scholarly journals Correlation of ADIPOQ Gene Single Nucleotide Polymorphisms with Bone Strength Index in Middle-Aged and the Elderly of Guangxi Mulam Ethnic Group

2021 ◽  
Vol 18 (24) ◽  
pp. 13034
Author(s):  
Min Zhou ◽  
Ning Ning ◽  
Yueming Jiang ◽  
Michael Aschner ◽  
Xiufeng Huang ◽  
...  
Keyword(s):  
Bone Mass ◽  
Bone Strength ◽  
Susceptibility Gene ◽  
Subcutaneous Fat ◽  
The Elderly ◽  
Strength Index ◽  
Middle Aged ◽  
Single Nucleotide ◽  
Adipoq Gene ◽  
Bone Strength Index

Background: Osteoporosis (OP) is a common orthopedic disease in the elderly, and Adiponectin (ADIPOQ) is closely related to bone metabolism. Objective: To determine the relationship between five single nucleotide polymorphism (SNP) loci in the ADIPOQ gene and osteoporosis in middle-aged and elderly Mulam subjects in Hechi, Guangxi. Methods: This case-control study included 297 middle-aged and elderly Mulam subjects with normal bone mass, 49 subjects with reduced bone mass, and 38 subjects with osteoporosis. Five loci (rs266729, rs1063539, rs2241766, rs3774261, rs710445) of the ADIPOQ in the Mulam subjects were genotyped using SNP with multiple-base extension. Results: The bone strength index (SI) of middle-aged and elderly Mulam subjects showed an overall decreasing trend when the subjects were older. Age, muscle mass, and subcutaneous fat content were the main factors influencing the SI in Mulam subjects. The GC genotype of rs266729 and the GA and GG genotypes of rs710445 were significantly correlated with risk of bone loss (p < 0.05). rs2241766 and rs1063539 showed strong LD (D’ > 0.8, r2 > 0.33). rs710445 and rs266729 loci and rs3774261 and rs2241766 loci showed complete LD (D’ = 1). Conclusions: The GC genotype at rs266729 of the ADIPOQ gene, the GA and GG genotypes at rs710445, and the haplotypes CCGAA and GGTAG correlated with osteoporosis (p < 0.05). The allele C of rs1063539, rs266729 and rs710445 may afford protection for osteoporosis. The allele G may be the genetic susceptibility gene for osteoporosis, increasing the risk of osteoporosis.

Correlation of pQCT bone strength index with mechanical testing in distraction osteogenesis

Bone ◽  
2009 ◽  
Vol 45 (3) ◽  
pp. 512-516 ◽  
Author(s):  
Constantinos Kokoroghiannis ◽  
Ioannis Charopoulos ◽  
Georgios Lyritis ◽  
Panagiota Raptou ◽  
Theofilos Karachalios ◽  
...  
Keyword(s):  
Mechanical Testing ◽  
Bone Strength ◽  
Distraction Osteogenesis ◽  
Strength Index ◽  
Bone Strength Index

CORRELATIONS BETWEEN MAXIMAL MUSCLE-FORCE/-TORQUE AND A BONE STRENGTH INDEX IN UPPER LIMBS

1998 ◽  
Vol 30 (Supplement) ◽  
pp. 290
Author(s):  
M. Hartard ◽  
H. Schiessl ◽  
P. Bartenstein ◽  
Th. Hilberg ◽  
D. Jeschke
Keyword(s):  
Bone Strength ◽  
Muscle Force ◽  
Upper Limbs ◽  
Strength Index ◽  
Bone Strength Index

scholarly journals Vascular Elasticity and Grip Strength Are Associated With Bone Health of the Hemiparetic Radius in People With Chronic Stroke: Implications for Rehabilitation

2013 ◽  
Vol 93 (6) ◽  
pp. 774-785 ◽  
Author(s):  
Marco Y.C. Pang ◽  
Feigo Z.H. Yang ◽  
Alice Y.M. Jones
Keyword(s):  
Bone Loss ◽  
Grip Strength ◽  
Bone Strength ◽  
Bone Health ◽  
Chronic Stroke ◽  
Fracture Rate ◽  
Large Artery ◽  
Strength Index ◽  
Mineral Density ◽  
Bone Strength Index

Background People with stroke often have increased bone loss and fracture rate. Increasing evidence has demonstrated a link between cardiovascular health and bone loss in other patient populations. Objective The study objectives were: (1) to compare the bone density and geometry of the radius diaphysis on the left and right sides in people with chronic stroke and people who were matched for age (control participants) and (2) to examine the relationship between the bone strength index at the hemiparetic radius diaphysis and vascular health in people with chronic stroke. Design This was a case-control study. Methods The radius diaphysis on both sides was scanned with peripheral quantitative computed tomography in 65 participants with chronic stroke and 34 control participants. Large-artery and small-artery elasticity indexes were evaluated with a cardiovascular profiling system. Results The paretic radius diaphysis had significantly lower values for cortical bone mineral density, cortical thickness, cortical area, and the bone strength index but a larger marrow cavity area than the nonparetic radius diaphysis in participants with chronic stroke, whereas no bone measurement showed a significant side-to-side difference in control participants. Multiple regression analyses showed that the large-artery elasticity index and grip strength remained significantly associated with the bone strength index at the hemiparetic radius diaphysis after controlling for age, sex, time since stroke diagnosis, body mass index, and physical activity (R2=.790). Limitations This study was cross-sectional and could not establish causality. The radius diaphysis is not the most common site of fracture after stroke. Conclusions Both the integrity of the vasculature and muscle strength were significantly associated with the bone strength index at the hemiparetic radius diaphysis in participants with chronic stroke. The results may be useful in guiding rehabilitative programs for enhancing bone health in the paretic arm after stroke.

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