scholarly journals Serum Levels of TNF-α Are Increased in Patients with Rotator Cuff Tear and Sleep Disturbance

Diagnostics ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 2215
Author(s):  
Chul-Hyun Cho ◽  
Du-Hwan Kim ◽  
Eun-Hee Baek ◽  
Du-Han Kim
Keyword(s):  
Rotator Cuff ◽  
Serum Concentration ◽  
Sleep Disturbance ◽  
Rotator Cuff Tear ◽  
Serum Levels ◽  
Control Group ◽  
Cuff Tear ◽  
Clinical Scores ◽  
Tnf Α ◽  
Concentration Levels

The purpose of this study was to determine serum levels of sleep-related cytokines in patients with rotator cuff tear (RCT) who were experiencing pain-related sleep disturbance. Peripheral blood samples before surgery were collected from 63 study participants and divided into three groups: RCT with sleep disturbance group; SD group (n = 21), RCT with normal sleep group; NS group (n = 21), and patients with chronic shoulder instability; control group (n = 21). Serum concentration levels of interleukin-1α (IL-1α), IL-1β, IL-2, IL-6, IL-8, IL-10, and tumor necrosis factor-α (TNF-α) were measured via ELISA. The associations between serum levels of sleep-related cytokines and clinical scores and the Pittsburgh Sleep Quality Index (PSQI) were analyzed. Serum concentration levels of TNF-α were significantly higher in the SD group compared with those of the NS and control groups (p ≤ 0.001 and 0.05). Serum levels of IL-8 and IL-10 were significantly higher in the SD group compared with those of control group (p = 0.01 and = 0.05), but did not differ significantly from that of the NS group. There were no associations between serum levels of sleep-related cytokines and all clinical scores. The current findings suggest that TNF-α may be associated with sleep disturbance in patients with RCT.

TNF-α plays a role in sleep disturbance in patients with rotator cuff tear

2021 ◽  
Author(s):  
Chul-Hyun Cho ◽  
Du Hwan Kim ◽  
Eun Hee Baek ◽  
Du-Han Kim
Keyword(s):  
Rotator Cuff ◽  
Sleep Disturbance ◽  
Serum Levels ◽  
Control Group ◽  
Control Groups ◽  
Cuff Tear ◽  
Clinical Scores ◽  
Tnf Α ◽  
And Control ◽  
Concentration Levels

Abstract Background The purpose of this study was to determine serum levels of sleep-related cytokines in patients with rotator cuff tear (RCT) and to investigate the correlations between serum levels of sleep-related cytokines and clinical scores. Methods Peripheral blood samples were collected from 63 study participants were divided into three groups: RCT patients with sleep disturbance (sleep disturbance group; SD group) (n = 21), RCT patients without sleep disturbance (normal sleep group; NS group) (n = 21), and patients with shoulder instability (control group) (n = 21). Serum concentration levels of sleep-related cytokines including interleukin-1α (IL-1α), IL-1β, IL-2, IL-6, IL-8, IL-10, and tumor necrosis factor-α (TNF-α) were measured via enzyme-linked immunosorbent assay. The associations between serum levels of sleep-related cytokines and clinical scores including the Visual Analogue Scale (VAS) pain score, the University of California at Los Angeles (UCLA) score, and the Pittsburgh Sleep Quality Index (PSQI) were analyzed. Results Serum concentration levels of TNF-α were significantly higher in the SD group compared with those of the NS and control groups (P = < 0.001 and 0.05). Serum levels of IL-8 and IL-10 were significantly higher in the SD group compared with those of control group (P = 0.01 and = 0.05), but did not differ significantly from that of the NS group (P > 0.05). Serum level of IL-6 was significantly lower in the SD group compared with those of the NS and control groups (P = < 0.001 and 0.01). There were no associations between serum levels of sleep-related cytokines and all clinical scores including VAS pain, UCLA, and PSQI scores (all P > 0.05). Conclusion The current findings suggest that TNF-α may play a significant role in the pathophysiology of sleep disturbance in patients with RCT and be a possible therapeutic target to improve sleep disturbance in patients with RCT.

scholarly journals DOES HYPERCHOLESTOLEMIA PREDISPOSE TO ROTATOR CUFF PATHOLOGIES?

