Shift Work and Prostate Cancer: An Updated Systematic Review and Meta-Analysis

The International Agency of Research in Cancer (IARC) has recently confirmed shift work as a type 2A carcinogen. The results presented in published epidemiological studies regarding prostate cancer are inconsistent and the association remains controversial. The aims of this study were: (a) to investigate the possible association between shift work and prostate cancer incidence, identifying possible sources of heterogeneity; and (b) to analyze the potential effect of publication bias. A search for cohort and case-control studies published from January 1980 to November 2019 was conducted. The quality of the articles was assessed using the Newcastle–Ottawa Scale. Pooled OR were calculated using random-effects models. Heterogeneity was evaluated using Cochran’s Q test and data were stratified by potential sources of heterogeneity. Publication bias was analyzed. Eighteen studies were included. No association was found between rotating/night-shift work and prostate cancer, pooled OR 1.07 (95%CI 0.99 to 1.15), I2 = 45.7%, p = 0.016. Heterogeneity was eliminated when only cohort studies (pooled OR 1.03; 95%CI 0.96 to 1.10; I2 = 18.9%, p = 0.264) or high-quality studies (pooled OR 0.99; 95%CI 0.89 to 1.08; I2 = 0.0%, p = 0.571) were considered. A publication bias was detected. An association between shift work and prostate cancer cannot be confirmed with the available current data. Future analytical studies assessing more objective homogeneous exposure variables still seem necessary.

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Is shift-work associated with increased risk of esophageal cancer for males? A meta-analysis.

Journal of Clinical Oncology ◽

10.1200/jco.2021.39.3_suppl.190 ◽

2021 ◽

Vol 39 (3_suppl) ◽

pp. 190-190

Author(s):

Chenyu Sun ◽

Ce Cheng

Keyword(s):

Sensitivity Analysis ◽

Esophageal Cancer ◽

Cancer Risk ◽

Publication Bias ◽

Shift Work ◽

Meta Analysis ◽

Night Shift ◽

Night Shift Work ◽

Increased Risk ◽

Subgroup Analyses

190 Background: Globally, more than 570,000 people are diagnosed of esophageal cancer each year. Shift-work involving circadian disruption was designated as a probable cause of cancer by The International Agency for Research on Cancer. Previous studies investigating the relationship between shift-work and esophageal cancer among showed controversial results. Thus, this meta-analysis was conducted. Methods: A comprehensive literature search on PubMed was conducted to identify all relevant studies published prior to September 2020 according to the established inclusion criteria. The quality assessment was performed by the Newcastle-Ottawa Scale (NOS). The pooled odds risk (OR) and 95% confidence intervals (CI) were calculated to estimate the association between the shift-work and esophageal cancer risk. Random-effect or fixed-effect model was used to calculate the pooled OR, based on heterogeneity significance. Subgroup analyses were conducted based on night-shift versus rotating-shift. Sensitivity analysis and publication bias detection were also performed. All statistical analyses were performed using RevMan software (version 5.3; Cochrane library) and STATA 12.0 statistical software (Stata Corp., College Station, TX), and all P values were two-tailed, the test level was 0.05. Results: 21 articles were obtained from database searching, and 9 articles were obtained from other sources. 3 articles involving 52,098 participants were included. All studies were considered moderate to high quality. All included studies investigated only males on the association between shift-work and esophageal cancer risk. A statistically significant association between shift-work and increased esophageal cancer risk among males was found (OR 2.09, 95%CI: 1.48, 2.94, P< 0.0001, I 2= 29%). In subgroup analyses, night-shift work was associated with a non-statistically significant increased risk of esophageal cancer (OR 1.56, 95%CI: 0.96, 2.53, P= 0.07, I 2= 0%). In contrast, Rotating-shift was associated with increased esophageal cancer risk (OR 2.80, 95%CI: 1.72, 4.57, P < 0.0001, I 2= 0%). Sensitivity analysis confirmed the stability of the result. Funnel plot, Egger's test, and Begg's test found no publication bias of analysis (P = 0.572). Conclusions: The current meta-analysis demonstrates that shift-work is associated with increased esophageal cancer risk for males. However, no association between night-shift work and esophageal cancer risk was found. In contrast, association between rotating-shift work and increased esophageal cancer risk was found. Original studies on females regarding shift-work and esophageal cancer risk are lacking. More original studies on this topic for both male and female are needed to further explore shift-work impacts on esophageal cancer risk.

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Association between selenium intake and the risk of pancreatic cancer: a meta-analysis of observational studies

Bioscience Reports ◽

10.1042/bsr20160345 ◽

2016 ◽

Vol 36 (5) ◽

Cited By ~ 6

Author(s):

Lei Wang ◽

Jianfeng Wang ◽

Xudong Liu ◽

Qian Liu ◽

Guozhuan Zhang ◽

...

