Prenatal diagnosis of exomphalos and prediction of outcome

AbstractThe aim of this study was to detect a parameter for predicting prenatal complications or postnatal surgical options after detecting a fetal exomphalos. This was a retrospective analysis of prenatal diagnosis and outcome of fetuses with 41 cases of exomphalos in between 2007 and 2017, considering the measurement of ratios. The 41 fetuses with exomphalos were examined, 34 cases (82.9%) with karyotyping and 16 cases (39%) with an abnormal karyotype. Outcome of 39 cases showed 6 abortions (15.4%), 15 terminations (38.5%), an intrauterine fetal death (2.5%) and 17 alive babies (43.6%), which were grouped in two: small exomphalos (n = 6, 35.3%) and big exomphalos (n = 11, 64.7%). Maximal diameter of exomphalos/abdomen circumference-ratio (EDmax/AC-ratio) with a cut-off of 0.24 showed a better predictive value of postnatal primary closure. Exomphalos is correlated with abnormal karyotype. EDmax/AC-ratio gives the best prediction for postnatal primary closure of the defect.

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Causes of intrauterine fetal death are changing in recent years

Journal of Perinatal Medicine ◽

10.1515/jpm-2016-0337 ◽

2018 ◽

Vol 46 (1) ◽

pp. 97-101 ◽

Cited By ~ 1

Author(s):

Hiroko Takita ◽

Junichi Hasegawa ◽

Masamitsu Nakamura ◽

Tatsuya Arakaki ◽

Tomohiro Oba ◽

...

Keyword(s):

Prenatal Diagnosis ◽

Umbilical Cord ◽

Medical Records ◽

Fetal Death ◽

Chromosomal Abnormalities ◽

Intrauterine Fetal Death ◽

Fetal Abnormalities ◽

Perinatal Center ◽

Umbilical Cord Entanglement ◽

Velamentous Cord Insertion

AbstractObjective:To investigate, how causes of intrauterine fetal death (IUFD) have changed in recent years with the advancement of prenatal diagnosis at a single perinatal center in Japan.Methods:Medical records were retrospectively reviewed for all cases of IUFDs that occurred between 2001 and 2014. The most commonly associated causes of fetal deaths were compared between 2001–2007 and 2008–2014.Results:The number of IUFD after 20 weeks’ gestation/all deliveries in our center was 38/6878 cases (0.53%) in 2001–2007 and 35/7326 (0.48%) in 2008–2014. The leading cause of IUFD in 2001–2007 was fetal abnormalities (43.2%), the prevalence of which was only 8.6% in 2008–2014 (P<0.01). Meanwhile, the prevalence of umbilical cord abnormalities was relatively increased from 30.0% in 2001–2007 to 54.5% in 2008–2014 (P=0.06). In 2001–2007, chromosomal abnormalities were frequently observed (56% of IUFDs due to fetal abnormalities). Hyper-coiled cord (HCC) and umbilical ring constrictions were the most frequent cause of IUFD in both periods. The relatively decreased prevalence of IUFD due to velamentous cord insertion and umbilical cord entanglement, HCC and umbilical cord constriction was increased.Conclusions:The prevalence of IUFD due to fetal abnormalities was reduced, but IUFD associated with umbilical cord abnormalities tended to increase relatively.

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Prenatal Prediction of Outcome by Fetal Gastroschisis in a Tertiary Referral Center

Diagnostics ◽

10.3390/diagnostics10080540 ◽

2020 ◽

Vol 10 (8) ◽

pp. 540

Author(s):

Katharina Nitzsche ◽

Guido Fitze ◽

Mario Rüdiger ◽

Cahit Birdir

Keyword(s):

Prenatal Diagnosis ◽

Positive Predictive Value ◽

Prediction Of Outcome ◽

Tertiary Referral ◽

Fetal Medicine ◽

Tertiary Referral Center ◽

Surgical Options ◽

Versus Complex ◽

Low Sensitivity ◽

Bowel Dilatation

: The aim of this study was to find a prenatal parameter to be able to predict possible prenatal complications or postnatal surgical options, thus allowing the fetal medicine specialist, together with pediatric surgeons and neonatologists, to improve the counseling of the parents and to determine the timing of delivery and therapy. This was a retrospective analysis of prenatal diagnosis and outcome of fetuses with 34 cases of gastroschisis between the years 2007 and 2017. A total of 34 fetuses with gastroschisis were examined and 33 outcomes registered: 22 cases of simple gastroschisis (66.7%) and 11 cases of complex gastroschisis (33.3%). A cut-off value of 18 mm for intraabdominal bowel dilatation (IABD) showed a positive predictive value (PPV) of 100% for predicting simple gastroschisis. IABD gives the best prediction for simple versus complex gastroschisis (cut-off of 18 mm). Extra-abdominal bowel dilatation (EABD) cut-off values of 10 mm and 18 mm showed low sensitivity and specificity to predict complex gastroschisis.

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Intrauterine Fetal Death and Delivery Complications Associated with Coagulopathy: A Retrospective Analysis of 104 Cases

Journal of Women s Health ◽

10.1089/jwh.2008.0938 ◽

2009 ◽

Vol 18 (4) ◽

pp. 469-474 ◽

Cited By ~ 10

Author(s):

Clemens B. Tempfer ◽

Andreas Brunner ◽

Eva-Katrin Bentz ◽

Martin Langer ◽

Alexander Reinthaller ◽

...