2017 ◽  
Vol 10 (4) ◽  
pp. 373 ◽  
Author(s):  
Surendra Umesh Kamath ◽  
Sunil Murthy
Keyword(s):  
Rotator Cuff ◽  
Total Cholesterol ◽  
Rotator Cuff Tear ◽  
Indian Population ◽  
Statistical Significance ◽  
Elevated Serum ◽  
Density Lipoprotein ◽  
Rotator Cuff Tears ◽  
Control Group ◽  
Cuff Tear

Background:  Rotator cuff tear are one of most common orthopedic musculoskeletal problem gaining importance due to large health scale expenditure. Causes of rotator cuff tears are multifactorial and unclear.  Previous studies have suggested relation between elevated serum lipid profile and rotator cuff tear in western population. We therefore undertook study in our Indian population to correlate association of hypercholesterolemia with rotator cuff tear.Objective: To find association of rotator cuff pathology with hypercholesterolemia in Indian patients.Materials and methods: After obtaining clearance from institutional ethics committee. We prospectively collected fasting lipid samples of population who came to our hospitals with complaints of shoulder pain during our study period. 50 patients had rupture of rotator cuff which was confirmed by ultrasound of involved shoulder. 50 were seen for non-cuff related complaints.  We followed strict inclusion and exclusion criteria.Results: Total cholesterol, Triglycerides and low density lipoprotein concentration of patients with rotator cuff tendon tear were on higher side than control group. High density lipoprotein trend showed being lower than control group.  21 of 50 (42%) had high cholesterol (total cholesterol greater than 240mg/dl) than compared to 18 of 50 (36%) in control group. however P value=0.539 and showed no statistical significance between groups.Conclusion: In Indian population there was no correlation between hypercholesterolemia and rotator cuff tear which is statistically significant.Key words Rotator cuff tear, Hypercholesterolemia, Indian population.   

scholarly journals Recombinant Human Bone Morphogenetic Proteins-4 Enhanced the Tendon-to-bone Attachment Healing in a Murine Model of Rotator Cuff Tear: A Randomized Controlled Trial

2020 ◽  
Author(s):  
Huabin Chen ◽  
Zhanwen Wang ◽  
Li Zhou ◽  
Bing Wu ◽  
Hongbin Lu ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Rotator Cuff Tear ◽  
Bone Morphogenetic Proteins ◽  
Murine Model ◽  
Controlled Trial ◽  
Supraspinatus Tendon ◽  
Control Group ◽  
Cuff Tear ◽  
Tendon Insertion ◽  
And Control

Abstract Background: Injuries on tendon-to-bone attachment (TBA) are common clinical dilemmas. Bone Morphogenetic Proteins-4 (BMP-4) has been found the potency in chondrogenesis. But there is rare studies focusing the influence of BMP-4 on the TBA healing. Thus, the objective of this study was to explore the effect of BMP-4 on the healing of TBA in murine model of rotator cuff tear.Methods: 120 mature C57BL/6 mice (12 weeks old) were randomly divided into BMP-4 group, noggin (an inhibitor of all BMP activities) group and control group after being established an injury model of supraspinatus tendon insertion. At week 2 and 4 after surgery, the supraspinatus tendon- humerus complex (SSTHC) were harvested for microradiographic, histologic, immunofluorescent and biomechanical evaluations.Results: Radiographic data showed that BMP-4 was able to improve the quality of subchondral bone, manifested as higher BV/TV, Tb.N, TB.Th, and lower Tb.Sp. Histologically, the BMP-4 group at week-2 and -4 showed better BTA healing interface, characterized by better organizational integration and remodeling, thicker fibrocartilage layer and more fibrocartilage cells. Immunoflorescence evaluation demonstrated the number of SOX 9 positive cells in the BMP-4 group was significantly more than that in the control or noggin group at postoperative weeks 2 and 4 (p<0.05 for all). Mechanical testing results demonstrated the failure load and stiffness in the BMP-4 group were significantly higher (p<0.05 for both), while in the noggin group were lower (p<0.05 for both), compared to the control group at postoperative weeks 4.Conclusion: BMP-4 might enhance the TBA healing by promoting the regeneration of fibrocartilaginous enthesis and mineralization, while noggin inhibited this process.Clinical Relevance: BMP-4 may be a potential therapy to augment TBA healing, and finally lead to more rapid rehabilitation and reduce risk of recurrent repair.

