Burden of Mortality from Asbestos-Related Diseases in Italy

Asbestos is one of the major worldwide occupational carcinogens. The global burden of asbestos-related diseases (ARDs) was estimated around 231,000 cases/year. Italy was one of the main European asbestos producers until the 1992 ban. The WHO recommended national programs, including epidemiological surveillance, to eliminate ARDs. The present paper shows the estimate of the burden of mortality from ARDs in Italy, established for the first time. National standardized rates of mortality from mesothelioma and asbestosis and their temporal trends, based on the National Institute of Statistics database, were computed. Deaths from lung cancer attributable to asbestos exposure were estimated using population-based case-control studies. Asbestos-related lung and ovarian cancer deaths attributable to occupational exposure were estimated, considering the Italian occupational cohort studies. In the 2010–2016 period, 4400 deaths/year attributable to asbestos were estimated: 1515 from mesothelioma, 58 from asbestosis, 2830 from lung and 16 from ovarian cancers. The estimates based on occupational cohorts showed that each year 271 deaths from mesothelioma, 302 from lung cancer and 16 from ovarian cancer were attributable to occupational asbestos exposure in industrial sectors with high asbestos levels. The important health impact of asbestos in Italy, 10–25 years after the ban, was highlighted. These results suggest the need for appropriate interventions in terms of prevention, health care and social security at the local level and could contribute to the global estimate of ARDs.

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Increasing trends in the prevalence of prior cancer in newly diagnosed lung, stomach, colorectal, breast, cervical, and corpus uterine cancer patients: A population-based study

10.21203/rs.3.rs-41046/v2 ◽

2021 ◽

Author(s):

Akira Sato ◽

Keisuke Matsubayashi ◽

Toshitaka Morishima ◽

Kayo Nakata ◽

Koji Kawakami ◽

...

Keyword(s):

Lung Cancer ◽

Clinical Research ◽

Cancer Patients ◽

Uterine Cancer ◽

Treatment Options ◽

Temporal Trends ◽

Treatment Strategies ◽

Population Based ◽

Trend Test ◽

Newly Diagnosed

Abstract Background: Cancer survivors are frequently excluded from clinical research, resulting in their omission from the development of many cancer treatment strategies. Quantifying the prevalence of prior cancer in newly diagnosed cancer patients can inform research and clinical practice. This study aimed to describe the prevalence, characteristics, and trends of prior cancer in newly diagnosed cancer patients in Japan. Methods: Using Osaka Cancer Registry data, we examined the prevalence, characteristics, and temporal trends of prior cancer in patients who received new diagnoses of lung, stomach, colorectal, female breast, cervical, and corpus uterine cancer between 2004 and 2015. Site-specific prior cancers were examined for a maximum of 15 years before the new cancer was diagnosed. Temporal trends were evaluated using the Cochran-Armitage trend test. Results: Among 275,720 newly diagnosed cancer patients, 21,784 (7.9%) had prior cancer. The prevalence of prior cancer ranged from 3.3% (breast cancer) to 11.1% (lung cancer). In both sexes, the age-adjusted prevalence of prior cancer had increased in recent years (P values for trend < 0.001), especially in newly diagnosed lung cancer patients. The proportion of smoking-related prior cancers exceeded 50% in patients with newly diagnosed lung, stomach, colorectal, breast, and cervical cancer. Conclusions: The prevalence of prior cancer in newly diagnosed cancer patients is relatively high, and has increased in recent years. Our findings suggest that a deeper understanding of the prevalence and characteristics of prior cancer in cancer patients is needed to promote more inclusive clinical research and support the expansion of treatment options.

