scholarly journals Soil Microbiome Response to Contamination with Bisphenol A, Bisphenol F and Bisphenol S

2020 ◽  
Vol 21 (10) ◽  
pp. 3529 ◽  
Author(s):  
Magdalena Zaborowska ◽  
Jadwiga Wyszkowska ◽  
Agata Borowik
Keyword(s):  
Genetic Diversity ◽  
Alkaline Phosphatase ◽  
Bisphenol A ◽  
Negative Impact ◽  
Soil Microbiome ◽  
Colony Development ◽  
Biochemical Activity ◽  
Bisphenol S ◽  
Study Objective ◽  
Bisphenol F

The choice of the study objective was affected by numerous controversies and concerns around bisphenol F (BPF) and bisphenol S (BPS)—analogues of bisphenol A (BPA). The study focused on the determination and comparison of the scale of the BPA, BPF, and BPS impact on the soil microbiome and its enzymatic activity. The following parameters were determined in soil uncontaminated and contaminated with BPA, BPF, and BPS: the count of eleven groups of microorganisms, colony development (CD) index, microorganism ecophysiological diversity (EP) index, genetic diversity of bacteria and activity of dehydrogenases (Deh), urease (Ure), catalase (Cat), acid phosphatase (Pac), alkaline phosphatase (Pal), arylsulphatase (Aryl) and β-glucosidase (Glu). Bisphenols A, S and F significantly disrupted the soil homeostasis. BPF is regarded as the most toxic, followed by BPS and BPA. BPF and BPS reduced the abundance of Proteobacteria and Acidobacteria and increased that of Actinobacteria. Unique types of bacteria were identified as well as the characteristics of each bisphenol: Lysobacter, Steroidobacter, Variovorax, Mycoplana, for BPA, Caldilinea, Arthrobacter, Cellulosimicrobium and Promicromonospora for BPF and Dactylosporangium Geodermatophilus, Sphingopyxis for BPS. Considering the strength of a negative impact of bisphenols on the soil biochemical activity, they can be arranged as follows: BPS > BPF > BPA. Urease and arylsulphatase proved to be the most susceptible and dehydrogenases the least susceptible to bisphenols pressure, regardless of the study duration.

scholarly journals Bisphenol S and bisphenol F are less disruptive to cardiac electrophysiology and potentially safer for use in medical products, as compared to bisphenol A

2021 ◽  
Author(s):  
Tomas Prudencio ◽  
Luther Swift ◽  
Devon Guerrelli ◽  
Blake Cooper ◽  
Marissa Reilly ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Safety Profile ◽  
Intracellular Signaling ◽  
Cardiac Electrophysiology ◽  
Field Potential ◽  
Production Volume ◽  
Bisphenol S ◽  
Bisphenol F ◽  
Bisphenol Analogues ◽  
Whole Heart

ABSTRACTBackgroundBisphenol A (BPA) is a high-production volume chemical that is commonly used to manufacture consumer and medical-grade plastic products. Due to its ubiquity, the general population can incur daily environmental exposure to BPA, while heightened BPA exposure has been reported in intensive care patients and industrial workers. Due to health concerns, structural analogues are being explored as replacements for BPA.ObjectiveThis study aimed to examine the direct nongenomic effects of BPA on cardiac electrophysiology and compare its safety profile to recently developed alternatives, including BPS (bisphenol S) and BPF (bisphenol F).MethodsWhole-cell voltage-clamp recordings were performed on cell lines transfected with Nav1.5, hERG, or Cav1.2. Results of single channel experiments were validated by conducting electrophysiology studies on human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) and intact, whole heart preparations.ResultsOf the chemicals tested, BPA was the most potent inhibitor of both fast (INa-P) and late (INa-L) sodium channel (IC50 = 55.3 and 23.6 μM, respectively), L-type calcium channel (IC50 = 30.8 μM) and hERG channel current (IC50 = 127 μM). The inhibitory effects of BPA and BPF on L-type calcium channels were supported by microelectrode array recordings, which revealed shortening of the extracellular field potential (akin to QT interval). Further, BPA and BPF exposure impaired atrioventricular conduction in intact, whole heart experiments. BPS did not alter any of the cardiac electrophysiology parameters tested.DiscussionResults of this study demonstrate that BPA and BPF exert an immediate inhibitory effect on cardiac ion channels, and that BPS may be a safer alternative. Intracellular signaling or genomic effects of bisphenol analogues were not investigated; therefore, additional mechanistic studies are necessary to fully elucidate the safety profile of bisphenol analogues on the heart.

Bisphenol A and its analogs bisphenol B, bisphenol F, and bisphenol S: Comparative in vitro and in vivo studies on the sperms and testicular tissues of rats

Chemosphere ◽  
2018 ◽  
Vol 209 ◽  
pp. 508-516 ◽  
Author(s):  
Asad Ullah ◽  
Madeeha Pirzada ◽  
Sarwat Jahan ◽  
Hizb Ullah ◽  
Ghazala Shaheen ◽  
...  
Keyword(s):  
Bisphenol A ◽  
In Vivo Studies ◽  
Bisphenol S ◽  
Bisphenol F

scholarly journals Toxicokinetics of bisphenol A, bisphenol S, and bisphenol F in a pregnancy sheep model