Keyword(s):

Retrospective Analysis ◽

Fetal Death ◽

Intrauterine Fetal Death ◽

Delivery Complications

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Modern aspects of tactics in the genital herpes viral infection (literature review)

GYNECOLOGY ◽

10.26442/2079-5696_2018.2.67-73 ◽

2018 ◽

Vol 20 (2) ◽

pp. 67-73

Author(s):

T Yu Pestrikova ◽

E A Yurasova ◽

I V Yurasov ◽

A V Kotelnikova

Keyword(s):

Literature Review ◽

Viral Infection ◽

Genital Herpes ◽

Fetal Death ◽

Malignant Tumors ◽

Adult Population ◽

Viral Disease ◽

Intrauterine Fetal Death ◽

Complicated Course ◽

Simplex Virus

Genital herpes affects all population groups. 98% of the adult population worldwide have antibodies to the herpes simplex virus (HSV-1 or 2). This viral infection is a significant medical and social problem. HSV can lead to a complicated course of pregnancy, causing miscarriages, premature birth, intrauterine fetal death, systemic viral disease in newborns. There is evidence that HSV has a connection with malignant tumors of the prostate and cervix, contributing to their development. This literature review contains modern aspects of epidemiology, etiology, pathogenesis, clinic, diagnosis, treatment of genital herpes, including its recurring forms with valacyclovir (Valvir). Indications for hospitalization of patients with genital herpes were noted and the prognosis of this pathology was determined. The tactics of managing pregnant women with this pathology is presented.

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A prostaglandin analogue (ONO-802) in treatment of missed abortion, intrauterine fetal death and hydatiform mole: a dose-finding trial

European Journal of Obstetrics & Gynecology and Reproductive Biology ◽

10.1016/0028-2243(87)90087-6 ◽

1987 ◽

Vol 25 (1) ◽

pp. 15-22 ◽

Cited By ~ 8

Author(s):

Nicola Garcea ◽

Ruggero Dargenio ◽

Vincenzo Panetta ◽

Ernesto Moneta ◽

Giulietta Tancredi ◽

...

Keyword(s):

Fetal Death ◽

Dose Finding ◽

Intrauterine Fetal Death ◽

Prostaglandin Analogue ◽

Missed Abortion

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Prenatal particulate matter exposure and Intrauterine Fetal Death

International Journal of Hygiene and Environmental Health ◽

10.1016/j.ijheh.2021.113720 ◽

2021 ◽

Vol 234 ◽

pp. 113720

Author(s):

Tamar Wainstock ◽

Israel Yoles ◽

Ruslan Sergienko ◽

Itai Kloog ◽

Eyal Sheiner

Keyword(s):

Particulate Matter ◽

Fetal Death ◽

Intrauterine Fetal Death ◽

Particulate Matter Exposure

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Intrauterine fetal death in triplet gestation caused by feto-fetal transfusion syndrome – a case report

Forensic Sciences Research ◽

10.1080/20961790.2016.1264915 ◽

2016 ◽

Vol 2 (4) ◽

pp. 213-217

Author(s):

Lingling Long ◽

Jie Yan ◽

Qiyan Li ◽

Ziqi Zhou ◽

Haixiao Deng ◽

...

Keyword(s):

Case Report ◽

Fetal Death ◽

Intrauterine Fetal Death

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Frequency of human parvovirus B19 infection in intrauterine fetal death

The Lancet ◽

10.1016/s0140-6736(00)04647-x ◽

2001 ◽

Vol 357 (9267) ◽

pp. 1494-1497 ◽

Cited By ~ 119

Author(s):

Thomas Tolfvenstam ◽

Nikos Papadogiannakis ◽

Oscar Norbeck ◽

Karin Petersson ◽

Kristina Broliden

Keyword(s):

Fetal Death ◽

Parvovirus B19 ◽

Intrauterine Fetal Death ◽

Human Parvovirus B19 ◽

Parvovirus B19 Infection

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Neopterin predicts disease severity in hospitalized patients with COVID-19

Open Forum Infectious Diseases ◽

10.1093/ofid/ofaa521 ◽

2020 ◽

Author(s):

Rosa Bellmann-Weiler ◽

Lukas Lanser ◽

Francesco Burkert ◽

Stefanie Seiwald ◽

Gernot Fritsche ◽

...

Keyword(s):

Mechanical Ventilation ◽

Retrospective Analysis ◽

Disease Severity ◽

Predictive Value ◽

Clinical Management ◽

Inflammatory Markers ◽

Predictive Marker ◽

Hospitalized Patients ◽

Icu Admission ◽

Circulating Inflammatory Markers

Abstract This study evaluates the predictive value of circulating inflammatory markers, especially neopterin, in patients with COVID-19. Within this retrospective analysis of 115 hospitalized COVID-19 patients, elevated neopterin levels upon admission were significantly associated with disease severity, risk for ICU admission, need for mechanical ventilation and death. Therefore, neopterin is a reliable predictive marker in patients with COVID-19 and may help to improve the clinical management of patients.

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