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Occupational exposure to wood dust and risk of lung cancer in two population-based case–control studies in Montreal, Canada

Environmental Health ◽

10.1186/1476-069x-14-1 ◽

2015 ◽

Vol 14 (1) ◽

Cited By ~ 25

Author(s):

Eric Vallières ◽

Javier Pintos ◽

Marie-Elise Parent ◽

Jack Siemiatycki

Keyword(s):

Lung Cancer ◽

Occupational Exposure ◽

Population Based ◽

Case Control ◽

Wood Dust ◽

Case Control Studies

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Occupational Exposure to Diesel Motor Exhaust and Lung Cancer: A Dose-Response Relationship Hidden by Asbestos Exposure Adjustment? The ICARE Study

Journal of Cancer Epidemiology ◽

10.1155/2015/879302 ◽

2015 ◽

Vol 2015 ◽

pp. 1-10 ◽

Cited By ~ 5

Author(s):

Mireille Matrat ◽

Florence Guida ◽

Sylvie Cénée ◽

Joelle Févotte ◽

Matthieu Carton ◽

...

Keyword(s):

Lung Cancer ◽

Occupational Exposure ◽

Dose Response ◽

Asbestos Exposure ◽

Large Population ◽

Population Based ◽

Cumulative Exposure ◽

Response Relationship ◽

Dose Response Relationship ◽

Motor Exhaust

Background. In a French large population-based case-control study we investigated the dose-response relationship between lung cancer and occupational exposure to diesel motor exhaust (DME), taking into account asbestos exposure.Methods. Exposure to DME was assessed by questionnaire. Asbestos was taken into account through a global indicator of exposure to occupational carcinogens or by a specific JEM.Results. We found a crude dose response relationship with most of the indicators of DME exposure, including with the cumulative exposure index. All results were affected by adjustment for asbestos exposure. The dose response relationships between DME and lung cancer were observed among subjects never exposed to asbestos.Conclusions. Exposure to DME and to asbestos is frequently found among the same subjects, which may explain why dose-response relationships in previous studies that adjusted for asbestos exposure were inconsistent.

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Temporal trends of subsequent breast cancer among women with ovarian cancer: a population-based study

Archives of Gynecology and Obstetrics ◽

10.1007/s00404-020-05508-3 ◽

2020 ◽

Vol 301 (5) ◽

pp. 1235-1245

Author(s):

Koji Matsuo ◽

Rachel S. Mandelbaum ◽

Hiroko Machida ◽

Kosuke Yoshihara ◽

Shinya Matsuzaki ◽

...

Keyword(s):

Breast Cancer ◽

Ovarian Cancer ◽

Temporal Trends ◽

Population Based ◽

Population Based Study

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Increasing trends in the prevalence of prior cancer in newly diagnosed lung, stomach, colorectal, breast, cervical, and corpus uterine cancer patients: a population-based study

BMC Cancer ◽

10.1186/s12885-021-08011-3 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Akira Sato ◽

Keisuke Matsubayashi ◽

Toshitaka Morishima ◽

Kayo Nakata ◽

Koji Kawakami ◽

...

Keyword(s):

Lung Cancer ◽

Clinical Research ◽

Cancer Patients ◽

Uterine Cancer ◽

Treatment Options ◽

Temporal Trends ◽

Treatment Strategies ◽

Population Based ◽

Trend Test ◽

Newly Diagnosed

Abstract Background Cancer survivors are frequently excluded from clinical research, resulting in their omission from the development of many cancer treatment strategies. Quantifying the prevalence of prior cancer in newly diagnosed cancer patients can inform research and clinical practice. This study aimed to describe the prevalence, characteristics, and trends of prior cancer in newly diagnosed cancer patients in Japan. Methods Using Osaka Cancer Registry data, we examined the prevalence, characteristics, and temporal trends of prior cancer in patients who received new diagnoses of lung, stomach, colorectal, female breast, cervical, and corpus uterine cancer between 2004 and 2015. Site-specific prior cancers were examined for a maximum of 15 years before the new cancer was diagnosed. Temporal trends were evaluated using the Cochran-Armitage trend test. Results Among 275,720 newly diagnosed cancer patients, 21,784 (7.9%) had prior cancer. The prevalence of prior cancer ranged from 3.3% (breast cancer) to 11.1% (lung cancer). In both sexes, the age-adjusted prevalence of prior cancer had increased in recent years (P values for trend < 0.001), especially in newly diagnosed lung cancer patients. The proportion of smoking-related prior cancers exceeded 50% in patients with newly diagnosed lung, stomach, colorectal, breast, and cervical cancer. Conclusions The prevalence of prior cancer in newly diagnosed cancer patients is relatively high, and has increased in recent years. Our findings suggest that a deeper understanding of the prevalence and characteristics of prior cancer in cancer patients is needed to promote more inclusive clinical research and support the expansion of treatment options.

