scholarly journals Influence of Depression and Anxiety on Non-Surgical Periodontal Treatment Outcomes: A 6-Month Prospective Study

2021 ◽  
Vol 18 (17) ◽  
pp. 9394
Author(s):  
Catherine Petit ◽  
Victor Anadon-Rosinach ◽  
Nicolas Tuzin ◽  
Jean-Luc Davideau ◽  
Olivier Huck
Keyword(s):  
Risk Factors ◽  
Treatment Outcomes ◽  
Periodontal Treatment ◽  
Scaling And Root Planing ◽  
Depression And Anxiety ◽  
Clinical Attachment Loss ◽  
Probing Depth ◽  
Severe Periodontitis ◽  
Risk Patients ◽  
Periodontal Probing

Periodontal treatment could be worsened by risk factors. Depression and anxiety have been suggested as potentially influencing periodontal treatment outcomes. The aim of this study was to determine their association with non-surgical periodontal treatment outcomes in patients with generalized severe periodontitis (stage III/IV generalized periodontitis) at 6 months. A total of 68 patients diagnosed with generalized severe periodontitis were treated with scaling and root planing (SRP) and were followed at 3 and 6 months. The data of the 54 patients that followed the entire protocol were considered for analysis. Depression and anxiety levels were determined at baseline by the Beck Depression Inventory (BDI) and State-Trait Inventory (STAI) questionnaires. The association between psychological scores and periodontal parameters was evaluated by multivariate analysis. At 3 and 6 months, SRP induced an improvement for all periodontal parameters (plaque index (PI), bleeding on probing (BOP), periodontal probing depth (PPD) and clinical attachment loss (CAL)). BDI and STAI scores were associated with the evolution of PI, BOP, mean PPD and number of sites with PPD > 3 mm and with CAL > 3 mm. Depression and anxiety should be considered as risk factors for SRP and the identification of at-risk patients should be performed using well-established tools.

scholarly journals Fine-Tuning Multilevel Modeling of Risk Factors Associated with Nonsurgical Periodontal Treatment Outcome

2019 ◽  
Author(s):  
João Botelho ◽  
Vanessa Machado ◽  
Paulo Mascarenhas ◽  
Ricardo Alves ◽  
Maria Alzira Cavacas ◽  
...  
Keyword(s):  
Risk Factors ◽  
Fine Tuning ◽  
Periodontal Treatment ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Probing Depth ◽  
Nonsurgical Periodontal Therapy ◽  
Hierarchical Levels ◽  
Variance Component Models

This retrospective study aimed to investigate the effect of known risk factors on nonsurgical periodontal treatment (NSPT) response using a pocket depth fine-tuning multilevel linear model (MLM). Thirty-seven patients (24 males and 13 females) with moderate to severe chronic periodontitis were treated with nonsurgical periodontal therapy. Follow-up visits at 3, 6, and 12 months included measurement of several clinical periodontal parameters. Data were extracted from a database system. Probing depth (PD) and Clinical Attachment Loss (CAL) reductions after NSPT in an overall of 1416 initially affected sites (baseline PD ≥ 4 mm), distributed on 536 teeth, were analyzed against known risk factors at three hierarchical levels (patient, tooth and site). The variance component models fitted to assess the three-level variance of PD and CAL decrease for each post-treatment follow-up showed that all levels contributed significantly to the overall variance (P < 0.001). Patients that underwent NSPT and were continually monitored had very curative results. All three hierarchical levels included risk factors who had impact on the to influence the magnitude of PD and CAL reduction. Specifically, the tooth’s type, surfaces involved and teeth mobility site-level risk factors showed the highest influence on these reductions, being highly relevant factors for the NSPT success.

scholarly journals Determination of Cortisol and Dehydroepiandrosterone Levels in Saliva for Screening of Periodontitis in Older Japanese Adults

2009 ◽  
Vol 2009 ◽  
pp. 1-8 ◽  
Author(s):  
Toshihiro Ansai ◽  
Inho Soh ◽  
Aiko Ishisaka ◽  
Akihiro Yoshida ◽  
Shuji Awano ◽  
...  
Keyword(s):  
Positive Relationship ◽  
Roc Analysis ◽  
Screening Method ◽  
Elderly Subjects ◽  
Clinical Attachment Loss ◽  
Probing Depth ◽  
Japanese Adults ◽  
Severe Periodontitis ◽  
Never Smokers