Sleep disturbance does not correlate with rotator cuff tear severity

2017 ◽  
Vol 26 (5) ◽  
pp. e170
Author(s):  
Bryan A. Reyes ◽  
Brandon R. Hull ◽  
Alexander Kurth ◽  
Nathan Kukowski ◽  
Edward P. Mulligan ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Sleep Disturbance ◽  
Rotator Cuff Tear ◽  
Cuff Tear

scholarly journals Correlation between anatomy of the scapula and the incidence of rotator cuff tear and glenohumeral osteoarthritis via radiological study

2017 ◽  
Vol 25 (1) ◽  
pp. 230949901769031 ◽  
Author(s):  
Mohd Fairudz bin Mohd Miswan ◽  
Mohd Shahril bin Ahmad Saman ◽  
Teo Seow Hui ◽  
Mohamed Zubair Mohamed Al-Fayyadh ◽  
Mohamed Razif bin Mohamed Ali ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Rotator Cuff Tear ◽  
Pearson Correlation ◽  
Control Group ◽  
P Value ◽  
Cuff Tear ◽  
Line Parallel ◽  
Glenoid Surface ◽  
Measured Angle ◽  
Glenohumeral Osteoarthritis

Introduction: We conducted a study to elucidate the correlation between the anatomy of the shoulder joint with the development of rotator cuff tear (RCT) and glenohumeral osteoarthritis (GHOA) by using acromioglenoid angle (AGA). Materials and Methods: The AGA is a new measured angle formed between the line from midglenoid to lateral end of the acromion with the line parallel to the glenoid surface. The AGA was measured in a group of 85 shoulders with RCT, 49 with GHOA and 103 non-RCT/GHOA control shoulders. The AGA was compared with other radiological parameters, such as, the critical shoulder angle (CSA), the acromion index (AI) and the acromiohumeral interval (AHI). Correlational and regression analysis were performed using SPSS 20. Results: The mean AGA was 50.9° (45.2–56.5°) in the control group, 53.3° (47.6–59.1°) in RCT group and 45.5° (37.7–53.2°) in OA group. Among patients with AGA > 51.5°, 61% were in the RCT group and among patients with AGA < 44.5°, 56% were in OA group. Pearson correlation analysis had shown significant correlation between AGA and CSA ( r = 0.925, p < 0.001). It was also significant of AHI in RCT group with mean 6.6 mm (4.7–8.5 mm) and significant AI in OA group with mean 0.68 (0.57–0.78) with p value < 0.001 respectively. Conclusion: The AGA method of measurement is an excellent predictive parameter for diagnosing RCT and GHOA.

scholarly journals TNF-α serum levels are elevated in women with clinically symptomatic uterine fibroids

2018 ◽  
Vol 32 ◽  
pp. 205873841877946 ◽  
Author(s):  
Michał Ciebiera ◽  
Marta Włodarczyk ◽  
Małgorzata Wrzosek ◽  
Cezary Wojtyła ◽  
Błażej Męczekalski ◽  
...  
Keyword(s):  
Serum Concentration ◽  
Female Genital Tract ◽  
Uterine Fibroids ◽  
Serum Levels ◽  
Control Group ◽  
Study Group ◽  
Phase Reaction ◽  
Serum Concentrations ◽  
Tnf Α ◽  
The Impact

Uterine fibroids (UFs) are one of the most common pathologies of the female genital tract. The incidence of UFs has been estimated at 25–80%. Tumor necrosis factor (TNF)-α is a cell-signaling protein involved in systemic inflammation and is one of the cytokines responsible for the acute phase reaction. The aim of the study was to evaluate the impact of clinically symptomatic UFs on TNF-α serum levels. A total of 149 Caucasian women were included: 85 patients admitted for surgery due to clinically symptomatic UFs (n = 85; study group) and 64 age-matched UF-free controls (n = 64). TNF-α serum concentrations between the groups were compared. Receiver operating characteristic (ROC) curves were also used as a statistical model to evaluate TNF-α as a marker for UFs. Mean TNF-α serum concentration in the study group was 0.34 ± 0.14 pg/mL; (in half of the subjects, the level did not exceed 0.39 pg/mL. Mean TNF-α serum concentration in the control group was 0.17 ± 0.09 pg/mL; in half of the subjects, the level did not exceed 0.14 pg/mL. The difference was statistically significant. Using the area under the ROC curve, we found that TNF-α serum concentration of 0.34 pg/mL can be used as a predictor for UFs in selected populations. In our study, we confirmed higher TNF-α serum concentrations in women with clinically symptomatic UFs.

