scholarly journals Opposing Roles of FoxA1 and FoxA3 in Intrahepatic Cholangiocarcinoma Progression

2020 ◽  
Vol 21 (5) ◽  
pp. 1796
Author(s):  
Raynoo Thanan ◽  
Waleeporn Kaewlert ◽  
Chadamas Sakonsinsiri ◽  
Timpika Chaiprasert ◽  
Napat Armartmuntree ◽  
...  
Keyword(s):  
Stem Cell ◽  
Transcription Factors ◽  
Cell Differentiation ◽  
Bile Duct ◽  
Intrahepatic Cholangiocarcinoma ◽  
Poor Prognosis ◽  
Stem Cell Differentiation ◽  
Biliary Epithelium ◽  
Cancer Tissues ◽  
Low Expression

Cholangiocarcinoma (CCA), a malignancy of biliary epithelium, is related to liver stem cell deregulation. FoxAs are a group of transcription factors that play critical roles in liver stem cell differentiation. In this study, the expression levels of FoxAs (i.e., FoxA1, FoxA2 and FoxA3) were detected in intrahepatic CCA tissues and the functions of FoxAs were studied in CCA cell lines. FoxA1 and FoxA2 were mainly localized in the nuclei of normal bile duct (NBD) cells and some of the cancer cells. Low expression of FoxA1 in CCA tissues (72%) was significantly correlated with poor prognosis. FoxA3 expression of CCA cells was localized in the nucleus and cytoplasm, whereas it was slightly detected in NBDs. High expression of FoxA3 in cancer tissues (61%) was significantly related to high metastasis status. These findings suggest the opposing roles of FoxA1 and FoxA3 in CCA. Moreover, the FoxA1-over-expressing CCA cell line exhibited a significant reduction in proliferative and invasive activities compared to control cells. Knockdown of FoxA3 in CCA cells resulted in a significant decrease in proliferative and invasive activities compared with control cells. Taken together, in CCA, FoxA1 is down-regulated and has tumor suppressive roles, whereas FoxA3 is up-regulated and has oncogenic roles.

Regulation of Neural Stem Cell Differentiation by Transcription Factors HNF4-1 and MAZ-1

2012 ◽  
Vol 47 (1) ◽  
pp. 228-240 ◽  
Author(s):  
Jiao Wang ◽  
Hua Cheng ◽  
Xiao Li ◽  
Wei Lu ◽  
Kai Wang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Transcription Factors ◽  
Cell Differentiation ◽  
Neural Stem Cell ◽  
Stem Cell Differentiation

Transcription Factors for Dental Stem Cell Differentiation

2013 ◽  
Vol 28 (6) ◽  
pp. e478-e486 ◽  
Author(s):  
Sandra Viale-Bouroncle ◽  
Oliver Felthaus ◽  
Gottfried Schmalz ◽  
Torsten E. Reichert ◽  
Christian Morsczeck
Keyword(s):  
Stem Cell ◽  
Transcription Factors ◽  
Cell Differentiation ◽  
Stem Cell Differentiation ◽  
Dental Stem Cell

scholarly journals Delayed Accumulation of H3K27me3 on Nascent DNA Is Essential for Recruitment of Transcription Factors at Early Stages of Stem Cell Differentiation

2017 ◽  
Vol 66 (2) ◽  
pp. 247-257.e5 ◽  
Author(s):  
Svetlana Petruk ◽  
Jingli Cai ◽  
Robyn Sussman ◽  
Guizhi Sun ◽  
Sina K. Kovermann ◽  
...  
Keyword(s):  
Stem Cell ◽  
Transcription Factors ◽  
Cell Differentiation ◽  
Stem Cell Differentiation ◽  
Early Stages

Potential Utility of Cell-Permeable Transcription Factors to Direct Stem Cell Differentiation

2004 ◽  
Vol 13 (5) ◽  
pp. 460-462 ◽  
Author(s):  
Boon Chin Heng ◽  
Tong Cao ◽  
Guo Qing Tong ◽  
Soon Chye Ng
Keyword(s):  
Stem Cell ◽  
Transcription Factors ◽  
Cell Differentiation ◽  
Stem Cell Differentiation ◽  
Potential Utility

The mechanism of stem cell differentiation into smooth muscle cells

2010 ◽  
Vol 104 (09) ◽  
pp. 440-448 ◽  
Author(s):  
Gang Wang ◽  
Zhenling Luo ◽  
Qingbo Xu ◽  
Qingzhong Xiao
Keyword(s):  
Stem Cells ◽  
Smooth Muscle ◽  
Stem Cell ◽  
Transcription Factors ◽  
Cell Differentiation ◽  
Histone Deacetylases ◽  
Stem Cell Differentiation ◽  
Response Factors ◽  
Serum Response

SummaryStem cells represent one of the most promising areas in biological and medical research. All stem cells are defined as having two basic properties: unlimited self-renewal and the broad potential to differentiate in vitro, via ″progenitor cells″, into somatic cells of many tissue types, in which smooth muscle cell (SMC) differentiation is a complicated and not well defined process. It is known that serum response factors (SRF) and co-activator myocardin are essential transcription factors in SMC differentiation. Upstream activators or regulators for the transcription factors have been recently identified, such as reactive oxygen species, histone deacetylases, microRNAs and extracellular matrix (ECM) proteins and integrins. In this review we, therefore, aim to briefly summarise recent progress in the mechanism of stem cell differentiation into SMCs to highlight the potential targets for promoting/inhibiting SMC differentiation useful for vessel-tissue engineering and treatment of vascular disease.

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