scholarly journals TargetAntiAngio: A Sequence-Based Tool for the Prediction and Analysis of Anti-Angiogenic Peptides

2019 ◽  
Vol 20 (12) ◽  
pp. 2950 ◽  
Author(s):  
Vishuda Laengsri ◽  
Chanin Nantasenamat ◽  
Nalini Schaduangrat ◽  
Pornlada Nuchnoi ◽  
Virapong Prachayasittikul ◽  
...  
Keyword(s):  
Random Forest ◽  
Causes Of Death ◽  
Biochemical Properties ◽  
Random Forest Classifier ◽  
Bond Forming ◽  
Independent Validation ◽  
Validation Test ◽  
Average Accuracy ◽  
Anti Cancer ◽  
Inhibition Of Angiogenesis

Cancer remains one of the major causes of death worldwide. Angiogenesis is crucial for the pathogenesis of various human diseases, especially solid tumors. The discovery of anti-angiogenic peptides is a promising therapeutic route for cancer treatment. Thus, reliably identifying anti-angiogenic peptides is extremely important for understanding their biophysical and biochemical properties that serve as the basis for the discovery of new anti-cancer drugs. This study aims to develop an efficient and interpretable computational model called TargetAntiAngio for predicting and characterizing anti-angiogenic peptides. TargetAntiAngio was developed using the random forest classifier in conjunction with various classes of peptide features. It was observed via an independent validation test that TargetAntiAngio can identify anti-angiogenic peptides with an average accuracy of 77.50% on an objective benchmark dataset. Comparisons demonstrated that TargetAntiAngio is superior to other existing methods. In addition, results revealed the following important characteristics of anti-angiogenic peptides: (i) disulfide bond forming Cys residues play an important role for inhibiting blood vessel proliferation; (ii) Cys located at the C-terminal domain can decrease endothelial formatting activity and suppress tumor growth; and (iii) Cyclic disulfide-rich peptides contribute to the inhibition of angiogenesis and cell migration, selectivity and stability. Finally, for the convenience of experimental scientists, the TargetAntiAngio web server was established and made freely available online.

scholarly journals Species-specific audio detection: A comparison of three template-based classification algorithms using random forests

2017 ◽  
Author(s):  
Carlos J Corrada Bravo ◽  
Rafael Álvarez Berríos ◽  
T. Mitchell Aide
Keyword(s):  
Random Forest ◽  
Random Forests ◽  
Random Forest Classifier ◽  
Classification Algorithms ◽  
Statistical Features ◽  
Web Based ◽  
Average Accuracy ◽  
Species Specific ◽  
Web Based System

We developed a web-based cloud-hosted system that allow users to archive, listen, visualize, and annotate recordings. The system also provides tools to convert these annotations into datasets that can be used to train a computer to detect the presence or absence of a species. The algorithm used by the system was selected after comparing the accuracy and efficiency of three variants of a template-based classification. The algorithm computes a similarity vector by comparing a template of a species call with time increments across the spectrogram. Statistical features are extracted from this vector and used as input for a Random Forest classifier that predicts presence or absence of the species in the recording. The fastest algorithm variant had the highest average accuracy and specificity; therefore, it was implemented in the ARBIMON web-based system.

scholarly journals Species-specific audio detection: A comparison of three template-based classification algorithms using random forests

2017 ◽  
Author(s):  
Carlos J Corrada Bravo ◽  
Rafael Álvarez Berríos ◽  
T. Mitchell Aide
Keyword(s):  
Random Forest ◽  
Random Forests ◽  
Random Forest Classifier ◽  
Classification Algorithms ◽  
Statistical Features ◽  
Web Based ◽  
Average Accuracy ◽  
Species Specific ◽  
Web Based System

We developed a web-based cloud-hosted system that allow users to archive, listen, visualize, and annotate recordings. The system also provides tools to convert these annotations into datasets that can be used to train a computer to detect the presence or absence of a species. The algorithm used by the system was selected after comparing the accuracy and efficiency of three variants of a template-based classification. The algorithm computes a similarity vector by comparing a template of a species call with time increments across the spectrogram. Statistical features are extracted from this vector and used as input for a Random Forest classifier that predicts presence or absence of the species in the recording. The fastest algorithm variant had the highest average accuracy and specificity; therefore, it was implemented in the ARBIMON web-based system.