The role of magnetic resonance imaging in the assessment of acromial morphology in association with rotator cuff tear

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Ahmed Fathy Abdelghany ◽  
Ahmed Mohamed Osman ◽  
Taha Kamal Hussein
Keyword(s):  
Rotator Cuff ◽  
Rotator Cuff Tear ◽  
Statistical Difference ◽  
Control Group ◽  
P Value ◽  
Type I ◽  
Full Thickness ◽  
Resonance Imaging ◽  
Cuff Tear ◽  
Significant Statistical Difference

Abstract   Background: The pathogenesis of rotator cuff tear (RCT) remains controversial. The acromion portion ofthe scapula and its morphology may be attributable for a variety of shoulder disorders such as RCT. Patients and Methods: This was a retrospective study that included 40 patients divided into two groups; a group with RCT included 20 patients and a control group with no RCT included the other 20 patients. 19 were males and 21 females, their age 20-69 years old with a mean age of 45. Cases were selected from the PACS system of the Radiology department of Ain Shams University Hospital. Statistical data analysis was done using IBM SPSS software package version 20.0. (Armonk, NY: IBM Corp) Results: The study revealed that Type Il acromion was encountered in most of the male patients (42.1%) and type Ill acromion was encountered in most of the female patients (42.9%) while type IV acromion was less frequently seen among males and females (5% & 0%) respectively. It also revealed that Type Ill is mostly encountered in RCT (50%); 58% of full-thickness tear and 37% of partial thickness tear. while type I is less frequently associated with a partial tear or full thickness tear (8%) for each. Acromion type Ill was the commonest type of acromion found between the patients of the case group with a significant statistical difference found between the case and control groups (P value: 0.006). However, type I acromion was the commonest acromion type found between the control group with also a significant statistical difference (P value: 0.011). Conclusion: Type Ill acromion may be a risk factor leading to rotator cuff tear. This may help guide therapy in patients with shoulder pain and findings suggesting type Ill acromion shape Keywords acromion shapes, magnetic resonance imaging, rotator cuff tear

Sleep Disturbance Associated With Rotator Cuff Tear

2015 ◽  
Vol 43 (6) ◽  
pp. 1455-1459 ◽  
Author(s):  
Luke Austin ◽  
Matthew Pepe ◽  
Bradford Tucker ◽  
Alvin Ong ◽  
Robert Nugent ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Sleep Disturbance ◽  
Rotator Cuff Tear ◽  
Cuff Tear

scholarly journals Dynamic scapulohumeral rhythm: Comparison between healthy shoulders and those with large or massive rotator cuff tear

2020 ◽  
Vol 28 (3) ◽  
pp. 230949902098177
Author(s):  
Naoya Kozono ◽  
Naohide Takeuchi ◽  
Takamitsu Okada ◽  
Satoshi Hamai ◽  
Hidehiko Higaki ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Rotator Cuff Tear ◽  
External Rotation ◽  
Three Dimensional ◽  
Control Group ◽  
Scapular Kinematics ◽  
Cuff Tear ◽  
And Control ◽  
Matching Techniques ◽  
Scapular Plane

Introduction: Assessment of scapular kinematics and the dynamics of the scapulohumeral rhythm (SHR) would be important for understanding pathologies of the shoulder and to inform treatment. Our aim in this study was to evaluate the SHR and scapular kinematics in patients with a rotator cuff tear (RCT), compared to a control group with healthy shoulders using image-matching techniques. Materials and Methods: The shoulder kinematics of large or massive RCT patients were evaluated and compared to a control group with healthy shoulders. Radiographic surveillance was performed throughout the full range of external rotation and scapular plane abduction. Computed tomography imaging of the shoulder complex was performed, with three-dimensional image reconstruction and matching to the radiographs to measure three-dimensional positions and orientations. SHR and angular values of the scapula were measured. Results: Scapular external rotation in the late phase of external rotation movement was greater in the RCT group than in the control group ( p < 0.05), but with no difference in the SHR. During scapular plane abduction, there were significant differences in SHR, scapular posterior tilt and scapular upward rotation between the RCT and control group ( p < 0.05). Conclusions: Regarding clinical relevance, this study clarified the differences of SHR and angular values of the scapula between the RCT and control group. These results underline the importance of assessment the SHR and scapular kinematics in individuals with a RCT. RCT is associated with specific compensation in the kinematics of the scapula and SHR during external rotation and scapular plane abduction, which could inform treatment.

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