scholarly journals New Opportunity to Formulate Intranasal Vaccines and Drug Delivery Systems Based on Chitosan

2020 ◽  
Vol 21 (14) ◽  
pp. 5016
Author(s):  
Roxana Popescu ◽  
Mihaela Violeta Ghica ◽  
Cristina-Elena Dinu-Pîrvu ◽  
Valentina Anuța ◽  
Dumitru Lupuliasa ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Surface Tension ◽  
Zeta Potential ◽  
Conformational Changes ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Active Pharmaceutical Ingredients ◽  
Nasal Drug Delivery ◽  
Pharmaceutical Ingredients ◽  
Permeability Enhancement

In an attempt to develop drug delivery systems that bypass the blood–brain barrier (BBB) and prevent liver and intestinal degradation, it was concluded that nasal medication meets these criteria and can be used for drugs that have these drawbacks. The aim of this review is to present the influence of the properties of chitosan and its derivatives (mucoadhesion, permeability enhancement, surface tension, and zeta potential) on the development of suitable nasal drug delivery systems and on the nasal bioavailability of various active pharmaceutical ingredients. Interactions between chitosan and proteins, lipids, antigens, and other molecules lead to complexes that have their own applications or to changing characteristics of the substances involved in the bond (conformational changes, increased stability or solubility, etc.). Chitosan and its derivatives have their own actions (antibacterial, antifungal, immunostimulant, antioxidant, etc.) and can be used as such or in combination with other molecules from the same class to achieve a synergistic effect. The applicability of the properties is set out in the second part of the paper, where nasal formulations based on chitosan are described (vaccines, hydrogels, nanoparticles, nanostructured lipid carriers (NLC), powders, emulsions, etc.).

scholarly journals Elastic and Ultradeformable Liposomes for Transdermal Delivery of Active Pharmaceutical Ingredients (APIs)

2021 ◽  
Vol 22 (18) ◽  
pp. 9743
Author(s):  
Eliana B. Souto ◽  
Ana S. Macedo ◽  
João Dias-Ferreira ◽  
Amanda Cano ◽  
Aleksandra Zielińska ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
First Generation ◽  
Delivery Systems ◽  
Topical Drug Delivery ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients

Administration of active pharmaceutical ingredients (APIs) through the skin, by means of topical drug delivery systems, is an advanced therapeutic approach. As the skin is the largest organ of the human body, primarily acting as a natural protective barrier against permeation of xenobiotics, specific strategies to overcome this barrier are needed. Liposomes are nanometric-sized delivery systems composed of phospholipids, which are key components of cell membranes, making liposomes well tolerated and devoid of toxicity. As their lipid compositions are similar to those of the skin, liposomes are used as topical, dermal, and transdermal delivery systems. However, permeation of the first generation of liposomes through the skin posed some limitations; thus, a second generation of liposomes has emerged, overcoming permeability problems. Various mechanisms of permeation/penetration of elastic/ultra-deformable liposomes into the skin have been proposed; however, debate continues on their extent/mechanisms of permeation/penetration. In vivo bioavailability of an API administered in the form of ultra-deformable liposomes is similar to the bioavailability achieved when the same API is administered in the form of a solution by subcutaneous or epi-cutaneous injection, which demonstrates their applicability in transdermal drug delivery.

Complex Drug Delivery Systems: Controlling Transdermal Permeation Rates with Multiple Active Pharmaceutical Ingredients

2020 ◽  
Vol 21 (5) ◽  
Author(s):  
Daniel A. Davis ◽  
Patricia P. Martins ◽  
Michael S. Zamloot ◽  
Shawn A. Kucera ◽  
Robert O. Williams ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
Transdermal Permeation ◽  
Complex Drug

Scintigraphic evaluation in rabbits of nasal drug delivery systems based on carbopol 971p® and carboxymethylcellulose

2000 ◽  
Vol 68 (2) ◽  
pp. 207-214 ◽  
Author(s):  
Michael Ikechukwu Ugwoke ◽  
Remigius Uchenna Agu ◽  
Hubert Vanbilloen ◽  
Jan Baetens ◽  
Patrick Augustijns ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Nasal Drug Delivery

Phosphorylated PEG-emulsifier: Powerful tool for development of zeta potential changing self-emulsifying drug delivery systems (SEDDS)