Keyword(s):

Pancreatic Cancer ◽

Publication Bias ◽

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Epidemiological Studies ◽

Case Control Studies ◽

Selenium Intake ◽

Effect Model ◽

Summary Relative Risk

Quantification of the association between the intake of selenium and risk of pancreatic cancer is still conflicting. Thus, we conducted a meta-analysis to summarize the evidence from epidemiological studies of selenium intake with the risk of pancreatic cancer. Pertinent studies were identified by a search of PubMed and Web of Knowledge to July 2016. The random-effect model was used. Sensitivity analysis and publication bias were conducted. Data from six studies including 1424 pancreatic cancer cases were used in this meta-analysis. Pooled results suggested that highest selenium intake amount compared with lowest amount was significantly associated with the risk of pancreatic cancer [summary relative risk (RR)=0.659, 95% confidence interval (CI)=0.489–0.889, I2=47.6%]. The associations were significant both in case–control studies [RR=0.618, 95%CI=0.399–0.956, I2=59.1%] and Americas [RR=0.570, 95%CI=0.357–0.909, I2=65.6%]. No publication bias was found. Our analysis suggested that the higher intake of selenium might reduce the risk of pancreatic cancer.

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Hubungan Kerja Shift Malam dan Kejadian Kanker Payudara Pada Pekerja Wanita: Tinjauan Kasus Berbasis Bukti

Pro Health Jurnal Ilmiah Kesehatan ◽

10.35473/proheallth.v2i1.386 ◽

2020 ◽

Vol 2 (1) ◽

Author(s):

Ayu Munawaroh

Keyword(s):

Breast Cancer ◽

Shift Work ◽

Service Sector ◽

Meta Analysis ◽

Night Shift ◽

International Agency ◽

Night Shift Work ◽

Female Workers ◽

Increased Risk ◽

Negative Impacts

Within the last decade, shift work has been an important issue, because it can give negative impacts to the worker’s body. International Agency for Research on Cancer (IARC) on 2007 had classified the shift work which disturb circadian rhythm as probably carcinogenic. One of the cancer which often been researched is breast cancer. Moreover, Around 572% of female workers are in professional and service sector that closely related to night shift work. This evidence based case report aims to know the relation between night shift work and breast cancer in female workers. Based on electronic database literature searching on September 26th 2018 using PubMed, EBSCo (MEDLINE with fulltext), and ProQuest, there are seven meta-analysis which useful to be critically appraised. The result of critical appraisal was increased risk of breast cancer in night shift female workers. Therefore, there was a sufficient validity with number needed to harm by 15 people. It can be concluded that night shift work, with duration and certain period could be risk factor for breast cancer in female workers, then further approaches are needed regarding this matter.

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Night-shift work and breast and prostate cancer risk: updating the evidence from epidemiological studies

Anales del Sistema Sanitario de Navarra ◽

10.23938/assn.0307 ◽

2018 ◽

Vol 41 (2) ◽

Keyword(s):

Prostate Cancer ◽

Cancer Risk ◽

Shift Work ◽

Night Shift ◽

Prostate Cancer Risk ◽

Epidemiological Studies ◽

Night Shift Work ◽

Breast And Prostate Cancer

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The association between dietary vitamin A intake and pancreatic cancer risk: a meta-analysis of 11 studies

Bioscience Reports ◽

10.1042/bsr20160341 ◽

2016 ◽

Vol 36 (6) ◽

Cited By ~ 6

Author(s):

Tao Zhang ◽

Hongqiang Chen ◽

Shiyong Qin ◽

Minghai Wang ◽

Xianming Wang ◽

...

Keyword(s):

Pancreatic Cancer ◽

Cancer Risk ◽

Vitamin A ◽

Publication Bias ◽

Meta Analysis ◽

Epidemiological Studies ◽

Case Control ◽

Dietary Vitamin ◽

Case Control Studies ◽

Pancreatic Cancer Risk

Whether dietary vitamin A intake could reduce pancreatic cancer risk is still conflicting. We therefore conducted a meta-analysis to summarize the evidence from epidemiological studies. We searched the databases of PubMed and Web of Knowledge up to July 2016. Random model was used to combine study-specific relative risks (RR) and 95% confidence interval (CI). Publication bias was assessed by Egger regression asymmetry test and Begg's funnel plot. Eleven studies (10 case-control studies and 1 cohort study) involving 2705 pancreatic cancer cases were included in the present study. The RR (95% CI) of pancreatic cancer for highest category of vitamin A intake compared with lowest category was 0.839 (95% CI=0.712–0.988) with low heterogeneity detected (I2=17.8%, Pheterogeneity=0.274). The relationships were also significant for studies designed by case-control [RR=0.808, 95% CI=0.690–0.947], as well as in European population [RR=0.821, 95% CI=0.693–0.972]. No evidence of publication bias was found. This meta-analysis demonstrated that dietary vitamin A intake might inversely associated with the risk of pancreatic cancer.

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