Isotropic and Anisotropic Scaffolds for Tissue Engineering: Collagen, Conventional, and Textile Fabrication Technologies and Properties

In this review article, tissue engineering and regenerative medicine are briefly explained and the importance of scaffolds is highlighted. Furthermore, the requirements of scaffolds and how they can be fulfilled by using specific biomaterials and fabrication methods are presented. Detailed insight is given into the two biopolymers chitosan and collagen. The fabrication methods are divided into two categories: isotropic and anisotropic scaffold fabrication methods. Processable biomaterials and achievable pore sizes are assigned to each method. In addition, fiber spinning methods and textile fabrication methods used to produce anisotropic scaffolds are described in detail and the advantages of anisotropic scaffolds for tissue engineering and regenerative medicine are highlighted.

Download Full-text

Synthesis and microfabrication of biomaterials for soft-tissue engineering

Pure and Applied Chemistry ◽

10.1351/pac-con-09-07-10 ◽

2009 ◽

Vol 81 (12) ◽

pp. 2183-2201 ◽

Cited By ~ 15

Author(s):

Christopher J. Bettinger

Keyword(s):

Tissue Engineering ◽

Soft Tissue ◽

Regenerative Medicine ◽

Cell Function ◽

Systems Design ◽

Review Article ◽

Tissue Formation ◽

Scaffold Design ◽

Scaffold Fabrication ◽

Soft Tissue Engineering

Biomaterials synthesis and scaffold fabrication will play an increasingly important role in the design of systems for regenerative medicine and tissue engineering. These rapidly growing fields are converging as scaffold design must begin to incorporate multidisciplinary aspects in order to effectively organize cell-seeded constructs into functional tissue. This review article examines the use of synthetic biomaterials and fabrication strategies across length scales with the ultimate goal of guiding cell function and directing tissue formation. This discussion is parsed into three subsections: (1) biomaterials synthesis, including elastomers and gels; (2) synthetic micro- and nanostructures for engineering the cell–biomaterial interface; and (3) complex biomaterials systems design for controlling aspects of the cellular microenvironment.

Download Full-text

Review of the Applications of Biomedical Compositions Containing Hydroxyapatite and Collagen Modified by Bioactive Components

Materials ◽

10.3390/ma14092096 ◽

2021 ◽

Vol 14 (9) ◽

pp. 2096

Author(s):

Agnieszka Sobczak-Kupiec ◽

Anna Drabczyk ◽

Wioletta Florkiewicz ◽

Magdalena Głąb ◽

Sonia Kudłacik-Kramarczyk ◽

...

Keyword(s):

Tissue Engineering ◽

Regenerative Medicine ◽

Bone Tissue Engineering ◽

Biomedical Engineering ◽

Biomedical Applications ◽

Review Article ◽

Inorganic Materials ◽

Bioactive Components ◽

The World ◽

Implantable Biomedical Devices

Regenerative medicine is becoming a rapidly evolving technique in today’s biomedical progress scenario. Scientists around the world suggest the use of naturally synthesized biomaterials to repair and heal damaged cells. Hydroxyapatite (HAp) has the potential to replace drugs in biomedical engineering and regenerative drugs. HAp is easily biodegradable, biocompatible, and correlated with macromolecules, which facilitates their incorporation into inorganic materials. This review article provides extensive knowledge on HAp and collagen-containing compositions modified with drugs, bioactive components, metals, and selected nanoparticles. Such compositions consisting of HAp and collagen modified with various additives are used in a variety of biomedical applications such as bone tissue engineering, vascular transplantation, cartilage, and other implantable biomedical devices.

Download Full-text

Tissue engineering in regenerative medicine

Forum Zakażeń ◽

10.15374/fz2015052 ◽

2015 ◽

Vol 6 (5) ◽

pp. 291-298

Author(s):

Barbara Różalska ◽

Bartłomiej Micota ◽

Małgorzata Paszkiewicz ◽

Beata Sadowska

Keyword(s):

Tissue Engineering ◽

Regenerative Medicine

Download Full-text

Graphene and Graphene-Based Materials in Biomedical Applications

Current Medicinal Chemistry ◽

10.2174/0929867326666190705155854 ◽

2019 ◽

Vol 26 (38) ◽

pp. 6834-6850 ◽

Cited By ~ 5

Author(s):

Mohammad Omaish Ansari ◽

Kalamegam Gauthaman ◽

Abdurahman Essa ◽

Sidi A. Bencherif ◽

Adnan Memic

Keyword(s):

Tissue Engineering ◽

Thermal Properties ◽

Gene Delivery ◽

Regenerative Medicine ◽

Biomedical Research ◽

Biomedical Applications ◽

Biomedical Application ◽

Two Dimensional ◽

Drug And Gene Delivery ◽

Biomedical Fields

: Nanobiotechnology has huge potential in the field of regenerative medicine. One of the main drivers has been the development of novel nanomaterials. One developing class of materials is graphene and its derivatives recognized for their novel properties present on the nanoscale. In particular, graphene and graphene-based nanomaterials have been shown to have excellent electrical, mechanical, optical and thermal properties. Due to these unique properties coupled with the ability to tune their biocompatibility, these nanomaterials have been propelled for various applications. Most recently, these two-dimensional nanomaterials have been widely recognized for their utility in biomedical research. In this review, a brief overview of the strategies to synthesize graphene and its derivatives are discussed. Next, the biocompatibility profile of these nanomaterials as a precursor to their biomedical application is reviewed. Finally, recent applications of graphene-based nanomaterials in various biomedical fields including tissue engineering, drug and gene delivery, biosensing and bioimaging as well as other biorelated studies are highlighted.

Download Full-text