scholarly journals Discovery of Novel Non-Steroidal Cytochrome P450 17A1 Inhibitors as Potential Prostate Cancer Agents

2020 ◽  
Vol 21 (14) ◽  
pp. 4868
Author(s):  
Tomasz M. Wróbel ◽  
Oksana Rogova ◽  
Kasper L. Andersen ◽  
Rahul Yadav ◽  
Simone Brixius-Anderko ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cytochrome P450 ◽  
Cell Lines ◽  
Antiproliferative Activity ◽  
Enzyme Inhibitors ◽  
Prostate Cancer Cell ◽  
Binding Mode ◽  
Prostate Cancer Cell Lines ◽  
Design Synthesis ◽  
Key Enzyme

The current study presents the design, synthesis, and evaluation of novel cytochrome P450 17A1 (CYP17A1) ligands. CYP17A1 is a key enzyme in the steroidogenic pathway that produces androgens among other steroids, and it is implicated in prostate cancer. The obtained compounds are potent enzyme inhibitors (sub µM) with antiproliferative activity in prostate cancer cell lines. The binding mode of these compounds is also discussed.

scholarly journals The induction of Maspin expression by a glucosamine-derivative has an antiproliferative activity in prostate cancer cell lines

2019 ◽  
Vol 300 ◽  
pp. 63-72 ◽  
Author(s):  
Rossana Cocchiola ◽  
Mariangela Lopreiato ◽  
Raffaella Guazzo ◽  
Maria Margherita de Santi ◽  
Margherita Eufemi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Antiproliferative Activity ◽  
Prostate Cancer Cell ◽  
Cancer Cell Lines ◽  
Prostate Cancer Cell Lines ◽  
Maspin Expression

scholarly journals Limited Expression of Cytochrome P450 17α-Hydroxylase/17,20-Lyase in Prostate Cancer Cell Lines

2011 ◽  
Vol 52 (7) ◽  
pp. 494 ◽  
Author(s):  
Chang Wook Jeong ◽  
Cheol Yong Yoon ◽  
Seong Jin Jeong ◽  
Sung Kyu Hong ◽  
Seok-Soo Byun ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cytochrome P450 ◽  
Cell Lines ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Lines ◽  
Prostate Cancer Cell Lines

scholarly journals Synthesis and Antiproliferative Activity of Novel 1,2,3-Triazole-Sulfonamide Hybrids

2018 ◽  
Vol 42 (1) ◽  
pp. 50-53 ◽  
Author(s):  
Na Li ◽  
Nan Liu ◽  
Shu Tang ◽  
Duo-Lu Li ◽  
Xiao-Jian Zhang
Keyword(s):  
Prostate Cancer ◽  
Click Chemistry ◽  
Cell Line ◽  
Cell Lines ◽  
Cancer Cell ◽  
Antiproliferative Activity ◽  
Prostate Cancer Cell ◽  
Prostate Cancer Cell Lines ◽  
Lead Compounds ◽  
Antitumour Drugs

Nine novel 1-(4′-sulfamoylphenyl)-1,2,3-triazole derivatives bearing an N-heterocycle moiety were designed using a molecular hybridisation approach and synthesised by alkyne/azide click chemistry. Most of the synthesised compounds exhibited good to moderate antiproliferative activity (IC50 values 3.7 to 77.1 μM) against stomach, oesophagus and prostate cancer cell lines, but a compound containing an S-(2-pyridyl)thiomethyl moiety showed 10-fold greater activity against the stomach cell line than 5-fluorouracil. These results demonstrate that N-heterocycle-1,2,3-triazolylsulfonamides could be promising lead compounds to develop new antitumour drugs.

scholarly journals A [3]Ferrocenophane Polyphenol Showing a Remarkable Antiproliferative Activity on Breast and Prostate Cancer Cell Lines

2009 ◽  
Vol 52 (15) ◽  
pp. 4964-4967 ◽  
Author(s):  
Damian Plażuk ◽  
Anne Vessières ◽  
Elizabeth A. Hillard ◽  
Olivier Buriez ◽  
Eric Labbé ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Antiproliferative Activity ◽  
Prostate Cancer Cell ◽  
Cancer Cell Lines ◽  
Prostate Cancer Cell Lines ◽  
Breast And Prostate Cancer

scholarly journals Design, synthesis and cytotoxicity studies of dithiocarbamate ester derivatives of emetine in prostate cancer cell lines

2015 ◽  
Vol 23 (17) ◽  
pp. 5839-5845 ◽  
Author(s):  
Emmanuel S. Akinboye ◽  
Zebalda D. Bamji ◽  
Bernard Kwabi-Addo ◽  
David Ejeh ◽  
Robert L. Copeland ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Lines ◽  
Prostate Cancer Cell Lines ◽  
Design Synthesis ◽  
Cytotoxicity Studies ◽  
Derivatives Of
Sign in / Sign up

Export Citation Format

Share Document