Background. Recent reports have found a positive relationship between periodontitis and the hormones cortisol and dehydroepiandrosterone (DHEA). We investigated the associations between those levels and periodontitis in never-smokers and smokers of elderly subjects.Subjects and Methods. Cortisol and DHEA levels in saliva were determined in 171 subjects (85 males, 86 females), with clinical examinations including probing depth (PD) and clinical attachment loss (CAL) also performed.Results. Smoking had effects on cortisol and DHEA levels, and those were significantly associated with severe PD and CAL in never-smokers. According to ROC analysis, the cutoff values of cortisol and DHEA to obtain the optimal sensitivity and specificity for detecting severe periodontitis were 2.06 ng/mL and 60.24 pg/mL, respectively, for PD, and 2.12 ng/mL and 61.78 pg/mL, respectively, for CAL.Conclusions. Assessment of hormone levels may be a useful screening method for periodontitis, though limited to never-smokers.

scholarly journals Use of digital periodontal software to compare periodontal treatment outcomes in a practice-based research network (PBRN) – a proof of concept

2020 ◽  
Author(s):  
Stefanie Anna Peikert ◽  
Felix Mittelhamm ◽  
Eberhard Frisch ◽  
Kirstin Vach ◽  
Petra Ratka-Krüger ◽  
...  
Keyword(s):  
Treatment Outcomes ◽  
Study Data ◽  
Periodontal Treatment ◽  
Research Network ◽  
Proof Of Concept ◽  
Postgraduate Students ◽  
Probing Depth ◽  
Supportive Periodontal Therapy ◽  
Study Centre ◽  
Practice Based Research

Abstract Background: The aim of this non-interventional, observationalstudy was to develop and evaluate a digital procedure to access, extract and analyse recorded clinical data in practices to assess periodontal treatment outcomes. Methods: Participating periodontists were former or active postgraduate students of a master’s course in periodontics in Freiburg who routinely used a digital periodontal diagnostic program. All available stored periodontal patient charts were extracted, anonymized and digitally sent to the study centre. Results: In this study, data were collected from6401 patients from 9 different practices. Information such as probing depth (PD), bleeding on probing (BOP), mobility, furcation and gingival attachment for 153163 teeth at first visit were successfully transferred to the study centre. During the observational period, which was from 2.08 years to 18.35 yearson average,only 2.8% of all teeth were lost. The number of visits was significantly negatively correlated withBOP (p<0.0001),and the number of BOP-positive sites was significantlycorrelated withdeeper PDs (p<0.001). Conclusion: The presented procedure was able to gather a large amount of practice-based periodontal data, and thus this study may support practice-based research networks. The data indicatethat systematic and supportive periodontal therapy is successful on a practice-based level. Trial registration: The study was internationally registered on 4 January 2017 in the German Clinical Trials Register (DRKS 00011448). https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00011448

scholarly journals Rheumatoid arthritis serotype and synthetic disease-modifying anti-rheumatic drugs in patients with periodontitis: A case-control study

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0252859
Author(s):  
Nik-Madihah Nik-Azis ◽  
Nurulhuda Mohd ◽  
Fazalina Mohd Fadzilah ◽  
Nor Hazla Mohamed Haflah ◽  
Mohd Shahrir Mohamed Said ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Health Assessment ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Probing Pocket Depth ◽  
Probing Depth ◽  
Disease Modifying ◽  
And Control ◽  
The Relationship ◽  
Periodontal Probing

Patients with rheumatoid arthritis (RA) experience a higher prevalence of periodontitis. This study aimed to examine the variation of periodontitis experienced with different serotypes suffered by RA patients and to examine the relationship between the different medications taken for RA that may influence this relationship. Two hundred and sixty RA and control participants underwent standardized periodontal examinations. Medical, serological and radiological (Sharp/van der Heijde) records were assessed. Functional status was assessed using the administered Health Assessment Questionnaire. Moreover, disease parameters, including disease activity (DAS28-ESR) and anti-citrullinated protein antibodies (ACPA) and rheumatoid factor (RF) seropositivity were evaluated. Periodontitis was higher in RA (71.54%) compared with controls (54.62%). The stage of periodontitis experienced by ACPA-positive participants were higher than APCA-negative participants. The probing pocket depth and recession experienced by RF-positive participants were higher than those who were RF-negative. RA participants on methotrexate had lower clinical attachment loss and lower periodontal probing depth compared with participants on a combination methotrexate and other disease-modifying antirheumatic drugs. Participants taking corticosteroids had lower gingival index scores. The association between seropositivity and the type of medications taken with periodontal health parameters in this group of patients suggests that both seropositivity and medications taken are important modifiers in the relationship between periodontitis and RA.

scholarly journals JP2 Genotype of Aggregatibacter actinomycetemcomitans in Caucasian Patients: A Presentation of Two Cases

