scholarly journals Association of Serum Bilirubin Level with Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study of 1672 Obese Children

2021 ◽  
Vol 10 (13) ◽  
pp. 2812
Author(s):  
Cristina Bellarosa ◽  
Giorgio Bedogni ◽  
Annalisa Bianco ◽  
Sabrina Cicolini ◽  
Diana Caroli ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Serum Bilirubin ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Obese Children ◽  
Cross Sectional ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

As in adults, obesity also plays a central role in the development of metabolic syndrome (MS) in children. Non-alcoholic fatty liver disease (NAFLD) is considered a manifestation of MS. Not only MS but also NAFLD seem to be inversely associated with serum bilirubin concentrations, an important endogenous tissue protector when only mild elevated. The aim of the study was to evaluate the association between serum bilirubin levels and the prevalence of MS and NAFLD in Italian obese children and adolescents. A retrospective cross-sectional study was performed in 1672 patients aged from 5 to 18 years. Clinical and laboratory parameters were assessed. NAFLD was measured by liver ultrasonography. The study was approved by the Ethical Committee of the Istituto Auxologico Italiano (research project code 1C021_2020, acronym BILOB). MS was present in 24% and fatty liver (FL) in 38% of this population. Bilirubin was not associated with FL and MS as a whole, but it was inversely associated only with selected components of MS, i.e., large WC, high blood pressure and high triglycerides. Our data suggest that bilirubin is not protective against MS and NAFLD in the presence of severe obesity.

scholarly journals Association of serum methionine metabolites with non-alcoholic fatty liver disease: a cross-sectional study

2021 ◽  
Author(s):  
Yi Tang ◽  
Xu Chen ◽  
Qian Chen ◽  
Jinghe Xiao ◽  
Jiaxin Mi ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Elevated Serum ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Abstract Background Non-alcoholic fatty liver disease (NAFLD) is viewed as the hepatic manifestation of metabolic syndrome. Methionine metabolites have been linked to metabolic syndrome and its related diseases. Whether methionine metabolites levels are associated with NAFLD remains unclear. The study aimed to assess the association between methionine metabolites and NAFLD. Methods This cross-sectional study included a total of 2814 individuals aged 40–75 years old. All participants underwent anthropometric measurements, laboratory tests and abdominal ultrasonography. Multivariable logistic regression analysis was performed to estimate the association of methionine metabolites with NAFLD. Results Overall, 1446 with and 1368 without NAFLD were enrolled in this study. Participants with NAFLD had significantly higher serum S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH) and homocysteine (Hcy) levels, and a lower S-adenosylmethionine/S-adenosylhomocysteine (SAM/SAH) ratio than those without NAFLD (all P < 0.001). After adjusting multiple confounders, odds ratios (ORs) (95% confidence interval [CI]) for quartile 4 vs quartile 1 of SAH, Hcy and SAM/SAH ratio were 1.65 (1.27–2.14), 1.63 (1.26–2.12) and 0.63 (0.49–0.83), respectively (all P for trend < 0.01). In addition, serum SAH, Hcy levels and SAM/SAH ratio were significantly correlated with degree of hepatic steatosis (all P for trend < 0.001). Conclusion Elevated serum SAH, Hcy levels and lower SAM/SAH ratio were independently associated with the presence of NAFLD in middle-aged and elder Chinese.

scholarly journals OC49 Non-alcoholic fatty liver disease in obese and overweight iranian children: a cross sectional study

2019 ◽  
Author(s):  
Farzad Maleki ◽  
Marjan Hosseinpour ◽  
Bahman Mansouri motlagh ◽  
Hadi Esmaeili Gouvarchin Ghaleh ◽  
Shahsanam Gheibi
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Alcoholic Fatty Liver ◽  
Iranian Children ◽  
Alcoholic Fatty Liver Disease

scholarly journals Low Urine pH Is Associated with Non-alcoholic Fatty Liver Disease: A Community-based Cross-sectional Study

2018 ◽  
Vol 57 (19) ◽  
pp. 2799-2805 ◽  
Author(s):  
Teruki Miyake ◽  
Sakiko Yoshida ◽  
Shin Yamamoto ◽  
Shinya Furukawa ◽  
Osamu Yoshida ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Urine Ph ◽  
Community Based ◽  
Cross Sectional ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

scholarly journals How is silent ‘non-alcoholic fatty liver disease’ epidemic perceived in India? A community based cross sectional study

2019 ◽  
Vol 6 (12) ◽  
pp. 5256
Author(s):  
Anurag Lavekar ◽  
Pradeep Tarikere Satyanarayana ◽  
Anagha Lavekar
Keyword(s):  
Liver Disease ◽  
General Population ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Community Based ◽  
Cross Sectional ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Background: One of the diseases assuming fast importance is non-alcoholic fatty liver disease (NAFLD) which is a clinical syndrome characterized by predominant macrovesicular steatosis of the liver which is an umbrella term for a range of liver conditions affecting people who drink little or no alcohol. Only mild to moderate elevation of serum transaminases which could be only laboratory abnormality found in NAFLD. So with this background, the study was started with the objectives of assessing the perceptions of general population regarding NAFLD and factors influencing perceptions of general population regarding NAFLD.Methods: It was a community based cross sectional study carried out for a period of 12 months from January 2018 to December 2018 among in Nanded, Maharashtra. Around 422 households were involved after simple random sampling. To assess perceptions a pretested semi-structured questionnaire was used which had 27 questions. All data collected was entered in Microsoft excel and analysed using SPSS v22.Results: Out of 422 participants, 147 (34.8%) were in the age group of 31-40 years, 333 (78.9%) were male participants, 179 (42.5%) were graduates, 284 (67.3%) belonged to joint family, 140 (33.2%) belonged to Modified BG Prasad classification 2018. 181 (42.9%) had satisfactory perception regarding NAFLD. Females, participants aged more than 40 years, nuclear family participants had better scores.Conclusions: The present study showed majority of the participants had little awareness of NAFLD regardless of their age, gender, or educational status. Awareness of NAFLD must be promoted for prevention, early detection, and treatment especially counseling by primary care physicians preponderant influence in preventive strategy for NAFLD breaking the chain of disease progression.

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