Antiepileptic Drug Selection in Pediatric Epilepsy

2002 ◽  
Vol 17 (2_suppl) ◽  
pp. 2S2-2S8 ◽  
Author(s):  
Patricia K. Crumrine
Keyword(s):  
Antiepileptic Drug ◽  
Antiepileptic Drugs ◽  
Treatment Options ◽  
Epilepsy Syndrome ◽  
Pediatric Epilepsy ◽  
Drug Selection ◽  
Seizure Recurrence ◽  
Selection For ◽  
Selection Of ◽  
Made In

This review article presents information concerning treatment options for various pediatric epilepsy syndromes. The decisions made in the selection of antiepileptic drugs are determined by a number of variables that include, but are exclusive of, risk of seizure recurrence, patient age, epilepsy syndrome, known drug reactions, and prognosis of the epilepsy syndrome. The review discusses issues pertinent to antiepileptic drug selection including simple pharmacokinetic principles, antiepileptic drug formulations, and information concerning clinical studies using some of the antiepileptic drugs. Information is provided concerning the issues of seizure recurrence. Suggested paradigms for antiepileptic drug selection for partial seizures are provided. A table of antiepileptic drug costs is provided for assistance in prescribing and advising families. Psychosocial issues pertinent to the treatment of children are discussed. (J Child Neurol 2002;17:2S2—2S8).

scholarly journals Adopting an Orphan Drug: Rufinamide for Lennox–Gastaut Syndrome

2009 ◽  
Vol 9 (3) ◽  
pp. 72-74 ◽  
Author(s):  
Susan T. Herman
Keyword(s):  
Seizure Frequency ◽  
Therapy Group ◽  
Controlled Trial ◽  
Treatment Options ◽  
Baseline Period ◽  
Epilepsy Syndrome ◽  
Pediatric Epilepsy ◽  
Percentage Reduction ◽  
Double Blind ◽  
Median Percentage

Rufinamide for Generalized Seizures Associated with Lennox–Gastaut Syndrome. Glauser T, Kluger G, Sachdeo R, Krauss G, Perdomo C, Arroyo S. Neurology 2008;70(21):1950–1958. BACKGROUND: Lennox–Gastaut syndrome is a catastrophic pediatric epilepsy syndrome characterized by multiple types of treatment-resistant seizures and high rates of seizure-related injury. Current available treatments are inadequate, leaving patients with few treatment options and opportunities. METHODS: We conducted a double-blind, randomized, placebo-controlled trial of the antiepileptic drug rufinamide in patients with Lennox–Gastaut syndrome. Eligible patients between 4 and 30 years of age had multiple types of seizures (including tonic–atonic and atypical absence seizures) with a minimum of 90 seizures in the month before baseline and a recent history of a slow spike-and-wave pattern on EEG. RESULTS: After a 28-day baseline period, 139 eligible patients were randomized; 138 patients received either rufinamide (n = 74) or placebo (n = 64) in addition to their other antiepileptic drugs. The median percentage reduction in total seizure frequency was greater in the rufinamide therapy group than in the placebo group (32.7% vs 11.7%, p = 0.0015). There was a difference ( p < 0.0001) in tonic–atonic (“drop attack”) seizure frequency with rufinamide (42.5% median percentage reduction) vs placebo (1.4% increase). The rufinamide group had a greater improvement in seizure severity ( p = 0.0041) and a higher 50% responder rate compared with placebo for total seizures ( p = 0.0045) and tonic–atonic seizures ( p = 0.002). The common adverse events (reported by 10% of patients receiving rufinamide) were somnolence (24.3% with rufinamide vs 12.5% with placebo) and vomiting (21.6% vs 6.3%). CONCLUSIONS: Rufinamide was an effective and well-tolerated treatment for seizures associated with Lennox–Gastaut syndrome.

scholarly journals Antiepileptic drug selection for people with HIV/AIDS: Evidence-based guidelines from the ILAE and AAN