2020 ◽  
Vol 150 ◽  
pp. 77-86 ◽  
Author(s):  
Julian Dominik Wolf ◽  
Markus Kurpiers ◽  
Roman Xaver Götz ◽  
Sergey Zaichik ◽  
Andrea Hupfauf ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Zeta Potential ◽  
Drug Delivery Systems ◽  
Delivery Systems

Zeta potential changing self-emulsifying drug delivery systems utilizing a novel Janus-headed surfactant: A promising strategy for enhanced mucus permeation

2019 ◽  
Vol 291 ◽  
pp. 111285 ◽  
Author(s):  
Faezeh Sharifi ◽  
Imran Nazir ◽  
Mulazim Hussain Asim ◽  
Mansour Jahangiri ◽  
Pedram Ebrahimnejad ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Zeta Potential ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Promising Strategy

scholarly journals Novel 3D printing concept for the fabrication of time-controlled drug delivery systems

2018 ◽  
Vol 4 (1) ◽  
pp. 141-144 ◽  
Author(s):  
Jan Konasch ◽  
Alexander Riess ◽  
Michael Teske ◽  
Natalia Rekowska ◽  
Natalia Rekowska ◽  
...  
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Inkjet Printing ◽  
Drug Delivery Systems ◽  
Three Dimensional ◽  
Delivery Systems ◽  
Glycol Diacrylate ◽  
Pharmaceutical Ingredients ◽  
Poly Ethylene ◽  
Novel Concept

AbstractThree-dimensional (3D) printing has become a popular technique in many areas. One emerging field is the use of 3D printing for the development of 3D drug delivery systems (DDS) and drug-loaded medical devices. This article describes a novel concept for the fabrication of timecontrolled drug delivery systems based on stereolithography combined with inkjet printing. An inkjet printhead and an UV-LED light source have been integrated into an existing stereolithography system. Inkjet printing is used to selectively incorporate active pharmaceutical ingredients (API) during a stereolithographic 3D printing process. In an initial experimental study, poly (ethylene glycol) diacrylate (PEGDA) was used as polymer whereas 2-Hydroxy-4´-(2- hydroxyethoxy)-2-methylpropiophenone (Irgacure 2959) and Lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) were used as photoinitiators. Basic structures could be manufactured successfully by the new hybrid 3D printing system.

Sulpiride microemulsions as antipsychotic nasal drug delivery systems: In-vitro and pharmacodynamic study

2016 ◽  
Vol 36 ◽  
pp. 10-22 ◽  
Author(s):  
Abdallah Mohamed Ayoub ◽  
Mahmoud Mokhtar Ibrahim ◽  
Marwa Helmy Abdallah ◽  
Mahmoud A. Mahdy
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Nasal Drug Delivery ◽  
Pharmacodynamic Study

scholarly journals Fluorinated Ionic Liquids as Task-Specific Materials: An Overview of Current Research

2021 ◽  
Author(s):  
Nicole S.M. Vieira ◽  
Margarida L. Ferreira ◽  
Paulo J. Castro ◽  
João M.M. Araújo ◽  
Ana B. Pereiro
Keyword(s):  
Drug Delivery ◽  
Thermal Stability ◽  
Surface Tension ◽  
Ionic Liquids ◽  
Surface Activity ◽  
Vapour Pressure ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
High Thermal Stability ◽  
Gas Solubility

This chapter is focused on the massive potential and increasing interest on Fluorinated Ionic Liquids (FILs) as task-specific materials. FILs are a specific family of ionic liquids, with fluorine tags equal or longer than four carbon atoms, that share and improve the properties of both traditional ionic liquids and perfluoro surfactants. These compounds have unique properties such as three nanosegregated domains, a great surfactant power, chemical/biological inertness, easy recovery and recyclability, low surface tension, extreme surface activity, high gas solubility, negligible vapour pressure, null flammability, and high thermal stability. These properties allied to the countless possible combinations between cations and anions allow the design and development of FILs with remarkable properties to be used in specific applications. In this review, we highlight not only the unique thermophysical, surfactant and toxicological properties of these fluorinated compounds, but also their application as task-specific materials in many fields of interest, including biomedical applications, as artificial gas carries and drug delivery systems, as well as solvents for separations in engineering processes.

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