scholarly journals Newborn Screening for SCD in the USA and Canada

2018 ◽  
Vol 4 (4) ◽  
pp. 36 ◽  
Author(s):  
Nura El-Haj ◽  
Carolyn Hoppe
Keyword(s):  
United States ◽  
Newborn Screening ◽  
The United States ◽  
Historical Background ◽  
Current Status ◽  
The Usa ◽  
Abnormal Hemoglobin ◽  
Hb S ◽  
Laboratory Procedures ◽  
Canadian Provinces

Sickle cell disease (SCD) encompasses a group of inherited red cell disorders characterized by an abnormal hemoglobin, Hb S. The most common forms of SCD in the United States and Canada are identified through universal newborn screening (NBS) programs. Now carried out in all fifty U.S. states and 8 Canadian provinces, NBS for SCD represents one of the major public health advances in North America. The current status of NBS programs for hemoglobinopathies and the screening techniques employed in many regions worldwide reflect in large part the U.S. and Canadian experiences. Although the structure, screening algorithms and laboratory procedures, as well as reporting and follow up, vary between NBS programs, the overall workflow is similar. The current review summarized the historical background, current approaches, and methods used to screen newborns for SCD in the United States and Canada.

scholarly journals Predicting the Dynamics of the COVID-19 Pandemic in the United States Using Graph Theory-Based Neural Networks

2021 ◽  
Vol 18 (7) ◽  
pp. 3834
Author(s):  
Mohammad Reza Davahli ◽  
Krzysztof Fiok ◽  
Waldemar Karwowski ◽  
Awad M. Aljuaid ◽  
Redha Taiar
Keyword(s):  
United States ◽  
Neural Networks ◽  
Graph Theory ◽  
Predictive Model ◽  
Short Term Memory ◽  
The United States ◽  
Graphical Analysis ◽  
Economic Consequences ◽  
Current Status ◽  
The Usa

The COVID-19 pandemic has had unprecedented social and economic consequences in the United States. Therefore, accurately predicting the dynamics of the pandemic can be very beneficial. Two main elements required for developing reliable predictions include: (1) a predictive model and (2) an indicator of the current condition and status of the pandemic. As a pandemic indicator, we used the effective reproduction number (Rt), which is defined as the number of new infections transmitted by a single contagious individual in a population that may no longer be fully susceptible. To bring the pandemic under control, Rt must be less than one. To eliminate the pandemic, Rt should be close to zero. Therefore, this value may serve as a strong indicator of the current status of the pandemic. For a predictive model, we used graph neural networks (GNNs), a method that combines graphical analysis with the structure of neural networks. We developed two types of GNN models, including: (1) graph-theory-based neural networks (GTNN) and (2) neighborhood-based neural networks (NGNN). The nodes in both graphs indicated individual states in the US states. While the GTNN model’s edges document functional connectivity between states, those in the NGNN model link neighboring states to one another. We trained both models with Rt numbers collected over the previous four days and asked them to predict the following day for all states in the USA. The performance of these models was evaluated with the datasets that included Rt values reflecting conditions from 22 January through 26 November 2020 (before the start of COVID-19 vaccination in the USA). To determine the efficiency, we compared the results of two models with each other and with those generated by a baseline Long short-term memory (LSTM) model. The results indicated that the GTNN model outperformed both the NGNN and LSTM models for predicting Rt.

A Brief History of Education in China and the United States

2020 ◽  
pp. 79-94
Author(s):  
Stacy R. Reeves
Keyword(s):  
United States ◽  
History Of Education ◽  
The United States ◽  
Learning Opportunities ◽  
Historical Background ◽  
Current Status ◽  
Access To Education ◽  
History Of ◽  
Unequal Access ◽  
Education In China

China and the United States have long histories of educating their populations. Currently, all children in both China and the United States are mandated to attend for a minimum of nine years, and schools are free for students. Although education in China and the United States may be accessible to all, do all groups have equal opportunities for success? While addressing this topic, some questions arise: What is the historical background of education and schools in each nation? What is the current status of literacy in both countries? Are there inequality in learning opportunities for children in China and in the United States? What are some possible reasons for unequal access to education?