Epilepsia ◽  
2012 ◽  
Vol 53 (1) ◽  
pp. 207-214 ◽  
Author(s):  
Gretchen L. Birbeck ◽  
Jacqueline A. French ◽  
Emilio Perucca ◽  
David M. Simpson ◽  
Henry Fraimow ◽  
...  
Keyword(s):  
Antiepileptic Drug ◽  
Evidence Based ◽  
Drug Selection ◽  
Selection For ◽  
Evidence Based Guidelines ◽  
Hiv Aids

scholarly journals Typical Errors in the Writing of the Students Participating in Mawapres Selection in ITS Surabaya

2015 ◽  
Vol 6 (1) ◽  
pp. 61-70
Author(s):  
Hermanto Hermanto
Keyword(s):  
Classification System ◽  
English Abstract ◽  
The Common ◽  
Error Classification ◽  
Selection For ◽  
Speaking Performance ◽  
National Selection ◽  
Writing Errors ◽  
Selection Of ◽  
Made In

One of the elements in the selection of the “ITS Heroes 2015” to be the candidates for National Selection for Student Competition (Mawapres) is the ability of the participants to communicate in English in the form of writing and speaking performance. In the writing performance, the participants must submit an English abstract of their papers, and in the speaking performance, the participants are required to tell themselves in English. From these two evaluation items, the abstract is more interesting to analyze in terms of the writing errors the participants made in it. This paper presents the analysis of the common writing errors made by the participants of “ITS Heroes 2015”. The errors are categorized and analyzed based on the checklist items by adopting Kim (2009)’s error classification system, which is based on Dulay, Burt, and Krashen’s classification system.

scholarly journals Expected response to early-generation selection for yield and tuber appearance traits in potatoes

2016 ◽  
Vol 37 (5) ◽  
pp. 2849 ◽  
Author(s):  
Vicenti Gonçalves Ney ◽  
Laerte Reis Terres ◽  
Giovani Olegário da Silva ◽  
Arione Da Silva Pereira
Keyword(s):  
Tuber Yield ◽  
High Heritability ◽  
Clonal Generation ◽  
Seedling Generation ◽  
Selection For ◽  
Group 2 ◽  
Selection Of ◽  
Made In ◽  
Eye Depth ◽  
Group 1

The aim of this study was to evaluate the performance of potato clonal families, and to estimate genetic variance, heritability and the expected response to selection of tuber yield and appearance traits in early generations. Twelve potato families were obtained from crosses between two groups of randomly-selected genotypes, including Eliza, C1730-7-94, and C-1742-8-95 in group 1; and Shepody, Asterix, Caesar, and White Lady in group 2. The crosses were made in factorial design (3 genotypes x4 genotypes), and each family consisted of 75 genotypes. Experiments were conducted in the fall of 2010, with a seedling generation under greenhouse conditions, and in the fall of 2011, with a clonal generation under field condition. High heritability estimates suggest that mild to moderate selection can be applied in the seedling generation to eye depth, eyebrow prominence, tuber curvature, flattening and shape uniformity. The C1742-8-95/White Lady stood out as a superior cross, as did all other crosses with White Lady, regarding tuber appearance and yield traits.

Antiepileptic Drug Selection for Partial-Onset Seizures

2012 ◽  
Vol 14 (4) ◽  
pp. 356-368
Author(s):  
Bassel F. Shneker ◽  
Nathan B. Fountain
Keyword(s):  
Antiepileptic Drug ◽  
Drug Selection ◽  
Selection For

scholarly journals Proposed Algorithm for Management of Meibomian Gland Dysfunction Based on Noninvasive Meibography

2020 ◽  
Vol 10 (1) ◽  
pp. 65
Author(s):  
Reiko Arita ◽  
Shima Fukuoka ◽  
Motoko Kawashima
Keyword(s):  
International Workshop ◽  
Treatment Options ◽  
Meibomian Gland ◽  
Meibomian Gland Dysfunction ◽  
Ocular Symptoms ◽  
Appropriate Treatment ◽  
Stage Classification ◽  
Surface Staining ◽  
Selection For ◽  
Selection Of

