Scintigraphic evaluation in rabbits of nasal drug delivery systems based on carbopol 971p® and carboxymethylcellulose

2000 ◽  
Vol 68 (2) ◽  
pp. 207-214 ◽  
Author(s):  
Michael Ikechukwu Ugwoke ◽  
Remigius Uchenna Agu ◽  
Hubert Vanbilloen ◽  
Jan Baetens ◽  
Patrick Augustijns ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Nasal Drug Delivery

scholarly journals New Opportunity to Formulate Intranasal Vaccines and Drug Delivery Systems Based on Chitosan

2020 ◽  
Vol 21 (14) ◽  
pp. 5016
Author(s):  
Roxana Popescu ◽  
Mihaela Violeta Ghica ◽  
Cristina-Elena Dinu-Pîrvu ◽  
Valentina Anuța ◽  
Dumitru Lupuliasa ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Surface Tension ◽  
Zeta Potential ◽  
Conformational Changes ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Active Pharmaceutical Ingredients ◽  
Nasal Drug Delivery ◽  
Pharmaceutical Ingredients ◽  
Permeability Enhancement

In an attempt to develop drug delivery systems that bypass the blood–brain barrier (BBB) and prevent liver and intestinal degradation, it was concluded that nasal medication meets these criteria and can be used for drugs that have these drawbacks. The aim of this review is to present the influence of the properties of chitosan and its derivatives (mucoadhesion, permeability enhancement, surface tension, and zeta potential) on the development of suitable nasal drug delivery systems and on the nasal bioavailability of various active pharmaceutical ingredients. Interactions between chitosan and proteins, lipids, antigens, and other molecules lead to complexes that have their own applications or to changing characteristics of the substances involved in the bond (conformational changes, increased stability or solubility, etc.). Chitosan and its derivatives have their own actions (antibacterial, antifungal, immunostimulant, antioxidant, etc.) and can be used as such or in combination with other molecules from the same class to achieve a synergistic effect. The applicability of the properties is set out in the second part of the paper, where nasal formulations based on chitosan are described (vaccines, hydrogels, nanoparticles, nanostructured lipid carriers (NLC), powders, emulsions, etc.).

Sulpiride microemulsions as antipsychotic nasal drug delivery systems: In-vitro and pharmacodynamic study

2016 ◽  
Vol 36 ◽  
pp. 10-22 ◽  
Author(s):  
Abdallah Mohamed Ayoub ◽  
Mahmoud Mokhtar Ibrahim ◽  
Marwa Helmy Abdallah ◽  
Mahmoud A. Mahdy
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Nasal Drug Delivery ◽  
Pharmacodynamic Study

scholarly journals Nasal In Situ Gel: Novel Approach for Nasal Drug Delivery

2020 ◽  
Vol 10 (2-s) ◽  
pp. 183-197
Author(s):  
Anjali Sunil Sabale ◽  
Abhijeet D Kulkarni ◽  
Ajay Sunil Sabale
Keyword(s):  
Drug Delivery ◽  
Patient Compliance ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Nasal Drug Delivery ◽  
In Situ Gel ◽  
Reduced Frequency ◽  
Conventional Drug ◽  
In Situ Gelling

Nasal delivery is an alternative to oral or parenteral administration due to certain limitations such as absorption of the drug, drug targeting to particular organs can cause a problem for administration through oral route.  The nasal route has also been successfully used for bypassing the blood-brain barrier and afterword delivering drug molecules to the central nervous system. Also, lag time related to oral drug delivery is reduces by this route and offers noninvasiveness, self-medication, patient comfort, and patient compliance. Extend drug delivery can be attained by different new dosage forms like in situ gel. In situ formulations are drug delivery systems. The in-situ gelling system is a process in which the solution forms of a gel before administration in the body, but once administrated, it undergoes gelation in-situ, to form a gel. In situ gelling system becomes very popular nowadays because of their several advantages over conventional drug delivery systems like a sustained and prolonged release of a drug, reduced Frequency of administration, improved patient compliance and comfort. Approaches towards the various formulation of in-situ gel concerning temperature, pH, and physicochemical conditions. The in situ gel-forming polymeric formulations offer several advantages like sustained and prolonged action reduced Frequency of administration, in comparison to conventional drug delivery systems.  From a manufacturing point of view, the production of such systems is less complex and thus lowers the investment and manufacturing cost. Various evaluation parameters are considered during the preparation of In-Situ gel. Keywords: Nasal Drug Delivery, In Situ gel, gelation, polymers, etc

