scholarly journals Quantitative Analysis of Seven New Prostate Cancer Biomarkers and the Potential Future of the ‘Biomarker Laboratory’

Diagnostics ◽  
2018 ◽  
Vol 8 (3) ◽  
pp. 49 ◽  
Author(s):  
Kevin Cao ◽  
Callum Arthurs ◽  
Ali Atta-ul ◽  
Michael Millar ◽  
Mariana Beltran ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Biomarkers ◽  
Tissue Microarrays ◽  
Male Mortality ◽  
Hospital Laboratory ◽  
Additional Information ◽  
The Third ◽  
Risk Profiling ◽  
New Thinking ◽  
Developed World

Prostate cancer is the third highest cause of male mortality in the developed world, with the burden of the disease increasing dramatically with demographic change. There are significant limitations to the current diagnostic regimens and no established effective screening modality. To this end, research has discovered hundreds of potential ‘biomarkers’ that may one day be of use in screening, diagnosis or prognostication. However, the barriers to bringing biomarkers to clinical evaluation and eventually into clinical usage have yet to be realised. This is an operational challenge that requires some new thinking and development of paradigms to increase the efficiency of the laboratory process and add ‘value’ to the clinician. Value comes in various forms, whether it be a process that is seamlessly integrated into the hospital laboratory environment or one that can provide additional ‘information’ for the clinical pathologist in terms of risk profiling. We describe, herein, an efficient and tissue-conserving pipeline that uses Tissue Microarrays in a semi-automated process that could, one day, be integrated into the hospital laboratory domain, using seven putative prostate cancer biomarkers for illustration.

The Long Road to Sustainability

2018 ◽  
Author(s):  
Alexander Gillespie
Keyword(s):  
Sustainable Development ◽  
Environmental Problem ◽  
Social Sustainability ◽  
Good News ◽  
Correct Selection ◽  
The Third ◽  
Positive Indicators ◽  
Laws And Policies ◽  
Developed World ◽  
Selection Of

This book examines the idea of sustainable development, made up of economic, social, and environmental parts over the period of human history. This work suggests humanity has been unsustainable in all three areas for most of its history, although in the last few hundred years the scale of unsustainability has increased, while, simultaneously, answers have started to emerge. This conclusion can be seen in two parts, namely the economic and social sides of sustainable development and then the environmental ones. This work suggests that, with the correct selection of tools, solid and positive foundations for the economic and social sides of sustainable development is possible as the world globalizes. This is not, however, a foregone conclusion. Despite a number of recent positive indicators in this area, there are still very large unanswered questions with existing mechanisms and other gaps in the international architecture which, if not fixed, could quickly make problems of economic and social sustainability worse, not better. With the third leg of sustainable development, that for the environment, the optimism is not as strong. The good news is that science, laws, and policies have evolved and expanded to the level that, in theory, there is no environmental problem which cannot be solved. In many areas, especially in the developed world, success is already easy to measure. Where it is not easy to measure, and pessimism creeps in, is in the developing world, which is now inheriting a scale and mixture of environmental difficulties which are simply unprecedented.

scholarly journals Identification of prostate cancer biomarkers in urinary exosomes

Oncotarget ◽  
2015 ◽  
Vol 6 (30) ◽  
pp. 30357-30376 ◽  
Author(s):  
Anders Øverbye ◽  
Tore Skotland ◽  
Christian J. Koehler ◽  
Bernd Thiede ◽  
Therese Seierstad ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Biomarkers ◽  
Urinary Exosomes

scholarly journals Predictors of complications occurring after open and robot-assisted prostate cancer surgery: a retrospective evaluation of 1062 consecutive patients treated in a tertiary referral high volume center

2021 ◽  
Author(s):  
Antonio Benito Porcaro ◽  
Alessandro Tafuri ◽  
Riccardo Rizzetto ◽  
Nelia Amigoni ◽  
Marco Sebben ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Postoperative Complications ◽  
Radical Prostatectomy ◽  
Blood Loss ◽  
Open Approach ◽  
Intraoperative Blood Loss ◽  
Tertiary Referral ◽  
Robot Assisted ◽  
The Third ◽  
Major Complications