scholarly journals Species-specific audio detection: a comparison of three template-based detection algorithms using random forests

2017 ◽  
Vol 3 ◽  
pp. e113 ◽  
Author(s):  
Carlos J. Corrada Bravo ◽  
Rafael Álvarez Berríos ◽  
T. Mitchell Aide
Keyword(s):  
Random Forest ◽  
Random Forests ◽  
Random Forest Classifier ◽  
Statistical Features ◽  
Web Based ◽  
Detection Algorithms ◽  
Average Accuracy ◽  
Species Specific ◽  
Web Based System

We developed a web-based cloud-hosted system that allow users to archive, listen, visualize, and annotate recordings. The system also provides tools to convert these annotations into datasets that can be used to train a computer to detect the presence or absence of a species. The algorithm used by the system was selected after comparing the accuracy and efficiency of three variants of a template-based detection. The algorithm computes a similarity vector by comparing a template of a species call with time increments across the spectrogram. Statistical features are extracted from this vector and used as input for a Random Forest classifier that predicts presence or absence of the species in the recording. The fastest algorithm variant had the highest average accuracy and specificity; therefore, it was implemented in the ARBIMON web-based system.

The Performance Improvement on 4-FB Face using Random Forest Classifier

2018 ◽  
Vol 10 (5) ◽  
pp. 1-12
Author(s):  
B. Nassih ◽  
A. Amine ◽  
M. Ngadi ◽  
D. Naji ◽  
N. Hmina
Keyword(s):  
Random Forest ◽  
Performance Improvement ◽  
Random Forest Classifier

Methodology for Malware Classification using a Random Forest Classifier

2018 ◽  
Author(s):  
Carlos Domenick Morales-Molina ◽  
Diego Santamaria-Guerrero ◽  
Gabriel Sanchez-Perez ◽  
Hector Perez-Meana ◽  
Aldo Hernandez-Suarez
Keyword(s):  
Random Forest ◽  
Random Forest Classifier ◽  
Malware Classification

scholarly journals Amide proton transfer weighted (APTw) imaging based radiomics allows for the differentiation of gliomas from metastases

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Elisabeth Sartoretti ◽  
Thomas Sartoretti ◽  
Michael Wyss ◽  
Carolin Reischauer ◽  
Luuk van Smoorenburg ◽  
...  
Keyword(s):  
Machine Learning ◽  
Random Forest ◽  
Brain Tumors ◽  
Proton Transfer ◽  
Multilayer Perceptron ◽  
Random Forest Classifier ◽  
Amide Proton ◽  
Low Grade ◽  
Who Grade ◽  
Amide Proton Transfer

AbstractWe sought to evaluate the utility of radiomics for Amide Proton Transfer weighted (APTw) imaging by assessing its value in differentiating brain metastases from high- and low grade glial brain tumors. We retrospectively identified 48 treatment-naïve patients (10 WHO grade 2, 1 WHO grade 3, 10 WHO grade 4 primary glial brain tumors and 27 metastases) with either primary glial brain tumors or metastases who had undergone APTw MR imaging. After image analysis with radiomics feature extraction and post-processing, machine learning algorithms (multilayer perceptron machine learning algorithm; random forest classifier) with stratified tenfold cross validation were trained on features and were used to differentiate the brain neoplasms. The multilayer perceptron achieved an AUC of 0.836 (receiver operating characteristic curve) in differentiating primary glial brain tumors from metastases. The random forest classifier achieved an AUC of 0.868 in differentiating WHO grade 4 from WHO grade 2/3 primary glial brain tumors. For the differentiation of WHO grade 4 tumors from grade 2/3 tumors and metastases an average AUC of 0.797 was achieved. Our results indicate that the use of radiomics for APTw imaging is feasible and the differentiation of primary glial brain tumors from metastases is achievable with a high degree of accuracy.

scholarly journals Fully automated analysis combining [18F]-FET-PET and multiparametric MRI including DSC perfusion and APTw imaging: a promising tool for objective evaluation of glioma progression

2021 ◽  
Author(s):  
K. J. Paprottka ◽  
S. Kleiner ◽  
C. Preibisch ◽  
F. Kofler ◽  
F. Schmidt-Graf ◽  
...  
Keyword(s):  
Random Forest ◽  
Tumor Progression ◽  
Automated Analysis ◽  
Random Forest Classifier ◽  
Imaging Modalities ◽  
Amide Proton ◽  
Tumor Board ◽  
Dynamic Susceptibility ◽  
Fet Pet ◽  
Promising Tool

