scholarly journals Proposed Algorithm for Management of Meibomian Gland Dysfunction Based on Noninvasive Meibography

2020 ◽  
Vol 10 (1) ◽  
pp. 65
Author(s):  
Reiko Arita ◽  
Shima Fukuoka ◽  
Motoko Kawashima
Keyword(s):  
International Workshop ◽  
Treatment Options ◽  
Meibomian Gland ◽  
Meibomian Gland Dysfunction ◽  
Ocular Symptoms ◽  
Appropriate Treatment ◽  
Stage Classification ◽  
Surface Staining ◽  
Selection For ◽  
Selection Of

Although the pathophysiology of meibomian gland dysfunction (MGD) remains incompletely understood, many treatment options have recently become available. According to an international workshop report, treatment selection for MGD should be based on a comprehensive stage classification dependent on ocular symptoms, lid margin abnormalities, meibum grade, and ocular surface staining. However, it is often difficult to evaluate all parameters required for such classification in routine clinical practice. We have now retrospectively evaluated therapeutic efficacy in MGD patients who received five types of treatment in the clinic setting: (1) meibocare (application of a warm compress and practice of lid hygiene), (2) meibum expression plus meibocare, (3) azithromycin eyedrops plus meibocare, (4) thermal pulsation therapy plus meibocare, or (5) intense pulsed light (IPL) therapy plus meibocare. Patients in each treatment group were classified into three subsets according to the meiboscore determined by noncontact meibography at baseline. Eyes in the IPL group showed improvement even if the meiboscore was high (5 or 6), whereas meibocare tended to be effective only if the meiboscore was low (1 or 2). The meiboscore may thus serve to guide selection of the most appropriate treatment in MGD patients. Prospective studies are warranted to confirm these outcomes.

scholarly journals The International Workshop on Meibomian Gland Dysfunction: Executive Summary

2011 ◽  
Vol 52 (4) ◽  
pp. 1922 ◽  
Author(s):  
Kelly K. Nichols ◽  
Gary N. Foulks ◽  
Anthony J. Bron ◽  
Ben J. Glasgow ◽  
Murat Dogru ◽  
...  
Keyword(s):  
International Workshop ◽  
Meibomian Gland ◽  
Meibomian Gland Dysfunction ◽  
Executive Summary

scholarly journals The International Workshop on Meibomian Gland Dysfunction: Report of the Definition and Classification Subcommittee

2011 ◽  
Vol 52 (4) ◽  
pp. 1930 ◽  
Author(s):  
J. Daniel Nelson ◽  
Jun Shimazaki ◽  
Jose M. Benitez-del-Castillo ◽  
Jennifer P. Craig ◽  
James P. McCulley ◽  
...  
Keyword(s):  
International Workshop ◽  
Meibomian Gland ◽  
Meibomian Gland Dysfunction

Antiepileptic Drug Selection in Pediatric Epilepsy

2002 ◽  
Vol 17 (2_suppl) ◽  
pp. 2S2-2S8 ◽  
Author(s):  
Patricia K. Crumrine
Keyword(s):  
Antiepileptic Drug ◽  
Antiepileptic Drugs ◽  
Treatment Options ◽  
Epilepsy Syndrome ◽  
Pediatric Epilepsy ◽  
Drug Selection ◽  
Seizure Recurrence ◽  
Selection For ◽  
Selection Of ◽  
Made In

This review article presents information concerning treatment options for various pediatric epilepsy syndromes. The decisions made in the selection of antiepileptic drugs are determined by a number of variables that include, but are exclusive of, risk of seizure recurrence, patient age, epilepsy syndrome, known drug reactions, and prognosis of the epilepsy syndrome. The review discusses issues pertinent to antiepileptic drug selection including simple pharmacokinetic principles, antiepileptic drug formulations, and information concerning clinical studies using some of the antiepileptic drugs. Information is provided concerning the issues of seizure recurrence. Suggested paradigms for antiepileptic drug selection for partial seizures are provided. A table of antiepileptic drug costs is provided for assistance in prescribing and advising families. Psychosocial issues pertinent to the treatment of children are discussed. (J Child Neurol 2002;17:2S2—2S8).

scholarly journals Research progress on meibomian gland dysfunction from 2011 to 2020: a bibliometric and visualized analysis

2021 ◽  
Author(s):  
Qian Liu ◽  
Fangkun Zhao ◽  
Jun Kong
Keyword(s):  
Core Collection ◽  
Web Of Science ◽  
International Workshop ◽  
The United States ◽  
Meibomian Gland ◽  
Research Progress ◽  
Meibomian Gland Dysfunction ◽  
Research Areas ◽  
Visual Science ◽  
The Web

