Prenatal Prediction of Outcome by Fetal Gastroschisis in a Tertiary Referral Center

: The aim of this study was to find a prenatal parameter to be able to predict possible prenatal complications or postnatal surgical options, thus allowing the fetal medicine specialist, together with pediatric surgeons and neonatologists, to improve the counseling of the parents and to determine the timing of delivery and therapy. This was a retrospective analysis of prenatal diagnosis and outcome of fetuses with 34 cases of gastroschisis between the years 2007 and 2017. A total of 34 fetuses with gastroschisis were examined and 33 outcomes registered: 22 cases of simple gastroschisis (66.7%) and 11 cases of complex gastroschisis (33.3%). A cut-off value of 18 mm for intraabdominal bowel dilatation (IABD) showed a positive predictive value (PPV) of 100% for predicting simple gastroschisis. IABD gives the best prediction for simple versus complex gastroschisis (cut-off of 18 mm). Extra-abdominal bowel dilatation (EABD) cut-off values of 10 mm and 18 mm showed low sensitivity and specificity to predict complex gastroschisis.

Download Full-text

Positive predictive value of non-invasive prenatal screening for fetal chromosome disorders using cell-free DNA in maternal serum: independent clinical experience of a tertiary referral center

BMC Medicine ◽

10.1186/s12916-015-0374-8 ◽

2015 ◽

Vol 13 (1) ◽

Cited By ~ 18

Author(s):

Whitney A. Neufeld-Kaiser ◽

Edith Y. Cheng ◽

Yajuan J. Liu

Keyword(s):

Positive Predictive Value ◽

Clinical Experience ◽

Predictive Value ◽

Prenatal Screening ◽

Maternal Serum ◽

Tertiary Referral ◽

Tertiary Referral Center ◽

Referral Center ◽

Non Invasive ◽

Free Dna

Download Full-text

Fetal intra-abdominal tumors: assessment of spectrum, accuracy of prenatal diagnosis, perinatal outcome and therapy at a tertiary referral center

European Journal of Obstetrics & Gynecology and Reproductive Biology ◽

10.1016/j.ejogrb.2012.11.023 ◽

2013 ◽

Vol 167 (2) ◽

pp. 160-166 ◽

Cited By ~ 5

Author(s):

Feriel Amari ◽

Daniel A. Beyer ◽

Klaus Diedrich ◽

Jan Weichert

Keyword(s):

Prenatal Diagnosis ◽

Perinatal Outcome ◽

Tertiary Referral ◽

Tertiary Referral Center ◽

Referral Center ◽

Abdominal Tumors

Download Full-text

Prenatal diagnosis of exomphalos and prediction of outcome

Scientific Reports ◽

10.1038/s41598-021-88245-0 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

K. Nitzsche ◽

G. Fitze ◽

M. Rüdiger ◽

P. Wimberger ◽

C. Birdir

Keyword(s):

Prenatal Diagnosis ◽

Retrospective Analysis ◽

Predictive Value ◽

Primary Closure ◽

Fetal Death ◽

Intrauterine Fetal Death ◽

Prediction Of Outcome ◽

Abnormal Karyotype ◽

Maximal Diameter ◽

Surgical Options

AbstractThe aim of this study was to detect a parameter for predicting prenatal complications or postnatal surgical options after detecting a fetal exomphalos. This was a retrospective analysis of prenatal diagnosis and outcome of fetuses with 41 cases of exomphalos in between 2007 and 2017, considering the measurement of ratios. The 41 fetuses with exomphalos were examined, 34 cases (82.9%) with karyotyping and 16 cases (39%) with an abnormal karyotype. Outcome of 39 cases showed 6 abortions (15.4%), 15 terminations (38.5%), an intrauterine fetal death (2.5%) and 17 alive babies (43.6%), which were grouped in two: small exomphalos (n = 6, 35.3%) and big exomphalos (n = 11, 64.7%). Maximal diameter of exomphalos/abdomen circumference-ratio (EDmax/AC-ratio) with a cut-off of 0.24 showed a better predictive value of postnatal primary closure. Exomphalos is correlated with abnormal karyotype. EDmax/AC-ratio gives the best prediction for postnatal primary closure of the defect.

Download Full-text