The Arbitral Award on Turkish-Armenian Boundary by Woodrow Wilson (Historical Background, Legal Aspects, and International Dimensions)

2007 ◽  
Vol 11 (2) ◽  
pp. 255-294
Author(s):  
Ara Papian
Keyword(s):  
United States ◽  
Middle East ◽  
The United States ◽  
Legal Aspects ◽  
Historical Background ◽  
Woodrow Wilson ◽  
Arbitral Award ◽  
Starting Point ◽  
The Usa ◽  
The Republic

AbstractThe paper is a complex study of the history of the involvement of Woodrow Wilson (the 28th President of the USA, 1913-1921), in the fate of Armenian people after WWI and the Republic Armenia (1918-1920), especially in determining the boundary between Armenia and Turkey. It presents an analysis of Wilson's Arbitral Award according to the international law and the United Nation's official methodology. The article focuses on the historical background, legal aspects and political implications of Wilson's Arbitral Award (November 22, 1920), officially titled: Decision of the President of the United States of America respecting the Frontier between Turkey and Armenia, Access for Armenia to the Sea, and the Demilitarization of Turkish Territory adjacent to the Armenian Frontier. The Arbitration's significance goes beyond Armenian-Turkish and Armenian-US relations. Border conflicts are still relevant issues on the regional and international agenda. American involvement in the Middle East is one of the key components of the United States' present foreign policy. An accurate and a broad understanding of the nuances of the extremely complex legal situation in the region and the bases for the behaviour of the players can be vital for the security, political and economic interests of the region. Moreover, due to the active participation of the United States in the Armenian-Turkish relations through Wilson's Arbitration, the Arbitral Award becomes a logical starting point for a stronger historical, political, and legal understanding of the conflict-prone region. The article also contributes to the better understanding of President Wilson's policy towards the Middle East during the dramatic period of 1917-1921 and its possible consequences for critical relationships in the region today.

scholarly journals Current status of newborn screening for Pompe disease in Japan

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Takaaki Sawada ◽  
Jun Kido ◽  
Keishin Sugawara ◽  
Ken Momosaki ◽  
Shinichiro Yoshida ◽  
...  
Keyword(s):  
United States ◽  
Newborn Screening ◽  
Pompe Disease ◽  
Autosomal Recessive ◽  
Late Onset ◽  
The United States ◽  
Current Status ◽  
Inherited Metabolic Disorder ◽  
Enzyme Replacement

Abstract Background Pompe disease is an autosomal recessive inherited metabolic disorder caused by a deficiency of the acid α-glucosidase (GAA). Pompe disease manifests as an accumulation of lysosomal glycogen in the skeletal and heart muscle. We conducted newborn screening (NBS) for Pompe disease in Japan from April 2013 to October 2020 to determine the feasibility and utility of NBS for Pompe disease. Results From the 296,759 newborns whose enzyme activity was measured, 107 of which underwent GAA analysis, we found one patient with infantile-onset Pompe disease (IOPD) and seven with potential late-onset Pompe disease (LOPD). We identified 34 pseudodeficient individuals and 65 carriers or potential carriers. The frequency of patients with IOPD was similar to that in the United States, but significantly lower than that in Taiwan. One patient with IOPD underwent early enzyme replacement therapy within a month after birth before presenting exacerbated manifestations, whereas those with potential LOPD showed no manifestations during the follow-up period of six years. Conclusions The frequency of IOPD in Japan was similar to that in the United States, where NBS for Pompe disease is recommended. This indicates that NBS for Pompe disease may also be useful in Japan. Therefore, it should be used over a wider region in Japan.

scholarly journals Current Status of Newborn Screening for Pompe Disease in Japan

2021 ◽  
Author(s):  
Takaaki Sawada ◽  
Jun Kido ◽  
Keishin Sugawara ◽  
Ken Momosaki ◽  
Shinichiro Yoshida ◽  
...  
Keyword(s):  
United States ◽  
Newborn Screening ◽  
Pompe Disease ◽  
Autosomal Recessive ◽  
Late Onset ◽  
The United States ◽  
Current Status ◽  
Inherited Metabolic Disorder ◽  
Enzyme Replacement

Abstract Background: Pompe disease is an autosomal recessive inherited metabolic disorder caused by a deficiency of the acid α-glucosidase (AαGlu). Pompe disease manifests as an accumulation of lysosomal glycogen in the skeletal and heart muscle. We conducted newborn screening (NBS) for Pompe disease in Japan from April 2013 to October 2020 to determine the feasibility and utility of NBS for Pompe disease.Results: From the 296,759 newborns whose enzyme activity was measured, 107 of which underwent GAA analysis, we found one patient with infantile-onset Pompe disease (IOPD) and seven with potential late-onset Pompe disease (LOPD). We identified 34 pseudodeficient individuals and 65 carriers or potential carriers. The frequency of patients with IOPD was similar to that in the United States, but significantly lower than that in Taiwan. One patient with IOPD underwent early enzyme replacement therapy within a month after birth before presenting exacerbated manifestations, whereas those with potential LOPD showed no manifestations during the follow-up period of six years.Conclusions: The frequency of IOPD in Japan was similar to that in the United States, where NBS for Pompe disease is recommended. This indicates that NBS for Pompe disease may also be useful in Japan. Therefore, it should be used over a wider region in Japan.

