scholarly journals Papillary Meningioma: Case Presentation with Emphasis on Surgical and Medical Therapy of a Rare Variant of Meningioma

Diseases ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 63
Author(s):  
Gerardo Cazzato ◽  
Valeria Internò ◽  
Antonietta Cimmino ◽  
Raffaella Messina ◽  
Marco Tucci ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Rare Case ◽  
Point Of View ◽  
Molecular Characteristics ◽  
Case Presentation ◽  
Papillary Meningioma ◽  
Risk Of Progression ◽  
The Central Nervous System ◽  
Histological Characteristics

Meningioma is one of the most frequent neoplasms of all in the central nervous system. Different variants are known, and of these some have peculiar characteristics, both from a morphological point of view and from a biological point of view. Here, we present a rare case of relapsed papillary meningioma in a young patient, focusing on histological characteristics, medical-surgical therapy and focusing on the risk of progression and/or recurrence of the lesion if not completely eradicated. Finally, we provide detailed molecular characteristics of the case in question.

scholarly journals A Rare Case of Cysticercosis Involving the Whole Spinal Canal

2021 ◽  
Author(s):  
Xiaoyan Zheng ◽  
Fei Wang ◽  
Lei Wang ◽  
Xiaoli Li ◽  
Jingjing Li ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Spinal Canal ◽  
Rare Case ◽  
Parasitic Disease ◽  
Epidemiological Investigation ◽  
Case Presentation ◽  
Life Threatening ◽  
The Central Nervous System

Abstract Background Cysticercosis is the commonest parasitic disease to affect the central nervous system (CNS). However, cysticercosis affecting the spine is extremely rare. We reported a rare case of cysticercosis involving the whole spinal canal in China. Case Presentation A rare case of cysticercosis involving the entire spinal cord, in a 52-year-old Chinese man, was detected in 2021. Epidemiological investigation, clinical and etiological examination was performed. Conclusion Since spinal cysticercosis is a rare but potentially life-threatening disease, clinicians should always consider the differential diagnosis of space-occupying lesions.

New Advanced Strategies for the Treatment of Lysosomal Diseases Affecting the Central Nervous System

2019 ◽  
Vol 25 (17) ◽  
pp. 1933-1950 ◽  
Author(s):  
Maria R. Gigliobianco ◽  
Piera Di Martino ◽  
Siyuan Deng ◽  
Cristina Casadidio ◽  
Roberta Censi
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Polymeric Nanoparticles ◽  
Genetic Diseases ◽  
Point Of View ◽  
Lysosomal Storage ◽  
Enzyme Replacement ◽  
Lysosomal Diseases ◽  
The Central Nervous System ◽  
Enzyme Delivery

Lysosomal Storage Disorders (LSDs), also known as lysosomal diseases (LDs) are a group of serious genetic diseases characterized by not only the accumulation of non-catabolized compounds in the lysosomes due to the deficiency of specific enzymes which usually eliminate these compounds, but also by trafficking, calcium changes and acidification. LDs mainly affect the central nervous system (CNS), which is difficult to reach for drugs and biological molecules due to the presence of the blood-brain barrier (BBB). While some therapies have proven highly effective in treating peripheral disorders in LD patients, they fail to overcome the BBB. Researchers have developed many strategies to circumvent this problem, for example, by creating carriers for enzyme delivery, which improve the enzyme’s half-life and the overexpression of receptors and transporters in the luminal or abluminal membranes of the BBB. This review aims to successfully examine the strategies developed during the last decade for the treatment of LDs, which mainly affect the CNS. Among the LD treatments, enzyme-replacement therapy (ERT) and gene therapy have proven effective, while nanoparticle, fusion protein, and small molecule-based therapies seem to offer considerable promise to treat the CNS pathology. This work also analyzed the challenges of the study to design new drug delivery systems for the effective treatment of LDs. Polymeric nanoparticles and liposomes are explored from their technological point of view and for the most relevant preclinical studies showing that they are excellent choices to protect active molecules and transport them through the BBB to target specific brain substrates for the treatment of LDs.

THE FAMILY HISTORY OF SPINA BIFIDA CYSTICA

PEDIATRICS ◽  
1965 ◽  
Vol 35 (4) ◽  
pp. 589-595
Author(s):  
John Lorber
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Spina Bifida ◽  
Index Case ◽  
Progressive Increase ◽  
Point Of View ◽  
The Family ◽  
History Of ◽  
The Central Nervous System ◽  
Spina Bifida Cystica

1. The family histories of 722 infants who were born with spina bifida cystica were studied. 2. The index cases were referred for surgical treatment and were not selected in any way from the genetic point of view. 3. Intensive inquiries were made to obtain a complete family pedigree, including a prospective follow-up of siblings born after the index case. 4. Of 1,256 siblings 85 or 6.8% had gross malformation of the central nervous system: spina bifida cystica in 54, anencephaly in 22, and uncomplicated hydrocephalus in 9. 5. Of 306 children born after the index case 25 (8%) or 1 in 12 were affected. 6. There was a progressive increase in multiple cases in the family with increasing family size. In sibships of five or more, multiple cases occurred in 24.1%. 7. In 118 families cases of gross malformation of the central nervous system were known to have occurred among members of the family other than siblings. Cases occurred in three generations. 8. It is possible that spina bifida cystica might be a recessively inherited condition.

