scholarly journals Exhaled Breath Condensate—A Non-Invasive Approach for Diagnostic Methods in Asthma

2021 ◽  
Vol 10 (12) ◽  
pp. 2697
Author(s):  
Joanna Połomska ◽  
Kamil Bar ◽  
Barbara Sozańska
Keyword(s):  
Airway Inflammation ◽  
Exhaled Breath Condensate ◽  
Clinical Manifestations ◽  
Diagnostic Methods ◽  
Diagnostic Tools ◽  
Exhaled Breath ◽  
Invasive Approach ◽  
Non Invasive ◽  
Airway Tone ◽  
Breath Condensate

The pathophysiology of asthma has been intensively studied, but its underlying mechanisms such as airway inflammation, control of airway tone, and bronchial reactivity are still not completely explained. There is an urgent need to implement novel, non-invasive diagnostic tools that can help to investigate local airway inflammation and connect the molecular pathways with the broad spectrum of clinical manifestations of asthma. The new biomarkers of different asthma endotypes could be used to confirm diagnosis, predict asthma exacerbations, or evaluate treatment response. In this paper, we briefly describe the characteristics of exhaled breath condensate (EBC) that is considered to be an interesting source of biomarkers of lung disorders. We look at the composition of EBC, some aspects of the collection procedure, the proposed biomarkers for asthma, and its clinical implications. We also indicate the limitations of the method and potential strategies to standardize the procedure of EBC collection and analytical methods.

scholarly journals Non-Invasive Infections Diagnosis in Lung Transplant Recipients in Exhaled Breath Condensate

2021 ◽  
Vol 40 (4) ◽  
pp. S63
Author(s):  
E. Ibáñez-Martínez ◽  
M. López-Nogueroles ◽  
M. Alcoriza-Balaguer ◽  
I. Pérez ◽  
M. Roca-Marugán ◽  
...  
Keyword(s):  
Lung Transplant ◽  
Exhaled Breath Condensate ◽  
Exhaled Breath ◽  
Transplant Recipients ◽  
Non Invasive ◽  
Invasive Infections ◽  
Lung Transplant Recipients ◽  
Breath Condensate

scholarly journals Exhaled Breath Condensate pH as a Non-invasive Measure of Inflammation in Non-CF Bronchiectasis

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
A. Shoemark ◽  
R. Wilson
Keyword(s):  
Repeated Measures ◽  
Ex Vivo ◽  
Exhaled Breath Condensate ◽  
Exhaled Breath ◽  
Noninvasive Test ◽  
Need For Treatment ◽  
Non Invasive ◽  
Bronchial Inflammation ◽  
Breath Condensate ◽  
Ciliary Dyskinesia

Bronchiectasis is characterised by neutrophilic bronchial inflammation. Direct measurement of lung inflammation would be useful to assess disease activity, guide need for treatment, and monitor response. The aim of this study was to test whether exhaled breath condensate (EBC) pH, a simple noninvasive test, provides a clinically useful measure of inflammation in the lungs of patients with bronchiectasis. 96 consecutively referred patients were studied when clinically stable, 20 followed up over two years, and a further 22 patients seen during an exacerbation. Subjects breathed tidally for 10 minutes into a condensing chamber (Ecoscreen, Erich Jaeger, Hoechberg, Germany). pH in EBC was measured immediately using a pH probe. In a representative group of 25 patients samples were deaerated with argon gas. This was to control for variations in pH ex vivo by removing CO2. EBC was acidic in bronchiectasis patients () compared to controls () and primary ciliary dyskinesia patients (). pH was related to lung volume but not disease severity. Repeated measures show EBC pH changes with symptoms. EBC is further acidified during an exacerbation of bronchiectasis (), this acidification persists following treatment (). EBC pH is not sufficiently sensitive or specific to monitor patients' health status or provide information to inform acute treatment decisions.

Non-invasive collection of exhaled breath condensate in rats: Evaluation of pH, H2O2 and NOx in lipopolysaccharide-induced acute lung injury

2012 ◽  
Vol 194 (2) ◽  
pp. 222-228 ◽  
Author(s):  
Virginie de Broucker ◽  
Sidi Mohamed Hassoun ◽  
Sébastien Hulo ◽  
Nathalie Chérot-Kornobis ◽  
Rémi Nevière ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Exhaled Breath Condensate ◽  
Exhaled Breath ◽  
Non Invasive ◽  
Breath Condensate

scholarly journals Nitric Oxide and Biological Mediators in Pediatric Chronic Rhinosinusitis and Asthma

2019 ◽  
Vol 8 (11) ◽  
pp. 1783 ◽  
Author(s):  
Valentina Agnese Ferraro ◽  
Stefania Zanconato ◽  
Eugenio Baraldi ◽  
Silvia Carraro
Keyword(s):  
Nitric Oxide ◽  
Chronic Rhinosinusitis ◽  
Exhaled Breath Condensate ◽  
Main Body ◽  
Exhaled Breath ◽  
Non Invasive ◽  
Volatile Organic ◽  
Exhaled Air ◽  
Breath Condensate

Background: In the context of the so-called unified airway theory, chronic rhinosinusitis (CRS) and asthma may coexist. The inflammation underlying these conditions can be studied through the aid of biomarkers. Main body: We described the main biological mediators that have been studied in pediatric CRS and asthma, and, according to the available literature, we reported their potential role in the diagnosis and management of these conditions. As for CRS, we discussed the studies that investigated nasal nitric oxide (nNO), pendrin, and periostin. As for asthma, we discussed the role of fractional exhaled nitric oxide (feNO), the role of periostin, and that of biological mediators measured in exhaled breath condensate (EBC) and exhaled air (volatile organic compounds, VOCs). Conclusion: Among non-invasive biomarkers, nNO seems the most informative in CRS and feNO in asthma. Other biological mediators seem promising, but further studies are needed before they can be applied in clinical practice.

Using the exhaled breath condensate as a tool for non-invasive evaluation of pollutant exposure

2010 ◽  
Vol 4 (2/3) ◽  
pp. 293 ◽  
Author(s):  
S. Marta Almeida ◽  
Pedro M. Felix ◽  
Cristiana Franco ◽  
Maria Do Carmo Freitas ◽  
Luis Cerqueira Alves ◽  
...  
Keyword(s):  
Exhaled Breath Condensate ◽  
Exhaled Breath ◽  
Non Invasive ◽  
Breath Condensate ◽  
Invasive Evaluation
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