Abstract Background To explore the research areas, hotspots, and progress of meibomian gland dysfunction through bibliometrics. Methods Related publications were retrieved from the Web of Science Core Collection from 2011 to 2020. VOSviewer1.6.16, Citespace.5.7.R2, and GraphPad Prism 8 were used to visualize the distribution of countries, research institutions, journals, authors, keywords, and annual publication numbers in this field. Results A total number of 716 relevant publications were retrieved. The United States and Keio University ranked the first among the countries and organizations with the most publications. Cornea, Investigative Ophthalmology & Visual Science, and Ocular Surface were the top three journals with the highest publication counts and citations. The authors who contributed to this topic mainly formed three clusters which manifested the research areas, and the extracted keywords mainly formed four clusters which manifested the hotspots were explored. Conclusions The research areas and hotspots of meibomian gland dysfunction were as follow: (1) Pathogenesis or potential etiology of meibomian gland dysfunction; (2) Diagnosis of meibomian gland dysfunction; (3) Therapy of meibomian gland dysfunction and the International Workshop`s dedication to it; (4) Epidemiology of meibomian gland dysfunction.

scholarly journals Meibomian gland dysfunction with involutional eyelids malposition

2016 ◽  
Vol 9 (1) ◽  
pp. 5-12 ◽  
Author(s):  
Vitaly V Potemkin ◽  
Vyacheslav V Rakhmanov ◽  
Elena V Ageeva ◽  
Aisa S Alchinova ◽  
Elena V Meshveliani
Keyword(s):  
International Workshop ◽  
Clinical Score ◽  
Lower Eyelid ◽  
Meibomian Gland ◽  
Meibomian Gland Dysfunction ◽  
Control Group ◽  
Lack Of Information ◽  
Clinical Relationship ◽  
Eyelid Malposition ◽  
Meibomian Glands

The state of the ocular surface and visual functions depends on ocular adnexal tissues. Involutional changes of the eyelids and meibomian glands occur with age. There is a lack of information about possible relationship between involutional lower lid malposition and meibomian gland dysfunction. Purpose. To evaluate meibomian glands dysfunction in patients with lower eyelid malposition. Methods. Two groups of patients were enrolled: 26 patients (52 eyelids) with involutional lower eyelid malposition and a control group of 22 patients (44 eyelids) without eyelid malposition. Groups were comparable by age and sex. The clinical examination included general eye examination; evaluation of the degree of the eyelids laxity, signs of retractors dehiscence and clinical score of meibomian gland’s dysfunction (The International Workshop on Meibomian Gland Dysfunction, 2011). Results. Atonic eyelid changes and meibomian gland dysfunction were significantly more expressed in patients with involutional eyelid malposition (р < 0,05). Conclusion. Our study showed an age-independent clinical relationship between involutional lower eyelid malposition and dysfunction of meibomian glands.

scholarly journals The International Workshop on Meibomian Gland Dysfunction: Report of the Clinical Trials Subcommittee

2011 ◽  
Vol 52 (4) ◽  
pp. 2065 ◽  
Author(s):  
Penny A. Asbell ◽  
Fiona J. Stapleton ◽  
Kerstin Wickström ◽  
Esen K. Akpek ◽  
Pasquale Aragona ◽  
...  
Keyword(s):  
Clinical Trials ◽  
International Workshop ◽  
Meibomian Gland ◽  
Meibomian Gland Dysfunction

scholarly journals Selection of treatment for hepatic epithelioid hemangioendothelioma: a single-center experience

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Linping Cao ◽  
Jiawei Hong ◽  
Lingfeng Zhou ◽  
Yufu Ye ◽  
Yuanxing Liu ◽  
...  
Keyword(s):  
Treatment Options ◽  
Needle Aspiration ◽  
Epithelioid Hemangioendothelioma ◽  
Multiple Strategies ◽  
Single Center Experience ◽  
Appropriate Treatment ◽  
Significant Disease ◽  
Selection Of ◽  
Observation Period

Abstract Background Hepatic epithelioid hemangioendothelioma (HEHE) is a rare angiogenic tumor with no recognized effective treatment. Treatment options used worldwide include liver transplantation (LT), liver resection (LR), radiofrequency ablation (RFA), chemotherapy, and observation. The aim of this study was to describe the efficacy of different treatment options used for HEHE at our center. Methods The medical charts of 12 patients with HEHE (9 women and 3 men) who were diagnosed and treated at the First Affiliated Hospital of Zhejiang University, China, between January 2011 and December 2017 were retrospectively reviewed. Results The patients were diagnosed by postoperative histopathology or fine needle aspiration biopsy. Two patients with diffuse lesions received LT and were alive without recurrence at the last follow-up. Three patients received LR as the initial treatment, and all of them developed recurrence during the follow-up period. One patient received RFA and remained free of disease, while the remaining six patients opted for simple observation rather than treatment. One of the patients who received LR passed away because of tumor recurrence within 32 months after surgery; the other patients showed no significant disease activity after treatments for their recurrent lesions. As of April 2018, the mean follow-up duration was 39.6 ± 20.1 months (15–82 months). Conclusions There are multiple strategies for HEHE. Considering its indolent course, initial observation for assessment of the lesion behavior may aid in the selection of appropriate treatment. Surgery or LT is suitable for patients with disease progression during the observation period. However, our sample size was small, and further studies are required to gather more information that can aid in optimal treatment selection.

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