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Temporal trends in lung cancer survival: a population-based study

Acta Oncologica ◽

10.1080/0284186x.2021.2013529 ◽

2021 ◽

pp. 1-7

Author(s):

Lukas Löfling ◽

Shahram Bahmanyar ◽

Helle Kieler ◽

Mats Lambe ◽

Gunnar Wagenius

Keyword(s):

Lung Cancer ◽

Cancer Survival ◽

Temporal Trends ◽

Population Based ◽

Population Based Study ◽

Lung Cancer Survival

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A regression model for risk difference estimation in population-based case–control studies clarifies gender differences in lung cancer risk of smokers and never smokers

BMC Medical Research Methodology ◽

10.1186/1471-2288-13-143 ◽

2013 ◽

Vol 13 (1) ◽

Cited By ~ 14

Author(s):

Stephanie A Kovalchik ◽

Sara De Matteis ◽

Maria Teresa Landi ◽

Neil E Caporaso ◽

Ravi Varadhan ◽

...

Keyword(s):

Lung Cancer ◽

Gender Differences ◽

Cancer Risk ◽

Regression Model ◽

Lung Cancer Risk ◽

Population Based ◽

Case Control ◽

Risk Difference ◽

Case Control Studies ◽

Never Smokers

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Assessment of the effect of occupational exposure to formaldehyde on the risk of lung cancer in two Canadian population-based case–control studies

Scandinavian Journal of Work Environment & Health ◽

10.5271/sjweh.3344 ◽

2013 ◽

Vol 39 (4) ◽

pp. 401-410 ◽

Cited By ~ 12

Author(s):

Amel Mahboubi ◽

Anita Koushik ◽

Jack Siemiatycki ◽

Jérôme Lavoué ◽

Marie-Claude Rousseau

Keyword(s):

Lung Cancer ◽

Occupational Exposure ◽

Population Based ◽

Case Control ◽

Case Control Studies ◽

Canadian Population

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Kreftrisiko blant norske papir- og cellulosearbeidere

Norsk Epidemiologi ◽

10.5324/nje.v11i2.555 ◽

2009 ◽

Vol 11 (2) ◽

Author(s):

Hilde Langseth

Keyword(s):

Lung Cancer ◽

Ovarian Cancer ◽

Asbestos Exposure ◽

Paper Industry ◽

English Summary ◽

Pulp And Paper ◽

Pleural Mesothelioma ◽

Font Size ◽

Work Related ◽

Increased Risk

ENGLISH SUMMARYLangseth H. Cancer risk in Norwegian pulp and paper workers. Nor J Epidemiol 2001; 11 (2): 187-192.Results from a historical prospective cohort study on Norwegian pulp and paper workers showed a significantincrease in risk of lung cancer, pleural mesothelioma, colon cancer and malignant melanomas amongmen, compared to the Norwegian population. The risk of lung cancer was highest among sulphite millworkers. The risk of pleural mesothelioma was highest among maintenance workers with asbestos exposure.Most of the increased risk in lung cancer can be explained by a combination of smoking habits andasbestos use, although an effect of other work-related exposures (sulfur and chloride compounds, wooddust) cannot be excluded. Among the female part of the cohort we found a significant excess in risk ofovarian cancer. The risk was highest among those younger than 55 years, and mostly among those workingin paper departments. Relatively little is known about the causes of ovarian cancer, but it is howeverknown that 5-7% can be explained by hereditary factors. Furthermore, fertility pattern plays a role.Asbestos and talc, which both have been used in the pulp and paper industry, are occupational and environmentalagents, discussed as possible carcinogens for ovarian cancer.

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