Thyroid Microcarcinoma ◽  
Tumor Diameter ◽  
Capsular Invasion ◽  
Papillary Thyroid ◽  
Central Lymph Node ◽  
Node Metastasis ◽  
Thyroid Microcarcinoma ◽  
Central Lymph

Objective: Multifocal cancer is not uncommon in papillary thyroid microcarcinoma (PTMC) . Our aim was to investigate the correlation between multifocal PTMC, total tumor diameter (TTD) and clinicopathological features. Methods: In total, 206 patients were included and grouped as stage cT1a or cT1b. The primary tumor diameter (PTD) and TTD (the sum of the maximal diameter of each focus) were calculated. These patients were further subgrouped as TTD ≤1 cm or 1 cm<TTD ≤2 cm. The relationships of clinicopathological features between these groups were analyzed. Results: Multifocal cancer was more likely to occur with stage cT1a than stage cT1b (p=0.028). Stage cT1b PTC was more prone to central lymph node metastasis (CLNM) (p=0.001) and capsular invasion (p<0.001) than stage cT1a. There was no difference in clinicopathological factors, such as sex (p=0.448), age (p=0.227), CLNM (p=0.739), number of CLNMs (p=0.142), capsular invasion (p=0.804), BRAF mutation (p=0.905) or recurrence (p=0.789), between the multifocal PTMC and TTD>1 cm and PTD+ TTD≤1 cm groups. For the comparison of stage cT1a and cT1b tumors with a 1 cm<TTD≤2 cm, the multivariate analysis, stage cT1b tumors were more prone to capsular invasion than stage cT1a tumors (p=0.006), with an OR of 19.013 (95% CI: 2.295-157.478), but there was no significant correlation with CLNM. Conclusions: Tumors in stage cT1b are more prone to capsular invasion and CLNM than those in stage cT1a. For multifocal PTMC, calculating the TTD to evaluate adverse biological behavior is insufficient and limited, and further research is needed. Abbreviations: PTC = Papillary thyroid carcinoma; PTMC = Papillary thyroid microcarcinoma ; ETE = Extrathyroidal extension; ATA = American Thyroid Association; CLNM = Central lymph node metastasis; TTD = Total tumor diameter; CLND = Central lymph node dissection; DTC =Differentiated thyroid carcinoma ; US = Ultrasound; CT = Computed tomography; PTD = Primary tumor diameter ; Tg = Thyroglobulin ; Anti-Tg = Anti-thyroglobulin antibody ; FNA = Fine needle aspiration; SD = Standard deviation; OR = Odds ratio; CI = Confidence interval.

scholarly journals The Overdiagnosis of Thyroid Micropapillary Carcinoma: The Rising Incidence, Inert Biological Behavior, and Countermeasures

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Shujian Xu ◽  
Yong Han
Keyword(s):  
Thyroid Cancer ◽  
Thyroid Carcinoma ◽  
Clinical Management ◽  
Low Risk ◽  
Biological Behavior ◽  
Papillary Thyroid ◽  
Micropapillary Carcinoma ◽  
The Past ◽  
Thyroid Microcarcinoma ◽  
Rising Incidence

The incidence of papillary thyroid microcarcinoma (PTMC) has exponentially increased in the past three decades. The 2014 World Cancer Report stated that, among the new cases of thyroid carcinoma, >50% are PTMC. The incidence of thyroid cancer was growing by 20.1% annually in China. Most of PTMC have low risk and excellent prognoses. It must be realized that the problem of overdiagnosis of thyroid cancer is quite serious. In this article, we summarized the phenomenon and the cause of “overdiagnosis” of PTMC, the progress of clinical management, and the countermeasures.

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