Emigrant Psychoanalysts in the USA and the FBI Archives

2004 ◽  
Vol 6 (1) ◽  
pp. 75-92 ◽  
Author(s):  
James E. Goggin
Keyword(s):  
United States ◽  
Civil Rights ◽  
National Socialism ◽  
Cultural Context ◽  
Due Process ◽  
The United States ◽  
External Threats ◽  
The Usa ◽  
The Rich ◽  
New Nation

Interest in the fate of the German psychoanalysts who had to flee Hitler's Germany and find refuge in a new nation, such as the United States, has increased. The ‘émigré research’ shows that several themes recur: (1) the theme of ‘loss’ of one's culture, homeland, language, and family; and (2) the ambiva-lent welcome these émigrés received in their new country. We describe the political-social-cultural context that existed in the United States during the 1930s, 1940s and 1950s. Documentary evidence found in the FBI files of three émigré psychoanalysts, Clara Happel, Martin Grotjahn, and Otto Fenichel, are then presented in combination with other source material. This provides a provisional impression of how each of these three individuals experienced their emigration. As such, it gives us elements of a history. The FBI documents suggest that the American atmosphere of political insecurity and fear-based ethnocentric nationalism may have reinforced their old fears of National Socialism, and contributed to their inclination to inhibit or seal off parts of them-selves and their personal histories in order to adapt to their new home and become Americanized. They abandoned the rich social, cultural, political tradition that was part of European psychoanalysis. Finally, we look at these elements of a history in order to ask a larger question about the appropriate balance between a liberal democratic government's right to protect itself from internal and external threats on the one hand, or crossover into the blatant invasion of civil rights and due process on the other.

Sandra Ramos Revisited

2020 ◽  
Vol 2 (4) ◽  
pp. 32-54
Author(s):  
Silvia Spitta
Keyword(s):  
United States ◽  
The United States ◽  
Ancient Greek ◽  
Graphic Arts ◽  
Left Behind ◽  
The World ◽  
The Usa ◽  
Political Choices ◽  
The Rich

Sandra Ramos (b. 1969) is one of the few artists to reflect critically on both sides of the Cuban di-lemma, fully embodying the etymological origins of the word in ancient Greek: di-, meaning twice, and lemma, denoting a form of argument involving a choice between equally unfavorable alternatives. Throughout her works she shines a light on the dilemmas faced by Cubans whether in Cuba or the United States, underlining the bad personal and political choices people face in both countries. During the hard 1990s, while still in Havana, the artist focused on the traumatic one-way journey into exile by thousands, as well as the experience of profound abandonment experienced by those who were left behind on the island. Today she lives in Miami and operates a studio there as well as one in Havana. Her initial disorientation in the USA has morphed into an acerbic representation and critique of the current administration and a deep concern with the environmental collapse we face. A buffoonlike Trumpito has joined el Bobo de Abela and Liborio in her gallery of comic characters derived from the rich Cuban graphic arts tradition where she was formed. While Cuba is now represented as a rotten cake with menacing flies hovering over it ready to pounce, a bombastic Trumpito marches across the world stage, trampling everything underfoot, a dollar sign for a face.

Russian Federation and the United States of America: geostrategic directions to manage the Ukrainian crisis

2019 ◽  
pp. 123
Author(s):  
Attarid Awadh Abdulhameed
Keyword(s):  
United States ◽  
European Union ◽  
National Security ◽  
Russian Federation ◽  
United States Of America ◽  
The United States ◽  
The European Union ◽  
The Usa ◽  
Ukrainian Crisis ◽  
Zero Sum

Ukrainia Remains of huge importance to Russian Strategy because of its Strategic importance. For being a privileged Postion in new Eurasia, without its existence there would be no logical resons for eastward Expansion by European Powers.  As well as in Connection with the progress of Ukrainian is no less important for the USA (VSD, NDI, CIA, or pentagon) and the European Union with all organs, and this is announced by John Kerry. There has always ben Russian Fear and Fear of any move by NATO or USA in the area that it poses a threat to  Russians national Security and its independent role and in funence  on its forces especially the Navy Forces. There for, the Crisis manyement was not Zero sum game, there are gains and offset losses, but Russia does not accept this and want a Zero Sun game because the USA. And European exteance is a Foot hold in Regin Which Russian sees as a threat to its national security and want to monopolize control in the strategic Qirim.

The Current Status of Retirement Mentoring in Academic Surgery in the United States

2019 ◽  
Vol 02 (03) ◽  
Author(s):  
Sherif Aly ◽  
Allan Stolarski ◽  
Patrick O’Neal ◽  
Edward Whang ◽  
Gentian Kristo
Keyword(s):  
United States ◽  
The United States ◽  
Current Status ◽  
Academic Surgery
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