scholarly journals Metabolically Active Brown Adipose Tissue Is Found in Adult Subjects with Type 1 Diabetes

2019 ◽  
Vol 20 (23) ◽  
pp. 5827 ◽  
Author(s):  
Eriksson ◽  
Selvaraju ◽  
Berglund ◽  
Espes
Keyword(s):  
Skeletal Muscle ◽  
Type 1 Diabetes ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Metabolic Control ◽  
Metabolic Activity ◽  
Glucose Utilization ◽  
Insulin Requirements ◽  
Brown Adipose

Type 1 diabetes (T1D) is characterized by the loss of insulin-producing cells and hence insulin secretion and metabolic control. In addition to insulin, there are a number of hormones and cytokines that influence metabolism, and many of these can be secreted from brown adipose tissue (BAT). However, the presence and activity of BAT in T1D have not been studied, despite the fact that preclinical studies have shown that transplantation of BAT in mouse models of T1D can restore metabolic control. The metabolic activity of BAT, white adipose tissue (WAT), and skeletal muscle was investigated in patients with T1D (n = 11) by 2-deoxy-2-(18F)fluoro-D-glucose PET/CT after cold stimulation. Functional BAT was detected in 4 out of 11 individuals with T1D with a prevalence of 36%. The glucose utilization rate in the supraclavicular BAT regions ranged from 0.75–38.7 µmol × min−1 × 100 g−1. The glucose utilization per gram tissue was higher in BAT when compared with both WAT (p = 0.049) and skeletal muscle (p = 0.039). However, no correlation between BAT activity and metabolic control or insulin requirements was found. In conclusion, for the first time, cold-induced BAT was detected in patients with T1D with a wide range in metabolic activity. Contrary to findings in animal models, the metabolic activity of BAT had negligible impact on insulin requirements or metabolic control in T1D under normal physiological conditions.

scholarly journals Quantification in vivo of the effects of insulin on glucose utilization in individual tissues of warm- and cold-acclimated rats

1986 ◽  
Vol 237 (3) ◽  
pp. 789-795 ◽  
Author(s):  
S A Smith ◽  
P Young ◽  
M A Cawthorne
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Cold Acclimation ◽  
Glucose Utilization ◽  
Insulin Treatment ◽  
Glucose Production ◽  
Whole Body ◽  
Metabolic Index ◽  
Brown Adipose

Cold-acclimation of rats (3 weeks, 4 degrees C) had no effect on basal rates of glucose production or utilization. Under euglycaemic-clamp conditions, in which the circulating insulin concentration was increased by approx. 50 microunits/ml, cold-acclimated rats showed a greater increase in glucose utilization and a greater suppression of endogenous glucose production. Tissue sites of glucose utilization were investigated by using a tracer dose of 2-deoxy-D-[14C]glucose and a glucose metabolic index determined for each tissue. In 5 h-starved warm-acclimated rats, heart had the highest glucose metabolic index. This was increased further by both cold-acclimation and insulin treatment. The glucose metabolic index of skeletal muscle was 3.5-14-fold lower than that of heart, but, as a result of the large muscle mass, skeletal muscle made the largest contribution to whole-body glucose utilization. White and brown adipose tissue had low glucose metabolic indices in warm-acclimated rats under basal conditions, and the indices were not increased by the insulin treatment. However, cold-acclimation produced a significant increase in the glucose metabolic index of brown adipose tissue, but not of white adipose tissue. In contrast with the warm-acclimated rats, insulin treatment of cold-acclimated rats resulted in a marked increase in the glucose metabolic index of brown adipose tissue. The results provide evidence that cold-acclimation produces a selective alteration in the insulin-sensitivity of brown adipose tissue.

scholarly journals Deiodinase Activities in Thyroids and Tissues of Iodine-Deficient Female Rats

Endocrinology ◽  
2013 ◽  
Vol 154 (1) ◽  
pp. 529-536 ◽  
Author(s):  
Rosalia Lavado-Autric ◽  
Rosa Maria Calvo ◽  
Raquel Martinez de Mena ◽  
Gabriella Morreale de Escobar ◽  
Maria-Jesus Obregon
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Cerebral Cortex ◽  
Brown Adipose Tissue ◽  
Female Rats ◽  
Iodothyronine Deiodinase ◽  
Brown Adipose ◽  
Type 3

Severe iodine deficiency is characterized by goiter, preferential synthesis, and secretion of T3 in thyroids, hypothyroxinemia in plasma and tissues, normal or low plasma T3, and slightly increased plasma TSH. We studied changes in deiodinase activities and mRNA in several tissues of rats maintained on low-iodine diets (LIDs) or LIDs supplemented with iodine (LID+I). T4 and T3 concentrations decreased in plasma, tissues, and thyroids of LID rats, and T4 decreased more than T3 (50%). The highest type 1 iodothyronine deiodinase (D1) activities were found in the thyroid, kidney, and the liver; pituitary, lung, and ovary had lower D1 activities; but the lowest levels were found in the heart and skeletal muscle. D1 activity decreased in all tissues of LID rats (10–40% of LID+I rats), except for ovary and thyroids, which D1 activity increased 2.5-fold. Maximal type 2 iodothyronine deiodinase (D2) activities were found in thyroid, brown adipose tissue, and pituitary, increasing 6.5-fold in thyroids of LID rats and about 20-fold in the whole gland. D2 always increased in response to LID, and maximal increases were found in the cerebral cortex (19-fold), thyroid, brown adipose tissue, and pituitary (6-fold). Lower D2 activities were found in the ovary, heart, and adrenal gland, which increased in LID. Type 3 iodothyronine deiodinase activity was undetectable. Thyroidal Dio1 and Dio2 mRNA increased in the LID rats, and Dio1 decreased in the lung, with no changes in mRNA expression in other tissues. Our data indicate that LID induces changes in deiodinase activities, especially in the thyroid, to counteract the low T4 synthesis and secretion, contributing to maintain the local T3 concentrations in the tissues with D2 activity.

