scholarly journals Variability of Urinary Creatinine in Healthy Individuals

2021 ◽  
Vol 18 (6) ◽  
pp. 3166
Author(s):  
Gerd Sallsten ◽  
Lars Barregard
Keyword(s):  
Flow Rate ◽  
Excretion Rate ◽  
Time Of Day ◽  
Urinary Flow Rate ◽  
Urinary Flow ◽  
Diurnal Variability ◽  
Creatinine Excretion ◽  
Blood Samples ◽  
Urinary Creatinine ◽  
Creatinine Excretion Rate

Many urinary biomarkers are adjusted for dilution using creatinine or specific gravity. The aim was to evaluate the variability of creatinine excretion, in 24 h and spot samples, and to describe an openly available variability biobank. Urine and blood samples were collected from 60 healthy non-smoking adults, 29 men and 31 women. All urine was collected at six time points during two 24 h periods. Blood samples were also collected twice and stored frozen. Analyses of creatinine in urine was performed in fresh urine using an enzymatic method. For creatinine in urine, the intra-class correlation (ICC) was calculated for 24 h urine and spot samples. Diurnal variability was examined, as well as association with urinary flow rate. The creatinine excretion rate was lowest in overnight samples and relatively constant in the other five samples. The creatinine excretion rate in each individual was positively correlated with urinary flow rate. The creatinine concentration was highest in the overnight sample and at 09:30. For 24 h samples the ICC was 0.64, for overnight samples it was 0.5, and for all spot samples, it was much lower. The ICC for urinary creatinine depends on the time of day of sampling. Frozen samples from this variability biobank are open for researchers examining normal variability of their favorite biomarker(s).

scholarly journals Posttransplant muscle mass measured by urinary creatinine excretion rate predicts long-term outcomes after liver transplantation

2018 ◽  
Vol 19 (2) ◽  
pp. 540-550 ◽  
Author(s):  
Suzanne P. Stam ◽  
Maryse C. J. Osté ◽  
Michele F. Eisenga ◽  
Hans Blokzijl ◽  
Aad P. van den Berg ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Muscle Mass ◽  
Excretion Rate ◽  
Long Term Outcomes ◽  
Creatinine Excretion ◽  
Urinary Creatinine ◽  
Urinary Creatinine Excretion ◽  
Creatinine Excretion Rate

scholarly journals Urinary Creatinine Excretion Rate and Mortality in Persons With Coronary Artery Disease

Circulation ◽  
2010 ◽  
Vol 121 (11) ◽  
pp. 1295-1303 ◽  
Author(s):  
Joachim H. Ix ◽  
Ian H. de Boer ◽  
Christina L. Wassel ◽  
Michael H. Criqui ◽  
Michael G. Shlipak ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Excretion Rate ◽  
Creatinine Excretion ◽  
Urinary Creatinine ◽  
Artery Disease ◽  
Urinary Creatinine Excretion ◽  
Creatinine Excretion Rate

Urinary creatinine excretion in the ICU: low excretion does not mean inadequate collection

1993 ◽  
Vol 2 (6) ◽  
pp. 462-466 ◽  
Author(s):  
GR Pesola ◽  
I Akhavan ◽  
GC Carlon
Keyword(s):  
Body Weight ◽  
Actual Body ◽  
Excretion Rate ◽  
Lean Body Weight ◽  
Actual Body Weight ◽  
Creatinine Excretion ◽  
Urinary Creatinine ◽  
Group 2 ◽  
Urinary Creatinine Excretion ◽  
Creatinine Excretion Rate