scholarly journals Schwannoma of the arythenoid

2013 ◽  
Vol 11 (2) ◽  
pp. 224-226 ◽  
Author(s):  
Carlos Eduardo Molinari Nardi ◽  
Alexandre Wakil Burzichelli ◽  
Elio Gilberto Pfuetzenreiter ◽  
Rogerio Aparecido Dedivitis
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Schwann Cells ◽  
Rare Case ◽  
Nerve Fibers ◽  
Endoscopic Procedure ◽  
The Central Nervous System

Schwannoma is a benign encapsulated tumor that originates from the Schwann cells lining nerve fibers outside the central nervous system. We report a rare case of schwannoma that arose from the left arythenoid cartilage The patient underwent excision of the mass through microlaryngeal endoscopic procedure. No recurrence was observed during follow-up.

Central nervous system leiomyosarcoma in patients with acquired immunodeficiency syndrome

2000 ◽  
Vol 92 (4) ◽  
pp. 688-692 ◽  
Author(s):  
Ann M. Ritter ◽  
Barbara H. Amaker ◽  
R. Scott Graham ◽  
William C. Broaddus ◽  
John D. Ward
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Acquired Immunodeficiency Syndrome ◽  
Content Type ◽  
Barr Virus ◽  
The Central Nervous System ◽  
Histological Characteristics ◽  
Acquired Immunodeficiency ◽  
Epstein Barr ◽  
Immunodeficiency Syndrome

✓ Leiomyosarcomas (LMSs) of the central nervous system are extremely rare; however, they are becoming more prevalent in immunocompromised patients. The authors present the cases of two patients with acquired immunodeficiency syndrome: one with LMS of the thoracic vertebral body and the other with LMS originating from the region of the cavernous sinus. The epidemiological and histological characteristics of LMS and its association with latent Epstein—Barr virus are discussed, as well as the treatments for this neoplasm.

Diagnostic Difficulties in Primary Pauci-Melanotic Leptomeningeal Melanomatosis

2018 ◽  
Vol 80 (1-2) ◽  
pp. 68-70
Author(s):  
Ewa Koziorowska-Gawron ◽  
Maciej Kaczorowski ◽  
Joanna Bladowska ◽  
Sławomir Budrewicz ◽  
Magdalena Koszewicz ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Malignant Melanoma ◽  
Rare Case ◽  
Diagnostic Procedures ◽  
Postmortem Examination ◽  
Primary Malignant Melanoma ◽  
Diagnostic Difficulties ◽  
The Central Nervous System

We present a rare case of primary malignant melanoma of the central nervous system. We underline the difficulties we faced during diagnostic procedures. Finally, postmortem examination revealed the diagnosis of primary pauci-­melanotic leptomeningeal melanomatosis.

scholarly journals A STUDY ON A CASE OF SPINAL NEUROCYSTICERCOSIS: A RARE CASE REPORT

2021 ◽  
pp. 44-45
Author(s):  
Piyush Modi ◽  
Rajeev Kumar Singh ◽  
K.S Shahi ◽  
Prateek Shakya
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
Rare Case ◽  
Parasitic Infection ◽  
Review Of Literature ◽  
Rare Case Report ◽  
The Central Nervous System

Neurocysticercosis is the most common parasitic infection of the central nervous system worldwide. However , cysticercosis affecting the spine is considered extremely rare. We report one case of spinal cysticercosis with review of literature.

scholarly journals Fabry disease causes angiitis of the central nervous system:a case report

2018 ◽  
Author(s):  
De-Zheng Kong ◽  
Ya-Hui Lian ◽  
Lin-Jing Wang ◽  
Chun-Mei Wang ◽  
Yang-Yang Meng ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
Fabry Disease ◽  
Treated Patient ◽  
Young Patients ◽  
Vascular Wall ◽  
Black Blood ◽  
Case Presentation ◽  
The Central Nervous System

Abstract Background: Fabry disease is very rare and often delayed in diagnosis. Described herein are Fabry disease causes angiitis of the central nervous system. MRI black blood sequence has a unique advantage in showing vascular wall. It can clearly show the angiitis. Case presentation: A 27-year-old man came to our hospital for treatment because of "diplopia 6d". The patient was eventually diagnosed with Fabry disease causes angiitis of the central nervous system by a series of examinations. Then，we treated patient with hormones and the symptoms relieved. Two months later，the initial vasculitis was gone，but the new vasculitis appeared. Four months later，the last lesion disappeared，but the new lesion appeared. Conclusions: This case prompts the clinician should use MRI black blood sequence scan in time when young patients have repeated strokes and the lesions are migratory. If vasculitis is found and other systemic lesions are combined，we should think of the possibility of Fabry disease.

Sign in / Sign up

Export Citation Format

Share Document