Pathogens ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 178 ◽  
Author(s):  
Alexandra Stähli ◽  
Anton Sculean ◽  
Sigrun Eick
Keyword(s):  
Female Patient ◽  
Aggregatibacter Actinomycetemcomitans ◽  
West African ◽  
African Origin ◽  
Clinical Attachment Loss ◽  
Monocytic Cells ◽  
Probing Depth ◽  
Severe Periodontitis ◽  
Important Virulence Factor ◽  
Caucasian Patients

Aggregatibacter actinomycetemcomitans is a key pathogen that has been associated with periodontal disease. Its most important virulence factor is a leukotoxin capable of inactivating immune cells. The JP2 genotype of Aggregatibacter actinomycetemcomitans shows enhanced leukotoxic activity and is mostly present in individuals of North and West African origin with severe periodontitis. In this paper, two cases of Caucasians diagnosed with the JP2 genotype are presented. A 50-year-old female patient had three approximal sites with ≥ 6 mm clinical attachment loss (CAL) and eight sites with probing depth (PD) ≥ 5 mm. Microbiological diagnostics revealed A. actinomycetemcomitans JP2 genotype, but not Porphyromonas gingivalis. This JP2 genotype was highly leukotoxic to monocytic cells. The second case was a 55-year-old female patient with CAL of > 5 mm at all molars and PD of up to 12 mm. A. actinomycetemcomitans JP2 was identified, but not P. gingivalis. Her husband originated from North-Africa. In him, no A. actinomycetemcomitans was detected, but their 17-year-old daughter was diagnosed with periodontitis and was found to be positive for the JP2 genotype. Both patients were successfully treated with adjunctive antibiotics and the JP2 genotype was eliminated. In summary, here, the microbiological diagnosis was key for the treatment with adjunctive antibiotics.

scholarly journals Efficacy of Photodynamic Therapy as an Adjunct to Full-mouth Root Planing in the Treatment of Periodontitis Assessed by Real-time PCR: A Microbiological and Clinical Study

2018 ◽  
Vol 7 (1) ◽  
pp. 26-32 ◽  
Author(s):  
Mohammad Taghi Chitsazi ◽  
Adileh Shirmohammadi ◽  
Masoud Shirmohammadi ◽  
Atabak Kashefimehr ◽  
Vadood Ghasemi
Keyword(s):  
Photodynamic Therapy ◽  
Real Time ◽  
Real Time Pcr ◽  
Control Site ◽  
Group Differences ◽  
Scaling And Root Planing ◽  
Root Planing ◽  
Probing Depth ◽  
Clinical Measurements ◽  
Periodontal Probing

Background and aims. The aim of this investigation was to compare clinical and microbiological effectiveness of adjunctive photodynamic therapy (PDT) in the treatment of periodontitis. Materials and methods. Twenty-four subjects (14 women and 10 men) diagnosed with moderate to severe chronic periodontitis underwent scaling and root planing (SRP). One tooth in each quadrant (probing depth >4 mm) was selected for combined PDT and SRP (PDT group) with the contralateral tooth (SRP group), as a control site (SRP-treated site). Clinical assessment was carried out at baseline and 1 and 3 month later. Microbial assessment was carried out by real-time PCR. Periodontal probing depth (PPD) was considered as the primary outcome. Results. Baseline PPDs were 4.86±0.77 and 4.04±0.65 in the SRP and PDT groups, respectively (P>0.05), which decreased to 3.65±0.58 in the SRP and 3.86±0.56 in the PDT groups after one month and to 3.20±0.68 in the SRP and 3.34±0.56 in the PDT groups three months later. Although values decreased significantly in both groups after one (P=0.001 in the SRP and P=0.001 in the PDT groups) and three months (P=0.001 in the SRP and P=0.001 in the PDT groups) the inter-group differences were not significant after one (P=0.25) and three months (P=0.51). Clinical measurements showed significant decreases after one and three months at both sites, without inter-group differences, except for bleeding on probing after one (P=0.004) and three months (P=0.0001). Conclusion. Subgingival application of PDT combined with scaling and root planing could not improve clinical and microbiological results.

scholarly journals Antimicrobial or Subantimicrobial Antibiotic Therapy as an Adjunct to the Nonsurgical Periodontal Treatment: A Meta-Analysis

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Ana Patricia Moreno Villagrana ◽  
José Francisco Gómez Clavel
Keyword(s):  
Chronic Periodontitis ◽  
Meta Analysis ◽  
Periodontal Treatment ◽  
Randomized Controlled Clinical Trials ◽  
Probing Depth ◽  
Nonsurgical Periodontal Therapy ◽  
Post Hoc ◽  
Systemic Antibiotics ◽  
Periodontal Probing ◽  
Attachment Level

