scholarly journals 3-Arylaziridine-2-carboxylic Acid Derivatives and (3-Arylaziridin-2-yl)ketones: The Aziridination Approaches

2021 ◽  
Vol 22 (18) ◽  
pp. 9861
Author(s):  
Boriss Strumfs ◽  
Romans Uljanovs ◽  
Kirils Velikijs ◽  
Peteris Trapencieris ◽  
Ilze Strumfa
Keyword(s):  
Carboxylic Acid ◽  
Carbonyl Compounds ◽  
Synthetic Chemistry ◽  
Significant Progress ◽  
Current Review ◽  
Recent Advances ◽  
Year 2000

Aziridination reactions represent a powerful tool in aziridine synthesis. Significant progress has been achieved in this field in the last decades, whereas highly functionalized aziridines including 3-arylated aziridine-2-carbonyl compounds play an important role in both medical and synthetic chemistry. For the reasons listed, in the current review we have focused on the ways to obtain 3-arylated aziridines and on the recent advances (mainly since the year 2000) in the methodology of the synthesis of these compounds via aziridination.

Transition-metal-catalyzed direct β-functionalization of simple carbonyl compounds

2014 ◽  
Vol 1 (7) ◽  
pp. 838-842 ◽  
Author(s):  
Guobing Yan ◽  
Arun Jyoti Borah
Keyword(s):  
Transition Metal ◽  
Carbonyl Compounds ◽  
Bond Activation ◽  
Active Area ◽  
Synthetic Chemistry ◽  
Chemical Transformations ◽  
Recent Advances ◽  
Direct Functionalization ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

Chemical transformations via catalytic C–H bond activation have been established as one of the most powerful tools in organic synthetic chemistry. Transition-metal-catalyzed direct functionalization of β-C(sp3)–H bonds of carbonyl compounds has been developed in recent years. This highlight will focus on recent advances in this active area and their mechanisms are also discussed.

Recent advances in α,β-unsaturated carbonyl compounds as mitochondrial toxins

2019 ◽  
Vol 183 ◽  
pp. 111687 ◽  
Author(s):  
Mohammad Hossain ◽  
Umashankar Das ◽  
Jonathan R. Dimmock
Keyword(s):  
Carbonyl Compounds ◽  
Recent Advances ◽  
Mitochondrial Toxins

Recent Advances on Visible-Light-Promoted Copper Catalysis in Organic Reactions

Synthesis ◽  
2021 ◽  
Author(s):  
Yang Xiong ◽  
Sijia Li ◽  
Haijing Xiao ◽  
Guozhu Zhang
Keyword(s):  
Visible Light ◽  
Copper Complexes ◽  
Rapid Development ◽  
Cost Effective ◽  
Organic Reactions ◽  
Copper Catalysis ◽  
Synthetic Chemistry ◽  
Recent Advances ◽  
Intense Activity

In recent years, visible-light-mediated copper photocatalysis have emerged as an attractive strategy for the diverse constructions of basic bonds in an ecologically benign and cost-effective fashion. The intense activity and increasing work of these areas stimulated the exploit of the distinctive properties of copper photocatalysis and the rapid development and expansion of their applications. In this review, we focus on introducing a series of significant achievements in copper complexes as standalone photocatalysis in organic reactions to make an attempt to exhibit their potential capabilities and high flexibilities in synthetic chemistry.

Catalytic asymmetric enamine protonation reaction

2018 ◽  
Vol 16 (4) ◽  
pp. 510-520 ◽  
Author(s):  
Niankai Fu ◽  
Long Zhang ◽  
Sanzhong Luo
Keyword(s):  
Carbonyl Compounds ◽  
Optically Active ◽  
Protonation Reaction ◽  
Recent Advances ◽  
Catalytic Asymmetric

Recent advances in catalytic enantioselective enamine protonation for the synthesis of optically active carbonyl compounds are summarized in this review.

scholarly journals Direct Transamidation Reactions: Mechanism and Recent Advances

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2382 ◽  
Author(s):  
Paola Acosta-Guzmán ◽  
Alejandra Mateus-Gómez ◽  
Diego Gamba-Sánchez
Keyword(s):  
Carboxylic Acid ◽  
Chemical Industry ◽  
Metal Catalysts ◽  
Direct Reaction ◽  
Valuable Alternative ◽  
Recent Advances ◽  
Other Substances ◽  
Recent Developments ◽  
Nitrogen Nucleophiles ◽  
Reactions Mechanism

Amides are undeniably some of the most important compounds in Nature and the chemical industry, being present in biomolecules, materials, pharmaceuticals and many other substances. Unfortunately, the traditional synthesis of amides suffers from some important drawbacks, principally the use of stoichiometric activators or the need to use highly reactive carboxylic acid derivatives. In recent years, the transamidation reaction has emerged as a valuable alternative to prepare amides. The reactivity of amides makes their direct reaction with nitrogen nucleophiles difficult; thus, the direct transamidation reaction needs a catalyst in order to activate the amide moiety and to promote the completion of the reaction because equilibrium is established. In this review, we present research on direct transamidation reactions ranging from studies of the mechanism to the recent developments of more applicable and versatile methodologies, emphasizing those reactions involving activation with metal catalysts.

scholarly journals Acrylamide Formation in Food: A Mechanistic Perspective

2005 ◽  
Vol 88 (1) ◽  
pp. 262-267 ◽  
Author(s):  
Varoujan A Yaylayan ◽  
Richard H Stadler
Keyword(s):  
Amino Acid ◽  
Carbonyl Compounds ◽  
Azomethine Ylide ◽  
Significant Progress ◽  
Acid Moiety ◽  
Sugar Moiety ◽  
Acrylamide Formation ◽  
Amino Acid Moiety ◽  
Strecker Aldehyde

Abstract Earliest reports on the origin of acrylamide in food have confirmed asparagine as the main amino acid responsible for its formation. Available evidence suggests that sugars and other carbonyl compounds play a specific role in the decarboxylation process of asparagine, a necessary step in the generation of acrylamide. It has been proposed that Schiff base intermediate formed between asparagine and the sugar provides a low energy alternative to the decarboxylation from the intact Amadori product through generation and decomposition of oxazolidin-5-one intermediate, leading to the formation of a relatively stable azomethine ylide. Literature data indicate the propensity of such protonated ylides to undergo irreversible 1,2-prototropic shift and produce, in this case, decarboxylated Schiff bases which can easily rearrange into E Decarboxylated Amadori products can either undergo the well known β-elimination process initiated by the sugar moiety to produce 3-aminopropanamide and 1-deoxyglucosone or undergo 1,2-elimination initiated by the amino acid moiety to directly generate acrylamide. On the other hand, the Schiff intermediate can either hydrolyze and release 3-aminopropanamide or similarly undergo amino acid initiated 1,2-elimination to directly form acrylamide. Other thermolytic pathways to acrylamide—considered marginal at this stage—via the Strecker aldehyde, acrolein, and acrylic acid, are also addressed. Despite significant progress in the understanding of the mechanistic aspects of acrylamide formation, concrete evidence for the role of the different proposed intermediates in foods is still lacking.

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