scholarly journals Insulin-independent reversal of type 1 diabetes in nonobese diabetic mice with brown adipose tissue transplant

2015 ◽  
Vol 308 (12) ◽  
pp. E1043-E1055 ◽  
Author(s):  
Subhadra C. Gunawardana ◽  
David W. Piston
Keyword(s):  
Type 1 Diabetes ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Nod Mice ◽  
Nonobese Diabetic ◽  
Brown Adipose ◽  
Igf I ◽  
Onset Of Diabetes ◽  
Nonobese Diabetic Mice

Traditional therapies for type 1 diabetes (T1D) involve insulin replacement or islet/pancreas transplantation and have numerous limitations. Our previous work demonstrated the ability of embryonic brown adipose tissue (BAT) transplants to establish normoglycemia without insulin in chemically induced models of insulin-deficient diabetes. The current study sought to extend the technique to an autoimmune-mediated T1D model and document the underlying mechanisms. In nonobese diabetic (NOD) mice, BAT transplants result in complete reversal of T1D associated with rapid and long-lasting euglycemia. In addition, BAT transplants placed prior to the onset of diabetes on NOD mice can prevent or significantly delay the onset of diabetes. As with streptozotocin (STZ)-diabetic models, euglycemia is independent of insulin and strongly correlates with decrease of inflammation and increase of adipokines. Plasma insulin-like growth factor-I (IGF-I) is the first hormone to increase following BAT transplants. Adipose tissue of transplant recipients consistently express IGF-I compared with little or no expression in controls, and plasma IGF-I levels show a direct negative correlation with glucose, glucagon, and inflammatory cytokines. Adipogenic and anti-inflammatory properties of IGF-I may stimulate regeneration of new healthy white adipose tissue, which in turn secretes hypoglycemic adipokines that substitute for insulin. IGF-I can also directly decrease blood glucose through activating insulin receptor. These data demonstrate the potential for insulin-independent reversal of autoimmune-induced T1D with BAT transplants and implicate IGF-I as a likely mediator in the resulting equilibrium.

scholarly journals Glucose transporter expression and glucose utilization in skeletal muscle and brown adipose tissue during starvation and re-feeding

1992 ◽  
Vol 282 (1) ◽  
pp. 231-235 ◽  
Author(s):  
D M Smith ◽  
S R Bloom ◽  
M C Sugden ◽  
M J Holness
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Tibialis Anterior ◽  
Glucose Transporter ◽  
Glucose Utilization ◽  
Interscapular Brown Adipose Tissue ◽  
Glut 4 ◽  
Mrna Concentration ◽  
Brown Adipose ◽  
Transporter Expression

Starvation (48 h) decreased the concentration of mRNA of the insulin-responsive glucose transporter isoform (GLUT 4) in interscapular brown adipose tissue (IBAT) (56%) and tibialis anterior (10%). Despite dramatic [7-fold (tibialis anterior) and 40-fold (IBAT)] increases in glucose utilization after 2 and 4 h of chow re-feeding, no significant changes in GLUT 4 mRNA concentration were observed in these tissues over this re-feeding period. The results exclude changes in GLUT 4 mRNA concentration in mediating the responses of glucose transport in these tissues to acute re-feeding after prolonged starvation.

scholarly journals Corrigendum: Cvijic G, Lakic I, Vujovic P, Jasnic N, Djurasevic S, Dronjak-Cucakovic S, Djordjevic J. Single and combined effects of acute and chronic non-thermal stressors on rat interscapular brown adipose tissue metabolic activity. Arch biol sci. 2013;65(3):919-27 DOI:10.2298/ABS1303919C

2015 ◽  
Vol 67 (4) ◽  
pp. 1431-1431
Author(s):  
E Editorial
Keyword(s):  
Biological Sciences ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Metabolic Activity ◽  
Combined Effects ◽  
Interscapular Brown Adipose Tissue ◽  
Brown Adipose ◽  
New Findings ◽  
Partial Overlap ◽  
Font Color

The Editor-in-Chief has been informed that the results in Fig. 2A in the article: Single and combined effects of acute and chronic non-thermal stressors on rat interscapular brown adipose tissue metabolic activity, published in the Archives of Biological Sciences in 2013, Vol. 65, Issue 3, partially overlap with the results in Fig. 2, published in the article: Lakic I, Drenca T, Djordjevic J, Vujovic P, Jasnic N, Djurasevic S, Dronjak-Cucakovic S, Cvijic G. Arch Biol Sci. 2011;63(3):589-96, DOI:10.2298/ABS1103589L. After inspection of these articles and illustrations, and after discussion with the corresponding author of both articles, it was revealed that this is a case of partial overlap, i.e. of the authors presenting new findings that contain a comparatively small amount of previously published information. By publishing this corrigendum the journal is providing appropriate cross-referencing to the earlier work. <br><br><font color="red"><b> Link to the corrected article <u><a href="http://dx.doi.org/10.2298/ABS1303919C">10.2298/ABS1303919C</a></b></u>

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