Chemosphere ◽  
2019 ◽  
Vol 220 ◽  
pp. 185-194 ◽  
Author(s):  
Jeremy Gingrich ◽  
Yong Pu ◽  
Richard Ehrhardt ◽  
Rajendiran Karthikraj ◽  
Kurunthachalam Kannan ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Bisphenol S ◽  
Sheep Model ◽  
Bisphenol F

scholarly journals Comment on “Toxicokinetics of bisphenol A, bisphenol S, and bisphenol F in a pregnancy sheep model”

Chemosphere ◽  
2019 ◽  
Vol 227 ◽  
pp. 703-704 ◽  
Author(s):  
Flore C. Grandin ◽  
Véronique Gayrard ◽  
Nicole Picard-Hagen ◽  
Pierre-Louis Toutain
Keyword(s):  
Bisphenol A ◽  
Bisphenol S ◽  
Sheep Model ◽  
Bisphenol F

Bisphenol A analogues bisphenol B, bisphenol F, and bisphenol S induce oxidative stress, disrupt daily sperm production, and damage DNA in rat spermatozoa: a comparative in vitro and in vivo study

2019 ◽  
Vol 35 (4) ◽  
pp. 294-303 ◽  
Author(s):  
Asad Ullah ◽  
Madeeha Pirzada ◽  
Sarwat Jahan ◽  
Hizb Ullah ◽  
Muhammad Jamil Khan
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Bisphenol A ◽  
Estrogenic Activity ◽  
Bisphenol S ◽  
Endocrine Disrupting Chemical ◽  
Sperm Dna Damage ◽  
Bisphenol F

Bisphenol A (BPA) is a well-known endocrine-disrupting chemical with estrogenic activity. The widespread exposure of individuals to BPA is suspected to affect a variety of physiological functions, including reproduction, development, and metabolism. Here we report the mechanisms by which BPA and three of its analogues bisphenol B (BPB), bisphenol F (BPF), and bisphenol S (BPS) cause generation of reactive oxygen species (ROS), sperm DNA damage, and oxidative stress in both in vivo and in vitro rat models. Sperm were incubated with different concentrations (1, 10, and 100 µg/L) of BPA and its analogues BPB, BPF, and BPS for 2 h. BPA and its analogues were observed to increase DNA fragmentation, formation of ROS, and affected levels of superoxide dismutase at higher concentration groups. In an in vivo experiment, rats were exposed to different concentrations (5, 25, and 50 mg/kg/day) of BPA, BPB, BPF, and BPS for 28 days. In the higher dose (50 mg/kg/day) treated groups of BPA and its analogues BPB, BPF, and BPS, DNA damage was observed while the motility of sperm was not affected.

scholarly journals Exposure to bisphenol A, bisphenol F, and bisphenol S can result in obesity in human body

2018 ◽  
Vol 4 (1) ◽  
pp. 1506601 ◽  
Author(s):  
Joseph Apau ◽  
Akwasi Acheampong ◽  
Eric Adua ◽  
Bryan M. Wong
Keyword(s):  
Bisphenol A ◽  
Human Body ◽  
Bisphenol S ◽  
Bisphenol F

Bisphenol A alternatives bisphenol S and bisphenol F interfere with thyroid hormone signaling pathway in vitro and in vivo

2018 ◽  
Vol 237 ◽  
pp. 1072-1079 ◽  
Author(s):  
Yin-Feng Zhang ◽  
Xiao-Min Ren ◽  
Yuan-Yuan Li ◽  
Xiao-Fang Yao ◽  
Chuan-Hai Li ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Bisphenol A ◽  
Signaling Pathway ◽  
Hormone Signaling ◽  
Bisphenol S ◽  
Bisphenol F

scholarly journals Bisphenol A, Bisphenol F, and Bisphenol S: The Bad and the Ugly. Where Is the Good?

Life ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 314
Author(s):  
Sophie Fouyet ◽  
Elodie Olivier ◽  
Pascale Leproux ◽  
Mélody Dutot ◽  
Patrice Rat
Keyword(s):  
Bisphenol A ◽  
P2x7 Receptor ◽  
Chromatin Condensation ◽  
Receptor Activation ◽  
Bisphenol S ◽  
Safe Alternative ◽  
Bisphenol F ◽  
Placental Cells ◽  
Human Placental Cells

Background: Bisphenol A (BPA), a reprotoxic and endocrine-disrupting chemical, has been substituted by alternative bisphenols such as bisphenol F (BPF) and bisphenol S (BPS) in the plastic industry. Despite their detection in placenta and amniotic fluids, the effects of bisphenols on human placental cells have not been characterized. Our objective was to explore in vitro and to compare the toxicity of BPA to its substitutes BPF and BPS to highlight their potential risks for placenta and then pregnancy. Methods: Human placenta cells (JEG-Tox cells) were incubated with BPA, BPF, and BPS for 72 h. Cell viability, cell death, and degenerative P2X7 receptor and caspases activation, and chromatin condensation were assessed using microplate cytometry and fluorescence microscopy. Results: Incubation with BPA, BPF, or BPS was associated with P2X7 receptor activation and chromatin condensation. BPA and BPF induced more caspase-1, caspase-9, and caspase-3 activation than BPS. Only BPF enhanced caspase-8 activity. Conclusions: BPA, BPF, and BPS are all toxic to human placental cells, with the P2X7 receptor being a common key element. BPA substitution by BPF and BPS does not appear to be a safe alternative for human health, particularly for pregnant women and their fetuses.

Sign in / Sign up

Export Citation Format

Share Document