AbstractTo investigate factors associated with the risk of major complications after radical prostatectomy (RP) by the open (ORP) or robot-assisted (RARP) approach for prostate cancer (PCa) in a tertiary referral center. 1062 consecutive patients submitted to RP were prospectively collected. The following outcomes were addressed: (1) overall postoperative complications: subjects with Clavien-Dindo System (CD) one through five versus cases without any complication; (2) moderate to major postoperative complications: cases with CD < 2 vs.  ≥ 2, and 3) major post-operative complications: subjects with CDS CD ≥  3 vs.  < 3. The association of pre-operative and intra-operative factors with the risk of postoperative complications was assessed by the logistic regression model. Overall, complications occurred in 310 out of 1062 subjects (29.2%). Major complications occurred in 58 cases (5.5%). On multivariate analysis, major complications were predicted by PCa surgery and intraoperative estimated blood loss (EBL). ORP compared to RARP increased the risk of major CD complications from 2.8 to 19.3% (OR = 8283; p < 0.0001). Performing ePLND increased the risk of major complications from 2.4 to 7.4% (OR = 3090; p < 0.0001). Assessing intraoperative blood loss, the risk of major postoperative complications was increased by BL above the third quartile when compared to subjects with intraoperative blood loss up to the third quartile (10.2% vs. 4.6%; OR = 2239; 95%CI: 1233–4064). In the present cohort, radical prostatectomy showed major postoperative complications that were independently predicted by the open approach, extended lymph-node dissection, and excessive intraoperative blood loss.

scholarly journals Metastatic Prostate Cancer Involving the Sphenoid Sinus and Mandible

2021 ◽  
pp. 014556132110060
Author(s):  
Fadlullah Ba’th ◽  
Tanisha Hutchinson ◽  
Annie Meares ◽  
David Hamlar
Keyword(s):  
Prostate Cancer ◽  
Sphenoid Sinus ◽  
Metastatic Prostate Cancer ◽  
The United States ◽  
Endoscopic Examination ◽  
Atypical Presentation ◽  
Rare Presentation ◽  
The Third ◽  
Pathological Evaluation ◽  
Low Threshold

Prostate cancer is the third most leading cause of cancer in men in the United States. Although expected metastatic spread to bone, liver, and lymph nodes are often monitored, there are other rare presentations that can occur. This case report demonstrates a rare presentation of prostate cancer spreading to the paranasal sinuses and orbit. Not only did this case have an atypical presentation mimicking infection, the diagnosis was also only achieved through pathological evaluation after an endoscopic examination and biopsy. This case demonstrates the importance of a low threshold for endoscopic examinations in uncertain sinonasal presentations, and consistent biopsies when performing endoscopic examinations.

scholarly journals The expanded prostate cancer index composite short form (EPIC-26) for measuring health-related quality of life: content analysis of patients’ spontaneous comments written in survey margins

2021 ◽  
Author(s):  
Anna-Maija Talvitie ◽  
Hanna Ojala ◽  
Teuvo Tammela ◽  
Ilkka Pietilä
Keyword(s):  
Prostate Cancer ◽  
Content Analysis ◽  
Short Form ◽  
Health Related Quality ◽  
Urinary Catheters ◽  
Additional Information ◽  
Response Data ◽  
Related Quality ◽  
Health Related

Abstract Introduction This study investigates comments that prostate cancer patients spontaneously write in the margins of the Expanded Prostate Cancer Index Short Form (EPIC-26) questionnaire. We aim to show the possible barriers that patients face while answering the survey, and to consider how these barriers may affect the response data generated. We investigate the kind of information patients’ comments on EPIC-26 contain, and patients’ motivations to provide this information. We also study why some EPIC domains spark more comments than others. Method We analyzed 28 pages of transcribed comments and four pages of supplementary letters from our survey participants (n = 496). Using inductive content analysis, we generated 10 categories describing the content of participants’ comments, and four themes demonstrating their motives for commenting. The comments regarding each EPIC domain were quantified to discover any differences between domains. Results The sexual domain of EPIC-26 provoked over half of all comments. Patients without recent sexual activity or desire had difficulties answering sexual function questions 8–10. The lack of instructions on whether to take erectile aid use into account when answering erectile function questions led to a diversity of answering strategies. Patients with urinary catheters could not find suitable answer options for questions 1–4. All domains sparked comments containing additional information about experienced symptoms. Conclusion Patients are mainly willing to report their symptoms, but a lack of suitable answer options causes missing data and differing answering strategies in the sexual and urinary domains of EPIC-26, weakening the quality of the response data received.

404 DEVELOPMENT OF MULTIPARAMETRIC PROGNOSTIC MODELS USING LARGE PROSTATE CANCER TISSUE MICROARRAYS

2011 ◽  
Vol 10 (2) ◽  
pp. 141
Author(s):  
S. Minner ◽  
M.C. Tsourlakis ◽  
J. Müller ◽  
L. Burkhardt ◽  
P. Tennstedt ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tissue Microarrays ◽  
Prognostic Models ◽  
Cancer Tissue ◽  
Prostate Cancer Tissue ◽  
Large Prostate
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