scholarly journals Screening for Gestational Diabetes Mellitus in Early Pregnancy: What Is the Evidence?

2021 ◽  
Vol 10 (6) ◽  
pp. 1257
Author(s):  
Lore Raets ◽  
Kaat Beunen ◽  
Katrien Benhalima
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Early Pregnancy ◽  
Observational Studies ◽  
Screening Strategy ◽  
Current Evidence ◽  
Adverse Pregnancy ◽  
Low Sensitivity ◽  
In Pregnancy

The incidence of gestational diabetes mellitus (GDM) is increasing worldwide. This has a significant effect on the health of the mother and offspring. There is no doubt that screening for GDM between 24 and 28 weeks is important to reduce the risk of adverse pregnancy outcomes. However, there is no consensus about diagnosis and treatment of GDM in early pregnancy. In this narrative review on the current evidence on screening for GDM in early pregnancy, we included 37 cohort studies and eight randomized controlled trials (RCTs). Observational studies have shown that a high proportion (15–70%) of women with GDM can be detected early in pregnancy depending on the setting, criteria used and screening strategy. Data from observational studies on the potential benefit of screening and treatment of GDM in early pregnancy show conflicting results. In addition, there is substantial heterogeneity in age and BMI across the different study populations. Smaller RCTs could not show benefit but several large RCTs are ongoing. RCTs are also necessary to determine the appropriate cut-off for HbA1c in pregnancy as there is limited evidence showing that an HbA1c ≥6.5% has a low sensitivity to detect overt diabetes in early pregnancy.

scholarly journals Excessive Early Pregnancy Weight Gain and Risk of Gestational Diabetes Mellitus

2016 ◽  
Vol 8 (3) ◽  
pp. 189-192
Author(s):  
K Vasantha ◽  
Maya Menon
Keyword(s):  
Diabetes Mellitus ◽  
Weight Gain ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Early Pregnancy ◽  
Pregnancy Weight Gain ◽  
Excessive Weight Gain ◽  
Excessive Weight ◽  
Pregnancy Weight ◽  
In Pregnancy

ABSTRACT Objectives To study the association between excessive early pregnancy weight gain and risk of gestational diabetes mellitus (GDM). Materials and methods Study design-prospective observational study done at ESIC Medical College & PGIMSR, Chennai during the period November 2013 to May 2015. A total of 250 women who attended antenatal outpatient department at ESI Hospital Chennai were recruited for the study. Height and weight of the pregnant women was recorded during their first visit (up to 6 weeks) and at 14 weeks of gestation. Body mass index (BMI) was calculated according to Quetelet index. Waist hip ratio was measured at 6 weeks. The early gestation weight gain more than 2 kg was considered as excessive weight gain and was associated to the risk of developing GDM. Blood sugar was estimated using Diabetes in Pregnancy Study Group Index (DIPSI) standards. Results Of the 250 women studied, 104 women developed GDM. Excessive weight gain in the 1st trimester of pregnancy was significantly associated with the development of GDM with a p-value of 0.000. The other risk factors studied were BMI (p = 0.0064), waist/hip ratio (p = 0.0015), family history of diabetes mellitus (DM) (p = 0.00), which also had a significant association. Clinical significance This study shows that excessive weight gain in 1st trimester had an increased risk of GDM. The benefit of early identification of excess gestational weight gain would be the opportunity for intervention early in pregnancy to ideally decrease GDM. Conclusion Excessive early pregnancy weight gain, primarily in the 1st trimester may increase the risk of developing GDM. Thus, preventing excessive early pregnancy weight gain in the 1st trimester can be modified by lifestyle changes and simple exercise, which is a costless intervention, and can also decrease maternal and neonatal morbidity effectively. How to cite this article Menon M, Vasantha K. Excessive Early Pregnancy Weight Gain and Risk of Gestational Diabetes Mellitus. J South Asian Feder Obst Gynae 2016;8(3):189-192.

scholarly journals Modern approaches to the diagnosis of gestational diabetes mellitus

2020 ◽  
Vol 7 (1) ◽  
pp. 31-36
Author(s):  
A. O. Torosyan ◽  
Ch. G. Gagayev ◽  
V. E. Radzinskiy
Keyword(s):  
Diabetes Mellitus ◽  
High Risk ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Early Pregnancy ◽  
Pregnancy Outcomes ◽  
Adverse Outcomes ◽  
Screening Methods ◽  
Special Group ◽  
In Pregnancy

In a review there is provided information on modern approaches to the diagnosis of gestational diabetes mellitus. The use of various markers and screening methods and their role in pregnancy outcomes for the mother and fetus according to gestation of diagnosis are examined. The data obtained demonstrate that gestational diabetes, detected in early pregnancy, represents a special group of high risk of adverse outcomes and requires focused approaches in management.

IGFs and IGF-Binding Proteins in Pregnancy and Gestational Diabetes Mellitus

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1412-P
Author(s):  
KATEřINA ANDERLOVÁ ◽  
PATRIK SIMJAK ◽  
ANNA CINKAJZLOVA ◽  
JANA KLOUCKOVA ◽  
HELENA KRATOCHVILOVA ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Binding Proteins ◽  
Igf Binding Proteins ◽  
Igf Binding ◽  
In Pregnancy
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