Deep Learning Techniques for the Classification of Colorectal Cancer Tissue

It is very important to make an objective evaluation of colorectal cancer histological images. Current approaches are generally based on the use of different combinations of textual features and classifiers to assess the classification performance, or transfer learning to classify different organizational types. However, since histological images contain multiple tissue types and characteristics, classification is still challenging. In this study, we proposed the best classification methodology based on the selected optimizer and modified the parameters of CNN methods. Then, we used deep learning technology to distinguish between healthy and diseased large intestine tissues. Firstly, we trained a neural network and compared the network architecture optimizers. Secondly, we modified the parameters of the network layer to optimize the superior architecture. Finally, we compared our well-trained deep learning methods on two different histological image open datasets, which comprised 5000 H&E images of colorectal cancer. The other dataset was composed of nine organizational categories of 100,000 images with an external validation of 7180 images. The results showed that the accuracy of the recognition of histopathological images was significantly better than that of existing methods. Therefore, this method is expected to have great potential to assist physicians to make clinical diagnoses and reduce the number of disparate assessments based on the use of artificial intelligence to classify colorectal cancer tissue.

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Deep Learning Techniques for Colorectal Cancer Tissue Classification

2020 14th International Conference on Signal Processing and Communication Systems (ICSPCS) ◽

10.1109/icspcs50536.2020.9310053 ◽

2020 ◽

Author(s):

Min-Jen Tsai ◽

Yu-Han Tao

Keyword(s):

Colorectal Cancer ◽

Deep Learning ◽

Cancer Tissue ◽

Tissue Classification ◽

Colorectal Cancer Tissue ◽

Learning Techniques

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Classification of papillary thyroid carcinoma histological images based on deep learning

Journal of Intelligent & Fuzzy Systems ◽

10.3233/jifs-210100 ◽

2021 ◽

pp. 1-11

Author(s):

Yaning Liu ◽

Lin Han ◽

Hexiang Wang ◽

Bo Yin

Keyword(s):

Neural Network ◽

Differential Diagnosis ◽

Deep Learning ◽

Papillary Thyroid Carcinoma ◽

Thyroid Carcinoma ◽

Image Features ◽

Papillary Thyroid ◽

Histological Image ◽

Histological Images

Papillary thyroid carcinoma (PTC) is a common carcinoma in thyroid. As many benign thyroid nodules have the papillary structure which could easily be confused with PTC in morphology. Thus, pathologists have to take a lot of time on differential diagnosis of PTC besides personal diagnostic experience and there is no doubt that it is subjective and difficult to obtain consistency among observers. To address this issue, we applied deep learning to the differential diagnosis of PTC and proposed a histological image classification method for PTC based on the Inception Residual convolutional neural network (IRCNN) and support vector machine (SVM). First, in order to expand the dataset and solve the problem of histological image color inconsistency, a pre-processing module was constructed that included color transfer and mirror transform. Then, to alleviate overfitting of the deep learning model, we optimized the convolution neural network by combining Inception Network and Residual Network to extract image features. Finally, the SVM was trained via image features extracted by IRCNN to perform the classification task. Experimental results show effectiveness of the proposed method in the classification of PTC histological images.

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Two Ensemble-CNN Approaches for Colorectal Cancer Tissue Type Classification

Journal of Imaging ◽

10.3390/jimaging7030051 ◽

2021 ◽

Vol 7 (3) ◽

pp. 51

Author(s):

Emanuela Paladini ◽

Edoardo Vantaggiato ◽

Fares Bougourzi ◽

Cosimo Distante ◽

Abdenour Hadid ◽

...

Keyword(s):

Colorectal Cancer ◽

Deep Learning ◽

Digital Pathology ◽

Texture Features ◽

Tissue Type ◽

Cancer Tissue ◽

Learning Methods ◽

Feature Based ◽

Type Classification ◽

Whole Slide Images

In recent years, automatic tissue phenotyping has attracted increasing interest in the Digital Pathology (DP) field. For Colorectal Cancer (CRC), tissue phenotyping can diagnose the cancer and differentiate between different cancer grades. The development of Whole Slide Images (WSIs) has provided the required data for creating automatic tissue phenotyping systems. In this paper, we study different hand-crafted feature-based and deep learning methods using two popular multi-classes CRC-tissue-type databases: Kather-CRC-2016 and CRC-TP. For the hand-crafted features, we use two texture descriptors (LPQ and BSIF) and their combination. In addition, two classifiers are used (SVM and NN) to classify the texture features into distinct CRC tissue types. For the deep learning methods, we evaluate four Convolutional Neural Network (CNN) architectures (ResNet-101, ResNeXt-50, Inception-v3, and DenseNet-161). Moreover, we propose two Ensemble CNN approaches: Mean-Ensemble-CNN and NN-Ensemble-CNN. The experimental results show that the proposed approaches outperformed the hand-crafted feature-based methods, CNN architectures and the state-of-the-art methods in both databases.

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