Clinical Usefulness of FRAX Score for Predicting Sarcopenia in Patients with Chronic Liver Disease

We investigated the usefulness of the Fracture Risk Assessment tool (FRAX) for predicting sarcopenia in chronic liver disease (CLD). In this cross-sectional study, we evaluated 321 patients with CLD. The FRAX with and without bone mineral density (BMD) was employed to calculate the 10-year risks of major osteoporotic and hip fractures. The FRAX score for high fracture risk was defined as a 10-year major osteoporotic fracture probability of ≥20% or a 10-year hip fracture probability of ≥3%. The diagnosis of sarcopenia was based on the Japan Society of Hepatology criteria. According to the FRAX, with and without BMD, 134 (41.7%) and 193 (60.1%) patients had a high fracture risk, respectively. The high fracture risk group had a significantly higher frequency of sarcopenia than the non-high fracture risk group. FRAX scores of major osteoporotic and hip fractures were negatively correlated with handgrip strength and muscle mass. Using the FRAX with BMD, the cutoff scores of major osteoporotic and hip fractures for predicting sarcopenia were 8.55% (sensitivity/specificity, 0.847/0.568) and 3.35% (0.729/0.746), respectively. Using the FRAX without BMD, they were 18.5% (0.635/0.725) and 7.65% (0.729/0.758), respectively. The FRAX is a simple and convenient screening tool for predicting sarcopenia in patients with CLD.

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Mo1509 – Nonalcoholic Fatty Liver Disease is Associated with Lower Risk of Hip Fractures When Compared to No Chronic Liver Disease Controls: An Analysis of the 2014 National Inpatient Sample

Gastroenterology ◽

10.1016/s0016-5085(19)38880-8 ◽

2019 ◽

Vol 156 (6) ◽

pp. S-772

Author(s):

Grishma Hirode ◽

Benny Liu ◽

Taft Bhuket ◽

Robert J. Wong

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Chronic Liver Disease ◽

Hip Fractures ◽

Fatty Liver Disease ◽

Lower Risk ◽

Chronic Liver ◽

National Inpatient Sample ◽

Nonalcoholic Fatty Liver

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A cross-sectional study of chronic liver disease patients complicating to hepatic osteodystrophy

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20202121 ◽

2020 ◽

Vol 7 (6) ◽

pp. 1013

Author(s):

Mohammed Jaleel P. ◽

S. Bhagyabati Devi ◽

Ningthoukhongjam Reema ◽

Thangjam Gautam Singh ◽

Dhileeban Maharajan P.

Keyword(s):

Liver Disease ◽

Chronic Liver Disease ◽

Cross Sectional Study ◽

Bone Diseases ◽

Chronic Liver ◽

Sectional Study ◽

Mineral Density ◽

Cross Sectional ◽

Metabolic Bone Diseases ◽

Hepatic Osteodystrophy

Background: Hepatic osteodystrophy encompasses the spectrum of metabolic bone diseases in chronic liver disease (CLD) patients. CLD causing changes in BMD is well known. Although BMD evaluation in CLD cirrhosis are recommended by societies of British and American gastroenterology ,very less number of literature exist from India and none from the North-eastern region of India. Aim of the study to determine the association and severity of bone mineral density changes in patients with CLD and to correlate it with different aetiologies and severity of CLD.Methods: This cross-sectional study which included 79 patients with CLD was conducted in RIMS, Manipur from September 2017 to August 2019. All CLD patients of age 18-60 years were included. DEXA scan and other related blood investigations were performed.Results: Chronic alcohol intake (56.9%), viral infection (20.3%) and mixed (17.7%) were the main aetiology of CLD in our study. Seventy three (92.4%) of the total 79 patients had low BMD (Osteopenia in 29 (36.7%) and osteoporosis in 44 (55.7%) patients). Osteoporosis was detected in 53.4% of alcohol related Cirrhosis, 25%of viral liver disease. Majority of the severe CLD patients (Child class C) had osteoporosis (70.6%) as compared to less severe groups (23.5% and 36.4% in class B and A respectively).Conclusions: CLD patients have high prevalence of osteoporosis. Severity of liver disease, alcoholic liver disease, serum calcium and vitamin D deficiency predisposes to osteoporosis in these patients. Hence early screening of BMD is necessary in CLD patients.

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