BACKGROUND: It has been assumed that a urinary creatinine excretion rate of less than 10 mg/kg per day means an inadequately collected urine sample. OBJECTIVE: To determine the frequency of a urinary creatinine excretion rate of less than 10 mg/kg per day in intensive care unit patients with an adequately collected urine sample. METHOD: In a prospective study of creatinine excretion rates, 24-hour urine samples were evaluated for urinary creatinine in 209 critically ill patients with indwelling Foley catheters. Patients from three adult intensive care units in New York City were divided into two groups. Group 1 patients excreted less than 10 mg/kg per day of urinary creatinine, and group 2 patients excreted at least 10 mg/kg per day. Groups 1 and 2 were first evaluated by dividing the creatinine excretion data by actual body weight. Since actual body weight may overestimate body weight in the critically ill patient, data from groups 1 and 2 were also evaluated using lean body weight. RESULTS: Urinary creatinine excretion was less than 10 mg/kg per day in 36.8% of patients using actual body weight and 29.7% of patients adjusted for lean body weight. The average age of patients in group 1 was 74 +/- 17 years for both actual body weight and lean body weight. The average age of group 2 patients was 60 +/- 19 years for actual body weight and 62 +/- 19 years for lean body weight. There was a significant difference in age between group 1 and group 2 patients for both actual body weight and lean body weight. The proportion of female vs male patients with reduced creatinine excretion was significantly greater, whether the actual body weight or lean body weight adjustment was used. CONCLUSIONS: A urinary creatinine excretion rate of less than 10 mg/kg per day occurs in about one third of critically ill patients, who are more likely to be elderly and female.

Impact Of Transurethral Resection Of Prostate On International Prostate Symptom Score And Peak Urinary Flow Rate

2020 ◽  
Vol 16 (1) ◽  
pp. 11-15
Author(s):  
Md Waliul Islam ◽  
Md Abul Hossain ◽  
Md Nurul Hooda ◽  
Kazi Rafiqul Abedin ◽  
Husne Ara
Keyword(s):  
Flow Rate ◽  
Transurethral Resection ◽  
Urine Volume ◽  
T Test ◽  
Urinary Symptoms ◽  
Urinary Flow Rate ◽  
Transurethral Resection Of Prostate ◽  
Urinary Flow ◽  
Paired Student ◽  
The Impact

Objectives: To evaluate urinary symptoms and quality of life in patient with BPH before and after TURP. To determine the impact of TURP on the urinary symptoms (IPSS) and peak urinary flow rate. Methods: This study is prospective study carried out between 2010 and 2011 in the department of Urology, National Institute of Kidney Diseases & Urology. Total 102 cases were selected purposively according to selection criteria. Each patient was observed and followed up at 8 weeks (1st visit), 16 weeks (2nd visit) 24 weeks (3rd visit) after transurethral resection of prostate (TURP). IPSS score, QOL score also recorded and uroflowmetry was done to see the peak urinary flow rate (Qmax) of urine and voiding time. USG was done to see post voidal residual urine volume and DRE also done in selected cases. Data was complied and statistical analysis were done using computer based software, Statistical Package for Social Science (SPSS), using paired ‘t’ test. A P value <0.05 was taken as significance. Results: Before TURP, IPSS range 17-25 and mean 21.61+2.43, after TURP, range 0-7 and mean 4.27+1.71). Hence a significant improvement of IPSS was found from 2 months to 6 months follow up after TURP. The change was tested using “paired student ‘t’ test”. Before TURP Qmax range 7-12.2 and mean was 9.96+1.69, which became range 18-25 and mean was 22.61+2.28 after TURP and therefore change of mean Qmax was 12.64+2.69. The change was tested using “paired student ‘t’ test”. The change was found significant (P<0.001). Conclusion: Transurethral resection of prostate resolves obstructive symptoms, rapid improvement of urinary flow rate Bangladesh Journal of Urology, Vol. 16, No. 1, Jan 2013 p.11-15

MEASUREMENT OF URINARY FLOW RATE USING ULTRASOUND IN YOUNG BOYS AND INFANTS

2001 ◽  
Vol 166 (3) ◽  
pp. 1058-1061 ◽  
Author(s):  
KATJA P. WOLFFENBUTTEL ◽  
DIRK J. KOK ◽  
RON van MASTRIGT ◽  
ESTHER van den BERG ◽  
RIEN J.M. NIJMAN
Keyword(s):  
Flow Rate ◽  
Urinary Flow Rate ◽  
Urinary Flow
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