Although the pathophysiology of meibomian gland dysfunction (MGD) remains incompletely understood, many treatment options have recently become available. According to an international workshop report, treatment selection for MGD should be based on a comprehensive stage classification dependent on ocular symptoms, lid margin abnormalities, meibum grade, and ocular surface staining. However, it is often difficult to evaluate all parameters required for such classification in routine clinical practice. We have now retrospectively evaluated therapeutic efficacy in MGD patients who received five types of treatment in the clinic setting: (1) meibocare (application of a warm compress and practice of lid hygiene), (2) meibum expression plus meibocare, (3) azithromycin eyedrops plus meibocare, (4) thermal pulsation therapy plus meibocare, or (5) intense pulsed light (IPL) therapy plus meibocare. Patients in each treatment group were classified into three subsets according to the meiboscore determined by noncontact meibography at baseline. Eyes in the IPL group showed improvement even if the meiboscore was high (5 or 6), whereas meibocare tended to be effective only if the meiboscore was low (1 or 2). The meiboscore may thus serve to guide selection of the most appropriate treatment in MGD patients. Prospective studies are warranted to confirm these outcomes.

scholarly journals Selection of Simmental cattle on beef and meatiness traits in Serbia

2005 ◽  
Vol 21 (3-4) ◽  
pp. 25-34 ◽  
Author(s):  
Vladan Bogdanovic ◽  
Radica Djedovic ◽  
Milan Petrovic
Keyword(s):  
Cattle Population ◽  
Selection Methods ◽  
Dual Purpose ◽  
Dual Purpose Cattle ◽  
Beef Herds ◽  
Simmental Cattle ◽  
Selection For ◽  
Breed Selection ◽  
Selection Of ◽  
Made In

Population of domestic Simmental breed represents a dominant population of cattle in Serbia. According to importance of this breed, selection so far has been made in order to improve milk production. In other hand, beef and meatiness traits almost were ignored. Selection of dual-purpose cattle requires combining a various breeding goals and selection methods that are very differ from those applied in pure dairy or beef herds. Improving of beef and meatiness traits in our dominant cattle population will have great importance in future. The aim of this paper is to show possibility of selection for beef and meatiness traits in Serbian Simmental cattle.

An Overview of Dementias

2012 ◽  
Vol 21 (3) ◽  
pp. 75-84
Author(s):  
Venkata Vijaya K. Dalai ◽  
Jason E. Childress ◽  
Paul E Schulz
Keyword(s):  
Clinical Presentation ◽  
Treatment Options ◽  
Current Treatment ◽  
Great Variability ◽  
Health Concern ◽  
Public Health Concern ◽  
Life Threatening ◽  
The Common ◽  
Neurodegenerative Dementias ◽  
Made In

Dementia is a major public health concern that afflicts an estimated 24.3 million people worldwide. Great strides are being made in order to better diagnose, prevent, and treat these disorders. Dementia is associated with multiple complications, some of which can be life-threatening, such as dysphagia. There is great variability between dementias in terms of when dysphagia and other swallowing disorders occur. In order to prepare the reader for the other articles in this publication discussing swallowing issues in depth, the authors of this article will provide a brief overview of the prevalence, risk factors, pathogenesis, clinical presentation, diagnosis, current treatment options, and implications for eating for the common forms of neurodegenerative dementias.

Identifying Measurement Invariant Item Sets in Cross-Cultural Settings Using an Automated Item Selection Procedure

Methodology ◽  
2018 ◽  
Vol 14 (4) ◽  
pp. 177-188 ◽  
Author(s):  
Martin Schultze ◽  
Michael Eid
Keyword(s):  
Measurement Invariance ◽  
Optimal Solution ◽  
Selection Procedure ◽  
Cross Cultural ◽  
Item Selection ◽  
Ant System ◽  
Item Quality ◽  
Ant System Algorithm ◽  
Selection For ◽  
Selection Of

Abstract. In the construction of scales intended for the use in cross-cultural studies, the selection of items needs to be guided not only by traditional criteria of item quality, but has to take information about the measurement invariance of the scale into account. We present an approach to automated item selection which depicts the process as a combinatorial optimization problem and aims at finding a scale which fulfils predefined target criteria – such as measurement invariance across cultures. The search for an optimal solution is performed using an adaptation of the [Formula: see text] Ant System algorithm. The approach is illustrated using an application to item selection for a personality scale assuming measurement invariance across multiple countries.

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