The use of antibiotics in nonsurgical periodontal treatment is indicated in cases in which scaling and root planing present important limitations. However, their use is controversial due to the secondary effects associated with them and the disagreements regarding their prescription. The aim of this study is to determine the effectiveness of systemic antibiotics in the management of aggressive and chronic periodontitis. The study was based on a search of randomized, controlled clinical trials. Common data were concentrated and evaluated by means of an analysis of variance (ANOVA), and a meta-analysis of the results was performed. The meta-analysis (, 95% confidence interval, post hoc Bonferroni) determined that the supplementation of nonsurgical periodontal therapy with a systemic antibiotic treatment—amoxicillin with clavulanic acid and metronidazole or subantimicrobial dose doxycycline—provides statistically significant results in patients with aggressive or chronic periodontitis under periodontal treatment, whilst increasing the clinical attachment level of the gingiva and reducing periodontal probing depth.

scholarly journals Microbiologic Profiles of Patients with Dental Prosthetic Treatment and Periodontitis before and after Photoactivation Therapy—Randomized Clinical Trial

2021 ◽  
Vol 9 (4) ◽  
pp. 713
Author(s):  
Raluca Cristina Mocanu ◽  
Maria-Alexandra Martu ◽  
Ionut Luchian ◽  
Irina Georgeta Sufaru ◽  
George Alexandru Maftei ◽  
...  
Keyword(s):  
Bacterial Load ◽  
Tissue Loss ◽  
Scaling And Root Planing ◽  
Periodontal Pathogens ◽  
Clinical Attachment Loss ◽  
Periodontal Tissues ◽  
Dental Restorations ◽  
Fixed Dental Prosthesis ◽  
Root Planing ◽  
Severe Periodontitis

Fixed prosthodontic dental restorations can potentially affect the periodontal tissues and vice versa, the periodontium can influence the longevity and esthetic appearance of dental restorations. We proposed an investigation on total bacterial load, specific periodontal pathogens, and periodontal clinical parameters in patients with dental fixed prosthesis and different degrees of periodontal tissue loss that followed photoactivation therapy (PDT) adjunctive to scaling and root planing. The study was conducted on 160 subjects, which were randomly assigned to scaling and root planing (SRP) alone (52 subjects, 256 sites), SRP and chlorhexidine rinsing (58 subjects, 276 sites), and SRP plus PDT (50 subjects, 318 sites). Periodontal parameters (plaque index, bleeding on probing, probing depth, and clinical attachment loss), followed by total bacterial load and specific periodontal pathogens (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola) were examined in each patient at baseline, one and six months after. PDT exerted significant improvements both in clinical and microbiological load after one month, and these results were maintained 6 months after when compared to chlorhexidine rinsing or SRP alone, especially in severe periodontitis cases. Photoactivation therapy as an adjunctive periodontal therapeutic method was efficient in offering supplementary periodontal improvements in the clinical and microbiological parameters of patients with fixed dental prosthesis, particularly in severe periodontitis cases.

scholarly journals Use of digital periodontal software to compare periodontal treatment outcomes in a practice-based research network (PBRN) – a proof of concept

2020 ◽  
Author(s):  
Stefanie Anna Peikert ◽  
Felix Mittelhamm ◽  
Eberhard Frisch ◽  
Kirstin Vach ◽  
Petra Ratka-Krüger ◽  
...  
Keyword(s):  
Treatment Outcomes ◽  
Study Data ◽  
Periodontal Treatment ◽  
Research Network ◽  
Proof Of Concept ◽  
Postgraduate Students ◽  
Probing Depth ◽  
Supportive Periodontal Therapy ◽  
Study Centre ◽  
Practice Based Research

Abstract Background: The aim of this non-interventional, observational study was to develop and evaluate a digital procedure to access, extract and analyse recorded clinical data in practices to assess periodontal treatment outcomes.Methods: Participating periodontists were former or active postgraduate students of a master’s course in periodontics in Freiburg who routinely used a digital periodontal diagnostic program. All available stored periodontal patient charts were extracted, anonymized and digitally sent to the study centre.Results: In this study, data were collected from 6401 patients from 9 different practices. Information such as probing depth (PD), bleeding on probing (BOP), mobility, furcation and gingival attachment for 153163 teeth at first visit were successfully transferred to the study centre. During the observational period, which was from 2.08 years to 18.35 years on average, only 2.8% of all teeth were lost. The number of visits was significantly negatively correlated with BOP (p<0.0001), and the number of BOP-positive sites was significantly correlated with deeper PDs (p<0.001).Conclusion: The presented procedure was able to gather a large amount of practice-based periodontal data, and thus this study may support practice-based research networks. The data indicate that systematic and supportive periodontal therapy is successful on a practice-based level.

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