scholarly journals Three-Dimensional Quantification of Bone Mineral Density in the Distal Femur and Proximal Tibia Based on Computed Tomography: In Vitro Evaluation of an Extended Standardization Method

2021 ◽  
Vol 10 (1) ◽  
pp. 160
Author(s):  
Hugo Babel ◽  
Patrick Omoumi ◽  
Killian Cosendey ◽  
Hugues Cadas ◽  
Brigitte M. Jolles ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Distal Femur ◽  
Proximal Tibia ◽  
Intraclass Correlation ◽  
Three Dimensional ◽  
Standardization Method ◽  
Mineral Density ◽  
Precision Error

While alterations in bone mineral density (BMD) are of interest in a number of musculoskeletal conditions affecting the knee, their analysis is limited by a lack of tools able to take full advantage of modern imaging modalities. This study introduced a new method, combining computed tomography (CT) and computational anatomy algorithms, to produce standardized three-dimensional BMD quantification in the distal femur and proximal tibia. The method was evaluated on ten cadaveric knees CT-scanned twice and processed following three different experimental settings to assess the influence of different scans and operators. The median reliability (intraclass correlation coefficient (ICC)) ranged from 0.96 to 0.99 and the median reproducibility (precision error (RMSSD)) ranged from 3.97 to 10.75 mg/cc for the different experimental settings. In conclusion, this paper presented a method to standardize three-dimensional knee BMD with excellent reliability and adequate reproducibility to be used in research and clinical applications. The perspectives offered by this novel method are further reinforced by the fact it relies on conventional CT scan of the knee. The standardization method introduced in this work is not limited to BMD and could be adapted to quantify other bone parameters in three dimension based on CT images or images acquired using different modalities.

A Registration Method for Three-Dimensional Analysis of Bone Mineral Density in the Proximal Tibia

2020 ◽  
Vol 143 (1) ◽  
Author(s):  
Hugo Babel ◽  
Loïc Wägeli ◽  
Berke Sonmez ◽  
Jean-Philippe Thiran ◽  
Patrick Omoumi ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Proximal Tibia ◽  
Three Dimensional ◽  
Field Of View ◽  
3D Analysis ◽  
Mineral Density ◽  
Comprehensive Description ◽  
Registration Method ◽  
The Relationship

Abstract Although alterations in bone mineral density (BMD) at the proximal tibia have been suggested to play a role in various musculoskeletal conditions, their pathophysiological implications and their value as markers for diagnosis remain unclear. Improving our understanding of proximal tibial BMD requires novel tools for three-dimensional (3D) analysis of BMD distribution. Three-dimensional imaging is possible with computed tomography (CT), but computational anatomy algorithms are missing to standardize the quantification of 3D proximal tibial BMD, preventing distribution analyses. The objectives of this study were to develop and assess a registration method, suitable with routine knee CT scans, to allow the standardized quantification of 3D BMD distribution in the proximal tibia. Second, as an example of application, the study aimed to characterize the distribution of BMD below the tibial cartilages in healthy knees. A method was proposed to register both the surface (vertices) and the content (voxels) of proximal tibias. The method combines rigid transformations to account for differences in bone size and position in the scanner's field of view and to address inconsistencies in the portion of the tibial shaft included in routine CT scan, with a nonrigid transformation locally matching the proximal tibias. The method proved to be highly reproducible and provided a comprehensive description of the relationship between bone depth and BMD. Specifically it reported significantly higher BMD in the first 6 mm of bone than deeper in the proximal tibia. In conclusion, the proposed method offers promising possibilities to analyze BMD and other properties of the tibia in 3D.

scholarly journals Proximal tibia volumetric bone mineral density is correlated to the magnitude of local acceleration in male long-distance runners

2010 ◽  
Vol 108 (4) ◽  
pp. 852-857 ◽  
Author(s):  
Olivier Dériaz ◽  
Bijan Najafi ◽  
Pierluigi Ballabeni ◽  
Antoinette Crettenand ◽  
Charles Gobelet ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Proximal Tibia ◽  
Three Dimensional ◽  
Heel Strike ◽  
Volumetric Bone Mineral Density ◽  
Mineral Density ◽  
Long Distance ◽  
Beneficial Effects ◽  
A Prospective Study

The beneficial effect of physical exercise on bone mineral density (BMD) is at least partly explained by the forces exerted directly on the bones. Male runners present generally higher BMD than sedentary individuals. We postulated that the proximal tibia BMD is related to the running distance, as well as to the magnitude of the shocks (while running) in male runners. A prospective study (three yearly measurements) included 81 healthy male subjects: 16 sedentary lean subjects, and 3 groups of runners (5–30 km/wk, n = 19; 30–50 km/wk, n = 29; 50–100 km/wk, n = 17). Several measurements were performed at the proximal tibia level: volumetric BMD (vBMD) and cortical index (CI), i.e., an index of cortical bone thickness and peak accelerations (an index of shocks during heel strike) while running (measured by a three-dimensional accelerometer). A general linear model assessed the prediction of vBMD or CI by 1) simple effects (running distance, peak accelerations, time); and 2) interactions (for instance, if vBMD prediction by peak acceleration depends on running distance). CI and vBMD 1) increase with running distance to reach a plateau over 30 km/wk; and 2) are positively associated with peak accelerations over 30 km/wk. Running may be associated with high peak accelerations to have beneficial effects on BMD. More important strains are needed to be associated with the same increase in BMD during running sessions of short duration than those of long duration. CI and vBMD are associated with the magnitude of the shocks during heel strike in runners.