MUCOADHESIVE MICROSPHERES AS INTRANASAL DRUG DELIVERY SYSTEMS: A REVIEW

INDIAN DRUGS ◽  
2012 ◽  
Vol 49 (01) ◽  
pp. 5-23
Author(s):  
Z. Abbas ◽  
◽  
N. G. N. Swamy
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
High Surface ◽  
Research Work ◽  
Delivery Systems ◽  
The Body ◽  
Natural Polymers ◽  
Nasal Drug Delivery ◽  
In Vivo Evaluation ◽  
Intimate Contact

Mucoadhesive polymers are the topic of current interest in the design of drug delivery systems. Mucoadhesive microspheres provide the means of improving drug delivery by promoting the residence time at the site of application or absorption and facilitate intimate contact with the underlying absorption surface and thus contribute to improved and/or better therapeutic performance of drugs. Mucoadhesion is the process whereby synthetic and natural polymers adhere to mucosal surfaces in the body. If these materials are then incorporated into pharmaceutical formulations, drug absorption by mucosal cells maybe enhanced or the drug may be released at the site for an extended period of time. Microspheres, in general, have the potential to be used for targeted and controlled release drug delivery; however, coupling of mucoadhesive properties to microspheres has additional advantages like a much more intimate contact with the mucous layer, efficient absorption and enhanced bioavailability of the drugs due to a high surface to volume ratio. The present review describes the potential applications of mucoadhesive microspheres as a novel carrier system to improve nasal drug delivery for systemic or for local effects. The, methods of preparation of microspheres and their in vitro and in vivo evaluation methods and the research work carried out on these systems are also described.

Nanoparticlized System: Promising Approach for the Management of Alzheimer’s Disease through Intranasal Delivery

2020 ◽  
Vol 26 (12) ◽  
pp. 1331-1344
Author(s):  
Shiv Bahadur ◽  
Nidhi Sachan ◽  
Ranjit K. Harwansh ◽  
Rohitas Deshmukh
Keyword(s):  
Alzheimer’S Disease ◽  
Drug Delivery ◽  
Alzheimer's Disease ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Limiting Factor ◽  
Nasal Drug Delivery ◽  
The Brain

Alzheimer's disease (AD) is a neurodegenerative brain problem and responsible for causing dementia in aged people. AD has become most common neurological disease in the elderly population worldwide and its treatment remains still challengeable. Therefore, there is a need of an efficient drug delivery system which can deliver the drug to the target site. Nasal drug delivery has been used since prehistoric times for the treatment of neurological disorders like Alzheimer's disease (AD). For delivering drug to the brain, blood brain barrier (BBB) is a major rate limiting factor for the drugs. The desired drug concentration could not be achieved through the conventional drug delivery system. Thus, nanocarrier based drug delivery systems are promising for delivering drug to brain. Nasal route is a most convenient for targeting drug to the brain. Several factors and mechanisms need to be considered for an effective delivery of drug to the brain particularly AD. Various nanoparticlized systems such as nanoparticles, liposomes, exosomes, phytosomes, nanoemulsion, nanosphere, etc. have been recognized as an effective drug delivery system for the management of AD. These nanocarriers have been proven with improved permeability as well as bioavailability of the anti-Alzheimer’s drugs. Some novel drug delivery systems of anti-Alzheimer drugs are under investigation of different phase of clinical trials. Present article highlights on the nanotechnology based intranasal drug delivery system for the treatment of Alzheimer’s disease. Furthermore, consequences of AD, transportation mechanism, clinical updates and recent patents on nose to brain delivery for AD have been discussed.

Advances in nasal drug delivery systems

2020 ◽  
pp. 279-311 ◽  
Author(s):  
Nozad Rashid Hussein ◽  
Huner Kamal Omer ◽  
Abdelbary M.A. Elhissi ◽  
Waqar Ahmed
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Nasal Drug Delivery
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