Abstract Purpose To evaluate diagnostic accuracy of fully automated analysis of multimodal imaging data using [18F]-FET-PET and MRI (including amide proton transfer-weighted (APTw) imaging and dynamic-susceptibility-contrast (DSC) perfusion) in differentiation of tumor progression from treatment-related changes in patients with glioma. Material and methods At suspected tumor progression, MRI and [18F]-FET-PET data as part of a retrospective analysis of an observational cohort of 66 patients/74 scans (51 glioblastoma and 23 lower-grade-glioma, 8 patients included at two different time points) were automatically segmented into necrosis, FLAIR-hyperintense, and contrast-enhancing areas using an ensemble of deep learning algorithms. In parallel, previous MR exam was processed in a similar way to subtract preexisting tumor areas and focus on progressive tumor only. Within these progressive areas, intensity statistics were automatically extracted from [18F]-FET-PET, APTw, and DSC-derived cerebral-blood-volume (CBV) maps and used to train a Random Forest classifier with threefold cross-validation. To evaluate contribution of the imaging modalities to the classifier’s performance, impurity-based importance measures were collected. Classifier performance was compared with radiology reports and interdisciplinary tumor board assessments. Results In 57/74 cases (77%), tumor progression was confirmed histopathologically (39 cases) or via follow-up imaging (18 cases), while remaining 17 cases were diagnosed as treatment-related changes. The classification accuracy of the Random Forest classifier was 0.86, 95% CI 0.77–0.93 (sensitivity 0.91, 95% CI 0.81–0.97; specificity 0.71, 95% CI 0.44–0.9), significantly above the no-information rate of 0.77 (p = 0.03), and higher compared to an accuracy of 0.82 for MRI (95% CI 0.72–0.9), 0.81 for [18F]-FET-PET (95% CI 0.7–0.89), and 0.81 for expert consensus (95% CI 0.7–0.89), although these differences were not statistically significant (p > 0.1 for all comparisons, McNemar test). [18F]-FET-PET hot-spot volume was single-most important variable, with relevant contribution from all imaging modalities. Conclusion Automated, joint image analysis of [18F]-FET-PET and advanced MR imaging techniques APTw and DSC perfusion is a promising tool for objective response assessment in gliomas.

scholarly journals Development of a Safety Management System Tracking the Weight of Heavy Objects Carried by Construction Workers Using FSR Sensors

2021 ◽  
Vol 11 (4) ◽  
pp. 1378
Author(s):  
Seung Hyun Lee ◽  
Jaeho Son
Keyword(s):  
Random Forest ◽  
Decision Tree ◽  
Safety Management ◽  
Tracking System ◽  
Construction Workers ◽  
Gradient Boosting ◽  
Prototype System ◽  
Construction Site ◽  
Average Accuracy ◽  
Smart Safety

It has been pointed out that the act of carrying a heavy object that exceeds a certain weight by a worker at a construction site is a major factor that puts physical burden on the worker’s musculoskeletal system. However, due to the nature of the construction site, where there are a large number of workers simultaneously working in an irregular space, it is difficult to figure out the weight of the object carried by the worker in real time or keep track of the worker who carries the excess weight. This paper proposes a prototype system to track the weight of heavy objects carried by construction workers by developing smart safety shoes with FSR (Force Sensitive Resistor) sensors. The system consists of smart safety shoes with sensors attached, a mobile device for collecting initial sensing data, and a web-based server computer for storing, preprocessing and analyzing such data. The effectiveness and accuracy of the weight tracking system was verified through the experiments where a weight was lifted by each experimenter from +0 kg to +20 kg in 5 kg increments. The results of the experiment were analyzed by a newly developed machine learning based model, which adopts effective classification algorithms such as decision tree, random forest, gradient boosting algorithm (GBM), and light GBM. The average accuracy classifying the weight by each classification algorithm showed similar, but high accuracy in the following order: random forest (90.9%), light GBM (90.5%), decision tree (90.3%), and GBM (89%). Overall, the proposed weight tracking system has a significant 90.2% average accuracy in classifying how much weight each experimenter carries.

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