scholarly journals An Ovariectomy-Induced Rabbit Osteoporotic Model: A New Perspective

2018 ◽  
Vol 12 (1) ◽  
pp. 12-17 ◽  
Author(s):  
Nathan Robert Wanderman ◽  
Cindy Mallet ◽  
Hugo Giambini ◽  
Nirong Bao ◽  
Chunfeng Zhao ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
New Zealand ◽  
Postmenopausal Osteoporosis ◽  
Bone Mineral ◽  
Distal Femur ◽  
Proximal Tibia ◽  
Chemotherapeutic Agents ◽  
Mineral Density ◽  
Bmd Testing

<sec><title>Study Design</title><p>Experimental Animal Model.</p></sec><sec><title>Purpose</title><p>The aim of our study was to validate a pure bilateral ovariectomy (OVX) female New Zealand white rabbit model of postmenopausal osteoporosis utilizing animal-sparing <italic>in vivo</italic> techniques for evaluating bone mineral density (BMD). We also sought to demonstrate that bilateral OVX in female New Zealand white rabbits can produce diminished BMD in the spinal column and simulate osteoporosis, without the need for adjuvant chemotherapeutic agents (i.e., no additional glucocorticosteroids or other drugs were used for stimulating accelerated BMD loss), which can be assessed by <italic>in vivo</italic> BMD testing.</p></sec><sec><title>Overview of Literature</title><p>Multiple animal models of postmenopausal osteoporosis have been described. Rat ovariectomy models have been successful, but are limited by rats' inability to achieve true skeletal maturity and a slight morphology that limits surgical instrumentation. Rabbit models have been described which do not have these limitations, but previous models have relied on adjunctive steroid therapy to achieve osteoporosis and have required animal sacrifice for bone mineral density assessment.</p></sec><sec><title>Methods</title><p>Thirty-six skeletally mature female rabbits underwent bilateral OVX. BMD was measured using dual-energy X-ray absorptiometry on the metaphysis of the proximal tibia and distal femur, at baseline and 17 weeks postoperatively.</p></sec><sec><title>Results</title><p>Mean BMD values were significantly reduced by 21.9% (<italic>p</italic>&lt;0.05) in the proximal tibia and 11.9% (<italic>p</italic>&lt;0.001) in the distal femur at 17 weeks.</p></sec><sec><title>Conclusions</title><p>This study is the first to demonstrate a significant bone loss within four months of pure OVX in rabbits using animal-sparing validation techniques. We believe that this OVX model is safe, reproducible, and can be employed to longitudinally evaluate the effect of anti-osteoporosis therapeutics and surgical interventions.</p></sec>

scholarly journals Three-Dimensional Characterization of Trabecular Bone Mineral Density of the Distal Radius Utilizing Quantitative Computed Tomography

Hand ◽  
2018 ◽  
Vol 15 (1) ◽  
pp. 131-139 ◽  
Author(s):  
Tyler S. Pidgeon ◽  
Katia A. DaSilva ◽  
Joseph J. Crisco ◽  
Eric C. Johnson ◽  
Alison B. Chambers ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bone Mineral Density ◽  
Trabecular Bone ◽  
Distal Radius ◽  
Bone Mineral ◽  
Quantitative Computed Tomography ◽  
Three Dimensional ◽  
Mineral Density ◽  
Quantitative Ct ◽  
Trabecular Bone Mineral Density

Background: Distal radius (DR) fractures demonstrate patterns of predictable fragments. Bone mineral density (BMD) measurements of these regions of interest (ROIs) may guide more precise treatment. Methods: Computed tomography (CT) scans of the DR of 42 healthy volunteers (23 female) were analyzed using quantitative CT software, measuring BMD within trabecular bone. Seven ROIs were described by alignment with the distal (volar ulnar distal [VUD], dorsal ulnar distal [DUD], volar radial distal [VRD], and dorsal radial distal [DRD]) or proximal (middle ulnar proximal [MUP], middle proximal [MP], and middle radial proximal [MRP]) sigmoid notch. Additional ROIs were the radial styloid (RS) and metadiaphysis (MD). A general estimation equation assessed subject’s BMDs with predictive factors of gender, ROI, and age. The interaction between gender, ROI, and age was included in the model to allow for differences in ROI to vary with gender and/or age. Results: Comparing ROIs within the same gender and, separately, within the same age group revealed significantly higher BMD adjacent to the radioulnar and radiocarpal joints. Male and female individuals aged ≥50 years (mean: 172.7 mg/cm3 ± 6.1) had significantly lower BMD than those aged <50 years (mean: 202.7 mg/cm3 ± 5.8) when all ROIs were considered. Males had higher mean BMD at each ROI compared with females; these differences were significant in 5 of the 9 ROIs: VUD, DUD, DRD, RS, MUP. Conclusions: Trabecular BMD of the DR is highest adjacent to the radioulnar and radiocarpal joints. Female patients and those ≥50 years have lower trabecular BMD.

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